LOCUS       NM_025247               4006 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens acyl-CoA dehydrogenase family member 10 (ACAD10),
            transcript variant 2, mRNA.
ACCESSION   NM_025247
VERSION     NM_025247.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4006)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 4006)
  AUTHORS   Cho,S.B. and Jang,J.
  TITLE     A Genome-Wide Association Study of a Korean Population Identifies
            Genetic Susceptibility to Hypertension Based on Sex-Specific
            Differences
  JOURNAL   Genes (Basel) 12 (11), 1804 (2021)
   PUBMED   34828409
  REMARK    GeneRIF: A Genome-Wide Association Study of a Korean Population
            Identifies Genetic Susceptibility to Hypertension Based on
            Sex-Specific Differences.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4006)
  AUTHORS   Bloom,K., Karunanidhi,A., Tobita,K., Hoppel,C., Thiels,E., Peet,E.,
            Wang,Y., Basu,S. and Vockley,J.
  TITLE     ACAD10 protein expression and Neurobehavioral assessment of
            Acad10-deficient mice
  JOURNAL   PLoS One 15 (12), e0242445 (2020)
   PUBMED   33301490
  REMARK    GeneRIF: ACAD10 protein expression and Neurobehavioral assessment
            of Acad10-deficient mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4006)
  AUTHORS   Hallak,J.A., de Sisternes,L., Osborne,A., Yaspan,B., Rubin,D.L. and
            Leng,T.
  TITLE     Imaging, Genetic, and Demographic Factors Associated With
            Conversion to Neovascular Age-Related Macular Degeneration:
            Secondary Analysis of a Randomized Clinical Trial
  JOURNAL   JAMA Ophthalmol 137 (7), 738-744 (2019)
   PUBMED   31021381
  REMARK    GeneRIF: Two imaging features (total en face area of drusen
            restricted to a circular area 3 mm from the fovea and mean drusen
            reflectivity) and 1 genetic variant (ACAD10 locus) were associated
            with conversion to neovascular age-related macular degeneration
            (AMD).
REFERENCE   5  (bases 1 to 4006)
  AUTHORS   Yamada,Y., Sakuma,J., Takeuchi,I., Yasukochi,Y., Kato,K., Oguri,M.,
            Fujimaki,T., Horibe,H., Muramatsu,M., Sawabe,M., Fujiwara,Y.,
            Taniguchi,Y., Obuchi,S., Kawai,H., Shinkai,S., Mori,S., Arai,T. and
            Tanaka,M.
  TITLE     Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as
            novel genetic determinants of blood pressure in Japanese by
            exome-wide association studies
  JOURNAL   Oncotarget 8 (26), 43068-43079 (2017)
   PUBMED   28562329
  REMARK    GeneRIF: Six polymorphisms (rs12229654 at 12q24.1, rs671 of ALDH2,
            rs11066015 of ACAD10, rs2074356 and rs11066280 of HECTD4, and
            rs3782886 of BRAP) were found to be associated with both systolic
            and diastolic blood pressure, with those at 12q24.1 or in ACAD10 or
            BRAP being novel determinants of blood pressure in Japanese.
REFERENCE   6  (bases 1 to 4006)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4006)
  AUTHORS   Bian,L., Hanson,R.L., Muller,Y.L., Ma,L., Kobes,S., Knowler,W.C.,
            Bogardus,C. and Baier,L.J.
  CONSRTM   MAGIC Investigators
  TITLE     Variants in ACAD10 are associated with type 2 diabetes, insulin
            resistance and lipid oxidation in Pima Indians
  JOURNAL   Diabetologia 53 (7), 1349-1353 (2010)
   PUBMED   20390405
  REMARK    GeneRIF: Results propose that ACAD10 variation may increase type 2
            diabetes susceptibility by impairing insulin sensitivity via
            abnormal lipid oxidation.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 4006)
  AUTHORS   Vega,A., Salas,A., Milne,R.L., Carracedo,B., Ribas,G., Ruibal,A.,
            de Leon,A.C., Gonzalez-Hernandez,A., Benitez,J. and Carracedo,A.
