LOCUS       NM_001093               9368 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens acetyl-CoA carboxylase beta (ACACB), transcript
            variant 2, mRNA.
ACCESSION   NM_001093 XM_005253876
VERSION     NM_001093.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9368)
  AUTHORS   Hong,H.J., Shao,Y., Zhang,S., Yang,G., Jia,H., Yang,X., Huang,L.,
            Li,S., Aikemu,B., Zhang,L., Ma,J., Zang,L., Sun,J. and Zheng,M.
  TITLE     ACACB is a novel metabolism-related biomarker in the prediction of
            response to cetuximab therapy inmetastatic colorectal cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 54 (11), 1671-1683 (2022)
   PUBMED   36111743
  REMARK    GeneRIF: ACACB is a novel metabolism-related biomarker in the
            prediction of response to cetuximab therapy inmetastatic colorectal
            cancer.
REFERENCE   2  (bases 1 to 9368)
  AUTHORS   Chan,G.C.W., Zhi,H., Hicks,P.J., Freedman,B.I. and Tang,S.C.W.
  TITLE     Acetyl-coenzyme A carboxylase beta gene polymorphism does not
            predict cardiovascular risk susceptibility in Chinese type 2
            diabetic individuals
  JOURNAL   Nephrology (Carlton) 27 (5), 404-409 (2022)
   PUBMED   34939260
  REMARK    GeneRIF: Acetyl-coenzyme A carboxylase beta gene polymorphism does
            not predict cardiovascular risk susceptibility in Chinese type 2
            diabetic individuals.
REFERENCE   3  (bases 1 to 9368)
  AUTHORS   Dong,Z., Lei,X., Kujawa,S.A., Bolu,N., Zhao,H. and Wang,C.
  TITLE     Identification of core gene in obese type 2 diabetes patients using
            bioinformatics analysis
  JOURNAL   Adipocyte 10 (1), 310-321 (2021)
   PUBMED   34085602
  REMARK    GeneRIF: Identification of core gene in obese type 2 diabetes
            patients using bioinformatics analysis.
REFERENCE   4  (bases 1 to 9368)
  AUTHORS   Wang,Q., Zhao,B., Zhang,J., Sun,J., Wang,S., Zhang,X., Xu,Y. and
            Wang,R.
  TITLE     Faster lipid beta-oxidation rate by acetyl-CoA carboxylase 2
            inhibition alleviates high-glucose-induced insulin resistance via
            SIRT1/PGC-1alpha in human podocytes
  JOURNAL   J Biochem Mol Toxicol 35 (7), e22797 (2021)
   PUBMED   33957017
  REMARK    GeneRIF: Faster lipid beta-oxidation rate by acetyl-CoA carboxylase
            2 inhibition alleviates high-glucose-induced insulin resistance via
            SIRT1/PGC-1alpha in human podocytes.
REFERENCE   5  (bases 1 to 9368)
  AUTHORS   Jang,S., Gornicki,P., Marjanovic,J., Bass,E., P Iurcotta,T.,
            Rodriguez,P., Austin,J. 2nd and Haselkorn,R.
  TITLE     Activity and structure of human acetyl-CoA carboxylase targeted by
            a specific inhibitor
  JOURNAL   FEBS Lett 592 (12), 2048-2058 (2018)
   PUBMED   29772612
  REMARK    GeneRIF: Results identified ACC2 amino acid mutations affecting
            specific inhibition of the isozyme by compound CD-017-0191. They
            form two clusters separated by 60-90 A: one located in the vicinity
            of the BC active site and the other one in the vicinity of the ACC1
            phosphorylation sites in the central domain, suggesting a
            contribution of the interface of two ACC dimers in the polymer to
            the inhibitor binding site.
REFERENCE   6  (bases 1 to 9368)
  AUTHORS   Abu-Elheiga,L., Brinkley,W.R., Zhong,L., Chirala,S.S.,
            Woldegiorgis,G. and Wakil,S.J.
  TITLE     The subcellular localization of acetyl-CoA carboxylase 2
  JOURNAL   Proc Natl Acad Sci U S A 97 (4), 1444-1449 (2000)
   PUBMED   10677481
REFERENCE   7  (bases 1 to 9368)
  AUTHORS   Abu-Elheiga,L., Almarza-Ortega,D.B., Baldini,A. and Wakil,S.J.
