LOCUS       NM_022735               3584 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens acyl-CoA binding domain containing 3 (ACBD3), mRNA.
ACCESSION   NM_022735
VERSION     NM_022735.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3584)
  AUTHORS   Stalder,D., Yakunin,I., Pereira,C., Eden,J. and Gershlick,D.C.
  TITLE     Recruitment of PI4KIIIbeta to the Golgi by ACBD3 is dependent on an
            upstream pathway of a SNARE complex and golgins
  JOURNAL   Mol Biol Cell 35 (2), ar20 (2024)
   PUBMED   38134218
  REMARK    GeneRIF: Recruitment of PI4KIIIbeta to the Golgi by ACBD3 is
            dependent on an upstream pathway of a SNARE complex and golgins.
REFERENCE   2  (bases 1 to 3584)
  AUTHORS   Ma,X., Huang,S., Shi,H., Luo,R., Luo,B., Tan,Z., Shi,L., Zhang,W.,
            Yang,W., Zhong,X., Lu,M., Chen,X. and Tang,X.
  TITLE     Identification of ACBD3 as a new molecular biomarker in pan-cancers
            through bioinformatic analysis: a preclinical study
  JOURNAL   Eur J Med Res 28 (1), 590 (2023)
   PUBMED   38098097
  REMARK    GeneRIF: Identification of ACBD3 as a new molecular biomarker in
            pan-cancers through bioinformatic analysis: a preclinical study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3584)
  AUTHORS   Mizuike,A., Sakai,S., Katoh,K., Yamaji,T. and Hanada,K.
  TITLE     The C10orf76-PI4KB axis orchestrates CERT-mediated ceramide
            trafficking to the distal Golgi
  JOURNAL   J Cell Biol 222 (7) (2023)
   PUBMED   37195633
  REMARK    GeneRIF: The C10orf76-PI4KB axis orchestrates CERT-mediated
            ceramide trafficking to the distal Golgi.
REFERENCE   4  (bases 1 to 3584)
  AUTHORS   Jia,J., Tang,S., Yue,X., Jing,S., Zhu,L., Tan,C., Gao,J., Du,Y.,
            Lee,I. and Qian,Y.
  TITLE     An A-kinase anchoring protein (ACBD3) coordinates traffic-induced
            PKA activation at the Golgi
  JOURNAL   J Biol Chem 299 (5), 104696 (2023)
   PUBMED   37044218
  REMARK    GeneRIF: An A-kinase anchoring protein (ACBD3) coordinates
            traffic-induced PKA activation at the Golgi.
REFERENCE   5  (bases 1 to 3584)
  AUTHORS   Houghton-Gisby,J., Kerslake,R., Karteris,E., Mokbel,K. and
            Harvey,A.J.
  TITLE     ACBD3 Bioinformatic Analysis and Protein Expression in Breast
            Cancer Cells
  JOURNAL   Int J Mol Sci 23 (16), 8881 (2022)
   PUBMED   36012147
  REMARK    GeneRIF: ACBD3 Bioinformatic Analysis and Protein Expression in
            Breast Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3584)
  AUTHORS   Liu,J., Matyakhina,L., Han,Z., Sandrini,F., Bei,T., Stratakis,C.A.
            and Papadopoulos,V.
  TITLE     Molecular cloning, chromosomal localization of human
            peripheral-type benzodiazepine receptor and PKA regulatory subunit
            type 1A (PRKAR1A)-associated protein PAP7, and studies in PRKAR1A
            mutant cells and tissues
  JOURNAL   FASEB J 17 (9), 1189-1191 (2003)
   PUBMED   12692076
  REMARK    GeneRIF: Molecular cloning, chromosomal localization and expression
            pattern of PAP7.
REFERENCE   7  (bases 1 to 3584)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
REFERENCE   8  (bases 1 to 3584)
  AUTHORS   Liu,J., Cavalli,L.R., Haddad,B.R. and Papadopoulos,V.
