LOCUS       NM_032182               2955 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens abraxas 2, BRISC complex subunit (ABRAXAS2), mRNA.
ACCESSION   NM_032182
VERSION     NM_032182.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2955)
  AUTHORS   Trepte,P., Secker,C., Kostova,S., Maseko,S.B., Choi,S.G.,
            Blavier,J., Minia,I., Ramos,E.S., Cassonnet,P., Golusik,S.,
            Zenkner,M., Beetz,S., Liebich,M.J., Scharek,N., Schutz,A.,
            Sperling,M., Lisurek,M., Wang,Y., Spirohn,K., Hao,T.,
            Calderwood,M.A., Hill,D.E., Landthaler,M., Olivet,J., Twizere,J.C.,
            Vidal,M. and Wanker,E.E.
  TITLE     AI-guided pipeline for protein-protein interaction drug discovery
            identifies a SARS-CoV-2 inhibitor
  JOURNAL   bioRxiv (2023)
   PUBMED   37398436
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2955)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2955)
  AUTHORS   Song,P., Hong,J., Wang,Y., Yao,X., Zhan,Y., Yin,R., Yu,M., Li,C.,
            Yang,X. and Ge,C.
  TITLE     Transcriptional regulation of human abraxas brother protein 1
            expression by yin yang 1
  JOURNAL   Biochem Cell Biol 99 (2), 223-230 (2021)
   PUBMED   32845162
  REMARK    GeneRIF: Transcriptional regulation of human abraxas brother
            protein 1 expression by yin yang 1.
REFERENCE   4  (bases 1 to 2955)
  AUTHORS   Zhang,W., Tao,S.S., Wang,T., Zhang,J., Liu,X., Li,Y.T., Chen,H.,
            Zhan,Y.Q., Yu,M., Ge,C.H., Li,C.Y., Ren,G.M., Yang,X.M. and
            Yin,R.H.
  TITLE     ABRO1 stabilizes the deubiquitinase BRCC3 through inhibiting its
            degradation mediated by the E3 ubiquitin ligase WWP2
  JOURNAL   FEBS Lett 595 (2), 169-182 (2021)
   PUBMED   33107021
  REMARK    GeneRIF: ABRO1 stabilizes the deubiquitinase BRCC3 through
            inhibiting its degradation mediated by the E3 ubiquitin ligase
            WWP2.
REFERENCE   5  (bases 1 to 2955)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 2955)
  AUTHORS   Sowa,M.E., Bennett,E.J., Gygi,S.P. and Harper,J.W.
  TITLE     Defining the human deubiquitinating enzyme interaction landscape
  JOURNAL   Cell 138 (2), 389-403 (2009)
   PUBMED   19615732
REFERENCE   7  (bases 1 to 2955)
  AUTHORS   Cooper,E.M., Cutcliffe,C., Kristiansen,T.Z., Pandey,A.,
            Pickart,C.M. and Cohen,R.E.
  TITLE     K63-specific deubiquitination by two JAMM/MPN+ complexes:
            BRISC-associated Brcc36 and proteasomal Poh1
  JOURNAL   EMBO J 28 (6), 621-631 (2009)
   PUBMED   19214193
REFERENCE   8  (bases 1 to 2955)
  AUTHORS   Wang,B., Hurov,K., Hofmann,K. and Elledge,S.J.
  TITLE     NBA1, a new player in the Brca1 A complex, is required for DNA
            damage resistance and checkpoint control
  JOURNAL   Genes Dev 23 (6), 729-739 (2009)
   PUBMED   19261749
REFERENCE   9  (bases 1 to 2955)
  AUTHORS   Colland,F., Jacq,X., Trouplin,V., Mougin,C., Groizeleau,C.,
            Hamburger,A., Meil,A., Wojcik,J., Legrain,P. and Gauthier,J.M.
  TITLE     Functional proteomics mapping of a human signaling pathway
  JOURNAL   Genome Res 14 (7), 1324-1332 (2004)
   PUBMED   15231748
REFERENCE   10 (bases 1 to 2955)
  AUTHORS   Brill,L.M., Salomon,A.R., Ficarro,S.B., Mukherji,M.,
            Stettler-Gill,M. and Peters,E.C.
