LOCUS       NM_013375               2943 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens activator of basal transcription 1 (ABT1), mRNA.
ACCESSION   NM_013375
VERSION     NM_013375.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2943)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2943)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2943)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2943)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 2943)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 2943)
  AUTHORS   Satoh,J., Obayashi,S., Misawa,T., Sumiyoshi,K., Oosumi,K. and
            Tabunoki,H.
  TITLE     Protein microarray analysis identifies human cellular prion protein
            interactors
  JOURNAL   Neuropathol Appl Neurobiol 35 (1), 16-35 (2009)
   PUBMED   18482256
REFERENCE   7  (bases 1 to 2943)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   8  (bases 1 to 2943)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
REFERENCE   9  (bases 1 to 2943)
  AUTHORS   Andersen,J.S., Lyon,C.E., Fox,A.H., Leung,A.K., Lam,Y.W., Steen,H.,
            Mann,M. and Lamond,A.I.
  TITLE     Directed proteomic analysis of the human nucleolus
  JOURNAL   Curr Biol 12 (1), 1-11 (2002)
   PUBMED   11790298
REFERENCE   10 (bases 1 to 2943)
  AUTHORS   Oda,T., Kayukawa,K., Hagiwara,H., Yudate,H.T., Masuho,Y.,
            Murakami,Y., Tamura,T.A. and Muramatsu,M.A.
  TITLE     A novel TATA-binding protein-binding protein, ABT1, activates basal
            transcription and has a yeast homolog that is essential for growth
  JOURNAL   Mol Cell Biol 20 (4), 1407-1418 (2000)
   PUBMED   10648625
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL513548.8.
            
            On Nov 23, 2018 this sequence version replaced NM_013375.3.
            
            Summary: Basal transcription of genes by RNA polymerase II requires
            the interaction of TATA-binding protein (TBP) with the core region
            of class II promoters.  Studies in mouse suggest that the protein
            encoded by this gene likely activates basal transcription from
            class II promoters by interaction with TBP and the class II
            promoter DNA. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.268146.1,
                                           SRR1803612.188604.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274849.3/ ENSP00000274849.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-271               AL513548.8         11439-11709
            272-468             AL513548.8         12400-12596
            469-2943            AL513548.8         12751-15225
FEATURES             Location/Qualifiers
     source          1..2943
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p22.2"
     gene            1..2943
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /note="activator of basal transcription 1"
                     /db_xref="GeneID:29777"
                     /db_xref="HGNC:HGNC:17369"
                     /db_xref="MIM:618750"
     exon            1..271
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             31..849
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /note="basal transcriptional activator; TATA-binding
                     protein-binding protein"
                     /codon_start=1
                     /product="activator of basal transcription 1"
                     /protein_id="NP_037507.1"
                     /db_xref="CCDS:CCDS4616.1"
                     /db_xref="GeneID:29777"
                     /db_xref="HGNC:HGNC:17369"
                     /db_xref="MIM:618750"
                     /translation="MEAEESEKAATEQEPLEGTEQTLDAEEEQEESEEAACGSKKRVV
                     PGIVYLGHIPPRFRPLHVRNLLSAYGEVGRVFFQAEDRFVRRKKKAAAAAGGKKRSYT
                     KDYTEGWVEFRDKRIAKRVAASLHNTPMGARRRSPFRYDLWNLKYLHRFTWSHLSEHL
                     AFERQVRRQRLRAEVAQAKRETDFYLQSVERGQRFLAADGDPARPDGSWTFAQRPTEQ
                     ELRARKAARPGGRERARLATAQDKARSNKGLLARIFGAPPPSESMEGPSLVRDS"
     exon            272..468
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /inference="alignment:Splign:2.1.0"
     exon            469..2943
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1326..1331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /note="hexamer: AATAAA"
