LOCUS       NM_198834              10013 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens acetyl-CoA carboxylase alpha (ACACA), transcript
            variant 1, mRNA.
ACCESSION   NM_198834
VERSION     NM_198834.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 10013)
  AUTHORS   Jin,Y., Shangguan,Z., Pang,J., Chen,Y., Lin,S. and Liu,H.
  TITLE     Pin1 Exacerbates Non-Alcoholic Fatty Liver Disease by Enhancing Its
            Activity through Binding to ACC1
  JOURNAL   Int J Mol Sci 25 (11), 5822 (2024)
   PUBMED   38892011
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10013)
  AUTHORS   Zhang,Y., Chen,X.N., Zhang,H., Wen,J.K., Gao,H.T., Shi,B.,
            Wang,D.D., Han,Z.W., Gu,J.F., Zhao,C.M., Xue,W.Y., Zhang,Y.P.,
            Qu,C.B. and Yang,Z.
  TITLE     CDK13 promotes lipid deposition and prostate cancer progression by
            stimulating NSUN5-mediated m5C modification of ACC1 mRNA
  JOURNAL   Cell Death Differ 30 (12), 2462-2476 (2023)
   PUBMED   37845385
  REMARK    GeneRIF: CDK13 promotes lipid deposition and prostate cancer
            progression by stimulating NSUN5-mediated m5C modification of ACC1
            mRNA.
REFERENCE   3  (bases 1 to 10013)
  AUTHORS   Shen,Y., Wang,X., Ni,Z., Xu,S., Qiu,S., Zheng,W. and Zhang,J.
  TITLE     Identification of acetyl-CoA carboxylase alpha as a prognostic and
            targeted candidate for hepatocellular carcinoma
  JOURNAL   Clin Transl Oncol 25 (8), 2499-2513 (2023)
   PUBMED   36976490
  REMARK    GeneRIF: Identification of acetyl-CoA carboxylase alpha as a
            prognostic and targeted candidate for hepatocellular carcinoma.
REFERENCE   4  (bases 1 to 10013)
  AUTHORS   Saisomboon,S., Kariya,R., Boonnate,P., Sawanyawisuth,K., Cha'on,U.,
            Luvira,V., Chamgramol,Y., Pairojkul,C., Seubwai,W.,
            Silsirivanit,A., Wongkham,S., Okada,S., Jitrapakdee,S. and
            Vaeteewoottacharn,K.
  TITLE     Diminishing acetyl-CoA carboxylase 1 attenuates CCA migration via
            AMPK-NF-kappaB-snail axis
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166694 (2023)
   PUBMED   36972768
  REMARK    GeneRIF: Diminishing acetyl-CoA carboxylase 1 attenuates CCA
            migration via AMPK-NF-kappaB-snail axis.
            Erratum:[Biochim Biophys Acta Mol Basis Dis. 2024
            Jan;1870(1):166886. doi: 10.1016/j.bbadis.2023.166886.. PMID:
            37743108]
REFERENCE   5  (bases 1 to 10013)
  AUTHORS   Cao,H., Cai,Q., Guo,W., Su,Q., Qin,H., Wang,T., Xian,Y., Zeng,L.,
            Cai,M., Guan,H., Chen,S., Liang,H. and Xu,F.
  TITLE     Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic steatosis
            and is attenuated by ketogenic diet in NAFLD
  JOURNAL   Cell Rep 42 (4), 112319 (2023)
   PUBMED   37002924
  REMARK    GeneRIF: Malonylation of Acetyl-CoA carboxylase 1 promotes hepatic
            steatosis and is attenuated by ketogenic diet in NAFLD.
REFERENCE   6  (bases 1 to 10013)
  AUTHORS   Abu-Elheiga,L., Jayakumar,A., Baldini,A., Chirala,S.S. and
            Wakil,S.J.
  TITLE     Human acetyl-CoA carboxylase: characterization, molecular cloning,
            and evidence for two isoforms
  JOURNAL   Proc Natl Acad Sci U S A 92 (9), 4011-4015 (1995)
   PUBMED   7732023
REFERENCE   7  (bases 1 to 10013)
  AUTHORS   Ha,J., Daniel,S., Kong,I.S., Park,C.K., Tae,H.J. and Kim,K.H.