  TITLE     Molecular cloning, genomic organization, chromosomal mapping and
            subcellular localization of mouse PAP7: a PBR and PKA-RIalpha
            associated protein
  JOURNAL   Gene 308, 1-10 (2003)
   PUBMED   12711385
REFERENCE   9  (bases 1 to 3584)
  AUTHORS   Li,H., Degenhardt,B., Tobin,D., Yao,Z.X., Tasken,K. and
            Papadopoulos,V.
  TITLE     Identification, localization, and function in steroidogenesis of
            PAP7: a peripheral-type benzodiazepine receptor- and PKA
            (RIalpha)-associated protein
  JOURNAL   Mol Endocrinol 15 (12), 2211-2228 (2001)
   PUBMED   11731621
REFERENCE   10 (bases 1 to 3584)
  AUTHORS   Sohda,M., Misumi,Y., Yamamoto,A., Yano,A., Nakamura,N. and
            Ikehara,Y.
  TITLE     Identification and characterization of a novel Golgi protein,
            GCP60, that interacts with the integral membrane protein giantin
  JOURNAL   J Biol Chem 276 (48), 45298-45306 (2001)
   PUBMED   11590181
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL592045.28.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 27, 2018 this sequence version replaced NM_022735.3.
            
            Summary: The Golgi complex plays a key role in the sorting and
            modification of proteins exported from the endoplasmic reticulum.
            The protein encoded by this gene is involved in the maintenance of
            Golgi structure and function through its interaction with the
            integral membrane protein giantin. It may also be involved in the
            hormonal regulation of steroid formation. [provided by RefSeq, Jul
            2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB043587.2, BC045533.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366812.6/ ENSP00000355777.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-352               AL592045.28        58557-58908         c
            353-494             AL592045.28        38026-38167         c
            495-635             AL592045.28        36956-37096         c
            636-794             AL592045.28        33698-33856         c
            795-969             AL592045.28        31351-31525         c
            970-1156            AL592045.28        26814-27000         c
            1157-1441           AL592045.28        24502-24786         c
            1442-3584           AL592045.28        16846-18988         c
FEATURES             Location/Qualifiers
     source          1..3584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.12"
     gene            1..3584
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /note="acyl-CoA binding domain containing 3"
                     /db_xref="GeneID:64746"
                     /db_xref="HGNC:HGNC:15453"
                     /db_xref="MIM:606809"
     exon            1..352
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             67..1653
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /note="golgi phosphoprotein 1; acyl-Coenzyme A binding
                     domain containing 3; golgi complex associated protein 1,
                     60kDa; PKA (RIalpha)-associated protein; PBR- and
                     PKA-associated protein 7; peripheral benzodiazepine
