LOCUS       NM_012287               7093 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains
            2 (ACAP2), mRNA.
ACCESSION   NM_012287
VERSION     NM_012287.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7093)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 7093)
  AUTHORS   Zhang,G., Liu,Z., Zhong,J. and Lin,L.
  TITLE     Circ-ACAP2 facilitates the progression of colorectal cancer through
            mediating miR-143-3p/FZD4 axis
  JOURNAL   Eur J Clin Invest 51 (12), e13607 (2021)
   PUBMED   34085707
  REMARK    GeneRIF: Circ-ACAP2 facilitates the progression of colorectal
            cancer through mediating miR-143-3p/FZD4 axis.
REFERENCE   3  (bases 1 to 7093)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 7093)
  AUTHORS   Zhao,B., Song,X. and Guan,H.
  TITLE     CircACAP2 promotes breast cancer proliferation and metastasis by
            targeting miR-29a/b-3p-COL5A1 axis
  JOURNAL   Life Sci 244, 117179 (2020)
   PUBMED   31863774
  REMARK    GeneRIF: Elevated expression of circACAP2 in breast cancer tissues
            leads to malignant phenotype upon cancerous cells.
            CircACAP2-miR-29a/b-3p-COL5A1 axis leads to breast cancer
            tumorigenesis
REFERENCE   5  (bases 1 to 7093)
  AUTHORS   Lin,L., Shi,Y., Wang,M., Wang,C., Zhu,J. and Zhang,R.
  TITLE     Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular
            Basis for Effector Recognition by Rab35 GTPase
  JOURNAL   Structure 27 (5), 729-740 (2019)
   PUBMED   30905672
  REMARK    GeneRIF: analysis of structural basis for effector recognition in
            Rab35/ACAP2 and Rab35/RUSC2 complexes
REFERENCE   6  (bases 1 to 7093)
  AUTHORS   Cuthbert,E.J., Davis,K.K. and Casanova,J.E.
  TITLE     Substrate specificities and activities of AZAP family Arf GAPs in
            vivo
  JOURNAL   Am J Physiol Cell Physiol 294 (1), C263-C270 (2008)
   PUBMED   18003747
  REMARK    GeneRIF: ACAP2 has robust, constitutive Arf6 GAP activity in vivo,
            with little activity toward Arf1.
REFERENCE   7  (bases 1 to 7093)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   8  (bases 1 to 7093)
  AUTHORS   Jackson,T.R., Brown,F.D., Nie,Z., Miura,K., Foroni,L., Sun,J.,
            Hsu,V.W., Donaldson,J.G. and Randazzo,P.A.
  TITLE     ACAPs are arf6 GTPase-activating proteins that function in the cell
            periphery
  JOURNAL   J Cell Biol 151 (3), 627-638 (2000)
   PUBMED   11062263
REFERENCE   9  (bases 1 to 7093)
  AUTHORS   Dowler,S., Currie,R.A., Campbell,D.G., Deak,M., Kular,G.,
            Downes,C.P. and Alessi,D.R.
  TITLE     Identification of pleckstrin-homology-domain-containing proteins
            with novel phosphoinositide-binding specificities
  JOURNAL   Biochem J 351 (Pt 1), 19-31 (2000)
   PUBMED   11001876
REFERENCE   10 (bases 1 to 7093)
  AUTHORS   Jackson,T.R., Kearns,B.G. and Theibert,A.B.
  TITLE     Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf
            signaling
  JOURNAL   Trends Biochem Sci 25 (10), 489-495 (2000)
   PUBMED   11050434
  REMARK    GeneRIF: Centaurin beta2/KIAA0041, is a member of the centaurin
            family of ADP-ribosylation factor directed GTPase-activating
            proteins. Binding of phosphoinositides to a pleckstrin homology
            domain may regulate subcellular localisation and activity.
            Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB087306.1, D26069.3, AC090018.12, BC017120.1 and CA413842.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012287.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D26069.3, BC060767.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326793.11/ ENSP00000324287.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               DB087306.1         69-231
            164-2570            D26069.3           1-2407
            2571-3755           AC090018.12        126013-127197       c
            3756-7090           BC017120.1         1397-4731
            7091-7093           CA413842.1         27-29               c
FEATURES             Location/Qualifiers
     source          1..7093
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q29"
     gene            1..7093
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /note="ArfGAP with coiled-coil, ankyrin repeat and PH
                     domains 2"
                     /db_xref="GeneID:23527"
                     /db_xref="HGNC:HGNC:16469"
                     /db_xref="MIM:607766"
     exon            1..226
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     CDS             174..2510
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /note="Arf GAP with coiled coil, ANK repeat and PH domains
                     2; centaurin-beta-2"
                     /codon_start=1
                     /product="arf-GAP with coiled-coil, ANK repeat and PH
                     domain-containing protein 2"
                     /protein_id="NP_036419.3"
                     /db_xref="CCDS:CCDS33924.1"
                     /db_xref="GeneID:23527"
                     /db_xref="HGNC:HGNC:16469"
                     /db_xref="MIM:607766"
                     /translation="MKMTVDFEECLKDSPRFRAALEEVEGDVAELELKLDKLVKLCIA
                     MIDTGKAFCVANKQFMNGIRDLAQYSSNDAVVETSLTKFSDSLQEMINFHTILFDQTQ
                     RSIKAQLQNFVKEDLRKFKDAKKQFEKVSEEKENALVKNAQVQRNKQHEVEEATNILT
                     ATRKCFRHIALDYVLQINVLQSKRRSEILKSMLSFMYAHLAFFHQGYDLFSELGPYMK
                     DLGAQLDRLVVDAAKEKREMEQKHSTIQQKDFSSDDSKLEYNVDAANGIVMEGYLFKR
                     ASNAFKTWNRRWFSIQNNQLVYQKKFKDNPTVVVEDLRLCTVKHCEDIERRFCFEVVS
                     PTKSCMLQADSEKLRQAWIKAVQTSIATAYREKGDESEKLDKKSSPSTGSLDSGNESK
                     EKLLKGESALQRVQCIPGNASCCDCGLADPRWASINLGITLCIECSGIHRSLGVHFSK
                     VRSLTLDTWEPELLKLMCELGNDVINRVYEANVEKMGIKKPQPGQRQEKEAYIRAKYV
                     ERKFVDKYSISLSPPEQQKKFVSKSSEEKRLSISKFGPGDQVRASAQSSVRSNDSGIQ
                     QSSDDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAE
                     ALAHGADVNWANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHAT
                     VLGHTGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLARMNEEMRESEG
                     LYGQPGDETYQDIFRDFSQMASNNPEKLNRFQQDSQKF"
     exon            227..284
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            285..404
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            405..458
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            459..517
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            518..701
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            702..746
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            747..842
