LOCUS       NM_001135705            1827 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens acyl-CoA binding domain containing 4 (ACBD4),
            transcript variant 4, mRNA.
ACCESSION   NM_001135705
VERSION     NM_001135705.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1827)
  AUTHORS   Costello,J.L., Koster,J., Silva,B.S.C., Worthy,H.L., Schrader,T.A.,
            Hacker,C., Passmore,J., Kuypers,F.A., Waterham,H.R. and Schrader,M.
  TITLE     Differential roles for ACBD4 and ACBD5 in peroxisome-ER
            interactions and lipid metabolism
  JOURNAL   J Biol Chem 299 (8), 105013 (2023)
   PUBMED   37414147
  REMARK    GeneRIF: Differential roles for ACBD4 and ACBD5 in peroxisome-ER
            interactions and lipid metabolism.
REFERENCE   2  (bases 1 to 1827)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 1827)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1827)
  AUTHORS   Costello,J.L., Castro,I.G., Schrader,T.A., Islinger,M. and
            Schrader,M.
  TITLE     Peroxisomal ACBD4 interacts with VAPB and promotes ER-peroxisome
            associations
  JOURNAL   Cell Cycle 16 (11), 1039-1045 (2017)
   PUBMED   28463579
  REMARK    GeneRIF: acyl-CoA binding domain protein 4 (ACBD4) as a
            tail-anchored peroxisomal membrane protein which interacts with the
            endoplasmic reticulum (ER) protein, vesicle-associated membrane
            protein-associated protein-B (VAPB) to promote peroxisome-ER
            associations.
REFERENCE   5  (bases 1 to 1827)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   6  (bases 1 to 1827)
  AUTHORS   Benjamin,D.J., Cesarini,D., van der Loos,M.J., Dawes,C.T.,
            Koellinger,P.D., Magnusson,P.K., Chabris,C.F., Conley,D.,
            Laibson,D., Johannesson,M. and Visscher,P.M.
  TITLE     The genetic architecture of economic and political preferences
  JOURNAL   Proc Natl Acad Sci U S A 109 (21), 8026-8031 (2012)
   PUBMED   22566634
REFERENCE   7  (bases 1 to 1827)
  AUTHORS   Ho,J.E., Levy,D., Rose,L., Johnson,A.D., Ridker,P.M. and
            Chasman,D.I.
  TITLE     Discovery and replication of novel blood pressure genetic loci in
            the Women's Genome Health Study
  JOURNAL   J Hypertens 29 (1), 62-69 (2011)
   PUBMED   21045733
  REMARK    GeneRIF: Observational study and meta-analysis of gene-disease
            association. (HuGE Navigator)
REFERENCE   8  (bases 1 to 1827)
  AUTHORS   Lango Allen,H., Estrada,K., Lettre,G., Berndt,S.I., Weedon,M.N.,
            Rivadeneira,F., Willer,C.J., Jackson,A.U., Vedantam,S.,
            Raychaudhuri,S., Ferreira,T., Wood,A.R., Weyant,R.J., Segre,A.V.,
            Speliotes,E.K., Wheeler,E., Soranzo,N., Park,J.H., Yang,J.,
            Gudbjartsson,D., Heard-Costa,N.L., Randall,J.C., Qi,L., Vernon
            Smith,A., Magi,R., Pastinen,T., Liang,L., Heid,I.M., Luan,J.,
            Thorleifsson,G., Winkler,T.W., Goddard,M.E., Sin Lo,K., Palmer,C.,
            Workalemahu,T., Aulchenko,Y.S., Johansson,A., Zillikens,M.C.,
            Feitosa,M.F., Esko,T., Johnson,T., Ketkar,S., Kraft,P., Mangino,M.,