  TITLE     Cloning of human acetyl-CoA carboxylase cDNA
  JOURNAL   Eur J Biochem 219 (1-2), 297-306 (1994)
   PUBMED   7905825
REFERENCE   8  (bases 1 to 10013)
  AUTHORS   Haystead,T.A., Campbell,D.G. and Hardie,D.G.
  TITLE     Analysis of sites phosphorylated on acetyl-CoA carboxylase in
            response to insulin in isolated adipocytes. Comparison with sites
            phosphorylated by casein kinase-2 and the calmodulin-dependent
            multiprotein kinase
  JOURNAL   Eur J Biochem 175 (2), 347-354 (1988)
   PUBMED   2900140
REFERENCE   9  (bases 1 to 10013)
  AUTHORS   Munday,M.R., Campbell,D.G., Carling,D. and Hardie,D.G.
  TITLE     Identification by amino acid sequencing of three major regulatory
            phosphorylation sites on rat acetyl-CoA carboxylase
  JOURNAL   Eur J Biochem 175 (2), 331-338 (1988)
   PUBMED   2900138
REFERENCE   10 (bases 1 to 10013)
  AUTHORS   Milatovich,A., Plattner,R., Heerema,N.A., Palmer,C.G.,
            Lopez-Casillas,F. and Kim,K.H.
  TITLE     Localization of the gene for acetyl-CoA carboxylase to human
            chromosome 17
  JOURNAL   Cytogenet Cell Genet 48 (3), 190-192 (1988)
   PUBMED   2906852
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC243654.3, CF454424.1,
            AY315625.1, AB371587.1 and BC041598.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_198834.2.
            
            Summary: Acetyl-CoA carboxylase (ACC) is a complex multifunctional
            enzyme system. ACC is a biotin-containing enzyme which catalyzes
            the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting
            step in fatty acid synthesis. There are two ACC forms, alpha and
            beta, encoded by two different genes. ACC-alpha is highly enriched
            in lipogenic tissues. The enzyme is under long term control at the
            transcriptional and translational levels and under short term
            regulation by the phosphorylation/dephosphorylation of targeted
            serine residues and by allosteric transformation by citrate or
            palmitoyl-CoA. Multiple alternatively spliced transcript variants
            divergent in the 5' sequence and encoding distinct isoforms have
            been found for this gene. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.923878.1,
                                           SRR14038191.3180631.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000616317.5/ ENSP00000483300.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC243654.3         123286-123310       c
            26-452              CF454424.1         28-454
            453-1008            AY315625.1         398-953
            1009-9978           AB371587.1         531-9500
            9979-10013          BC041598.1         1580-1614
FEATURES             Location/Qualifiers
     source          1..10013
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..10013
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /note="acetyl-CoA carboxylase alpha"
                     /db_xref="GeneID:31"
                     /db_xref="HGNC:HGNC:84"
                     /db_xref="MIM:200350"
     exon            1..575
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             538..7689
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /EC_number="6.4.1.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     acetyl-Coenzyme A carboxylase alpha; acetyl-CoA