  TITLE     Human acetyl-CoA carboxylase 2. Molecular cloning,
            characterization, chromosomal mapping, and evidence for two
            isoforms
  JOURNAL   J Biol Chem 272 (16), 10669-10677 (1997)
   PUBMED   9099716
REFERENCE   8  (bases 1 to 9368)
  AUTHORS   Ullrich,C.K., Widmer,J., Park,J.P., Mohandas,T.K. and Witters,L.A.
  TITLE     Assignment of acetyl-CoA carboxylase-beta (ACACB) to human
            chromosome band 12q24.1 by in situ hybridization
  JOURNAL   Cytogenet Cell Genet 77 (3-4), 176-177 (1997)
   PUBMED   9284908
REFERENCE   9  (bases 1 to 9368)
  AUTHORS   Ha,J., Lee,J.K., Kim,K.S., Witters,L.A. and Kim,K.H.
  TITLE     Cloning of human acetyl-CoA carboxylase-beta and its unique
            features
  JOURNAL   Proc Natl Acad Sci U S A 93 (21), 11466-11470 (1996)
   PUBMED   8876158
REFERENCE   10 (bases 1 to 9368)
  AUTHORS   Widmer,J., Fassihi,K.S., Schlichter,S.C., Wheeler,K.S., Crute,B.E.,
            King,N., Nutile-McMenemy,N., Noll,W.W., Daniel,S., Ha,J., Kim,K.H.
            and Witters,L.A.
  TITLE     Identification of a second human acetyl-CoA carboxylase gene
  JOURNAL   Biochem J 316 (Pt 3) (Pt 3), 915-922 (1996)
   PUBMED   8670171
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC007637.9.
            This sequence is a reference standard in the RefSeqGene project.
            
            On or before Apr 15, 2019 this sequence version replaced
            XM_005253876.4, NM_001093.3.
            
            Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional
            enzyme system. ACC is a biotin-containing enzyme which catalyzes
            the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting
            step in fatty acid synthesis. ACC-beta is thought to control fatty
            acid oxidation by means of the ability of malonyl-CoA to inhibit
            carnitine-palmitoyl-CoA transferase I, the rate-limiting step in
            fatty acid uptake and oxidation by mitochondria. ACC-beta may be
            involved in the regulation of fatty acid oxidation, rather than
            fatty acid biosynthesis. [provided by RefSeq, Oct 2022].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1-3 all encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY382667.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000338432.12/ ENSP00000341044.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-118               AC007637.9         23482-23599
            119-780             AC007637.9         46292-46953
            781-913             AC007637.9         73756-73888
            914-1052            AC007637.9         74791-74929
            1053-1162           AC007637.9         78700-78809
            1163-1244           AC007637.9         79170-79251
            1245-1343           AC007637.9         81027-81125
            1344-1453           AC007637.9         82826-82935
            1454-1564           AC007637.9         83048-83158
            1565-1774           AC007637.9         85983-86192
            1775-1945           AC007637.9         86812-86982
            1946-2107           AC007637.9         92474-92635
            2108-2271           AC007637.9         94894-95057
            2272-2422           AC007637.9         98508-98658
            2423-2526           AC007637.9         98742-98845
            2527-2608           AC007637.9         100543-100624
            2609-2754           AC007637.9         103903-104048
            2755-2905           AC007637.9         106297-106447
            2906-3040           AC007637.9         108462-108596
            3041-3187           AC007637.9         113605-113751
            3188-3376           AC007637.9         116060-116248
