LOCUS       NM_014716               2511 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ArfGAP with coiled-coil, ankyrin repeat and PH domains
            1 (ACAP1), mRNA.
ACCESSION   NM_014716
VERSION     NM_014716.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2511)
  AUTHORS   Zhang,J., Zhang,Q., Zhang,J. and Wang,Q.
  TITLE     Expression of ACAP1 Is Associated with Tumor Immune Infiltration
            and Clinical Outcome of Ovarian Cancer
  JOURNAL   DNA Cell Biol 39 (9), 1545-1557 (2020)
   PUBMED   32456571
  REMARK    GeneRIF: Expression of ACAP1 Is Associated with Tumor Immune
            Infiltration and Clinical Outcome of Ovarian Cancer.
REFERENCE   2  (bases 1 to 2511)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2511)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2511)
  AUTHORS   Chan,C., Pang,X., Zhang,Y., Niu,T., Yang,S., Zhao,D., Li,J., Lu,L.,
            Hsu,V.W., Zhou,J., Sun,F. and Fan,J.
  TITLE     ACAP1 assembles into an unusual protein lattice for membrane
            deformation through multiple stages
  JOURNAL   PLoS Comput Biol 15 (7), e1007081 (2019)
   PUBMED   31291238
  REMARK    GeneRIF: As ACAP1 is an unconventional BAR protein, our findings
            broaden the understanding of the mechanistic spectrum by which
            proteins assemble into higher-ordered structures to achieve
            membrane deformation
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2511)
  AUTHORS   Grossmann,A., Benlasfer,N., Birth,P., Hegele,A., Wachsmuth,F.,
            Apelt,L. and Stelzl,U.
  TITLE     Phospho-tyrosine dependent protein-protein interaction network
  JOURNAL   Mol Syst Biol 11 (3), 794 (2015)
   PUBMED   25814554
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2511)
  AUTHORS   Zhan,X. and Desiderio,D.M.
  TITLE     Nitroproteins from a human pituitary adenoma tissue discovered with
            a nitrotyrosine affinity column and tandem mass spectrometry
  JOURNAL   Anal Biochem 354 (2), 279-289 (2006)
   PUBMED   16777052
REFERENCE   7  (bases 1 to 2511)
  AUTHORS   Dai,J., Li,J., Bos,E., Porcionatto,M., Premont,R.T., Bourgoin,S.,
            Peters,P.J. and Hsu,V.W.
  TITLE     ACAP1 promotes endocytic recycling by recognizing recycling sorting
            signals
  JOURNAL   Dev Cell 7 (5), 771-776 (2004)
   PUBMED   15525538
  REMARK    GeneRIF: ACAP1 promotes endocytic recycling by recognizing
            recycling sorting signals.
REFERENCE   8  (bases 1 to 2511)
  AUTHORS   Jackson,T.R., Brown,F.D., Nie,Z., Miura,K., Foroni,L., Sun,J.,
            Hsu,V.W., Donaldson,J.G. and Randazzo,P.A.
  TITLE     ACAPs are arf6 GTPase-activating proteins that function in the cell
            periphery
  JOURNAL   J Cell Biol 151 (3), 627-638 (2000)
   PUBMED   11062263
  REMARK    GeneRIF: Centaurin beta1/KIAA0050, or ACAP1, is a phospholipid
            dependent, ARF6 preferring GTPase-activating protein. It can
            regulate cytoskeletal and membrane trafficking events in the cell
            periphery and may be regulated via a phosphoinositide-binding PH
            domain.
REFERENCE   9  (bases 1 to 2511)
  AUTHORS   Jackson,T.R., Kearns,B.G. and Theibert,A.B.
  TITLE     Cytohesins and centaurins: mediators of PI 3-kinase-regulated Arf
            signaling
  JOURNAL   Trends Biochem Sci 25 (10), 489-495 (2000)
   PUBMED   11050434
  REMARK    GeneRIF: Centaurin beta1/KIAA0050, is a member of the centaurin
            family of ADP-ribosylation factor directed GTPase-activating
            proteins. Binding of phosphoinositides to a pleckstrin homology
            domain may regulate subcellular localisation and activity.