            Prokopenko,I., Absher,D., Albrecht,E., Ernst,F., Glazer,N.L.,
            Hayward,C., Hottenga,J.J., Jacobs,K.B., Knowles,J.W., Kutalik,Z.,
            Monda,K.L., Polasek,O., Preuss,M., Rayner,N.W., Robertson,N.R.,
            Steinthorsdottir,V., Tyrer,J.P., Voight,B.F., Wiklund,F., Xu,J.,
            Zhao,J.H., Nyholt,D.R., Pellikka,N., Perola,M., Perry,J.R.,
            Surakka,I., Tammesoo,M.L., Altmaier,E.L., Amin,N., Aspelund,T.,
            Bhangale,T., Boucher,G., Chasman,D.I., Chen,C., Coin,L.,
            Cooper,M.N., Dixon,A.L., Gibson,Q., Grundberg,E., Hao,K., Juhani
            Junttila,M., Kaplan,L.M., Kettunen,J., Konig,I.R., Kwan,T.,
            Lawrence,R.W., Levinson,D.F., Lorentzon,M., McKnight,B.,
            Morris,A.P., Muller,M., Suh Ngwa,J., Purcell,S., Rafelt,S.,
            Salem,R.M., Salvi,E., Sanna,S., Shi,J., Sovio,U., Thompson,J.R.,
            Turchin,M.C., Vandenput,L., Verlaan,D.J., Vitart,V., White,C.C.,
            Ziegler,A., Almgren,P., Balmforth,A.J., Campbell,H., Citterio,L.,
            De Grandi,A., Dominiczak,A., Duan,J., Elliott,P., Elosua,R.,
            Eriksson,J.G., Freimer,N.B., Geus,E.J., Glorioso,N., Haiqing,S.,
            Hartikainen,A.L., Havulinna,A.S., Hicks,A.A., Hui,J., Igl,W.,
            Illig,T., Jula,A., Kajantie,E., Kilpelainen,T.O., Koiranen,M.,
            Kolcic,I., Koskinen,S., Kovacs,P., Laitinen,J., Liu,J., Lokki,M.L.,
            Marusic,A., Maschio,A., Meitinger,T., Mulas,A., Pare,G.,
            Parker,A.N., Peden,J.F., Petersmann,A., Pichler,I.,
            Pietilainen,K.H., Pouta,A., Ridderstrale,M., Rotter,J.I.,
            Sambrook,J.G., Sanders,A.R., Schmidt,C.O., Sinisalo,J., Smit,J.H.,
            Stringham,H.M., Bragi Walters,G., Widen,E., Wild,S.H.,
            Willemsen,G., Zagato,L., Zgaga,L., Zitting,P., Alavere,H.,
            Farrall,M., McArdle,W.L., Nelis,M., Peters,M.J., Ripatti,S., van
            Meurs,J.B., Aben,K.K., Ardlie,K.G., Beckmann,J.S., Beilby,J.P.,
            Bergman,R.N., Bergmann,S., Collins,F.S., Cusi,D., den Heijer,M.,
            Eiriksdottir,G., Gejman,P.V., Hall,A.S., Hamsten,A., Huikuri,H.V.,
            Iribarren,C., Kahonen,M., Kaprio,J., Kathiresan,S., Kiemeney,L.,
            Kocher,T., Launer,L.J., Lehtimaki,T., Melander,O., Mosley,T.H. Jr.,
            Musk,A.W., Nieminen,M.S., O'Donnell,C.J., Ohlsson,C., Oostra,B.,
            Palmer,L.J., Raitakari,O., Ridker,P.M., Rioux,J.D., Rissanen,A.,
            Rivolta,C., Schunkert,H., Shuldiner,A.R., Siscovick,D.S.,
            Stumvoll,M., Tonjes,A., Tuomilehto,J., van Ommen,G.J., Viikari,J.,
            Heath,A.C., Martin,N.G., Montgomery,G.W., Province,M.A., Kayser,M.,
            Arnold,A.M., Atwood,L.D., Boerwinkle,E., Chanock,S.J., Deloukas,P.,
            Gieger,C., Gronberg,H., Hall,P., Hattersley,A.T., Hengstenberg,C.,
            Hoffman,W., Lathrop,G.M., Salomaa,V., Schreiber,S., Uda,M.,
            Waterworth,D., Wright,A.F., Assimes,T.L., Barroso,I., Hofman,A.,
            Mohlke,K.L., Boomsma,D.I., Caulfield,M.J., Cupples,L.A.,
            Erdmann,J., Fox,C.S., Gudnason,V., Gyllensten,U., Harris,T.B.,