                     carboxylase 1; ACC-alpha"
                     /codon_start=1
                     /product="acetyl-CoA carboxylase 1 isoform 1"
                     /protein_id="NP_942131.1"
                     /db_xref="CCDS:CCDS42302.1"
                     /db_xref="GeneID:31"
                     /db_xref="HGNC:HGNC:84"
                     /db_xref="MIM:200350"
                     /translation="MWWSTLMSILRARSFWKWISTQTVRIIRAVRAHFGGIMDEPSPL
                     AQPLELNQHSRFIIGSVSEDNSEDEISNLVKLDLLEEKEGSLSPASVGSDTLSDLGIS
                     SLQDGLALHIRSSMSGLHLVKQGRDRKKIDSQRDFTVASPAEFVTRFGGNKVIEKVLI
                     ANNGIAAVKCMRSIRRWSYEMFRNERAIRFVVMVTPEDLKANAEYIKMADHYVPVPGG
                     PNNNNYANVELILDIAKRIPVQAVWAGWGHASENPKLPELLLKNGIAFMGPPSQAMWA
                     LGDKIASSIVAQTAGIPTLPWSGSGLRVDWQENDFSKRILNVPQELYEKGYVKDVDDG
                     LQAAEEVGYPVMIKASEGGGGKGIRKVNNADDFPNLFRQVQAEVPGSPIFVMRLAKQS
                     RHLEVQILADQYGNAISLFGRDCSVQRRHQKIIEEAPATIATPAVFEHMEQCAVKLAK
                     MVGYVSAGTVEYLYSQDGSFYFLELNPRLQVEHPCTEMVADVNLPAAQLQIAMGIPLY
                     RIKDIRMMYGVSPWGDSPIDFEDSAHVPCPRGHVIAARITSENPDEGFKPSSGTVQEL
                     NFRSNKNVWGYFSVAAAGGLHEFADSQFGHCFSWGENREEAISNMVVALKELSIRGDF
                     RTTVEYLIKLLETESFQMNRIDTGWLDRLIAEKVQAERPDTMLGVVCGALHVADVSLR
                     NSVSNFLHSLERGQVLPAHTLLNTVDVELIYEGVKYVLKVTRQSPNSYVVIMNGSCVE
                     VDVHRLSDGGLLLSYDGSSYTTYMKEEVDRYRITIGNKTCVFEKENDPSVMRSPSAGK
                     LIQYIVEDGGHVFAGQCYAEIEVMKMVMTLTAVESGCIHYVKRPGAALDPGCVLAKMQ
                     LDNPSKVQQAELHTGSLPRIQSTALRGEKLHRVFHYVLDNLVNVMNGYCLPDPFFSSK
                     VKDWVERLMKTLRDPSLPLLELQDIMTSVSGRIPPNVEKSIKKEMAQYASNITSVLCQ
                     FPSQQIANILDSHAATLNRKSEREVFFMNTQSIVQLVQRYRSGIRGHMKAVVMDLLRQ
                     YLRVETQFQNGHYDKCVFALREENKSDMNTVLNYIFSHAQVTKKNLLVTMLIDQLCGR
                     DPTLTDELLNILTELTQLSKTTNAKVALRARQVLIASHLPSYELRHNQVESIFLSAID
                     MYGHQFCIENLQKLILSETSIFDVLPNFFYHSNQVVRMAALEVYVRRAYIAYELNSVQ
                     HRQLKDNTCVVEFQFMLPTSHPNRGNIPTLNRMSFSSNLNHYGMTHVASVSDVLLDNS
                     FTPPCQRMGGMVSFRTFEDFVRIFDEVMGCFSDSPPQSPTFPEAGHTSLYDEDKVPRD
                     EPIHILNVAIKTDCDIEDDRLAAMFREFTQQNKATLVDHGIRRLTFLVAQKDFRKQVN
                     YEVDRRFHREFPKFFTFRARDKFEEDRIYRHLEPALAFQLELNRMRNFDLTAIPCANH
                     KMHLYLGAAKVEVGTEVTDYRFFVRAIIRHSDLVTKEASFEYLQNEGERLLLEAMDEL
                     EVAFNNTNVRTDCNHIFLNFVPTVIMDPSKIEESVRSMVMRYGSRLWKLRVLQAELKI
                     NIRLTPTGKAIPIRLFLTNESGYYLDISLYKEVTDSRTAQIMFQAYGDKQGPLHGMLI
                     NTPYVTKDLLQSKRFQAQSLGTTYIYDIPEMFRQSLIKLWESMSTQAFLPSPPLPSDM
                     LTYTELVLDDQGQLVHMNRLPGGNEIGMVAWKMTFKSPEYPEGRDIIVIGNDITYRIG
                     SFGPQEDLLFLRASELARAEGIPRIYVSANSGARIGLAEEIRHMFHVAWVDPEDPYKG
                     YRYLYLTPQDYKRVSALNSVHCEHVEDEGESRYKITDIIGKEEGIGPENLRGSGMIAG
                     ESSLAYNEIITISLVTCRAIGIGAYLVRLGQRTIQVENSHLILTGAGALNKVLGREVY
                     TSNNQLGGIQIMHNNGVTHCTVCDDFEGVFTVLHWLSYMPKSVHSSVPLLNSKDPIDR
                     IIEFVPTKTPYDPRWMLAGRPHPTQKGQWLSGFFDYGSFSEIMQPWAQTVVVGRARLG
                     GIPVGVVAVETRTVELSIPADPANLDSEAKIIQQAGQVWFPDSAFKTYQAIKDFNREG
                     LPLMVFANWRGFSGGMKDMYDQVLKFGAYIVDGLRECCQPVLVYIPPQAELRGGSWVV