            3377-3477           AC007637.9         119731-119831
            3478-3566           AC007637.9         123513-123601
            3567-3691           AC007637.9         123691-123815
            3692-3805           AC007637.9         129402-129515
            3806-3919           AC007637.9         129694-129807
            3920-4009           AC007637.9         130710-130799
            4010-4128           AC007637.9         134266-134384
            4129-4266           AC007637.9         139564-139701
            4267-4366           AC007637.9         140643-140742
            4367-4474           AC007637.9         140833-140940
            4475-4531           AC007637.9         142208-142264
            4532-4573           AC007637.9         142501-142542
            4574-4789           AC007637.9         144060-144275
            4790-4945           AC007637.9         146725-146880
            4946-5149           AC007637.9         147973-148176
            5150-5305           AC007637.9         149332-149487
            5306-5428           AC007637.9         152521-152643
            5429-5698           AC007637.9         153074-153343
            5699-5796           AC007637.9         154501-154598
            5797-5917           AC007637.9         156879-156999
            5918-6028           AC007637.9         158941-159051
            6029-6172           AC007637.9         159910-160053
            6173-6293           AC007637.9         161109-161229
            6294-6390           AC007637.9         163035-163131
            6391-6487           AC007637.9         165163-165259
            6488-6623           AC007637.9         165868-166003
            6624-6801           AC007637.9         167375-167552
            6802-6914           AC007637.9         169252-169364
            6915-7069           AC007637.9         171127-171281
            7070-7240           AC007637.9         172005-172175
            7241-7377           AC007637.9         172284-172420
            7378-9368           AC007637.9         173131-175121
FEATURES             Location/Qualifiers
     source          1..9368
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.11"
     gene            1..9368
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /note="acetyl-CoA carboxylase beta"
                     /db_xref="GeneID:32"
                     /db_xref="HGNC:HGNC:85"
                     /db_xref="MIM:601557"
     exon            1..118
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            119..780
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..7504
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /EC_number="6.4.1.2"
                     /note="isoform a is encoded by transcript variant 2;
                     acetyl-Coenzyme A carboxylase beta; acetyl-CoA carboxylase
                     2"
                     /codon_start=1
                     /product="acetyl-CoA carboxylase 2 isoform a"
                     /protein_id="NP_001084.3"
                     /db_xref="CCDS:CCDS31898.1"
                     /db_xref="GeneID:32"
                     /db_xref="HGNC:HGNC:85"
                     /db_xref="MIM:601557"
                     /translation="MVLLLCLSCLIFSCLTFSWLKIWGKMTDSKPITKSKSEANLIPS
                     QEPFPASDNSGETPQRNGEGHTLPKTPSQAEPASHKGPKDAGRRRNSLPPSHQKPPRN
                     PLSSSDAAPSPELQANGTGTQGLEATDTNGLSSSARPQGQQAGSPSKEDKKQANIKRQ
                     LMTNFILGSFDDYSSDEDSVAGSSRESTRKGSRASLGALSLEAYLTTGEAETRVPTMR
                     PSMSGLHLVKRGREHKKLDLHRDFTVASPAEFVTRFGGDRVIEKVLIANNGIAAVKCM
                     RSIRRWAYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGGPNNNNYANVEL
                     IVDIAKRIPVQAVWAGWGHASENPKLPELLCKNGVAFLGPPSEAMWALGDKIASTVVA
                     QTLQVPTLPWSGSGLTVEWTEDDLQQGKRISVPEDVYDKGCVKDVDEGLEAAERIGFP
                     LMIKASEGGGGKGIRKAESAEDFPILFRQVQSEIPGSPIFLMKLAQHARHLEVQILAD
                     QYGNAVSLFGRDCSIQRRHQKIVEEAPATIAPLAIFEFMEQCAIRLAKTVGYVSAGTV
                     EYLYSQDGSFHFLELNPRLQVEHPCTEMIADVNLPAAQLQIAMGVPLHRLKDIRLLYG
                     ESPWGVTPISFETPSNPPLARGHVIAARITSENPDEGFKPSSGTVQELNFRSSKNVWG
                     YFSVAATGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDFRTTVEYLINL
                     LETESFQNNDIDTGWLDYLIAEKVQAEKPDIMLGVVCGALNVADAMFRTCMTDFLHSL
                     ERGQVLPADSLLNLVDVELIYGGVKYILKVARQSLTMFVLIMNGCHIEIDAHRLNDGG
                     LLLSYNGNSYTTYMKEEVDSYRITIGNKTCVFEKENDPTVLRSPSAGKLTQYTVEDGG
                     HVEAGSSYAEMEVMKMIMTLNVQERGRVKYIKRPGAVLEAGCVVARLELDDPSKVHPA
                     EPFTGELPAQQTLPILGEKLHQVFHSVLENLTNVMSGFCLPEPVFSIKLKEWVQKLMM
                     TLRHPSLPLLELQEIMTSVAGRIPAPVEKSVRRVMAQYASNITSVLCQFPSQQIATIL
                     DCHAATLQRKADREVFFINTQSIVQLVQRYRSGIRGYMKTVVLDLLRRYLRVEHHFQQ
                     AHYDKCVINLREQFKPDMSQVLDCIFSHAQVAKKNQLVIMLIDELCGPDPSLSDELIS
                     ILNELTQLSKSEHCKVALRARQILIASHLPSYELRHNQVESIFLSAIDMYGHQFCPEN
                     LKKLILSETTIFDVLPTFFYHANKVVCMASLEVYVRRGYIAYELNSLQHRQLPDGTCV
                     VEFQFMLPSSHPNRMTVPISITNPDLLRHSTELFMDSGFSPLCQRMGAMVAFRRFEDF
                     TRNFDEVISCFANVPKDTPLFSEARTSLYSEDDCKSLREEPIHILNVSIQCADHLEDE
                     ALVPILRTFVQSKKNILVDYGLRRITFLIAQEKEFPKFFTFRARDEFAEDRIYRHLEP
                     ALAFQLELNRMRNFDLTAVPCANHKMHLYLGAAKVKEGVEVTDHRFFIRAIIRHSDLI
                     TKEASFEYLQNEGERLLLEAMDELEVAFNNTSVRTDCNHIFLNFVPTVIMDPFKIEES
                     VRYMVMRYGSRLWKLRVLQAEVKINIRQTTTGSAVPIRLFITNESGYYLDISLYKEVT
                     DSRSGNIMFHSFGNKQGPQHGMLINTPYVTKDLLQAKRFQAQTLGTTYIYDFPEMFRQ
                     ALFKLWGSPDKYPKDILTYTELVLDSQGQLVEMNRLPGGNEVGMVAFKMRFKTQEYPE
                     GRDVIVIGNDITFRIGSFGPGEDLLYLRASEMARAEGIPKIYVAANSGARIGMAEEIK
                     HMFHVAWVDPEDPHKGFKYLYLTPQDYTRISSLNSVHCKHIEEGGESRYMITDIIGKD
                     DGLGVENLRGSGMIAGESSLAYEEIVTISLVTCRAIGIGAYLVRLGQRVIQVENSHII
                     LTGASALNKVLGREVYTSNNQLGGVQIMHYNGVSHITVPDDFEGVYTILEWLSYMPKD
                     NHSPVPIITPTDPIDREIEFLPSRAPYDPRWMLAGRPHPTLKGTWQSGFFDHGSFKEI
                     MAPWAQTVVTGRARLGGIPVGVIAVETRTVEVAVPADPANLDSEAKIIQQAGQVWFPD
                     SAYKTAQAVKDFNREKLPLMIFANWRGFSGGMKDMYDQVLKFGAYIVDGLRQYKQPIL
                     IYIPPYAELRGGSWVVIDATINPLCIEMYADKESRGGVLEPEGTVEIKFRKKDLIKSM
                     RRIDPAYKKLMEQLGEPDLSDKDRKDLEGRLKAREDLLLPIYHQVAVQFADFHDTPGR
                     MLEKGVISDILEWKTARTFLYWRLRRLLLEDQVKQEILQASGELSHVHIQSMLRRWFV
                     ETEGAVKAYLWDNNQVVVQWLEQHWQAGDGPRSTIRENITYLKHDSVLKTIRGLVEEN
                     PEVAVDCVIYLSQHISPAERAQVVHLLSTMDSPAST"
     exon            781..913
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            914..1052
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1162
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1163..1244
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1343
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1344..1453
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1564
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1774
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..1945
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2107
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2271
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..2422
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2423..2526
