LOCUS       NM_006111               2926 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens acetyl-CoA acyltransferase 2 (ACAA2), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_006111
VERSION     NM_006111.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Leng,Y., Tian,T., Tang,B., Ma,Y., Li,Z., Shi,Q., Liu,J., Zhou,Y.,
            Wang,W., Huang,C., Zhao,X., Feng,W., Liu,Y., Liang,J., Liu,T.,
            Liu,S., Ren,Q., Liu,J., Zhang,T., Zhou,J., Huang,Q., Zhang,Y.,
            Yin,B., Xu,Y., Liu,L., Shen,L. and Zhao,H.
  TITLE     The oncogenic role and regulatory mechanism of ACAA2 in human
            ovarian cancer
  JOURNAL   Mol Carcinog 63 (7), 1362-1377 (2024)
   PUBMED   38656551
  REMARK    GeneRIF: The oncogenic role and regulatory mechanism of ACAA2 in
            human ovarian cancer.
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Shen,M., Liu,S., Toland,A., Hsu,E.C., Hartono,A.B., Alabi,B.R.,
            Aslan,M., Nguyen,H.M., Sessions,C.J., Nolley,R., Shi,C., Huang,J.,
            Brooks,J.D., Corey,E. and Stoyanova,T.
  TITLE     ACAA2 is a novel molecular indicator for cancers with
            neuroendocrine phenotype
  JOURNAL   Br J Cancer 129 (11), 1818-1828 (2023)
   PUBMED   37798372
  REMARK    GeneRIF: ACAA2 is a novel molecular indicator for cancers with
            neuroendocrine phenotype.
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Yuan,Y., Sun,X., Liu,M., Li,S., Dong,Y., Hu,K., Zhang,J., Xu,B.,
            Ma,S., Jiang,H., Hou,P., Lin,Y., Gan,L. and Liu,T.
  TITLE     Negative correlation between acetyl-CoA acyltransferase 2 and
            cetuximab resistance in colorectal cancer
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 55 (9), 1467-1478 (2023)
   PUBMED   37310146
  REMARK    GeneRIF: Negative correlation between acetyl-CoA acyltransferase 2
            and cetuximab resistance in colorectal cancer.
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Zhang,H., Pan,E., Zhang,Y., Zhao,C., Liu,Q., Pu,Y. and Yin,L.
  TITLE     LncRNA RPL34-AS1 suppresses the proliferation, migration and
            invasion of esophageal squamous cell carcinoma via targeting
            miR-575/ACAA2 axis
  JOURNAL   BMC Cancer 22 (1), 1017 (2022)
   PUBMED   36162992
  REMARK    GeneRIF: LncRNA RPL34-AS1 suppresses the proliferation, migration
            and invasion of esophageal squamous cell carcinoma via targeting
            miR-575/ACAA2 axis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Cao,W., Liu,N., Tang,S., Bao,L., Shen,L., Yuan,H., Zhao,X. and
            Lu,H.
  TITLE     Acetyl-Coenzyme A acyltransferase 2 attenuates the apoptotic
            effects of BNIP3 in two human cell lines
  JOURNAL   Biochim Biophys Acta 1780 (6), 873-880 (2008)
   PUBMED   18371312
  REMARK    GeneRIF: ACAA2 is a functional BNIP3 binding partner and provide a
            possible linkage between fatty acid metabolism and apoptosis of
            cells.
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Kathiresan,S., Melander,O., Guiducci,C., Surti,A., Burtt,N.P.,
            Rieder,M.J., Cooper,G.M., Roos,C., Voight,B.F., Havulinna,A.S.,
            Wahlstrand,B., Hedner,T., Corella,D., Tai,E.S., Ordovas,J.M.,
            Berglund,G., Vartiainen,E., Jousilahti,P., Hedblad,B.,
            Taskinen,M.R., Newton-Cheh,C., Salomaa,V., Peltonen,L., Groop,L.,
            Altshuler,D.M. and Orho-Melander,M.
  TITLE     Six new loci associated with blood low-density lipoprotein
            cholesterol, high-density lipoprotein cholesterol or triglycerides
            in humans
  JOURNAL   Nat Genet 40 (2), 189-197 (2008)
   PUBMED   18193044
  REMARK    Erratum:[Nat Genet. 2008 Nov;40(11):1384]
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Aboulaich,N., Vainonen,J.P., Stralfors,P. and Vener,A.V.
  TITLE     Vectorial proteomics reveal targeting, phosphorylation and specific
            fragmentation of polymerase I and transcript release factor (PTRF)
            at the surface of caveolae in human adipocytes
  JOURNAL   Biochem J 383 (Pt 2), 237-248 (2004)
   PUBMED   15242332
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   Seedorf,U., Ellinghaus,P. and Roch Nofer,J.