                     IDSSINPRHMEMYADRESRGSVLEPEGTVEIKFRRKDLVKTMRRVDPVYIHLAERLGT
                     PELSTAERKELENKLKEREEFLIPIYHQVAVQFADLHDTPGRMQEKGVISDILDWKTS
                     RTFFYWRLRRLLLEDLVKKKIHNANPELTDGQIQAMLRRWFVEVEGTVKAYVWDNNKD
                     LAEWLEKQLTEEDGVHSVIEENIKCISRDYVLKQIRSLVQANPEVAMDSIIHMTQHIS
                     PTQRAEVIRILSTMDSPST"
     exon            576..622
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            623..875
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            876..1008
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1147
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1148..1257
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1258..1339
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1438
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1545
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1546..1656
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1657..1866
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1867..2037
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2199
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2200..2363
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2364..2514
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2515..2618
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2619..2700
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2701..2846
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2847..2997
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            2998..3132
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3133..3279
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3280..3468
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3469..3569
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3570..3658
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3659..3783
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3784..3897
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            3898..4011
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4012..4101
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4102..4220
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4221..4244
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4245..4388
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4389..4485
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4486..4593
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4594..4650
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4651..4695
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4696..4737
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4738..4953
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            4954..5109
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5110..5313
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5314..5469
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5470..5616
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5617..5886
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5887..5984
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            5985..6105
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6106..6216
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6217..6360
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6361..6481
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6482..6578
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6579..6675