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..917
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1030
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1031..1082
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1183
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1289
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1498
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1568
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1569..1660
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1845
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1846..1938
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            1939..2126
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2236
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2237..2347
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2409
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     exon            2410..7093
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7070..7075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /note="hexamer: AATAAA"
     polyA_site      7093
                     /gene="ACAP2"
                     /gene_synonym="CENTB2; CNT-B2"
                     /note="major polyA site"
ORIGIN      
        1 ctgactagtc gtcgccgtct tcgcggctgc tatgaccagc gggcgaggcg cccttcgcag
       61 ctccgcgcaa cgctagtcgc ggccgtgcgc ccgccgtagc cgtctgcgtc ccagcgcggc
      121 cgctcccgcg gccccctcgg ctttgccagc gccgcctgcg aggcggaggc aggatgaaga
      181 tgactgtgga tttcgaggag tgtctgaagg actcgccccg cttcagggca gctttggaag
      241 aagtagaagg tgatgtggca gaattggaac taaaacttga taagcttgtg aaactttgta
      301 ttgcaatgat tgatactgga aaagcctttt gtgttgcaaa taaacagttc atgaatggga
      361 ttcgagacct ggctcagtat tctagtaatg atgctgtcgt tgagacaagt ttgaccaagt
      421 tttctgacag tcttcaagaa atgataaatt ttcacacaat cctgtttgac caaactcaga
      481 gatcaattaa ggcacagctt cagaactttg ttaaagaaga tcttagaaaa ttcaaagatg
      541 ccaagaagca attcgaaaaa gtcagtgaag aaaaagaaaa tgcgttagta aaaaatgccc
      601 aagtacaaag aaacaaacaa catgaagttg aagaagccac caacattctg acagcaacaa
      661 gaaaatgttt ccgacacata gccctcgatt atgtgcttca gattaatgtt cttcaatcaa
      721 aaaggagatc agaaatccta aaatcaatgt tgtcatttat gtatgcccat ttggccttct
      781 ttcatcaagg atatgatctg tttagtgaac ttggacccta catgaaggat cttggtgcac
      841 agttggatcg actggttgtg gatgcagcaa aggagaaaag agaaatggag caaaaacatt
      901 ccaccattca acaaaaggat ttctccagtg atgattctaa gttagaatat aacgtagatg
      961 ctgcaaatgg catagttatg gaaggatatc tgttcaaacg agccagcaat gccttcaaaa
     1021 cttggaacag gcgctggttt tcaatacaga ataatcagtt ggtttaccag aaaaaattta
     1081 aggataatcc gactgtggta gttgaagacc tcaggctttg cacagtgaaa cattgtgaag
     1141 acatagagcg acgattctgc tttgaggtgg tctcgccaac aaaaagttgc atgctccagg
     1201 cagattccga aaagctgcgc caggcatgga ttaaggctgt tcagaccagt attgctactg
     1261 cttatagaga gaagggtgat gaatcagaga agctggataa gaaatcatct ccatccacag
     1321 gaagcctaga ttctggaaat gagtccaaag agaaattatt gaaaggagaa agtgcgcttc
     1381 agcgggtcca gtgtatccct ggcaatgcca gctgttgtga ctgtggcctg gcagatccac
     1441 ggtgggccag catcaacctg ggcatcacct tgtgtatcga gtgctccgga attcaccgga
     1501 gccttggggt tcatttttca aaagtacgat ctttaacttt agacacctgg gagccagaac
     1561 ttttaaagct tatgtgtgag ttggggaatg atgttataaa tcgagtttat gaagctaatg
     1621 tggaaaaaat gggaataaag aaaccccaac caggacaaag acaggagaag gaggcatata
     1681 tcagagcaaa atatgtggag aggaaatttg tggataaata ttctatatca ttatcacctc