            Hayes,R.B., Jarvelin,M.R., Mooser,V., Munroe,P.B., Ouwehand,W.H.,
            Penninx,B.W., Pramstaller,P.P., Quertermous,T., Rudan,I.,
            Samani,N.J., Spector,T.D., Volzke,H., Watkins,H., Wilson,J.F.,
            Groop,L.C., Haritunians,T., Hu,F.B., Kaplan,R.C., Metspalu,A.,
            North,K.E., Schlessinger,D., Wareham,N.J., Hunter,D.J.,
            O'Connell,J.R., Strachan,D.P., Wichmann,H.E., Borecki,I.B., van
            Duijn,C.M., Schadt,E.E., Thorsteinsdottir,U., Peltonen,L.,
            Uitterlinden,A.G., Visscher,P.M., Chatterjee,N., Loos,R.J.,
            Boehnke,M., McCarthy,M.I., Ingelsson,E., Lindgren,C.M.,
            Abecasis,G.R., Stefansson,K., Frayling,T.M. and Hirschhorn,J.N.
  TITLE     Hundreds of variants clustered in genomic loci and biological
            pathways affect human height
  JOURNAL   Nature 467 (7317), 832-838 (2010)
   PUBMED   20881960
REFERENCE   9  (bases 1 to 1827)
  AUTHORS   Newton-Cheh,C., Johnson,T., Gateva,V., Tobin,M.D., Bochud,M.,
            Coin,L., Najjar,S.S., Zhao,J.H., Heath,S.C., Eyheramendy,S.,
            Papadakis,K., Voight,B.F., Scott,L.J., Zhang,F., Farrall,M.,
            Tanaka,T., Wallace,C., Chambers,J.C., Khaw,K.T., Nilsson,P., van
            der Harst,P., Polidoro,S., Grobbee,D.E., Onland-Moret,N.C.,
            Bots,M.L., Wain,L.V., Elliott,K.S., Teumer,A., Luan,J., Lucas,G.,
            Kuusisto,J., Burton,P.R., Hadley,D., McArdle,W.L., Brown,M.,
            Dominiczak,A., Newhouse,S.J., Samani,N.J., Webster,J., Zeggini,E.,
            Beckmann,J.S., Bergmann,S., Lim,N., Song,K., Vollenweider,P.,
            Waeber,G., Waterworth,D.M., Yuan,X., Groop,L., Orho-Melander,M.,
            Allione,A., Di Gregorio,A., Guarrera,S., Panico,S., Ricceri,F.,
            Romanazzi,V., Sacerdote,C., Vineis,P., Barroso,I., Sandhu,M.S.,
            Luben,R.N., Crawford,G.J., Jousilahti,P., Perola,M., Boehnke,M.,
            Bonnycastle,L.L., Collins,F.S., Jackson,A.U., Mohlke,K.L.,
            Stringham,H.M., Valle,T.T., Willer,C.J., Bergman,R.N., Morken,M.A.,
            Doring,A., Gieger,C., Illig,T., Meitinger,T., Org,E., Pfeufer,A.,
            Wichmann,H.E., Kathiresan,S., Marrugat,J., O'Donnell,C.J.,
            Schwartz,S.M., Siscovick,D.S., Subirana,I., Freimer,N.B.,
            Hartikainen,A.L., McCarthy,M.I., O'Reilly,P.F., Peltonen,L.,
            Pouta,A., de Jong,P.E., Snieder,H., van Gilst,W.H., Clarke,R.,
            Goel,A., Hamsten,A., Peden,J.F., Seedorf,U., Syvanen,A.C.,
            Tognoni,G., Lakatta,E.G., Sanna,S., Scheet,P., Schlessinger,D.,
            Scuteri,A., Dorr,M., Ernst,F., Felix,S.B., Homuth,G., Lorbeer,R.,
            Reffelmann,T., Rettig,R., Volker,U., Galan,P., Gut,I.G.,
            Hercberg,S., Lathrop,G.M., Zelenika,D., Deloukas,P., Soranzo,N.,
            Williams,F.M., Zhai,G., Salomaa,V., Laakso,M., Elosua,R.,
            Forouhi,N.G., Volzke,H., Uiterwaal,C.S., van der Schouw,Y.T.,
            Numans,M.E., Matullo,G., Navis,G., Berglund,G., Bingham,S.A.,
            Kooner,J.S., Connell,J.M., Bandinelli,S., Ferrucci,L., Watkins,H.,
            Spector,T.D., Tuomilehto,J., Altshuler,D., Strachan,D.P., Laan,M.,