                     receptor-associated protein PAP7"
                     /codon_start=1
                     /product="Golgi resident protein GCP60"
                     /protein_id="NP_073572.2"
                     /db_xref="CCDS:CCDS1551.1"
                     /db_xref="GeneID:64746"
                     /db_xref="HGNC:HGNC:15453"
                     /db_xref="MIM:606809"
                     /translation="MAAVLNAERLEVSVDGLTLSPDPEERPGAEGAPLLPPPLPPPSP
                     PGSGRGPGASGEQPEPGEAAAGGAAEEARRLEQRWGFGLEELYGLALRFFKEKDGKAF
                     HPTYEEKLKLVALHKQVLMGPYNPDTCPEVGFFDVLGNDRRREWAALGNMSKEDAMVE
                     FVKLLNRCCHLFSTYVASHKIEKEEQEKKRKEEEERRRREEEERERLQKEEEKRRREE
                     EERLRREEEERRRIEEERLRLEQQKQQIMAALNSQTAVQFQQYAAQQYPGNYEQQQIL
                     IRQLQEQHYQQYMQQLYQVQLAQQQAALQKQQEVVVAGSSLPTSSKVNATVPSNMMSV
                     NGQAKTHTDSSEKELEPEAAEEALENGPKESLPVIAAPSMWTRPQIKDFKEKIQQDAD
                     SVITVGRGEVVTVRVPTHEEGSYLFWEFATDNYDIGFGVYFEWTDSPNTAVSVHVSES
                     SDDDEEEEENIGCEEKAKKNANKPLLDEIVPVYRRDCHEEVYAGSHQYPGRGVYLLKF
                     DNSYSLWRSKSVYYRVYYTR"
     exon            353..494
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            495..635
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            636..794
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            795..969
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1156
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1441
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     exon            1442..3584
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3565..3570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /note="hexamer: ATTAAA"
     polyA_site      3584
                     /gene="ACBD3"
                     /gene_synonym="GCP60; GOCAP1; GOLPH1; PAP7"
                     /note="major polyA site"
ORIGIN      
        1 agaggtcagc aggaagtcga tacgtggctg ccgtctgtcc ccgctgagga ggtgcagcag
       61 ccggagatgg cggcggtgct gaacgcagag cgactcgagg tgtccgtcga cggcctcacg
      121 ctcagcccgg acccggagga gcggcctggg gcggagggcg ccccgctgct gccgccaccg
      181 ctgccaccgc cctcgccacc tggatccggt cgcggcccgg gcgcctcagg ggagcagccc
      241 gagcccgggg aggcggcggc tgggggcgcg gcggaggagg cgcggcggct ggagcagcgc
      301 tggggtttcg gcctggagga gttgtacggc ctggcactgc gcttcttcaa agaaaaagat
      361 ggcaaagcat ttcatccaac ttatgaagaa aaattgaagc ttgtggcact gcataagcaa
      421 gttcttatgg gcccatataa tccagacact tgtcctgagg ttggattctt tgatgtgttg
      481 gggaatgaca ggaggagaga atgggcagcc ctgggaaaca tgtctaaaga ggatgccatg
      541 gtggagtttg tcaagctctt aaataggtgt tgccatctct tttcaacata tgttgcgtcc
      601 cacaaaatag agaaggaaga gcaagaaaaa aaaaggaagg aggaagagga gcgaaggcgg
      661 cgtgaagagg aagaaagaga acgtctgcaa aaggaggaag agaaacgtag gagagaagaa
      721 gaggaaaggc ttcgacggga ggaagaggaa aggagacgga tagaagaaga aaggcttcgg
      781 ttggagcagc aaaagcagca gataatggca gctttaaact cccagactgc cgtgcagttc
      841 cagcagtatg cagcccaaca gtatccaggg aactacgaac agcagcaaat tctcatccgc
      901 cagttgcagg agcaacacta tcagcagtac atgcagcagt tgtatcaagt ccagcttgca
      961 cagcaacagg cagcattaca gaaacaacag gaagtagtag tggctgggtc ttccttgcct