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2527..2608
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2609..2754
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2755..2905
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            2906..3040
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..3187
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3188..3376
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3377..3477
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3478..3566
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3567..3691
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3692..3805
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3806..3919
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            3920..4009
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4010..4128
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4129..4266
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4267..4366
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4367..4474
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4475..4531
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4532..4573
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4574..4789
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4790..4945
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            4946..5149
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            5150..5305
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            5306..5428
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            5429..5698
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            5699..5796
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            5797..5917
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            5918..6028
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6029..6172
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6173..6293
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6294..6390
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6391..6487
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6488..6623
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6624..6801
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6802..6914
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            6915..7069
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            7070..7240
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            7241..7377
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     exon            7378..9368
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9346..9351
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /note="hexamer: AATAAA"
     polyA_site      9368
                     /gene="ACACB"
                     /gene_synonym="ACACbeta; ACC-beta; ACC2; ACCB; ACCbeta;
                     HACC275"
                     /note="major polyA site"
ORIGIN      
        1 agagtaagca gctagcaggc ttagattcag gccctcagca aacaaggaac ctggaaaatg
       61 taaccctgaa tgcacggtgg ggaggacatg gcaagagaaa agcggcagga ataaagtgat
      121 tttctgaatg gtcttgcttc tttgtctatc ttgtctgatt ttctcctgtc tgaccttttc
      181 ctggttaaaa atctggggga aaatgacgga ctccaagccg atcaccaaga gtaaatcaga
      241 agcaaacctc atcccgagcc aggagccctt tccagcctct gataactcag gggagacacc
      301 gcagagaaat ggggagggcc acactctgcc caagacaccc agccaggccg agccagcctc
      361 ccacaaaggc cccaaagatg ccggtcggcg gagaaactcc ctaccaccct cccaccagaa
      421 gcccccaaga aacccccttt cttccagtga cgcagcaccc tccccagagc ttcaagccaa
      481 cgggactggg acacaaggtc tggaggccac agataccaat ggcctgtcct cctcagccag
      541 gccccagggc cagcaagctg gctccccctc caaagaagac aagaagcagg caaacatcaa