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6676..6811
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6812..6989
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            6990..7102
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            7103..7257
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            7258..7428
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            7429..7565
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     exon            7566..10013
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9989..9994
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /note="hexamer: AATAAA"
     polyA_site      10013
                     /gene="ACACA"
                     /gene_synonym="ACAC; Acac1; ACACAD; ACACalpha; ACC; ACC1;
                     ACCA; ACCalpha; hACC1"
                     /note="major polyA site"
ORIGIN      
        1 gccgcctccg cccctcggcc gtggaggccc ccgccgggtg ctgagcgccc gccaccgccc
       61 tcttggcctt ttcccggtcc ccgccgcgcg cctgctgctg tccccgtgcc cgaggactgg
      121 gaggatgggg ctgagccgct tgcctgactt ttgatccgac cagtaatcac tttgcccgtg
      181 tggcgcgtgg cccgttgcct gaggcttcct ggcgcgtggg gctgtttggt cccctccgga
      241 gtgcggtgag gcgggccgag ccgggactgc ctgggtttgg ggataacgtt cccatctcca
      301 cccctgttgc agcaagggaa attgaggctg agggaactgg gcccagggac ggcgagccgt
      361 ggcgcctctc cagtccgggc cccgaagggc tgctcgtgga tgaaccagac tgattttaag
      421 gggtgaagag ggtgcgtttc aatcagatgc tcctggaacg tcgaaattgt cttctttgga
      481 aagaaccatc ccctctttgg gcttcagagg cccaaattga ggcgcaatga tgagaggatg
      541 tggtggtcta ctctgatgtc aatcttgagg gctaggtctt tttggaagtg gatatctact
      601 cagacagtaa gaattataag agctgtaaga gctcattttg gaggaataat ggatgaacca
      661 tctcccttgg cccaacctct ggagctgaac cagcactctc gattcataat aggttctgtg
      721 tctgaagata actcagagga tgagatcagc aacctggtga agttggacct actggaggag
      781 aaggagggct ccttgtcacc tgcttctgtt ggctcagata cactctctga tttggggatc
      841 tctagcctac aggatggctt ggccttgcac ataaggtcca gcatgtctgg cttgcaccta
      901 gtaaagcagg gccgagacag aaagaaaata gattctcaac gagatttcac tgtggcttct
      961 ccagcagaat ttgttactcg ctttggggga aataaagtga ttgagaaggt tcttattgct
     1021 aacaatggca ttgcagcagt gaaatgcatg cggtctatcc gtaggtggtc ttatgaaatg
     1081 tttcgaaatg aacgtgcaat tagattcgtt gtcatggtca cacctgaaga ccttaaagcc
     1141 aatgcagaat acattaagat ggcagatcac tatgtgccag tgcctggagg accaaacaac
     1201 aacaactatg caaatgtgga attaattctt gatattgcta aaaggatccc agtacaagca
     1261 gtgtgggctg gctggggtca tgcttctgag aatcccaaac taccggaact tctcttgaaa
     1321 aatggcattg ccttcatggg tcctccaagc caggccatgt gggctttagg ggataagatt
     1381 gcatcttcca tagtggctca aactgcaggt atcccaactc ttccctggag cggcagtggt
     1441 cttcgtgtgg actggcagga aaatgatttt tcaaaacgta tcttaaatgt tccccaggag
     1501 ctatatgaaa aaggttatgt gaaagatgtg gatgatgggc tacaggcagc tgaggaagtt
     1561 ggatatccag taatgatcaa ggcctcagag ggaggaggag ggaagggaat tagaaaagtc
     1621 aacaatgcag atgacttccc taatctcttc agacaggttc aagctgaagt tcctggatct
     1681 cccatatttg tgatgagact agccaaacaa tctcgtcatc tggaggtgca gatcttagcg
     1741 gaccaatatg gcaatgctat ctctttgttt ggtcgtgatt gctctgtaca acgcaggcat
     1801 cagaagatta ttgaagaagc acctgctact attgctactc cagcagtatt tgaacacatg
     1861 gaacagtgtg cggtgaaact tgccaaaatg gtgggttatg tgagtgctgg gactgtggaa
     1921 tacctgtaca gccaggatgg cagcttctac tttctggaat tgaatcctcg gctgcaggta