            Meneton,P., Wareham,N.J., Uda,M., Jarvelin,M.R., Mooser,V.,
            Melander,O., Loos,R.J., Elliott,P., Abecasis,G.R., Caulfield,M. and
            Munroe,P.B.
  CONSRTM   Wellcome Trust Case Control Consortium
  TITLE     Genome-wide association study identifies eight loci associated with
            blood pressure
  JOURNAL   Nat Genet 41 (6), 666-676 (2009)
   PUBMED   19430483
REFERENCE   10 (bases 1 to 1827)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DC393065.1, BC029164.1 and
            BF514946.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001135705.2.
            
            Summary: This gene encodes a member of the acyl-coenzyme A binding
            domain containing protein family. All family members contain the
            conserved acyl-Coenzyme A binding domain, which binds acyl-CoA
            thiol esters. They are thought to play roles in acyl-CoA dependent
            lipid metabolism. Multiple transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029164.1, DRR138523.488221.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000321854.13/ ENSP00000314440.8
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                DC393065.1         41-61
            22-1823             BC029164.1         1-1802
            1824-1827           BF514946.1         23-26               c
FEATURES             Location/Qualifiers
     source          1..1827
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1827
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /note="acyl-CoA binding domain containing 4"
                     /db_xref="GeneID:79777"
                     /db_xref="HGNC:HGNC:23337"
                     /db_xref="MIM:619968"
     exon            1..267
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            268..392
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     CDS             305..1222
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /note="isoform 2 is encoded by transcript variant 4;
                     acyl-Coenzyme A binding domain containing 4;
                     acyl-CoA-binding domain-containing protein 4"
                     /codon_start=1
                     /product="acyl-CoA-binding domain-containing protein 4
                     isoform 2"
                     /protein_id="NP_001129177.1"
                     /db_xref="CCDS:CCDS42348.1"
                     /db_xref="GeneID:79777"
                     /db_xref="HGNC:HGNC:23337"
                     /db_xref="MIM:619968"
                     /translation="MGTEKESPEPDCQKQFQAAVSVIQNLPKNGSYRPSYEEMLRFYS
                     YYKQATMGPCLVPRPGFWDPIGRYKWDAWNSLGKMSREEAMSAYITEMKLVAQKVIDT
                     VPLGEVAEDMFGYFEPLYQVIPDMPRPPETFLRRVTGWKEQVVNGDVGAVSEPPCLPK
                     EPAPPSPESHSPRDLDSEVFCDSLEQLEPELVWTEQRAASGGKRDPRNSPVPPTKKEG
                     LRGSPPGPQELDVWLLGTVRALQESMQEVQARVQSLESMPRPPEQRPQPRPSARPWPL
                     GLPGPALLFFLLWPFVVQWLFRMFRTQKR"
     exon            393..513
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            514..598