      601 gaggcagctg atgaccaact tcatcctggg ctcttttgat gactactcct ccgacgagga
      661 ctctgttgct ggctcatctc gtgagtctac ccggaagggc agccgggcca gcttgggggc
      721 cctgtccctg gaggcttatc tgaccacagg tgaagctgag acccgcgtcc ccactatgag
      781 gccgagcatg tcgggactcc acctggtgaa gaggggacgg gaacacaaga agctggacct
      841 gcacagagac tttaccgtgg cttctcccgc tgagtttgtc acacgctttg ggggggatcg
      901 ggtcatcgag aaggtgctta ttgccaacaa cgggattgcc gccgtgaagt gcatgcgctc
      961 catccgcagg tgggcctatg agatgttccg caacgagcgg gccatccggt ttgttgtgat
     1021 ggtgaccccc gaggacctta aggccaacgc agagtacatc aagatggcgg atcattacgt
     1081 ccccgtccca ggagggccca ataacaacaa ctatgccaac gtggagctga ttgtggacat
     1141 tgccaagaga atccccgtgc aggcggtgtg ggctggctgg ggccatgctt cagaaaaccc
     1201 taaacttccg gagctgctgt gcaagaatgg agttgctttc ttaggccctc ccagtgaggc
     1261 catgtgggcc ttaggagata agatcgcctc caccgttgtc gcccagacgc tacaggtccc
     1321 aaccctgccc tggagtggaa gcggcctgac agtggagtgg acagaagatg atctgcagca
     1381 gggaaaaaga atcagtgtcc cagaagatgt ttatgacaag ggttgcgtga aagacgtaga
     1441 tgagggcttg gaggcagcag aaagaattgg ttttccattg atgatcaaag cttctgaagg
     1501 tggcggaggg aagggaatcc ggaaggctga gagtgcggag gacttcccga tccttttcag
     1561 acaagtacag agtgagatcc caggctcgcc catctttctc atgaagctgg cccagcacgc
     1621 ccgtcacctg gaagttcaga tcctcgctga ccagtatggg aatgctgtgt ctctgtttgg
     1681 tcgcgactgc tccatccagc ggcggcatca gaagatcgtt gaggaagcac cggccaccat
     1741 cgccccgctg gccatattcg agttcatgga gcagtgtgcc atccgcctgg ccaagaccgt
     1801 gggctatgtg agtgcaggga cagtggaata cctctatagt caggatggca gcttccactt
     1861 cttggagctg aatcctcgct tgcaggtgga acatccctgc acagaaatga ttgctgatgt
     1921 taatctgccg gccgcccagc tacagatcgc catgggcgtg ccactgcacc ggctgaagga
     1981 tatccggctt ctgtatggag agtcaccatg gggagtgact cccatttctt ttgaaacccc
     2041 ctcaaaccct cccctcgccc gaggccacgt cattgccgcc agaatcacca gcgaaaaccc
     2101 agacgagggt tttaagccga gctccgggac tgtccaggaa ctgaatttcc ggagcagcaa
     2161 gaacgtgtgg ggttacttca gcgtggccgc tactggaggc ctgcacgagt ttgcggattc
     2221 ccaatttggg cactgcttct cctggggaga gaaccgggaa gaggccattt cgaacatggt
     2281 ggtggctttg aaggaactgt ccatccgagg cgactttagg actaccgtgg aatacctcat
     2341 taacctcctg gagaccgaga gcttccagaa caacgacatc gacaccgggt ggttggacta
     2401 cctcattgct gagaaagtgc aggcggagaa accggatatc atgcttgggg tggtatgcgg
     2461 ggccttgaac gtggccgatg cgatgttcag aacgtgcatg acagatttct tacactccct
     2521 ggaaaggggc caggtcctcc cagcggattc actactgaac ctcgtagatg tggaattaat
     2581 ttacggaggt gttaagtaca ttctcaaggt ggcccggcag tctctgacca tgttcgttct
     2641 catcatgaat ggctgccaca tcgagattga tgcccaccgg ctgaatgatg gggggctcct
     2701 gctctcctac aatgggaaca gctacaccac ctacatgaag gaagaggttg acagttaccg
     2761 aattaccatc ggcaataaga cgtgtgtgtt tgagaaggag aacgatccta cagtcctgag
     2821 atccccctcg gctgggaagc tgacacagta cacagtggag gatgggggcc acgttgaggc
     2881 tgggagcagc tacgctgaga tggaggtgat gaagatgatc atgaccctga acgttcagga
     2941 aagaggccgg gtgaagtaca tcaagcgtcc aggtgccgtg ctggaagcag gctgcgtggt
     3001 ggccaggctg gagctcgatg acccttctaa agtccacccg gctgaaccgt tcacaggaga
     3061 actccctgcc cagcagacac tgcccatcct cggagagaaa ctgcaccagg tcttccacag
     3121 cgtcctggaa aacctcacca acgtcatgag tggcttttgt ctgccagagc ccgtttttag
     3181 cataaagctg aaggagtggg tgcagaagct catgatgacc ctccggcacc cgtcactgcc
     3241 gctgctggag ctgcaggaga tcatgaccag cgtggcaggc cgcatccccg cccctgtgga
     3301 gaagtctgtc cgcagggtga tggcccagta tgccagcaac atcacctcgg tgctgtgcca
     3361 gttccccagc cagcagatag ccaccatcct ggactgccat gcagccaccc tgcagcggaa
     3421 ggctgatcga gaggtcttct tcatcaacac ccagagcatc gtgcagttgg tccagagata
     3481 ccgcagcggg atccgcggct atatgaaaac agtggtgttg gatctcctga gaagatactt
