LOCUS       NM_032169               3231 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acyl-CoA dehydrogenase family member 11 (ACAD11),
            transcript variant 1, mRNA.
ACCESSION   NM_032169
VERSION     NM_032169.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3231)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   2  (bases 1 to 3231)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 3231)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 3231)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   5  (bases 1 to 3231)
  AUTHORS   Jiang,D., LaGory,E.L., Kenzelmann Broz,D., Bieging,K.T.,
            Brady,C.A., Link,N., Abrams,J.M., Giaccia,A.J. and Attardi,L.D.
  TITLE     Analysis of p53 transactivation domain mutants reveals Acad11 as a
            metabolic target important for p53 pro-survival function
  JOURNAL   Cell Rep 10 (7), 1096-1109 (2015)
   PUBMED   25704813
  REMARK    GeneRIF: Acad11, encoding a protein involved in fatty acid
            oxidation, is required for efficient OXPHOS and cell survival upon
            glucose starvation.
REFERENCE   6  (bases 1 to 3231)
  AUTHORS   Hong,M.G., Karlsson,R., Magnusson,P.K., Lewis,M.R., Isaacs,W.,
            Zheng,L.S., Xu,J., Gronberg,H., Ingelsson,E., Pawitan,Y.,
            Broeckling,C., Prenni,J.E., Wiklund,F. and Prince,J.A.
  TITLE     A genome-wide assessment of variability in human serum metabolism
  JOURNAL   Hum Mutat 34 (3), 515-524 (2013)
   PUBMED   23281178
REFERENCE   7  (bases 1 to 3231)
  AUTHORS   He,M., Pei,Z., Mohsen,A.W., Watkins,P., Murdoch,G., Van
            Veldhoven,P.P., Ensenauer,R. and Vockley,J.
  TITLE     Identification and characterization of new long chain acyl-CoA
            dehydrogenases
  JOURNAL   Mol Genet Metab 102 (4), 418-429 (2011)
   PUBMED   21237683
  REMARK    GeneRIF: ACAD11 utilizes substrates with primary carbon chain
            lengths between 20 and 26, with optimal activity towards C22CoA
REFERENCE   8  (bases 1 to 3231)
  AUTHORS   Swigonova,Z., Mohsen,A.W. and Vockley,J.
  TITLE     Acyl-CoA dehydrogenases: Dynamic history of protein family
            evolution
  JOURNAL   J Mol Evol 69 (2), 176-193 (2009)
   PUBMED   19639238
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC125204.1 and AI091999.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_032169.4.
            
            Summary: This gene encodes an acyl-CoA dehydrogenase enzyme with a
            preference for carbon chain lengths between 20 and 26. Naturally
            occurring read-through transcription occurs between the upstream
            gene NPHP3 (nephronophthisis 3 (adolescent)) and this gene.
            [provided by RefSeq, Aug 2015].
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.132221.1,
                                           SRR1660809.103163.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264990.11/ ENSP00000264990.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2900              BC125204.1         258-3157
            2901-3231           AI091999.1         8-338               c
FEATURES             Location/Qualifiers
     source          1..3231
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q22.1"
     gene            1..3231
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /note="acyl-CoA dehydrogenase family member 11"
                     /db_xref="GeneID:84129"
                     /db_xref="HGNC:HGNC:30211"
                     /db_xref="MIM:614288"
     exon            1..207
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     CDS             59..2401