     1981 gagcaccctt gtacagagat ggtggctgat gtcaatctcc ctgcagcaca gctccagatt
     2041 gccatgggga ttcctctata tagaatcaag gatatccgta tgatgtatgg ggtatctccc
     2101 tggggtgatt ctcccattga ttttgaagat tctgcacacg ttccttgtcc aaggggccat
     2161 gttattgctg ctcggatcac tagtgaaaat ccagatgagg gttttaagcc cagctcagga
     2221 acagttcagg agctaaattt ccgcagcaat aagaatgttt ggggatattt cagtgttgct
     2281 gctgcagggg gacttcatga atttgctgat tctcagtttg gtcactgctt ttcttgggga
     2341 gaaaacagag aagaggcaat ttcaaacatg gtggtggctt tgaaggagct gtctattcgg
     2401 ggtgactttc gaactacagt tgaatacctg atcaaattgt tagagactga aagctttcag
     2461 atgaacagaa ttgatactgg ctggctggac agactgatag cagaaaaagt acaggctgag
     2521 cgacctgaca ccatgttggg ggttgtgtgt ggtgccctcc acgtggcaga tgtgagcctg
     2581 cggaatagcg tctctaactt ccttcactcc ttagaaaggg gtcaagtcct tcctgctcat
     2641 acacttctga atacagtaga tgttgaactt atctatgagg gagtcaagta tgtacttaag
     2701 gtgactcgac agtcccccaa ctcctatgtg gtgatcatga atggctcatg tgtagaagta
     2761 gatgtacatc ggctgagtga cggtggactg ctcttgtcct atgatggcag cagttatact
     2821 acgtatatga aagaggaagt ggatagatat cgcatcacaa ttggcaataa aacctgtgtg
     2881 tttgagaagg aaaatgaccc atcggtgatg cgctcacctt ctgctgggaa gttaatccag
     2941 tacattgtag aagatggagg tcatgtgttt gccggccagt gctatgctga gattgaggta
     3001 atgaagatgg taatgacctt aacagctgtg gagtctggct gtatccatta cgtcaagcga
     3061 cctggagcag ctcttgaccc tggctgtgta ctagccaaaa tgcaactgga caaccccagc
     3121 aaggttcagc aggctgaact tcacacaggt agtctgccac ggatccagag cacggcactc
     3181 agaggcgaga aactccatcg agtgttccat tatgtcctgg ataatctggt caatgtaatg
     3241 aatggatact gccttccaga tcctttcttt agcagcaagg taaaagactg ggtagagcga
     3301 ttgatgaaaa ccctcagaga tccctccctg cctctcctag aattgcaaga tattatgacc
     3361 agtgtgtctg gccgcattcc ccccaatgtg gagaagtcta tcaagaagga aatggctcag
     3421 tatgctagca acatcacatc agtcctctgt cagtttccca gccagcagat tgcaaacatc
     3481 ctagatagcc atgcagctac attgaaccgg aaatctgaac gggaagtctt ctttatgaat
     3541 actcagagca ttgttcagct ggtacagagg taccgaagtg gcatccgagg ccacatgaag
     3601 gctgtggtga tggatctgct ccggcagtac ctgcgagtag agacacaatt ccagaatggt
     3661 cactatgaca aatgtgtatt cgccctccga gaagagaata aaagtgacat gaacactgta
     3721 ctgaactaca tcttctctca cgctcaagtc accaagaaga atcttctggt cacaatgctt
     3781 attgatcagt tgtgtggccg ggaccctact ctcactgatg agctgctgaa tattctcaca
     3841 gagctaactc aactcagtaa gaccaccaat gccaaagtag cacttcgagc acgccaggtt
     3901 cttattgcct cccatttgcc atcatatgag cttcgccata accaagtaga gtctatcttc
     3961 ctatcagcta ttgacatgta tggacatcaa ttttgcattg agaacctgca gaaactcatc
     4021 ctatcagaaa catctatttt tgatgtccta ccaaacttct tctatcacag caaccaagta
     4081 gtgaggatgg cagctctgga ggtgtatgtt cgaagggctt atattgccta tgaacttaac
     4141 agcgtacaac accgccagct taaggacaac acctgtgtgg tggaattcca gttcatgctg
     4201 cccacatctc atccaaacag agggaacatc cctacgctaa acagaatgtc cttctcctcc
     4261 aacctcaacc actatggcat gacccatgta gctagtgtca gcgatgtact gttggacaac
     4321 tcattcactc caccttgtca gcggatgggc ggaatggtct cttttcggac ttttgaagat
     4381 tttgtcagga tctttgatga agtgatgggc tgcttctctg actccccacc ccagagtccc
     4441 acattccctg aggcaggtca cacgtctctt tatgatgagg ataaggttcc cagggatgaa
     4501 ccaattcaca ttctcaatgt ggctatcaag actgactgtg atattgagga tgacaggctg
     4561 gcagctatgt tcagagaatt tacccagcaa aataaagcta ccctggttga ccatgggatc