     3541 gcgtgttgag caccattttc agcaagccca ctacgacaag tgtgtgataa acctcaggga
     3601 gcagttcaag ccagacatgt cccaggtgct ggactgcatc ttctcccacg cacaggtggc
     3661 caagaagaac cagctggtga tcatgttgat cgatgagctg tgtggcccag acccttccct
     3721 gtcggacgag ctgatctcca tcctcaacga gctcactcag ctgagcaaaa gcgagcactg
     3781 caaagtggcc ctcagagccc ggcagatcct gattgcctcc cacctcccct cctacgagct
     3841 gcggcataac caggtggagt ccattttcct gtctgccatt gacatgtacg gccaccagtt
     3901 ctgccccgag aacctcaaga aattaatact ttcggaaaca accatcttcg acgtcctgcc
     3961 tactttcttc tatcacgcaa acaaagtcgt gtgcatggcg tccttggagg tttacgtgcg
     4021 gaggggctac atcgcctatg agttaaacag cctgcagcac cggcagctcc cggacggcac
     4081 ctgcgtggta gaattccagt tcatgctgcc gtcctcccac ccaaaccgga tgaccgtgcc
     4141 catcagcatc accaaccctg acctgctgag gcacagcaca gagctcttca tggacagcgg
     4201 cttctcccca ctgtgccagc gcatgggagc catggtagcc ttcaggagat tcgaggactt
     4261 caccagaaat tttgatgaag tcatctcttg cttcgccaac gtgcccaaag acacccccct
     4321 cttcagcgag gcccgcacct ccctatactc cgaggatgac tgcaagagcc tcagagaaga
     4381 gcccatccac attctgaatg tgtccatcca gtgtgcagac cacctggagg atgaggcact
     4441 ggtgccgatt ttacggacat tcgtacagtc caagaaaaat atccttgtgg attatggact
     4501 ccgacgaatc acattcttga ttgcccaaga gaaagaattt cccaagtttt tcacattcag
     4561 agcaagagat gagtttgcag aagatcgcat ttaccgtcac ttggaacctg ccctggcctt
     4621 ccagctggaa cttaaccgga tgcgtaactt cgatctgacc gccgtgccct gtgccaacca
     4681 caagatgcac ctttacctgg gtgctgccaa ggtgaaggaa ggtgtggaag tgacggacca
     4741 taggttcttc atccgcgcca tcatcaggca ctctgacctg atcacaaagg aagcctcctt
     4801 cgaatacctg cagaacgagg gtgagcggct gctcctggag gccatggacg agctggaggt
     4861 ggcgttcaat aacaccagcg tgcgcaccga ctgcaaccac atcttcctca acttcgtgcc
     4921 cactgtcatc atggacccct tcaagatcga ggagtccgtg cgctacatgg ttatgcgcta
     4981 cggcagccgg ctgtggaaac tccgtgtgct acaggctgag gtcaagatca acatccgcca
     5041 gaccaccacc ggcagtgccg ttcccatccg cctgttcatc accaatgagt cgggctacta
     5101 cctggacatc agcctctaca aagaagtgac tgactccaga tctggaaata tcatgtttca
     5161 ctccttcggc aacaagcaag ggccccagca cgggatgctg atcaatactc cctacgtcac
     5221 caaggatctg ctccaggcca agcgattcca ggcccagacc ctgggaacca cctacatcta
     5281 tgacttcccg gaaatgttca ggcaggctct ctttaaactg tggggctccc cagacaagta
     5341 tcccaaagac atcctgacat acactgaatt agtgttggac tctcagggcc agctggtgga
     5401 gatgaaccga cttcctggtg gaaatgaggt gggcatggtg gccttcaaaa tgaggtttaa
     5461 gacccaggag tacccggaag gacgggatgt gatcgtcatc ggcaatgaca tcacctttcg
     5521 cattggatcc tttggccctg gagaggacct tctgtacctg cgggcatccg agatggcccg
     5581 ggcagagggc attcccaaaa tttacgtggc agccaacagt ggcgcccgta ttggcatggc
     5641 agaggagatc aaacacatgt tccacgtggc ttgggtggac ccagaagacc cccacaaagg
     5701 atttaaatac ctgtacctga ctccccaaga ctacaccaga atcagctccc tgaactccgt
     5761 ccactgtaaa cacatcgagg aaggaggaga gtccagatac atgatcacgg atatcatcgg
     5821 gaaggatgat ggcttgggcg tggagaatct gaggggctca ggcatgattg ctggggagtc
     5881 ctctctggct tacgaagaga tcgtcaccat tagcttggtg acctgccgag ccattgggat
     5941 tggggcctac ttggtgaggc tgggccagcg agtgatccag gtggagaatt cccacatcat
     6001 cctcacagga gcaagtgctc tcaacaaggt cctgggaaga gaggtctaca catccaacaa
     6061 ccagctgggt ggcgttcaga tcatgcatta caatggtgtc tcccacatca ccgtgccaga
     6121 tgactttgag ggggtttata ccatcctgga gtggctgtcc tatatgccaa aggataatca
     6181 cagccctgtc cctatcatca cacccactga ccccattgac agagaaattg aattcctccc
     6241 atccagagct ccctacgacc cccggtggat gcttgcagga aggcctcacc caactctgaa
     6301 gggaacgtgg cagagcggat tctttgacca cggcagtttc aaggaaatca tggcaccctg
     6361 ggcgcagacc gtggtgacag gacgagcaag gcttgggggg attcccgtgg gagtgattgc