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /EC_number="1.3.8.-"
                     /note="acyl-Coenzyme A dehydrogenase family, member 11"
                     /codon_start=1
                     /product="acyl-CoA dehydrogenase family member 11"
                     /protein_id="NP_115545.3"
                     /db_xref="CCDS:CCDS3074.1"
                     /db_xref="GeneID:84129"
                     /db_xref="HGNC:HGNC:30211"
                     /db_xref="MIM:614288"
                     /translation="MKPGATGESDLAEVLPQHKFDSKSLEAYLNQHLSGFGAEREATL
                     TIAQYRAGKSNPTFYLQKGFQTYVLRKKPPGSLLPKAHQIDREFKVQKALFSIGFPVP
                     KPILYCSDTSVIGTEFYVMEHVQGRIFRDLTIPGLSPAERSAIYVATVETLAQLHSLN
                     IQSLQLEGYGIGAGYCKRQVSTWTKQYQAAAHQDIPAMQQLSEWLMKNLPDNDNEENL
                     IHGDFRLDNIVFHPKECRVIAVLDWELSTIGHPLSDLAHFSLFYFWPRTVPMINQGSY
                     SENSGIPSMEELISIYCRCRGINSILPNWNFFLALSYFKMAGIAQGVYSRYLLGNNSS
                     EDSFLFANIVQPLAETGLQLSKRTFSTVLPQIDTTGQLFVQTRKGQEVLIKVKHFMKQ
                     HILPAEKEVTEFYVQNENSVDKWGKPLVIDKLKEMAKVEGLWNLFLPAVSGLSHVDYA
                     LIAEETGKCFFAPDVFNCQAPDTGNMEVLHLYGSEEQKKQWLEPLLQGNITSCFCMTE
                     PDVASSDATNIECSIQRDEDSYVINGKKWWSSGAGNPKCKIAIVLGRTQNTSLSRHKQ
                     HSMILVPMNTPGVKIIRPLSVFGYTDNFHGGHFEIHFNQVRVPATNLILGEGRGFEIS
                     QGRLGPGRIHHCMRTVGLAERALQIMCERATQRIAFKKKLYAHEVVAHWIAESRIAIE
                     KIRLLTLKAAHSMDTLGSAGAKKEIAMIKVAAPRAVSKIVDWAIQVCGGAGVSQDYPL
                     ANMYAITRVLRLADGPDEVHLSAIATMELRDQAKRLTAKI"
     exon            208..307
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            308..433
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            434..595
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            596..760
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            761..899
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1021
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1128
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1255
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1256..1333
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1334..1472
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1580
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1679
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1746
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1832
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1833..1904
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            1905..2059
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2060..2176
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2177..2286
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     exon            2287..3231
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3208..3213
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /note="hexamer: ATTAAA"
     polyA_site      3231
                     /gene="ACAD11"
                     /gene_synonym="ACAD-11"
                     /note="major polyA site"
ORIGIN      
        1 aggacttcgg cactcgagac ctgtggatgc cgcgttgctg tggcctgcgg gggtgatcat
       61 gaagccaggt gctactggcg agtccgattt ggccgaagtg ctgccccagc acaagttcga
      121 cagcaagtcc ctggaggcct acctaaacca gcacttgtct ggctttgggg ccgaacgtga
      181 ggctacgctg accattgccc agtacagagc aggaaagtcc aatccaacct tttatctcca
      241 gaagggcttt caaacatatg tgctcaggaa aaaaccacca ggttcacttc ttcctaaagc
      301 acatcagatt gatagagaat ttaaagtcca gaaagccttg ttttcaattg gattccccgt