  TITLE     Sterol carrier protein-2
  JOURNAL   Biochim Biophys Acta 1486 (1), 45-54 (2000)
   PUBMED   10856712
  REMARK    Review article
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Abe,H., Ohtake,A., Yamamoto,S., Satoh,Y., Takayanagi,M., Amaya,Y.,
            Takiguchi,M., Sakuraba,H., Suzuki,Y., Mori,M. et al.
  TITLE     Cloning and sequence analysis of a full length cDNA encoding human
            mitochondrial 3-oxoacyl-CoA thiolase
  JOURNAL   Biochim Biophys Acta 1216 (2), 304-306 (1993)
   PUBMED   8241273
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK054673.1, BC001918.1 and
            AC090227.10.
            
            On Nov 22, 2018 this sequence version replaced NM_006111.2.
            
            Summary: The encoded protein catalyzes the last step of the
            mitochondrial fatty acid beta-oxidation spiral. Unlike most
            mitochondrial matrix proteins, it contains a non-cleavable
            amino-terminal targeting signal. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.260875.1,
                                           SRR1803612.226072.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000285093.15/
                                                  ENSP00000285093.8
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1004              AK054673.1         349-1352
            1005-1586           BC001918.1         975-1556
            1587-2926           AC090227.10        46217-47556
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.1"
     gene            1..2926
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /note="acetyl-CoA acyltransferase 2"
                     /db_xref="GeneID:10449"
                     /db_xref="HGNC:HGNC:83"
                     /db_xref="MIM:604770"
     exon            1..65
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     CDS             50..1243
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /EC_number="2.3.1.9"
                     /EC_number="2.3.1.16"
                     /EC_number="3.1.2.2"
                     /EC_number="3.1.2.1"
                     /note="mitochondrial 3-oxoacyl-CoA thiolase; beta
                     ketothiolase; mitochondrial 3-oxoacyl-Coenzyme A thiolase;
                     acetyl-Coenzyme A acyltransferase 2; acetyl-CoA
                     acetyltransferase; acyl-CoA hydrolase, mitochondrial"
                     /codon_start=1
                     /product="3-ketoacyl-CoA thiolase, mitochondrial"
                     /protein_id="NP_006102.2"
                     /db_xref="CCDS:CCDS11939.1"
                     /db_xref="GeneID:10449"
                     /db_xref="HGNC:HGNC:83"
                     /db_xref="MIM:604770"
                     /translation="MALLRGVFVVAAKRTPFGAYGGLLKDFTATDLSEFAAKAALSAG
                     KVSPETVDSVIMGNVLQSSSDAIYLARHVGLRVGIPKETPALTINRLCGSGFQSIVNG
                     CQEICVKEAEVVLCGGTESMSQAPYCVRNVRFGTKLGSDIKLEDSLWVSLTDQHVQLP
                     MAMTAENLAVKHKISREECDKYALQSQQRWKAANDAGYFNDEMAPIEVKTKKGKQTMQ
                     VDEHARPQTTLEQLQKLPPVFKKDGTVTAGNASGVADGAGAVIIASEDAVKKHNFTPL
                     ARIVGYFVSGCDPSIMGIGPVPAISGALKKAGLSLKDMDLVEVNEAFAPQYLAVERSL
                     DLDISKTNVNGGAIALGHPLGGSGSRITAHLVHELRRRGGKYAVGSACIGGGQGIAVI
                     IQSTA"
     exon            66..232
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            233..361
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            362..478
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            479..626
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            627..802
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            803..932
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1003
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1158
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     exon            1159..2926
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1565..1570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /note="hexamer: AATAAA"
     polyA_site      1586