     6421 tgtggagaca cggactgtgg aggtggcagt ccctgcagac cctgccaacc tggattctga
     6481 ggccaagata attcagcagg caggacaggt gtggttccca gactcagcct acaaaaccgc
     6541 ccaggccgtc aaggacttca accgggagaa gttgcccctg atgatctttg ccaactggag
     6601 ggggttctcc ggtggcatga aagacatgta tgaccaggtg ctgaagtttg gagcctacat
     6661 cgtggacggc cttagacaat acaaacagcc catcctgatc tatatcccgc cctatgcgga
     6721 gctccgggga ggctcctggg tggtcataga tgccaccatc aacccgctgt gcatagaaat
     6781 gtatgcagac aaagagagca ggggtggtgt tctggaacca gaggggacag tggagattaa
     6841 gttccgaaag aaagatctga taaagtccat gagaaggatc gatccagctt acaagaagct
     6901 catggaacag ctaggggaac ctgatctctc cgacaaggac cgaaaggacc tggagggccg
     6961 gctaaaggct cgcgaggacc tgctgctccc catctaccac caggtggcgg tgcagttcgc
     7021 cgacttccat gacacacccg gccggatgct ggagaagggc gtcatatctg acatcctgga
     7081 gtggaagacc gcacgcacct tcctgtattg gcgtctgcgc cgcctcctcc tggaggacca
     7141 ggtcaagcag gagatcctgc aggccagcgg ggagctgagt cacgtgcata tccagtccat
     7201 gctgcgtcgc tggttcgtgg agacggaggg ggctgtcaag gcctacttgt gggacaacaa
     7261 ccaggtggtt gtgcagtggc tggaacagca ctggcaggca ggggatggcc cgcgctccac
     7321 catccgtgag aacatcacgt acctgaagca cgactctgtc ctcaagacca tccgaggcct
     7381 ggttgaagaa aaccccgagg tggccgtgga ctgtgtgata tacctgagcc agcacatcag
     7441 cccagctgag cgggcgcagg tcgttcacct gctgtctacc atggacagcc cggcctccac
     7501 ctgaccgtgg cccgcccagc cactcccggg accacggcaa aaggaaccac ccagacccac
     7561 cacccgtaca ccctcagcag accctgaaga cttgctttta aacaaagaaa atcctgggca
     7621 cttctgcagg gctgctggtt ccgagctgac acccgtctta acaaaaggcc caggagtgcc
     7681 tcttccaaac aaaaacagcc tcctctccat agctgggaag tttattttgt tttgtctctg
     7741 aagacagcag ttttattgca tcactaaatc taatcaagct aaaacatccc tgtttccttt
     7801 tgcaaaacag tgcctggcat gtgggatcca ggcgttcttt aggatccttg gataccacat
     7861 cgtgaaatct tttatttttt tactctgaga ccagcaccag atgtaagtaa gcatctcata
     7921 tatttcagcc aaataaatgg gccaagggaa aaaaatatat atatatagac aggactagag
     7981 aaaacctatt tttgtaatga tgtttctttg gatactgtct agtcacccag aaaaatgtat
     8041 ggatgaattt tttttttttt ttttgagaca aagtctcact gtgtcatgca ggctggagtg
     8101 cagtggcatg atctcactgc aacctccatc tcctgtctca gcctcctaga taactgggat
     8161 tacaggtgcc caccaccatg cccggctaat ttttgtattt ttggtagaga cagagtttca
     8221 ccaggttggt caggctggtc tcaaactctt gacttcaggt aatccaccca ccttggcctc
     8281 ccaaagtgct gggattacag gcatgagcca ccatcttcag ccagatgatt tttttattga
     8341 gagagtgaaa tgctattttg ttccccaaat ggcgctagtg aatcactagg agggtcccac
     8401 tgataggcca tgtttagcac tggttgccag ggattctctt tttgagagag ggaaagcaaa
     8461 atgaatggaa gtacccagct ggaggtttca gggcttctgg aggatgctct cgcatagctc
     8521 gaggtcctct gcccacctct tctctccaag gaaaatgagg actgcccctt ccccctgcag
     8581 gattggcccc cagcctgcgc atgcaccctc ctcttgccca agtggggagc acagaggcgg
     8641 agaggaatcc cttaccacac ccacggccca gcttgctcac gagtgtcacc tctgtgacgg
     8701 tcaccactgc tcccttggag ggccacttga gttactgttg cttcctcgcc tgctggcttg
     8761 atgagcaccg atggtgggat ctgaccccga ggggcagagc tgtcggtgac tgaggactgg
     8821 actgtggtga ccatgccgat ttgctcaggg agaacgttgc aatgcaccca gcagctcctg
     8881 gctctgcagg cggcacagcc tggggccctg tgatcctctg gtttcttcca ttggggcgga
     8941 gtcggggatg gagggagctg gccacaaccc actgctctga tgggtggttt gtccaaggat
     9001 gctgaatgta atgcctggtc aatgtggaag cccatgaggt tgcccaggga agcctccaaa
     9061 agctgggatg cttgagggta tccaagttga aaaagacaaa atctgaccat cagccagtga
     9121 cagtcctggc aaatgaaggt ggggcggggc agtgaggggt gggagaaggt gaatgattca
     9181 ttattccacc ccgaggtttg ctggggtgag gggaagaatc gatgctgctt tgggaactga
     9241 aggtttttct gttgggaagg ccctcttggt tttggagaga aagacaagtt atgagtagct
     9301 gctaccctgg aacggtgggc agagagccta ctaggaaatg tgcagaataa actatttttt
     9361 gaaggaaa
//