     4621 cggcgcctta ctttcctggt tgcacaaaag gatttcagaa agcaggtcaa ctatgaggtg
     4681 gatcggagat ttcatagaga attccctaaa ttttttacat tccgagcaag ggataagttt
     4741 gaggaggatc gtatctatcg tcatctggag cctgctctgg ctttccagtt agagctgaac
     4801 cggatgagaa attttgacct cactgccatt ccatgtgcta atcacaagat gcacctgtat
     4861 ctcggggcag ccaaggtgga agtgggcaca gaagtgacag actacaggtt ctttgttcgt
     4921 gcaatcatca ggcattctga tctggtcacc aaggaagctt cttttgaata tctgcaaaat
     4981 gaaggggagc ggctactcct ggaagccatg gatgagttgg aagttgcttt taacaataca
     5041 aatgtccgca ctgactgtaa ccacatcttc ctcaactttg tgcccacggt tatcatggac
     5101 ccatcaaaga ttgaggaatc cgtgcggagc atggtaatgc ggtatggaag tcgcctgtgg
     5161 aaattgcgcg tcctccaggc agaactgaaa atcaacattc gcctgacgcc aactggaaaa
     5221 gcaattccca tccgcctctt cctgacaaac gagtctggct attacttgga tatcagccta
     5281 tacaaggaag tgactgactc caggacagca cagatcatgt ttcaggcata tggagacaaa
     5341 cagggaccac tgcatggaat gttaatcaat actccatatg tgaccaaaga cctgctgcaa
     5401 tcaaagaggt tccaggcaca atccttaggg acaacataca tatatgatat cccagagatg
     5461 tttcggcagt ccctgatcaa actctgggag tctatgtcca ctcaagcatt tcttccatct
     5521 ccccctctgc cttctgacat gctgacttac actgaactgg tactggatga tcaaggtcag
     5581 ctggtccaca tgaacaggct tccaggagga aatgagattg gcatggtagc ttggaaaatg
     5641 acctttaaaa gtcctgaata tccagaaggc cgagatatca ttgttattgg caatgacatc
     5701 acataccgaa ttgggtcctt tgggcctcaa gaggatttgt tatttctcag agcttccgaa
     5761 cttgctaggg cagaaggtat tccacgcatc tatgtatcag ccaacagtgg agcaagaatc
     5821 ggactggcag aagaaattcg ccatatgttt catgtggcct gggtagatcc tgaggatcct
     5881 tacaagggat acaggtattt atatctgact cctcaagatt ataagagagt cagtgctctc
     5941 aactctgtcc attgtgaaca cgtggaagat gaaggagaat ccaggtacaa gataacagat
     6001 attattggga aagaagaggg aattggaccc gagaaccttc gaggttctgg aatgattgct
     6061 ggagaatcct cattggccta taatgagatc attaccatca gcctggtgac gtgccgggcc
     6121 attgggattg gggcttacct tgtccggctg ggacagagaa ccatccaggt tgagaattct
     6181 cacttaattc taacaggagc tggagccctc aacaaagtcc tcgggcggga agtgtacacc
     6241 tccaataacc agctgggggg catccagatt atgcacaaca atggggtgac ccactgcact
     6301 gtgtgtgatg actttgaagg ggttttcact gtcctgcact ggctgtctta catgcccaag
     6361 agcgtgcaca gttcagttcc tcttctgaac tcaaaggatc ctatagacag aatcatcgag
     6421 tttgttccca caaagacccc atacgatcct cgatggatgc tagcaggccg tcctcaccca
     6481 acccaaaaag gtcagtggtt gagtggcttt tttgactatg gatctttctc agagattatg
     6541 cagccctggg cacagactgt ggtggttggt agagccaggc taggaggaat acctgtggga
     6601 gttgttgctg tagaaacccg aacagtagaa ctaagtatcc cagctgatcc agcaaacctg
     6661 gattctgaag ccaagataat ccagcaggct ggccaggttt ggttcccaga ttctgcgttt
     6721 aagacgtatc aggccatcaa ggacttcaac cgggaagggc tgcctctgat ggtctttgcc
     6781 aactggagag gcttctctgg tggaatgaaa gatatgtacg accaagtgct gaagtttggt
     6841 gcttacattg tggatggctt gagggagtgc tgccagcctg tgctggttta cattcctccc
     6901 caggctgagc tgcggggtgg ctcctgggtg gtgattgact cctccatcaa cccccggcac
     6961 atggagatgt atgctgaccg agaaagcagg ggatctgttc tggagccaga agggacagta
     7021 gaaatcaaat tccgcagaaa ggatctggtg aaaaccatgc gtcgggtgga cccagtctac
     7081 atccacttgg ctgagcgatt ggggacccca gagctaagca cagctgagcg gaaggagttg
     7141 gagaacaagt tgaaggagcg ggaggaattc ctaattccca tttaccatca ggtagccgtg
     7201 cagtttgctg acttgcacga cacaccaggc cggatgcagg agaagggtgt tattagcgat
     7261 atcctggatt ggaaaacatc ccgtaccttc ttctactggc ggctgaggcg tcttctgctg