            Review article
REFERENCE   10 (bases 1 to 2511)
  AUTHORS   Adams,M.D., Kerlavage,A.R., Fleischmann,R.D., Fuldner,R.A.,
            Bult,C.J., Lee,N.H., Kirkness,E.F., Weinstock,K.G., Gocayne,J.D.,
            White,O. et al.
  TITLE     Initial assessment of human gene diversity and expression patterns
            based upon 83 million nucleotides of cDNA sequence
  JOURNAL   Nature 377 (6547 Suppl), 3-174 (1995)
   PUBMED   7566098
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AA356620.1, BC018543.1 and AC026954.14.
            
            On Nov 22, 2018 this sequence version replaced NM_014716.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.176167.1, D30758.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000158762.8/ ENSP00000158762.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AA356620.1         4-28
            26-63               BC018543.1         1-38
            64-64               AC026954.14        58078-58078
            65-2508             BC018543.1         40-2483
            2509-2511           AC026954.14        72961-72963
FEATURES             Location/Qualifiers
     source          1..2511
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.1"
     gene            1..2511
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /note="ArfGAP with coiled-coil, ankyrin repeat and PH
                     domains 1"
                     /db_xref="GeneID:9744"
                     /db_xref="HGNC:HGNC:16467"
                     /db_xref="MIM:607763"
     exon            1..259
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     CDS             207..2429
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /note="Arf GAP with coiled coil, ANK repeat and PH domains
                     1; cnt-b1; centaurin-beta-1"
                     /codon_start=1
                     /product="arf-GAP with coiled-coil, ANK repeat and PH
                     domain-containing protein 1"
                     /protein_id="NP_055531.1"
                     /db_xref="CCDS:CCDS11101.1"
                     /db_xref="GeneID:9744"
                     /db_xref="HGNC:HGNC:16467"
                     /db_xref="MIM:607763"
                     /translation="MTVKLDFEECLKDSPRFRASIELVEAEVSELETRLEKLLKLGTG
                     LLESGRHYLAASRAFVVGICDLARLGPPEPMMAECLEKFTVSLNHKLDSHAELLDATQ
                     HTLQQQIQTLVKEGLRGFREARRDFWRGAESLEAALTHNAEVPRRRAQEAEEAGAALR
                     TARAGYRGRALDYALQINVIEDKRKFDIMEFVLRLVEAQATHFQQGHEELSRLSQYRK
                     ELGAQLHQLVLNSAREKRDMEQRHVLLKQKELGGEEPEPSLREGPGGLVMEGHLFKRA
                     SNAFKTWSRRWFTIQSNQLVYQKKYKDPVTVVVDDLRLCTVKLCPDSERRFCFEVVST
                     SKSCLLQADSERLLQLWVSAVQSSIASAFSQARLDDSPRGPGQGSGHLAIGSAATLGS
                     GGMARGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSL
                     GVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEA
                     WIHAKYVEKKFLTKLPEIRGRRGGRGRPRGQPPVPPKPSIRPRPGSLRSKPEPPSEDL
                     GSLHPGALLFRASGHPPSLPTMADALAHGADVNWVNGGQDNATPLIQATAANSLLACE
                     FLLQNGANVNQADSAGRGPLHHATILGHTGLACLFLKRGADLGARDSEGRDPLTIAME
                     TANADIVTLLRLAKMREAEAAQGQAGDETYLDIFRDFSLMASDDPEKLSRRSHDLHTL
                     "
     exon            260..317
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..437
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            438..491
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            492..550
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            551..734
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            735..779
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..875
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..950
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            951..1060
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1061..1112
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1113..1213
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..1337