     polyA_site      1353
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /note="major polyA site"
     regulatory      2232..2237
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /note="hexamer: AATAAA"
     polyA_site      2254
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
     regulatory      2919..2924
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
                     /note="hexamer: ATTAAA"
     polyA_site      2943
                     /gene="ABT1"
                     /gene_synonym="Esf2; hABT1"
ORIGIN      
        1 acggccgtcg tgccgctcgt gtcagtcaac atggaggcag aggaatcgga gaaggccgca
       61 acggagcaag agccgctgga agggacagaa cagacactag atgcggagga ggagcaggag
      121 gaatccgaag aagcggcctg tggcagcaag aaacgggtag tgccaggtat tgtgtacctg
      181 ggccatatcc cgccgcgctt ccggcccctg cacgtccgca accttctcag cgcctatggc
      241 gaggtcggac gcgtcttctt tcaggctgag gaccggttcg tgagacgcaa gaagaaggca
      301 gcagcagctg ccggaggaaa aaagcggtcc tacaccaagg actacaccga gggatgggtg
      361 gagttccgtg acaagcgcat agccaagcgc gtggcggcca gtctacacaa cacgcctatg
      421 ggtgcccgca ggcgcagccc cttccgttat gatctttgga acctcaagta cttgcaccgt
      481 ttcacctggt cccacctcag cgagcacctc gcctttgagc gccaggtgcg caggcagcgc
      541 ttgagagcgg aggttgctca agccaagcgt gagaccgact tctatcttca aagtgtggaa
      601 cggggacaac gctttcttgc ggccgatggg gaccctgctc gcccagatgg ctcctggaca
      661 tttgcccagc gtcctactga gcaggaactg agggcccgta aagcagcacg gccaggggga
      721 cgtgaacggg ctcgcctggc aactgcccag gacaaggccc gctccaacaa agggctcctg
      781 gccaggatct ttggagcccc gccaccctca gagagcatgg agggaccttc ccttgtcagg
      841 gactcctgag ggcctgggtg gccccttcca tttcctggcc ctgctctgct tcctgtctac
      901 ctcatactag aatgatcgtg actacccggg cagacatttt actgtgtttc tcagaccaag
      961 tgtctactga tggcccaaac atggagtttt gtgggcttcc actgtcccca ctccgaactc
     1021 ctgtatgtgc ctggctgagt cacctaattc atactgtcat actagcataa ttatgactat
     1081 tgcatatgct tgttttgttt gactcttggc tgcctacgtc tgtagggtcc cctgaaaatc
     1141 ccacttcctg cccccagaaa gggcctttat ttccaactag gaggataatg cctagtccag
     1201 gcaatctttc tctgtttagc agtcacaggt gagggtggta ttagcatctt ttttatgtag
     1261 aaaaaattga gttaatgggg tggactgggt tgggaagaaa tacatttcct aatgtattta
     1321 tagaaaataa aaatattttt atgtgccttt ttatttttgt tggtggggag gtcattggac
     1381 aagttccaac tttcatcttg tgttcccttc accttcatat cctgatctta gagcccccct
     1441 ccccctgcca cccaccttac tgtttaacct ggattttttt ttctatttaa tttttgtcta
     1501 atatcttagc ccagtttatc aatcagttat cttaagtcag cattttctaa gccattgttt
     1561 gaggaaacag tgacaatagg taataacaca tcttagtatt aagagtttta caggccacta
     1621 gtataagata ggcatcgtgg tagatgcata taaagggtgg aatgggagcc atggcaggtc
     1681 atagagtcct ctcaatggga acctgattga tgatcacagt cttcagtggt gagtcagtcc
     1741 tcaccaagtt ttccagatca ttcctacaaa gtaaactggg agaataataa gtctgaaaga
     1801 gtgtggagtg ctcccacaat tacaaagaat gcttcctggg tggagtgttg agttggaacc
     1861 attgtaaagg tgggcaaagc ctagtagaga accagtgcac ctcaggtgca cttacatatg
     1921 gtggggctga ggcaaagcag ccctgtaggc ttcaaagaat cagtgtaagc cactaaaagg
     1981 aactgaaaac ctaggtgtca caataaacag tctacacagt ctcacgtaga ccaaaattct
     2041 gatcattttc caggctgttg catgaagtga tagagtatga ttataatttc tgtttgcttg
     2101 tgctgtttgt ttttgttttt catctgtcaa tgtgatgatc tgtgttttat agggtagagt
     2161 ggatttgtct actttggctg taaaataccc taatcacatt atgatcttga caggtgcact
     2221 ttactgggga gaataaaaag gaccatacgg taaagctggt ataacatttc tcacaaccca
     2281 catacctctt atacttggca cacaaactac gtttccattt agaaactttc gtcttgtttc
     2341 tgtttttaat tcttgtgggt ttgtttcatg tgaattgttt cctcagatca ttgatgtctt
     2401 aaagtgaaac agaaaaatcc agaatcagaa tttgacaggc tggcatattc atttattcag
     2461 aattccaagt gcccattgct acttctgcta gataaagaga taccaaggtg aagaagaaac
     2521 tttccctcta gttgctaaca gcttagaaag tacagtagac atactggggt tttatttaag
     2581 actttcttga atgaagaaat aaattgcatt cccacggtgg acagcgttag ataacagtat
     2641 gttcaagggc tggtatttca gggtccatct ccaaaacagt tctgtacaaa gagctcacac
     2701 ctgcggccag gcaagctaag taagtcacag gtggagtgag gaatgagaat aaatgggtgg
     2761 aagaaaatat cctaggaact ttcatcttga ctttaagccc attgagtgta ggaaaataat
     2821 tttttacatc cacaattttg tttctattta aacagcactt gtttttttat atgaagtaac
     2881 tcatttaatc cacaactata taatattgtt atccccccat taaaactgag ctcagagaga
     2941 tga
//