  TITLE     Evaluating new candidate SNPs as low penetrance risk factors in
            sporadic breast cancer: a two-stage Spanish case-control study
  JOURNAL   Gynecol Oncol 112 (1), 210-214 (2009)
   PUBMED   18950845
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   9  (bases 1 to 4006)
  AUTHORS   Ye,X., Ji,C., Zhou,C., Zeng,L., Gu,S., Ying,K., Xie,Y. and Mao,Y.
  TITLE     Cloning and characterization of a human cDNA ACAD10 mapped to
            chromosome 12q24.1
  JOURNAL   Mol Biol Rep 31 (3), 191-195 (2004)
   PUBMED   15560374
  REMARK    GeneRIF: cDNA ACAD10 maps to chromosome 12q24.1
REFERENCE   10 (bases 1 to 4006)
  AUTHORS   Sogayar,M.C., Camargo,A.A., Bettoni,F., Carraro,D.M., Pires,L.C.,
            Parmigiani,R.B., Ferreira,E.N., de Sa Moreira,E., do Rosario D de O
            Latorre,M., Simpson,A.J., Cruz,L.O., Degaki,T.L., Festa,F.,
            Massirer,K.B., Sogayar,M.C., Filho,F.C., Camargo,L.P., Cunha,M.A.,
            De Souza,S.J., Faria,M. Jr., Giuliatti,S., Kopp,L., de
            Oliveira,P.S., Paiva,P.B., Pereira,A.A., Pinheiro,D.G., Puga,R.D.,
            S de Souza,J.E., Albuquerque,D.M., Andrade,L.E., Baia,G.S.,
            Briones,M.R., Cavaleiro-Luna,A.M., Cerutti,J.M., Costa,F.F.,
            Costanzi-Strauss,E., Espreafico,E.M., Ferrasi,A.C., Ferro,E.S.,
            Fortes,M.A., Furchi,J.R., Giannella-Neto,D., Goldman,G.H.,
            Goldman,M.H., Gruber,A., Guimaraes,G.S., Hackel,C.,
            Henrique-Silva,F., Kimura,E.T., Leoni,S.G., Macedo,C., Malnic,B.,
            Manzini,B. CV, Marie,S.K., Martinez-Rossi,N.M., Menossi,M.,
            Miracca,E.C., Nagai,M.A., Nobrega,F.G., Nobrega,M.P.,
            Oba-Shinjo,S.M., Oliveira,M.K., Orabona,G.M., Otsuka,A.Y.,
            Paco-Larson,M.L., Paixao,B.M., Pandolfi,J.R., Pardini,M.I., Passos
            Bueno,M.R., Passos,G.A., Pesquero,J.B., Pessoa,J.G., Rahal,P.,
            Rainho,C.A., Reis,C.P., Ricca,T.I., Rodrigues,V., Rogatto,S.R.,
            Romano,C.M., Romeiro,J.G., Rossi,A., Sa,R.G., Sales,M.M.,
            Sant'Anna,S.C., Santarosa,P.L., Segato,F., Silva,W.A. Jr.,
            Silva,I.D., Silva,N.P., Soares-Costa,A., Sonati,M.F., Strauss,B.E.,
            Tajara,E.H., Valentini,S.R., Villanova,F.E., Ward,L.S. and
            Zanette,D.L.
  CONSRTM   Ludwig-FAPESP Transcript Finishing Initiative
  TITLE     A transcript finishing initiative for closing gaps in the human
            transcriptome
  JOURNAL   Genome Res 14 (7), 1413-1423 (2004)
   PUBMED   15197164
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA146693.1, AY323912.1,
            AL832043.1 and CA419108.1.
            
            On Jun 2, 2019 this sequence version replaced NM_025247.5.
            
            Summary: This gene encodes a member of the acyl-CoA dehydrogenase
            family of enzymes (ACADs), which participate in the beta-oxidation
            of fatty acids in mitochondria. The encoded enzyme contains a
            hydrolase domain at the N-terminal portion, a serine/threonine
            protein kinase catlytic domain in the central region, and a
            conserved ACAD domain at the C-terminus. Several alternatively
            spliced transcript variants of this gene have been described, but
            the full-length nature of some of these variants has not been
            determined. [provided by RefSeq, Nov 2008].