     1021 acatcatcaa aagtgaatgc aactgtacca agtaatatga tgtcagttaa tggacaggcc
     1081 aaaacacaca ctgacagctc cgaaaaagaa ctggaaccag aagctgcaga agaagccctg
     1141 gagaatggac caaaagaatc tcttccagta atagcagctc catccatgtg gacacgacct
     1201 cagatcaaag acttcaaaga gaagattcag caggatgcag attccgtgat tacagtgggc
     1261 cgaggagaag tggtcactgt tcgagtaccc acccatgaag aaggatcata tctcttttgg
     1321 gaatttgcca cagacaatta tgacattggg tttggggtgt attttgaatg gacagactct
     1381 ccaaacactg ctgtcagcgt gcatgtcagt gagtccagcg atgacgacga ggaggaagaa
     1441 gaaaacatcg gttgtgaaga gaaagccaaa aagaatgcca acaagccttt gctggatgag
     1501 attgtgcctg tgtaccgacg ggactgtcat gaggaggtgt atgctggcag ccatcaatat
     1561 ccagggagag gagtctatct cctcaagttt gacaactcct actctttgtg gcggtcaaaa
     1621 tcagtctact acagagtcta ttatactaga taaaaatgtt gttacaaagt ctggagtcta
     1681 gggttgggca gaagatgaca tttaatttgg aaatttcttt ttacttttgt ggagcattag
     1741 agtcacagtt taccttattg atattggtct gatggtttgt gaactcttgc tgggaatcaa
     1801 aatttccttg agactcttta gcattcatac tttggggtta aaggagattc ctcagactca
     1861 tccagccctt gggtgctgac cagcagagtc actagtggat gctgaagtta catgagctac
     1921 atgttaaata tttaaagtct ccaaaataaa acaccccaac gttgacctta cccggctgat
     1981 ggttagcccc ttgctgcctg ctccatgtgt cttatgagag cccgtagtta cagtgtcctc
     2041 taatttgaaa tccataagtt aacaagtcta tatcaggtgc agctggcttt gattaaaggc
     2101 catttttaaa acttaaaaac tcaacacctc acagattata atagaaaaag aaatggcctc
     2161 agtttgatct cgttcagaat gacccagatt gtttctgctt tgggtgcagc tgtttagttc
     2221 agagttatat tacagagaat tattttctga gataatctta aactagaatg ttcaaaacta
     2281 attgataatt gaagtatcaa gatacgtaga acacctcaga gatttttctt caggaacttc
     2341 cacaaacttt gaatccttgt atctttattt ggtattcata ctactagtag caaaatacag
     2401 gttttttgtt ttgttttgtt ttgttttggc ttcatagagt atctcaaatt gaaacttttc
     2461 tgcacaaaga ataaaattaa ggattttata aactcaaatt ggcacctact gaattaaaat
     2521 acataaaatc atttaaatat aattcagcat atgggaagta acattgcact aatatggaaa
     2581 tcactgccag agacagtcta ttttctttta atttgttact acttagtcac aaaccccaca
     2641 ttattccagt ttggaattac ttattaagga gaattggaaa tacatatgcc catgcttaaa
     2701 ttttatagct ttaatttgtg ttatttcttt attgacggga agaggtacat ctttttttcc
     2761 ttactgaaaa caaatatgga ttaattgcct caaatttgta taagtgattg gctagtgatt
     2821 cttgttttca gaagggagag tggtatagat agaaaatgac aaagatggca atatacactt
     2881 aatgttgtta ttgtatgttg ttactgaagt acttagattt ttaaaatttc aaatcctaaa
     2941 tcacttcttg taggagggtt ttcattaact gcagtatata cagttcacta catatgggtt
     3001 gtttgagttt tttgtgtgct gtatttcttt ctgtttttta atacctggtt ttgtacatat
     3061 ctaactctgt tctcttttgg ttgttcagaa actggatttt ttttttctta agcagtgctt
     3121 aatttgtgtt ttttaatttt gattcagaag tagtcccagc tcataggtgt tcatactgtt
     3181 acatccagaa catttgtcag gctctctgtc agctttcatg tacatatggt atagaaacca
     3241 tggagttagg cacttcctgg attttttttt tatgagaaaa atactgtatt taaaatgtaa
     3301 aataaacttt taaaaagcag gcactaatat atatttcttc cagcctttga ttacaaattt
     3361 gtccttgcac atgttaagat gaattatctc ctaaaaatat cattgttctt gggagcagtg
     3421 tatgttactt tacatagcag cggttcctgt catgtgttca tgtcagaata tttttggttt
     3481 taaactttct tattgccttt ggctgttgat tagtacagta caagtgcgat ttcaaaaaga
     3541 tcttgaaagt aatatattta atcaattaaa atgtttatct gtaa
//