     1741 ctgagcagca aaaaaagttt gtctctaaaa gttctgaaga aaagaggctg agcatttcta
     1801 aatttgggcc aggggaccaa gtcagagcat ctgcccaaag ttcagtcaga agtaatgaca
     1861 gtggaattca gcagagctct gatgatggaa gagaatcttt accctccacg gtgtcagcca
     1921 atagtttata tgagcctgaa ggagaaaggc aagattcttc tatgtttctt gactcgaaac
     1981 atcttaatcc aggacttcag ctttataggg cgtcatatga aaaaaacctt cctaaaatgg
     2041 ctgaggcttt ggctcatggt gcagacgtga actgggccaa ttcagaggaa aacaaagcga
     2101 caccacttat tcaggctgta ttagggggct ctttggtgac gtgtgagttc ctcctacaga
     2161 atggtgctaa tgtcaaccaa agagatgtcc aagggcgggg accattgcac catgccaccg
     2221 tcttagggca cacagggcag gtatgtttat tcctaaaacg aggtgccaat caacatgcca
     2281 ctgatgaaga agggaaagac cctttgagca tagctgtgga agcagccaat gctgatatag
     2341 tcaccttgtt acgtttagca agaatgaatg aagagatgcg ggaatcagaa ggactttatg
     2401 gacagccagg tgatgaaact tatcaggaca tatttcgtga tttttcccaa atggcatcca
     2461 ataatccaga gaaactaaat cgtttccagc aagattcaca gaaattctga atttttttaa
     2521 aaatgggaaa atatgaaatc tggtgacccc ctaatgtata cagctaaaaa atcacaattt
     2581 ttttactgct ttaattctac ttaattttgg tagatattga atggcttgga aaagaggtac
     2641 ccattcatat atttataaat taaaacatag ttatctagta gtaggagagg aacctagttt
     2701 aggacctctt ttattaaaaa agcctattta aagggctatt tctgtagaca gaagttcagt
     2761 ctagatttag gccatctcta ggttacaaga tgataggagg ttagacaaaa gtgattcttt
     2821 tgccaatggg tggtggcatt gatttttttc ctccatgcat cttgcccagg atcactcagt
     2881 caagcatgtc ttcatcaagt ggaagccaac tgtcctgcct gcctcaagaa tatgtgtttt
     2941 ctttagcttc cctgaggctt tttggtggtt cagaaatagg tgtgtgtgtt gatgtgtttt
     3001 tggtaaccta gctttcatac acataatata tgatttatta gaactagaga atgtgttttc
     3061 cccgtttgtt cataaatgcg gtcggttata cttcttaggt gacaggttat tgtccagtac
     3121 tttaatgtat gtatgtataa tggctgtaca ggtagaccat aattcagtcc tttagattta
     3181 ttttatgcag caaaaagaag ctcttttttt tttttaatca caaaaaaaaa ccccagttca
     3241 aaatgtgtag ttcttcattg ttgggttgat tccccaaaac cttgacagat gtatcgatgg
     3301 aataaaagta tgttttaaag gttacttgaa tgtcacaaaa ttatgccttc atcaaaactt
     3361 taaaggaaaa atcaatttat aaaatcatgt aggccatttt tatatttgaa atttgtcctt
     3421 ttaaagatag ttttgctgtt gctcctagtg aaagaaaaat ctctgtacaa aggagaaaaa
     3481 gaaccccact tattcttagt taatactaaa atatatagca ataaattgct gtttattttt
     3541 tctacatcta ttttgtgtac ttgtacacag tgtacattct tttaaattat atcgtgtata
     3601 tagctttagt attcggttac atgattcaca gacccctgaa ttccaaaata ttatggataa
     3661 acattaccat ttatatgcta caaattagtc tgattccatc tttgaaaatg tcttaaagta
     3721 taaaataatt aatttgcttt tttttttttt ttttcccgag atggcgtctt gctgtgtcac
     3781 ccaggctgga gtgcagtggc acgatctcag ctcactgcag cctcctcctc ttgggttcaa
     3841 gcaattctcc tgcctcagcc tcccgagtag ctgggactac aggcacccgc caccattccg
     3901 agctaatttc tatattttta gtaaagacgg gtttcaccat tttggccagg ttggtctcga
     3961 actcctgacc tcaggtgatc agcctgcttt agcctcccag agtgctggga ttacaggcgt
     4021 gagccaccgc acccagccta atttgccttt tgattccttc ccattgttgt caacaattaa
     4081 gtctattctt cttttagaaa ttatatgtaa atgatattat tgatactctt tctaaataag
     4141 aggttttaaa atatataaaa actttatgat ccaattatag ataaattttc taacatttcc
     4201 cagtcactag ggttttataa gttgattaaa catcaaatca gaatctagcc aagcaggaat
     4261 tatattgaaa taagttcaca ttacagaaaa ggttccataa tttggccaaa ctgcatgcat
     4321 gtaatgctta tttagtaatg gtcactgtat gttagataag gataaaaata tatttgtgaa
     4381 ttacttctga ggaaatgcta acttccacag cattgtattt aattataaca ataacaggaa