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon, compared to variant 1, resulting in a shorter protein
            (isoform b) compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803613.268777.1,
                                           SRR1803617.64313.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313698.9/ ENSP00000325137.5
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                DA146693.1         1-45
            46-3475             AY323912.1         2-3431
            3476-3687           AL832043.1         3547-3758
            3688-4006           CA419108.1         26-344              c
FEATURES             Location/Qualifiers
     source          1..4006
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.12"
     gene            1..4006
                     /gene="ACAD10"
                     /note="acyl-CoA dehydrogenase family member 10"
                     /db_xref="GeneID:80724"
                     /db_xref="HGNC:HGNC:21597"
                     /db_xref="MIM:611181"
     exon            1..187
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            188..387
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..3380
                     /gene="ACAD10"
                     /EC_number="1.2.1.3"
                     /note="isoform b is encoded by transcript variant 2;
                     acyl-Coenzyme A dehydrogenase family, member 10; ACAD-10"
                     /codon_start=1
                     /product="acyl-CoA dehydrogenase family member 10 isoform
                     b"
                     /protein_id="NP_079523.3"
                     /db_xref="CCDS:CCDS31903.1"
                     /db_xref="GeneID:80724"
                     /db_xref="HGNC:HGNC:21597"
                     /db_xref="MIM:611181"
                     /translation="MCVRSCFQSPRLQWVWRTAFLKHTQRRHQGSHRWTHLGGSTYRA
                     VIFDMGGVLIPSPGRVAAEWEVQNRIPSGTILKALMEGGENGPWMRFMRAEITAEGFL
                     REFGRLCSEMLKTSVPVDSFFSLLTSERVAKQFPVMTEAITQIRAKGLQTAVLSNNFY
                     LPNQKSFLPLDRKQFDVIVESCMEGICKPDPRIYKLCLEQLGLQPSESIFLDDLGTNL
                     KEAARLGIHTIKVNDPETAVKELEALLGFTLRVGVPNTRPVKKTMEIPKDSLQKYLKD
                     LLGIQTTGPLELLQFDHGQSNPTYYIRLANRDLVLRKKPPGTLLPSAHAIEREFRIMK
                     ALANAGVPVPNVLDLCEDSSVIGTPFYVMEYCPGLIYKDPSLPGLEPSHRRAIYTAMN
                     TVLCKIHSVDLQAVGLEDYGKQGDYIPRQVRTWVKQYRASETSTIPAMERLIEWLPLH
                     LPRQQRTTVVHGDFRLDNLVFHPEEPEVLAVLDWELSTLGDPLADVAYSCLAHYLPSS
                     FPVLRGINDCDLTQLGIPAAEEYFRMYCLQMGLPPTENWNFYMAFSFFRVAAILQGVY
                     KRSLTGQASSTYAEQTGKLTEFVSNLAWDFAVKEGFRVFKEMPFTNPLTRSYHTWARP
                     QSQWCPTGSRSYSSVPEASPAHTSRGGLVISPESLSPPVRELYHRLKHFMEQRVYPAE
                     PELQSHQASAARWSPSPLIEDLKEKAKAEGLWNLFLPLEADPEKKYGAGLTNVEYAHL
                     CELMGTSLYAPEVCNCSAPDTGNMELLVRYGTEAQKARWLIPLLEGKARSCFAMTEPQ
                     VASSDATNIEASIREEDSFYVINGHKWWITGILDPRCQLCVFMGKTDPHAPRHRQQSV
                     LLVPMDTPGIKIIRPLTVYGLEDAPGGHGEVRFEHVRVPKENMVLGPGRGFEIAQGRL
                     GPGRIHHCMRLIGFSERALALMKARVKSRLAFGKPLVEQGTVLADIAQSRVEIEQARL
                     LVLRAAHLMDLAGNKAAALDIAMIKMVAPSMASRVIDRAIQAFGAAGLSSDYPLAQFF
                     TWARALRFADGPDEVHRATVAKLELKHRI"