  TITLE     Robust phosphoproteomic profiling of tyrosine phosphorylation sites
            from human T cells using immobilized metal affinity chromatography
            and tandem mass spectrometry
  JOURNAL   Anal Chem 76 (10), 2763-2772 (2004)
   PUBMED   15144186
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC068896.9.
            
            On Nov 23, 2018 this sequence version replaced NM_032182.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008999.1, D63877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298492.6/ ENSP00000298492.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-83                AC068896.9         108819-108901
            84-174              AC068896.9         113831-113921
            175-211             AC068896.9         123576-123612
            212-278             AC068896.9         126384-126450
            279-469             AC068896.9         133595-133785
            470-589             AC068896.9         135756-135875
            590-674             AC068896.9         136393-136477
            675-789             AC068896.9         138349-138463
            790-2955            AC068896.9         141502-143667
FEATURES             Location/Qualifiers
     source          1..2955
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q26.13"
     gene            1..2955
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /note="abraxas 2, BRISC complex subunit"
                     /db_xref="GeneID:23172"
                     /db_xref="HGNC:HGNC:28975"
                     /db_xref="MIM:611144"
     exon            1..83
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..1259
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /note="abraxas brother 1; BRISC complex subunit Abro1;
                     abraxas brother protein 1; family with sequence similarity
                     175 member B"
                     /codon_start=1
                     /product="BRISC complex subunit Abraxas 2"
                     /protein_id="NP_115558.3"
                     /db_xref="CCDS:CCDS31308.2"
                     /db_xref="GeneID:23172"
                     /db_xref="HGNC:HGNC:28975"
                     /db_xref="MIM:611144"
                     /translation="MAASISGYTFSAVCFHSANSNADHEGFLLGEVRQEETFSISDSQ
                     ISNTEFLQVIEIHNHQPCSKLFSFYDYASKVNEESLDRILKDRRKKVIGWYRFRRNTQ
                     QQMSYREQVLHKQLTRILGVPDLVFLLFSFISTANNSTHALEYVLFRPNRRYNQRISL
                     AIPNLGNTSQQEYKVSSVPNTSQSYAKVIKEHGTDFFDKDGVMKDIRAIYQVYNALQE
                     KVQAVCADVEKSERVVESCQAEVNKLRRQITQRKNEKEQERRLQQAVLSRQMPSESLD
                     PAFSPRMPSSGFAAEGRSTLGDAEASDPPPPYSDFHPNNQESTLSHSRMERSVFMPRP
                     QAVGSSNYASTSAGLKYPGSGADLPPPQRAAGDSGEDSDDSDYENLIDPTEPSNSEYS
                     HSKDSRPMAHPDEDPRNTQTSQI"
     exon            84..174
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            175..211
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            212..278
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            279..469
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            470..589
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            590..674
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            675..789
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     exon            790..2955
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2209..2214
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /note="hexamer: AATAAA"
     polyA_site      2233
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
     regulatory      2933..2938
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /note="hexamer: AATAAA"
     polyA_site      2955
                     /gene="ABRAXAS2"
                     /gene_synonym="ABRO1; FAM175B; KIAA0157"
