LOCUS       NM_032360               1293 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens acyl-CoA binding domain containing 6 (ACBD6), mRNA.
ACCESSION   NM_032360
VERSION     NM_032360.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1293)
  AUTHORS   Kaiyrzhanov,R., Rad,A., Lin,S.J., Bertoli-Avella,A.,
            Kallemeijn,W.W., Godwin,A., Zaki,M.S., Huang,K., Lau,T., Petree,C.,
            Efthymiou,S., Karimiani,E.G., Hempel,M., Normand,E.A.,
            Rudnik-Schoneborn,S., Schatz,U.A., Baggelaar,M.P., Ilyas,M.,
            Sultan,T., Alvi,J.R., Ganieva,M., Fowler,B., Aanicai,R.,
            Tayfun,G.A., Al Saman,A., Alswaid,A., Amiri,N., Asilova,N.,
            Shotelersuk,V., Yeetong,P., Azam,M., Babaei,M., Monajemi,G.B.,
            Mohammadi,P., Samie,S., Banu,S.H., Pinto Basto,J., Kortum,F.,
            Bauer,M., Bauer,P., Beetz,C., Garshasbi,M., Issa,A.H., Eyaid,W.,
            Ahmed,H., Hashemi,N., Hassanpour,K., Herman,I., Ibrohimov,S.,
            Abdul-Majeed,B.A., Imdad,M., Isrofilov,M., Kaiyal,Q., Khan,S.,
            Kirmse,B., Koster,J., Lourenco,C.M., Mitani,T., Moldovan,O.,
            Murphy,D., Najafi,M., Pehlivan,D., Rocha,M.E., Salpietro,V.,
            Schmidts,M., Shalata,A., Mahroum,M., Talbeya,J.K., Taylor,R.W.,
            Vazquez,D., Vetro,A., Waterham,H.R., Zaman,M., Schrader,T.A.,
            Chung,W.K., Guerrini,R., Lupski,J.R., Gleeson,J., Suri,M.,
            Jamshidi,Y., Bhatia,K.P., Vona,B., Schrader,M., Severino,M.,
            Guille,M., Tate,E.W., Varshney,G.K., Houlden,H. and Maroofian,R.
  TITLE     Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome
            with progressive and complex movement disorders
  JOURNAL   Brain 147 (4), 1436-1456 (2024)
   PUBMED   37951597
  REMARK    GeneRIF: Bi-allelic ACBD6 variants lead to a neurodevelopmental
            syndrome with progressive and complex movement disorders.
REFERENCE   2  (bases 1 to 1293)
  AUTHORS   Soupene,E. and Kuypers,F.A.
  TITLE     Dual Role of ACBD6 in the Acylation Remodeling of Lipids and
            Proteins
  JOURNAL   Biomolecules 12 (12), 1726 (2022)
   PUBMED   36551154
  REMARK    GeneRIF: Dual Role of ACBD6 in the Acylation Remodeling of Lipids
            and Proteins.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1293)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1293)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 1293)
  AUTHORS   Soupene,E., Schatz,U.A., Rudnik-Schoneborn,S. and Kuypers,F.A.
  TITLE     Requirement of the acyl-CoA carrier ACBD6 in myristoylation of
            proteins: Activation by ligand binding and protein interaction
  JOURNAL   PLoS One 15 (2), e0229718 (2020)
   PUBMED   32108178
  REMARK    GeneRIF: The acyl-CoA binding domain (ACB) and the ankyrin-repeat
            motifs (ANK) of ACBD6 can perform their functions independently.
            Interaction of ANK with NMT2 was necessary and sufficient to
            provide protection.
            Erratum:[PLoS One. 2022 Apr 21;17(4):e0267678. doi:
            10.1371/journal.pone.0267678.. PMID: 35446914]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1293)
  AUTHORS   Soupene,E. and Kuypers,F.A.
  TITLE     ACBD6 protein controls acyl chain availability and specificity of
            the N-myristoylation modification of proteins
  JOURNAL   J Lipid Res 60 (3), 624-635 (2019)
   PUBMED   30642881
  REMARK    GeneRIF: ACBD6 proteins promote N-myristoylation in mammalian cells
REFERENCE   7  (bases 1 to 1293)
  AUTHORS   Dong,L., Li,H., Zhang,S. and Su,L.
  TITLE     Identification of genes related to consecutive trauma-induced
            sepsis via gene expression profiling analysis
  JOURNAL   Medicine (Baltimore) 97 (15), e0362 (2018)
   PUBMED   29642183
  REMARK    GeneRIF: ACBD6 gene, related to acyl-CoA binding, might play
            momentous roles in the initiation and development of consecutive
            Trauma-Induced Sepsis.
REFERENCE   8  (bases 1 to 1293)
  AUTHORS   Soupene,E., Kao,J., Cheng,D.H., Wang,D., Greninger,A.L.,
            Knudsen,G.M., DeRisi,J.L. and Kuypers,F.A.
  TITLE     Association of NMT2 with the acyl-CoA carrier ACBD6 protects the
            N-myristoyltransferase reaction from palmitoyl-CoA
  JOURNAL   J Lipid Res 57 (2), 288-298 (2016)
   PUBMED   26621918
  REMARK    GeneRIF: ligand binding properties of the NMT/ACBD6 complex can
            explain how the NMT reaction can proceed in the presence of the
            very abundant competitive substrate, C(16)-CoA.
REFERENCE   9  (bases 1 to 1293)
  AUTHORS   Soupene,E. and Kuypers,F.A.