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /note="major polyA site"
     regulatory      1869..1874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /note="hexamer: TATAAA"
     polyA_site      1891
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
     regulatory      2903..2908
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="ACAA2"
                     /gene_synonym="DSAEC; T1"
ORIGIN      
        1 agcgtccccc acaccacaga cccgcgccgc cgacgaccca gcagccgcca tggctctgct
       61 ccgaggtgtg tttgtagttg ctgctaagcg aacgcccttt ggagcttacg gaggccttct
      121 gaaagacttc actgctactg acttgtctga atttgctgcc aaggctgcct tgtctgctgg
      181 caaagtctca cctgaaacag ttgacagtgt gattatgggc aatgtcctgc agagttcttc
      241 agatgctata tatttggcaa ggcatgttgg tttgcgtgtg ggaatcccaa aggagacccc
      301 agctctcacg attaataggc tctgtggttc tggttttcag tccattgtga atggatgtca
      361 ggaaatttgt gttaaagaag ctgaagttgt tttatgtgga ggaaccgaaa gcatgagcca
      421 agctccctac tgtgtcagaa atgtgcgttt tggaaccaag cttggatcag atatcaagct
      481 ggaagattct ttatgggtat cattaacaga tcagcatgtc cagctcccca tggcaatgac
      541 tgcagagaat cttgctgtaa aacacaaaat aagcagagaa gaatgtgaca aatatgccct
      601 gcagtcacag cagagatgga aagctgctaa tgatgctggc tactttaatg atgaaatggc
      661 accaattgaa gtgaagacaa agaaaggaaa acagacaatg caggtagacg agcatgctcg
      721 gccccaaacc accctggaac agttacagaa acttcctcca gtattcaaga aagatggaac
      781 tgttactgca gggaatgcat cgggtgtagc tgatggtgct ggagctgtta tcatagctag
      841 tgaagatgct gttaagaaac ataacttcac accactggca agaattgtgg gctactttgt
      901 atctggatgt gatccctcta tcatgggtat tggtcctgtc cctgctatca gtggggcact
      961 gaagaaagca ggactgagtc ttaaggacat ggatttggta gaggtgaatg aagcttttgc
     1021 tccccagtac ttggctgttg agaggagttt ggatcttgac ataagtaaaa ccaatgtgaa
     1081 tggaggagcc attgctttgg gtcacccact gggaggatct ggatcaagaa ttactgcaca
     1141 cctggttcac gaattaaggc gtcgaggtgg aaaatatgcc gttggatcag cttgcattgg
     1201 aggtggccaa ggtattgctg tcatcattca gagcacagcc tgaagagacc agtgagctca
     1261 ctgtgaccca tccttactct acttggccag gccacagtaa aacaagtgac cttcagagca
     1321 gctgccacaa ctggccatgc cctgccattg aaacagtgat taagtttgat caagccatgg
     1381 tgacacaaaa atgcattgat catgaatagg agcccatgct agaagtacat tctctcagat
     1441 ttgaaccagt gaaatatgat gtatttctga gctaaaactc aactatagaa gacattaaaa
     1501 gaaatcgtat tcttgccaag taaccaccac ttctgcctta gataatatga ttataaggaa
     1561 atcaaataaa tgttgcctta acttcagtta atattttcct gtcatttata tttttaaaaa
     1621 ttttaaattg tgataagata cacattacat aaactttacc atcttaaccc ttttttagcg
     1681 tacaattcac tggtattaag tacattcaca tttttataca aacatcccca ctttttatca
     1741 acagaacttt ttcagtcacc acacatggaa acaataactc ctgattctcc catcccccat
     1801 cccctgacaa ccaccagtgt attttgtttc tataaatttg atgactcgag gtacctcata
     1861 agtgaaatta taaatatctg tcctttcgtg actggcttat tttactttac tttatataat
     1921 gttctcaaga ttcatccacc ttatggtgta gcatgtgtca gaatttcctt ctttttaaag
     1981 gctgaataat attctgctgt gtgtataaac cttacttcct tcttcccagc ttaaaggcca
     2041 tctttcatcc tttattttct ccctttaaaa tgcccccaca acacttccat tgctttattt
     2101 gtctgttcta agactggata tctagtaggg caaggcccta ttcttgttaa cttcatcaaa
     2161 gagccactgg aaattttaat taagattaaa ttgaatttat gggttataca tttattgggg
     2221 ggaaattttt tttttttttt ttgagacaga gtctcgctct gtcctccagg ctggagtgca
     2281 gtggcgcgat ctcagcttac tgcaagctcc gcctcctggg ttcatgccat tctcctgcct
     2341 cagcctcccc agtagctggg actacaggcg cctgccacta cgcccggcta attttttgta
     2401 tttttagtag agatggggtt tcaccgtgtt agccaggatg gtctcgatct cctgacctcg
     2461 tgatccaccc gcctcggcct cccaaagaag tgctgggatt acaggcgtga gccactgcac
     2521 ccggcctttt tttttttttt ttgagatagc atcttgctct gtcacccagg cagaattgca
     2581 gtggcacagt catggctcac tgaataatag atgttaaata atactagatg ttaaataata
     2641 gtatcataag tacctacact gtttcctcaa ccctttgctt atatggtttc cttcatttga
     2701 ttaaaaagct gaagtggcac atacatcccc ctttctgtca tagagaggca gatgacaagc
     2761 ggcctaccca cggtttggga taatggacta gtggcaacag gcaagtccag cttttattgt
     2821 ttgggatcct tactgagaag cagcaggctt cctctactgt cataaaaata ttaaaaagta
     2881 agagccctgt ataatttctc ataataaaac aatgttttgc agaaca
//