     exon            388..536
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            537..731
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            732..890
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            891..1050
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1192
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1193..1261
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1443
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1444..1594
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1740
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1914
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..2315
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2316..2456
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2594
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2595..2685
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2686..2844
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3017
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            3018..3161
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            3162..3239
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     exon            3240..4006
                     /gene="ACAD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3987..3992
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAD10"
                     /note="hexamer: AGTAAA"
     polyA_site      4006
                     /gene="ACAD10"
                     /note="major polyA site"
ORIGIN      
        1 actgctcttc cggacgcaat tttgaggagg tcggagcgga aggacgtcgt ggagattgct
       61 tgcgctgggg tgccacactt aggctgagct gcaggttttc gcacagtcgc gagttaacct
      121 ctgcttgctc cagaggcctc gtcctaatcc acctcggctg acggcgcggg atccctggct
      181 ccgcgagcct cagcctcacc atgtgtgtca ggagctgttt ccagtccccc cgtctccagt
      241 gggtgtggag aacagccttc ctgaaacaca cccagcgcag gcaccagggg tcccaccgat
      301 ggacacacct tggaggcagc acctacagag cggtgatttt cgacatgggc ggagttctca
      361 ttccttctcc agggagagtc gctgcagaat gggaggtaca gaatcgtatc ccttctggaa
      421 ctatattaaa ggccttgatg gaaggtggtg aaaatgggcc ctggatgaga tttatgagag
      481 cagaaataac agcagagggt tttttacgag aatttgggag actttgctct gaaatgttaa
      541 agacctccgt gcctgtggac tcatttttct ctctgttgac cagtgagcga gtggcaaagc
      601 agttcccagt gatgactgag gccataactc aaattcgggc aaaaggtctt cagactgcag
      661 tcttgagcaa taatttttat cttcccaacc agaaaagctt tttgcccctg gaccggaaac
      721 agtttgatgt gattgtggag tcctgcatgg aagggatctg taagccagac cctaggatct
      781 acaagctgtg cttggagcag ctcggcctgc agccctctga gtccatcttt cttgatgacc
      841 ttggaacaaa tctaaaagaa gctgccagac ttggtattca caccattaag gttaatgacc
      901 cagagactgc agtaaaggaa ttagaagctc tcttgggttt tacattgaga gtaggtgttc
      961 caaacactcg gcctgtgaaa aagacgatgg aaattccgaa agattccttg cagaagtacc
     1021 tcaaagactt actgggtatc cagaccacag gcccattgga actacttcag tttgatcacg
     1081 ggcagtcaaa tccaacttac tacatcaggc tggctaatcg tgatctagtt ctgaggaaga
     1141 agcccccagg gacactcctt ccatctgccc atgccataga gagggagttc aggattatga
     1201 aagcccttgc aaatgctgga gtacctgtcc ctaacgttct tgatctctgt gaagattcaa
     1261 gtgtcattgg cacccccttc tatgtgatgg agtactgccc aggtctcatc tacaaagacc
     1321 cttccctgcc aggcttggag cccagccaca gacgagccat atacactgcc atgaacacag