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1549
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1619
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1620..1714
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1884
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2057
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2058..2167
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2168..2278
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2279..2328
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     exon            2329..2511
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2486..2491
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /note="hexamer: ATTAAA"
     polyA_site      2511
                     /gene="ACAP1"
                     /gene_synonym="CENTB1"
                     /note="major polyA site"
ORIGIN      
        1 agcactgcct ggaagtgtgg ggtgagagct cctcctagga cacccctttc cccttgggga
       61 aagaattgtg cccccaggcc cttccccgcg gaggtccctc tcctccttcc ccctcatctc
      121 cccttcctgg gacagaaagt gcctccacct gcatccccag gggcccggcc tccagggccc
      181 gctggcccca cagcaggcaa gctgagatga cggtcaagct ggatttcgag gagtgtctca
      241 aggactcacc ccgtttccga gcctctattg agctggtgga agccgaagtg tcagaattgg
      301 agacccgtct ggaaaagctc ctgaaactgg gcactggtct cctggaaagt gggcgccatt
      361 accttgctgc cagccgcgcc ttcgttgtcg gcatttgtga cctggcccgc ctgggtccac
      421 cagagcccat gatggcggag tgtctggaaa aattcaccgt gagcctgaac cacaagctgg
      481 acagccatgc ggagcttcta gatgccaccc aacacacact gcagcagcag atccagaccc
      541 tggtcaagga aggtctgcgg ggtttccgag aggctcgccg ggatttctgg cggggggctg
      601 agagcctgga ggctgccctg acccacaacg cagaggttcc caggcgccgg gcccaggagg
      661 cagaagaggc aggagctgct ttgaggacgg ctcgagctgg gtaccgggga cgggcactgg
      721 attatgccct gcagatcaac gtgattgagg acaagaggaa gtttgacatc atggagtttg
      781 tgctgcgttt ggtggaggcc caggctaccc atttccagca gggccatgag gagctgagcc
      841 ggctgtccca gtatcgaaag gagctgggcg cccagttgca ccagctggtc ttgaattcag
      901 cacgagagaa gagggacatg gagcagagac acgtgctgct gaaacagaag gagctgggtg
      961 gggaggagcc agaaccaagc ttaagagagg ggcctggtgg cctggtgatg gaaggacatc
     1021 tcttcaaacg ggccagcaac gcatttaaga cctggagcag acgctggttc accattcaga
     1081 gcaaccaact ggtttaccag aagaagtaca aggaccctgt gactgtggtg gtggatgacc
     1141 ttcgtctctg cacagtgaaa ctctgccctg actcagaaag gcggttctgc tttgaggtgg
     1201 tgtccaccag caagtcctgc ctcctccagg ctgactcaga gcgcctcctg cagctgtggg
     1261 tcagtgctgt gcagagcagc attgcttctg ccttcagtca ggctcgcctt gatgacagcc
     1321 cccggggtcc aggccagggc tcaggacacc tggccatagg ctctgctgcc accctgggct
     1381 ctggtggaat ggccagggga agggagcctg ggggagtcgg gcacgtggtg gcccaggtcc
     1441 agagtgtgga tggcaatgcc cagtgctgcg actgccggga gccagccccg gagtgggcca
     1501 gcatcaacct tggtgtcacc ctctgcattc agtgttccgg catccacagg agccttggtg
     1561 ttcacttctc caaagtccgg tctctgaccc ttgactcatg ggagccagaa ctagtgaagc
     1621 tcatgtgtga gctgggaaat gtcatcatca accagatcta tgaggcccgc gtggaggcca
     1681 tggcagtgaa gaaaccaggg cccagctgct cccggcagga gaaggaggcc tggattcacg
     1741 ctaaatacgt ggagaagaag ttcctgacca agctgcctga gattcgaggg cgaagaggtg
     1801 gccgggggcg cccaaggggg cagcctcctg tgcccccaaa gccttccatc aggccccggc
     1861 cagggagctt gagatccaag ccagagcccc cctctgagga cctgggaagc ctgcaccctg
     1921 gggccctact gtttcgagcg tctgggcatc ctccatctct tcccaccatg gctgatgccc
     1981 ttgcccatgg agctgatgtc aactgggtca atgggggcca agataatgcc acaccgctga
     2041 tccaggccac agctgctaat tctcttctgg cctgtgagtt tctcctccag aacggggcga
     2101 acgtgaacca agcggacagt gcgggccggg gcccgctgca ccacgcaacc attcttggcc
     2161 acacggggct cgcctgcctg ttcctgaaac ggggagctga tctgggggct cgagactctg
     2221 aaggcaggga ccctctgacc atcgccatgg aaacagccaa cgctgacatc gtcaccctgc
     2281 tacgactggc aaagatgagg gaggctgaag cggcccaggg gcaggcagga gatgagacgt
     2341 atcttgacat cttccgcgac ttctccctca tggcgtcaga cgacccggag aagctgagcc
     2401 gtcgcagtca tgacctccac acgctgtgac ccgaggccca cggggcccgc gcctgcctcc
     2461 cttccccgcc accgggccct ctgccattaa agcctccgtg cttcgctctt c
//