  TITLE     Ligand binding to the ACBD6 protein regulates the acyl-CoA
            transferase reactions in membranes
  JOURNAL   J Lipid Res 56 (10), 1961-1971 (2015)
   PUBMED   26290611
  REMARK    GeneRIF: Findings provide evidence that the binding properties of
            ACBD6 are adapted to prevent its constant saturation by the very
            abundant C16:0-CoA and protect membrane systems.
REFERENCE   10 (bases 1 to 1293)
  AUTHORS   Soupene,E., Serikov,V. and Kuypers,F.A.
  TITLE     Characterization of an acyl-coenzyme A binding protein
            predominantly expressed in human primitive progenitor cells
  JOURNAL   J Lipid Res 49 (5), 1103-1112 (2008)
   PUBMED   18268358
  REMARK    GeneRIF: ACBD6 is a modular protein that carries an acyl-CoA
            binding domain at its N terminus and two ankyrin motifs at its C
            terminus.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU170874.1, AK314112.1 and AA085012.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032360.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC006505.2, AK314112.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367595.4/ ENSP00000356567.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-222               BU170874.1         239-460
            223-962             AK314112.1         508-1247
            963-1293            AA085012.1         15-345              c
FEATURES             Location/Qualifiers
     source          1..1293
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2-q25.3"
     gene            1..1293
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /note="acyl-CoA binding domain containing 6"
                     /db_xref="GeneID:84320"
                     /db_xref="HGNC:HGNC:23339"
                     /db_xref="MIM:616352"
     exon            1..533
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     CDS             312..1160
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /note="acyl-Coenzyme A binding domain containing 6"
                     /codon_start=1
                     /product="acyl-CoA-binding domain-containing protein 6"
                     /protein_id="NP_115736.1"
                     /db_xref="CCDS:CCDS1339.1"
                     /db_xref="GeneID:84320"
                     /db_xref="HGNC:HGNC:23339"
                     /db_xref="MIM:616352"
                     /translation="MASSFLPAGAITGDSGGELSSGDDSGEVEFPHSPEIEETSCLAE
                     LFEKAAAHLQGLIQVASREQLLYLYARYKQVKVGNCNTPKPSFFDFEGKQKWEAWKAL
                     GDSSPSQAMQEYIAVVKKLDPGWNPQIPEKKGKEANTGFGGPVISSLYHEETIREEDK
                     NIFDYCRENNIDHITKAIKSKNVDVNVKDEEGRALLHWACDRGHKELVTVLLQHRADI
                     NCQDNEGQTALHYASACEFLDIVELLLQSGADPTLRDQDGCLPEEVTGCKTVSLVLQR
                     HTTGKA"
     exon            534..598
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     exon            599..695
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     exon            696..778
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     exon            779..884
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     exon            885..974
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     exon            975..1005
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1293
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1267..1272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /note="hexamer: AATAAA"
     polyA_site      1293
                     /gene="ACBD6"
                     /gene_synonym="NEDPM"
                     /note="major polyA site"
ORIGIN      
        1 actgcccctc gactcctgtt ccgttggagg ggcctgaggc gagcctgagc gcgctgttgg
       61 ccggagggaa gccggaggag accgggtcga ctgggcagag cggcagaggg tcgaggagcc
      121 tgctctgcac gcccagggag tagaagtggg cagggagcag ggtcacgtga gggagcgcgc
      181 cgcgactgag cttgggtccg actggagctc aggctcgcga cccagactgg tgggccaggc
      241 ctccaagccg gccttacacc caatccaagg aggacagacc ggacacagag ggacggagcg
      301 agcaaggaga catggcttca tcattcctgc ccgcgggggc catcaccggc gacagcggtg
      361 gagagctgag ctcaggggac gactccgggg aggtggagtt cccccatagc cctgagatcg
      421 aggagaccag ttgcctggcc gagctgtttg agaaggctgc cgcgcacctg caaggcctga
      481 ttcaggtggc cagcagggag cagctcttgt acctgtatgc caggtacaaa caggtcaaag
      541 ttggaaattg taatactcct aaaccaagct tctttgattt tgaaggaaag caaaaatggg
      601 aagcttggaa agcacttggt gattcaagcc ccagccaagc aatgcaggaa tatatcgcag
      661 tagttaaaaa actagatcca ggttggaatc ctcagatacc agagaagaaa ggaaaagaag
      721 caaatacagg ttttggtggg ccagttatta gttctctata tcatgaagaa accatcaggg
      781 aagaagacaa aaatatattt gattactgca gggaaaacaa cattgaccat ataaccaaag
      841 ccatcaaatc gaaaaatgtg gatgtgaatg tgaaagatga agagggtagg gctctacttc
      901 actgggcctg tgatcgagga cataaggaac tagtcacagt gttgctgcaa catagagctg
      961 acattaactg tcaggacaat gaaggccaaa cagctctaca ttatgcctct gcctgtgagt
     1021 ttctggatat tgtagagctg ctgctccagt ctggtgctga ccccactctc cgagaccagg
     1081 atggctgcct gccagaggag gtgacaggct gcaaaacagt ttctttggtg ctgcagcggc
     1141 acacaactgg caaggcttaa tcaaaagact ggaaaactgc agtctgtaat agcataaggc
     1201 ttccattatg aaagaaaact acaaaaataa tacttctttt ccacccgtct ttggtatgta
     1261 ttggctaata aaatcagttc tgtggaactg gga
//