                     /note="major polyA site"
ORIGIN      
        1 agatttccat catggcggcg tccatttcgg gctacacctt cagtgctgtg tgtttccaca
       61 gcgccaacag caacgcggac cacgaaggat ttttactggg agaggtaaga caagaggaaa
      121 cgtttagcat cagtgactca caaatcagca acacagaatt tctgcaagta attgaaatcc
      181 ataaccatca gccttgttca aaacttttta gtttttatga ctacgcaagc aaagtgaatg
      241 aggagagttt ggacaggatt cttaaagatc ggagaaagaa agtcattggg tggtacagat
      301 tccggcgcaa tacgcagcag cagatgtcct acagagagca ggttcttcac aagcagctca
      361 cccgcatcct cggcgtgccc gacctcgtct ttcttctctt cagcttcatc tccactgcca
      421 acaattccac tcacgcttta gaatatgtgc tcttcagacc aaatagaagg tataatcaga
      481 ggatatcact cgctattccc aatctaggaa atactagcca gcaagagtac aaagtgtctt
      541 cagtgccaaa tacttctcag agttatgcca aagtgattaa agaacatggt actgactttt
      601 ttgacaagga tggagtgatg aaagacatca gggcgattta tcaggtttat aatgcacttc
      661 aggagaaagt tcaggcagtg tgtgcagatg ttgaaaagag tgagcgagtt gttgaatctt
      721 gtcaggcaga agtgaacaaa ttaagaagac aaatcactca gaggaaaaat gaaaaggaac
      781 aagaaagaag attgcagcag gcagtgttaa gcagacagat gccgtctgaa agcttggacc
      841 cagcgttcag tcctcggatg ccgtcctctg ggtttgcagc tgaaggcaga agtacacttg
      901 gagatgcaga ggcctcggat cctcctcccc cttactctga ttttcaccca aacaatcaag
      961 aaagtacttt gagccactct cgcatggaaa ggagtgtctt tatgcctcga cctcaagctg
     1021 tgggctcttc caattatgct tccaccagtg ccggactgaa gtatcctgga agtggggctg
     1081 accttcctcc tccccaaaga gcagctggag acagtggtga ggattcagac gacagtgatt
     1141 atgaaaattt gattgaccct acagagcctt ctaatagtga atactcacat tcaaaggatt
     1201 ctcgacccat ggcacatccc gacgaggacc ccaggaacac tcagacctcc cagatttaac
     1261 taaacaaaag aaactctcca cctagcactg tttttcttca ttgcttactg agagggtttt
     1321 tgagaactta atctgggggg agaactgctt tctcagatac cttaactccc gagaagagag
     1381 tccttgtgca cagaacttgt gggagcctcc atccgctgct ctttaccttt ggatacagtg
     1441 tgcaagtttc atgacagaat cattaagata atcaaattgt cctaattctg gtgcgattca
     1501 tggatatact ggtaaattta ggcaaagtga aacttatcag cgtagtttct gttctttaaa
     1561 ataaattgga aattagagac taagcacaat tagtctataa atgttctata aatcaaaaac
     1621 ttacctcttg cactatcatg ccttgaaatt tactttttca aagggaaaca agtttagcag
     1681 cagccttcaa agaacttctt tctatgatga gccaaattca tctttgccag aaaagaaatt
     1741 ttgataattc caagaagcct gattagaaca aatcagatat accttctctt gtctgcatga
     1801 ctttgtgaga taaaagagag ggcttccaac ttttttctac tagcttgata tgtattatca
     1861 cttaaaatgg ttgcctttaa aaaaaaaaag tagagatact aattaccagt aagtaatcat
     1921 ccaaataaat acgtcataaa ataaattaat tattttttct ttgatggatt acagtgacta
     1981 ctgtgttgca ctggcacatt tatggtctct gttctggaat cttggaggac acacagcagt
     2041 ggagaacaga aggagtgagt tttataatga acagattcca gacacggtag gtttagctga
     2101 gttcatacag aggagatata actcatttag atcttctgac aaatcctagt gttagtttta
     2161 tctgtggagg aaagacattt aataataaac tgtttgggaa tcttggtgaa taaagattca
     2221 ttttcaagct gaataaccat acttatttta ttttaagttg ccatttgggg aataattgca
     2281 gtatgtgtag agactctctt gggatgcact tatattttta tttaatgact acttgttttc
     2341 tagttttgcc cacaacgtct gaaaccacta agacattcag gagcatgttg agcttctggt
     2401 ttggaaacag caagacccac catttatgac aaggacagcc atgaggttaa tacttggagt
     2461 ttaactgcct tccctttgaa ctagttaaaa tctgtaagaa taaggaagtt gttgaaggct
     2521 taaaatctgg gttctgaaaa agtagtttca gtttatagga tacacattta ctcactgagc
     2581 tccagttcca atactaaatt agacagtatc atatagacgg aaaatgaaat gctagaactg
     2641 ccgttctttg gatcgccact ctatgggggt ctgtctttta actactctcc tggttatgtt
     2701 ggccttacac cactgccatt tgatttaaaa cgctgcagac cactttatct gcaaatgtgt
     2761 tccagttgtt atcagctacc tactacgcag cttcagcgcc agtgtgaatt tatttttttt
     2821 taagtgccat taccgtctcc tctgttcaga ttttgacatt caggaaaata tttttatttt
     2881 gatgccatac tgaaatctac aatgtatatc tgacaaagca gttaaatgtg acaataaaaa
     2941 acttatttaa tcatg
//