     1381 tcctgtgcaa aattcacagt gtggatctgc aggctgtggg acttgaagac tatgggaagc
     1441 aaggggacta tattccacgc caggtacgaa cctgggttaa gcagtatcga gcttccgaaa
     1501 ctagcaccat cccagccatg gagaggctga tcgaatggct gcccctccat cttccccgtc
     1561 agcagaggac cacagtggtg cacggggact tcaggctcga caacctggtg tttcatccag
     1621 aagagccaga ggtgcttgct gtccttgact gggaactttc taccttgggc gacccccttg
     1681 ctgatgtggc ctacagctgc ctggctcatt acctgccatc cagttttccc gtgctgagag
     1741 gtattaatga ctgtgacttg acacagctgg gaatccctgc tgcagaggag tatttcagga
     1801 tgtactgtct ccaaatgggg ctccctccca ctgagaactg gaacttctat atggcttttt
     1861 cctttttccg tgtggctgca atcctacagg gagtctacaa gcgatcactc acagggcaag
     1921 caagctccac atatgcggaa caaactggaa agctgaccga atttgtgtct aacctggcgt
     1981 gggatttcgc agtcaaagaa gggttccggg ttttcaaaga gatgcccttc acaaatccgt
     2041 taacaaggtc ctaccacacg tgggccaggc cccagtccca gtggtgcccc acaggcagca
     2101 ggagttatag ctccgttcca gaagcttccc cagctcatac ctcaagggga ggtctggtta
     2161 tctctccaga gagcctctct ccacctgtca gagagctgta tcaccggctg aagcacttca
     2221 tggagcaacg tgtgtaccct gcagagccag agctgcagag tcaccaggcc tcagcagcca
     2281 ggtggagccc ctccccactg atcgaagacc tcaaggagaa agccaaagct gaaggacttt
     2341 ggaacctttt cctaccctta gaggctgatc ccgagaaaaa atacggagca ggactgacca
     2401 atgtggaata tgcacatctg tgtgagctca tgggcacgtc cctgtatgcc cccgaggtat
     2461 gtaactgctc tgcgcctgac acgggcaaca tggagctgct ggtgaggtat ggcaccgaag
     2521 cgcagaaggc tcgctggctg attcctctgc tggaggggaa agcccgctcc tgttttgcta
     2581 tgaccgagcc ccaggttgcc tcttcagatg ccaccaacat tgaggcttcc atcagagagg
     2641 aggacagctt ctatgtcata aacggtcaca aatggtggat cacaggcatc ctggatcctc
     2701 gttgccaact ctgtgtgttt atgggaaaaa cagacccaca tgcaccaaga caccggcagc
     2761 agtctgtgct cttggttccc atggataccc cagggataaa aatcatccgg cctctgacgg
     2821 tgtatggact ggaagatgca ccaggtggcc atggtgaagt ccgatttgag cacgtgcgtg
     2881 tgcccaaaga gaacatggtc ctgggccctg gccgaggctt tgagatcgcc cagggcagac
     2941 tgggccccgg caggatccat cactgcatga ggctgatcgg gttctcagag agggccctgg
     3001 cactcatgaa ggcccgcgtg aagtcccgct tggcttttgg gaagcccctg gtggagcagg
     3061 gcacagtgct ggcggacatc gcgcagtcgc gcgtggagat tgagcaggca cggctgctgg
     3121 tgctgagagc tgcccacctc atggacctgg caggaaacaa ggctgcagcc ttggatatag
     3181 ccatgattaa aatggtcgcc ccgtccatgg cctcccgagt gattgatcgt gcgattcagg
     3241 cctttggagc agcaggcctg agcagcgact acccactggc tcagttcttc acctgggccc
     3301 gagccctgcg ctttgccgac ggccctgacg aggtgcaccg ggccacggtg gccaagctag
     3361 agctgaagca ccgcatttag agccttgggg ctgcagtggc tcaatgtcct ggctggtcca
     3421 gctgtgccca gatctgtcac tgatgtgcct cgaaagatcc ggtgtttgtg gctcctgcac
     3481 cctgctcagc agctctgtcc cgggacagtc agggtggact caatctttct ggttctccac
     3541 agaagacgtc tctgcaagaa gcctggagtc tgtttcaggc caggaggagg ggatttgctg
     3601 agggccaagg gggttctggg acagagtctg gaaagctggt cttcaggctc tcagtcccag
     3661 gctgggcagg cacggtcact tcacttcagc ctttcagtcc ctctctctct gcctgtggga
     3721 atctggacac attttgggag gcctcccaag gctgtgggac gtgcttgctc tggcagctgc
     3781 agggttcctg tctggcctcc ctggtgagca gaggggcggc cacggcgggc ggtggcctag
     3841 agacccagga cctgggcgcc tgggaaaatg gaatgcaacc cacattgtaa agccactggc
     3901 atctgattat ctccatttga acacacagca cagaacaatc atttaaatgt tattttggaa
     3961 aggggttttg gggacacaga agaataagta aacacatctc ggaggc
//