     4441 cattaaatct ttatctttgc tgtttcacct caaagtcata gatcatctgg ctttttaggc
     4501 accttcacta aaggcaaaaa tctgatttgt agtttttatt agcatgtacc ttgaaattat
     4561 ttgaccaaga agctcaaaga aaagaagtac gttaaagaaa aagaaaaaac ctcacttttc
     4621 ctttatagtg tcccttcctg ttttaattcc taaagatcct gacttttatc tgaggaagtc
     4681 taggtagttt tccttttgga tctggccatt ggtgcgtgtt tcattcagat cacctctgga
     4741 atctctgtgg ttgtgaaggc aattccttat gagactcttg cctcctgtgg cttacgtgat
     4801 gaattgttaa tatggcagta attaattagt atctacttaa atttagtggt cagaaatgta
     4861 tttgaagtgc cttaaagatg atcatggttc agaatatctt cagagaaagc aaaatcttta
     4921 atattgcagg gagcctagca atacaagtac acatttctgt ggcttgattt cttgaatatg
     4981 ctgagaccca atttggacta catttggcag aaatgatgga gtaaacagca aggctttaaa
     5041 ttaaattaat agttacaagg taggttggct cttaggtgaa tttagccatg tcaactaata
     5101 gcttttatat ggtatgtaac aaatctgaat tatgttatgc tgtgaattat tcagtgcatt
     5161 ataagaaatc ttagttaatc atgcttttgg gcttcattag tcaatgtgat tggcctttta
     5221 ttttctttcc ataacttatc tgctattatt agtttcttat tccttattat taatctgtta
     5281 gctcattatc attagcttac taacttgaaa gttagattaa tatcaaaata agaatagcag
     5341 cactatgaag agttaataaa atgcaatttc atgttagagc tagaataaaa gtaattgagc
     5401 agtcatttgc aaatgcttca ttataacatt tatgtgctta agatttctaa ggttttaaaa
     5461 agttaccttt aatacaatcc ttagaaactc agaaatttcc tgatattcat tagattatgg
     5521 tgtttgccta atttataccg gttttcactg tatattttaa tgaactttga ttggttactt
     5581 ttccagacat acagatttaa tttggaatat gaactttggt tcttcatgag tgcattttga
     5641 aaaagaaaaa aagtacacat tcagaatctg gccaatttaa gtttgtattt taaaaatatt
     5701 ttatgcatgt taagtatggt cgcagtaaat gaaattgtgt ttaagactaa atttactacc
     5761 gttttgaaca gacattccca gatcattctt atattgtcag ataacacttg tgtataatat
     5821 cactttggat catggacatg agctggaaaa atgatgtatt tttgtagatt gtatgtccag
     5881 aatgacttta gaaccgcatg atacggtgga aggagcactg gactagtcgt cactaccctt
     5941 tttggattca gggctcctca caattaaaat gagtgtaatg aaacaaggtg aaaatataga
     6001 agcatccctt tgtatactgt tttgctactt acagtgtact tggcattgct ttatctcact
     6061 ggattctcat ggtaggattt ctgagatctt aatctaagct ccaaagttgt ctactttttt
     6121 gatcctaggg tgctcctttt gttttacaga gcagggtcac ttgatttgct agctggtggc
     6181 agaattggca ccattaccca ggtctgactg accaccagtc agaggcactt tatttgtatc
     6241 atgaaatgat ttgaaatcat tgtaaagcag cgaagtctga taatgaatgc cagctttcct
     6301 tgtgctttga taacaaagac tccaaatatt ctggagaacc tggataaaag tttgaagggc
     6361 tagattggga tttgaagaca aaattgtagg aaatcttaca tttttgcaat aacaaacatt
     6421 aatgaaagca aaacattata aaagtaattt taattcacca catacttatc aatttcttga
     6481 tgcttccaaa tgacatctac agatatggtt ttgtggacat ctttttctgt ttacataaat
     6541 ttatccactt aaaatgtgat aatgtggaga caaagcaaga tttgattaca taaacttttc
     6601 tctgcattgg tcttttcact atcttatttg ctaacttttc ttatttttct tcaacctccc
     6661 caccctccat tttttggata ttaaacaggg aaagcttgct acattataaa gattgttggc
     6721 accatttatt ttacacaaag gctaaaggtt aacttttgga aatgatgagc tacttttata
     6781 tatgtgttta ctcatgcttt gtgatatttc tggatcattc cagtcataaa gacttattac
     6841 atgtactatt tcttgctacc tgtgaaaagg tatattttaa agaatgtata accaacagtc
     6901 catttacttt ttattagtat gtagaggatt tgtatctaat tcatgaatgt agttttacag
     6961 tagtttgtca ttgtaaatgg agcaaagtac attatcttct aaaatgtaca ttatgtaaga
     7021 attgtaaata tacttaagta atttgtatgc caaaaaatta caataagtca ataaagatct
     7081 cacctctggc tta
//