     7321 gaggacctgg tcaagaagaa aatccacaat gccaaccctg agctgactga tggccagatt
     7381 caagccatgt taaggcgctg gtttgtggaa gtggaaggaa cagtgaaggc ttatgtttgg
     7441 gacaataata aggatctggc ggagtggcta gagaaacagc tgacagagga ggatggtgtt
     7501 cactcggtaa tagaggaaaa catcaaatgc atcagcagag actacgtcct caagcaaatc
     7561 cgcagcttgg tccaggccaa tccagaggtt gccatggatt ccatcatcca tatgacgcag
     7621 cacatatcac ccactcagcg agcagaagtc atacggatcc tctccacaat ggattcccct
     7681 tccacgtagg aagagcttcc tgcctgtccc tgccctgtct ctggagaaaa gggctagagc
     7741 tgccttttac aactgtaacc actgtaatga gaaggcacag gagacccagc actggagtca
     7801 aatggcattt tacttcctct cgtttcaggt tatgcatgac atcctgggat gtaagatcac
     7861 agaatccccc tccagcccac cagtcacacc taccccattc agtatttatt accctggcca
     7921 ggcctagtcc tccactccct gcacaggact gagaaggcaa tgaaaggtac aaacatgtac
     7981 catgaggtct tactaaccaa agtagggctg cccctcctgt cctgacagcc ccttggcctc
     8041 ccagcatggg gaagcgtgag gagttgccca gcagtgagca gcccccctca ctcctggccc
     8101 catgagccgc agccacaggc agcagaggag ggctaaggag aggaggaagc ctcaagtcca
     8161 ttgtttatta ccccgactct tagcccagca cacagtaggc actggagagg aatgattccc
     8221 agtttaacca cactacggta ccttttatga agaaaaatta gagcataaaa tctactacaa
     8281 gctccatagg aactcaaaga tgagggcaaa actgtgagcc aagaagcaga gaaagaaaat
     8341 agaaccagtt attcttgatt taggggacct caaccttggg ttcagtctct gaggacaaag
     8401 ggaaaggtag ttgttggcct gcctctcgcc tgcacgtcac tgctggacta gctgtcgcat
     8461 gtggctggga gctgcaaggc cagtgcttga ggggccccag cagttccaca ggtggtgaag
     8521 cctgagttgg cagaggagga gccagaagag aactgccctt tctgcactgg tggaaactag
     8581 ttatttatgc catgtggaga gccagtgaga tagatagata gtctgtttgt tttgaggact
     8641 tggaaagttg ttcctatgaa gcctggagct tggatggttt tgagaggtta atggtgcctc
     8701 cacactcact cttccctagt tccaggatta ctgtcctagc agctaacggt tctactctct
     8761 tccccagagt gtagacaggc agcaggtctc cccacagctc tgaaaggacc ctggtgacag
     8821 ctacaccctc agcaccagga gctggccttc ctgatgaggg aggcttccag gaaacacaga
     8881 atccacatga ccttaagatt atttacaact cagtcatggt gctgctgtcc tccaggctta
     8941 ctggcccctc ctgactggca tcaggggctt cctcaggtgg tggagagagt ttactttcaa
     9001 caactagttt attcaagaaa agaacttact gattcctctg ttcctaaagc aagagtggca
     9061 ggtgatcagg gctggtgtag catccggttc ctttagtgca gctaactgca tttgtcactg
     9121 atgaccaagg aggaaatcac taagacattt gagaagcagt ggtatgaacg ttcttggaca
     9181 agccacagtt ctgagcctta accctgtagt ttgcacacaa gaacgagctc cacctcccct
     9241 tcttcaggag gaatctgtgc ggatagattg gctggacttt tcaatggttc tgggttgcag
     9301 gtgggcactg tatggctggg tatggagcgg acagccccca ggagtcagag cctcagcccg
     9361 gctgccctgg tggaaggtac aggtgttcag caccttcaga aaagggcata aagtggtggg
     9421 ggacaattct cagtccagga aaatgcattg accattgctg gctatttgct tacctagtaa
     9481 gaattggatt catttttgac cagattattc ttctatgctt ttttgcaata aatcaaatcc
     9541 cacatatcta caagtggtat gaagtcctgc accccccagg aggcctgtcc aggcatgtct
     9601 tcagaggcag ggtgggttac actcatttac ctcccctctc cccaccaaat tatgacacaa
     9661 acgagtatgt ttcctctcta gaaccctgta atgcctcctc ccccatcccc agagctcctt
     9721 actgtaggtc ttaccctgga caaggatttt ttcaagttgg aggcacagaa catgagcaat
     9781 ctgacattcc cacagcccct caaacatgca aggctactaa ggcaggagga gtataaatga
     9841 tggatattga ccaagacctg cttggacgga gaccgccata ttatctgttc tcttcgttca
     9901 caaaacagcc ttcacttgtc tcagaatttg atggacacat actgtgatga gcaggagctt
     9961 cagatgcact ctttacacat tttgttgaaa taaacctcta catttgtaga aga
//