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            599..719
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            720..806
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            807..877
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            878..953
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1093
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     exon            1094..1827
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1806..1811
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /note="hexamer: ACTAAA"
     regulatory      1810..1815
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
     polyA_site      1827
                     /gene="ACBD4"
                     /gene_synonym="HMFT0700"
                     /note="major polyA site"
ORIGIN      
        1 agtaggaagc cgcggggtgg tggcgagaga ggacccaggt gtcctggcag tgggcgccgc
       61 ggggcacacg ctgggccaag gtgcaggcgg ccagggtggg agactgttcg ccccgccctg
      121 agtactccta tcttgtttct ccacctgttc gggagttgga gatgtgcacc taaaggaggc
      181 gcatctgggg acggacacat ctggcactga ggccctcgcc acctgcctcg ccacctggcg
      241 accctgaccc caccacactg ccttgagagt cgctcaaaag tagggcccca gggctcgcag
      301 cagcatgggc accgagaaag aaagcccaga gcccgactgc cagaaacagt tccaggctgc
      361 agtgagcgtc atccagaacc tgcccaagaa cggttcttac cgcccctcct atgaagagat
      421 gctgcgattc tacagttact acaagcaggc caccatgggg ccctgcctgg tcccccggcc
      481 cgggttctgg gaccccattg gacgatataa gtgggacgcc tggaacagtc tgggcaagat
      541 gagcagggag gaggccatgt ctgcctacat cactgaaatg aaactggtgg cacagaaggt
      601 gatcgacaca gtgcccctgg gtgaggtggc agaggacatg tttggttact tcgagcccct
      661 gtaccaggtg atccctgaca tgccgaggcc cccagagacc ttcctgagaa gggtcacagg
      721 ttggaaagag caggttgtga atggagatgt tggggctgtt tcagagcctc cctgcctccc
      781 caaggaaccg gcacccccaa gcccagagtc ccattcaccc agggacctgg actccgaggt
      841 tttctgtgat tccctggagc agctggagcc tgagctggtt tggacagagc agcgggcagc
      901 atctggagga aagcgtgatc ccaggaacag ccccgtgccc cccacaaaga aagaggggtt
      961 gcggggcagc ccgccggggc cccaggagtt ggacgtgtgg ctgctgggga cagttcgagc
     1021 actacaggag agcatgcagg aggtgcaggc gagggtgcag agcctggaga gcatgccccg
     1081 gccccctgag cagaggccgc agcccaggcc cagtgctcgg ccatggcccc ttgggctccc
     1141 ggggcccgcg ctgctcttct tcctcctgtg gcccttcgtc gtccagtggc tcttccgaat
     1201 gtttcggacc caaaagaggt gactgtcagt ggaggggtct ctgcagccaa ctgagactat
     1261 cttgctgtgc cctgagcctt cctagggttt agaagaacag cattcaaaat tccccgtcct
     1321 gtcagtgttt gccttcgcac ctcctcccct aaagcagcgc ggggggcaaa taagacccca
     1381 cccctccctg cagcttcaca gggacgcttc cttccctccc cgcaaccacc ccaggctccc
     1441 ctgggaggct gcagttgtgg tacacgtccc cggtgctggg ttggccgtga ctcgggggcg
     1501 gggcgatcgg gtctcagccc ctgccttccc cagtctctgg gtcacccgaa ttttcccacc
     1561 cctgcttctc cccgaggagg ttgagctctt gagcaagttg ggacttgggc cggggcctgg
     1621 aagaatgatt ggctgggagg ccgcgggagg gaggccagga ggcccggacc agttgggagg
     1681 agtgagcagg ccccggggga gggggatgag cgcagtttgc tcgctttcct cccctgccgg
     1741 ccccctccgc ccccacacac actcgggacg tcttcattga agattcactt acaaaggaat
     1801 gtttcactaa ataaaagaaa accagaa
//