      361 tcccaagcct atactgtact gcagtgatac ttctgtcatt ggaacagaat tttacgtaat
      421 ggaacatgtg cagggtcgaa tcttccgtga tttaacaatt cctggactta gcccagcaga
      481 acgttcagcc atatatgtgg ccacggtaga aacattggct cagttacatt ccttgaatat
      541 acagtcactg cagctggaag gatatggtat aggtgctggg tactgcaaaa gacaggtatc
      601 aacctggaca aagcaatatc aagctgcagc tcatcaggac atccctgcca tgcaacagct
      661 atcggagtgg ctaatgaaga acttgcccga taatgacaat gaagagaatt tgattcatgg
      721 agatttcaga ctagataaca tagttttcca ccctaaagag tgtcgagtta tagcagtgct
      781 ggattgggag ctgtcaacca ttggtcatcc tttgtcagac ttagctcatt tttccctgtt
      841 ctacttttgg ccaaggacag ttccaatgat aaatcaaggt tcttatagtg aaaactcagg
      901 gataccatca atggaagaac tgatttcaat atattgccgc tgcaggggaa ttaattctat
      961 tcttcctaac tggaatttct ttcttgccct ttcatatttt aagatggctg gaatagcaca
     1021 gggagtatat agcagatatc ttctgggaaa taattcatct gaggatagct ttttatttgc
     1081 caatattgtg caacctctgg cagaaactgg actacaactc tccaaacgaa ctttcagtac
     1141 tgtactacca cagattgata ctactggaca gttgtttgta cagactcgga aaggtcagga
     1201 agttcttatt aaggtgaagc atttcatgaa acaacacatt cttccagctg aaaaggaggt
     1261 aactgagttc tatgttcaaa atgaaaattc agtggacaag tggggaaaac ctttagtgat
     1321 tgataaactc aaggaaatgg ccaaagtcga gggtctctgg aacttgtttt tgccagctgt
     1381 cagcggactc agccacgtgg actatgcctt gattgctgaa gaaacaggaa aatgcttttt
     1441 tgctccagat gtctttaact gccaagcacc agacacaggg aatatggagg ttctgcacct
     1501 gtatggaagt gaggaacaga agaaacagtg gcttgagcct cttcttcaag ggaacattac
     1561 ctcttgcttc tgtatgacag aacctgatgt agcttcaagt gatgccacga atattgaatg
     1621 cagcatccaa cgagatgaag atagctatgt aattaacggc aaaaaatggt ggagcagtgg
     1681 agctgggaat cccaagtgca aaattgcaat tgttttggga agaactcaaa atacttctct
     1741 ctccagacac aaacagcaca gcatgattct tgttcccatg aacacacctg gagtaaaaat
     1801 aataaggcct ttgtcagttt ttggctacac agataatttt catggaggac attttgagat
     1861 ccattttaat caagtgcgag ttcctgccac aaatctaata ctaggtgaag gtaggggatt
     1921 tgaaatttcc caaggccgcc ttggacctgg cagaatccac cactgtatga gaacagtagg
     1981 tttggcggaa cgcgctttgc agatcatgtg tgagcgggca acacaaagga tagctttcaa
     2041 gaagaagttg tatgcacatg aggttgtggc tcactggatt gctgaaagcc gcattgccat
     2101 tgagaagatc cgcttgttga ctctgaaagc tgctcacagc atggacactc tgggcagtgc
     2161 tggcgctaag aaagagattg caatgatcaa agtggctgcc ccacgggctg tcagcaaaat
     2221 cgttgactgg gccatccagg tgtgcggagg tgctggtgtt tcccaggatt accctctggc
     2281 taacatgtat gctataaccc gagttttgcg tttagcagat ggacctgacg aagttcatct
     2341 ttcagcaatc gcaacaatgg agctgcggga ccaagccaaa agactgacag ccaagatata
     2401 aggagggtgg cactgccaca tcccactggc agaaactctc ctttatacaa acttcattgg
     2461 ctccaacatt tgaatctcat atttttgtag cagtttgagc acagggttaa ttattcattt
     2521 gtggtaaaga ttatagcatc tattttgatc agtgggtttt attatttcaa gggtcacaca
     2581 gggttaagtt cagtaagaaa tgctgtagct gttgtcattc aatctagtgc ctccttgagg
     2641 ccaggagttc aggaccagcc tgggcaacat agcgagaccc ccattgctac aaaaaattta
     2701 aaaatgaaac aagtgtggtg gcacatgctt gtagtcctag ctacttggga ggctgaggca
     2761 ggaggattgc ttgagtctag gagtttgagg ttacagtaag ctgtgatcgt gacatggcct
     2821 ccagcctggg tgaccgagtg agactgtttc taaaaataaa aacaaaaaat aaatttcttc
     2881 ttgaggtggg gtggaggtgg ggagcaagaa tttgacctgg ctctgatccc tggtgtgttg
     2941 tgtgggcctc tttaacgttt gccactgagc cttaacctca ctgtacttca ctgtacttca
     3001 cacgcattgg tgttaacatt ttaatcttag aagaccctga cccactgagg gtttgttgtg
     3061 agaattgctg aagccacgta gaagcacctt gaaatctgta aaaccacaag aaagtacttt
     3121 ataaaaggta tccttatttg aagtggataa atcttgtaac tcgaaaagtt gtgatttaga
     3181 agacaggatt gtttttgaac attaggaatt aaaggctata tctggtcctt a
//
