LOCUS       NM_021243                782 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ABRA C-terminal like (ABRACL), mRNA.
ACCESSION   NM_021243 XM_371848 XM_941139
VERSION     NM_021243.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 782)
  AUTHORS   Li,J. and Chen,H.
  TITLE     Actin-binding Rho activating C-terminal like (ABRACL)
            transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2)
            promotes the proliferation, invasion, migration and
            epithelial-mesenchymal transition of breast cancer cells
  JOURNAL   Bioengineered 13 (4), 9019-9031 (2022)
   PUBMED   35341461
  REMARK    GeneRIF: Actin-binding Rho activating C-terminal like (ABRACL)
            transcriptionally regulated by MYB proto-oncogene like 2 (MYBL2)
            promotes the proliferation, invasion, migration and
            epithelial-mesenchymal transition of breast cancer cells.
REFERENCE   2  (bases 1 to 782)
  AUTHORS   Fan,S., Chen,P. and Li,S.
  TITLE     miR-145-5p Inhibits the Proliferation, Migration, and Invasion of
            Esophageal Carcinoma Cells by Targeting ABRACL
  JOURNAL   Biomed Res Int 2021, 6692544 (2021)
   PUBMED   33728339
  REMARK    GeneRIF: miR-145-5p Inhibits the Proliferation, Migration, and
            Invasion of Esophageal Carcinoma Cells by Targeting ABRACL.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 782)
  AUTHORS   Hsiao,B.Y., Chen,C.H., Chi,H.Y., Yen,P.R., Yu,Y.Z., Lin,C.H.,
            Pang,T.L., Lin,W.C., Li,M.L., Yeh,Y.C., Chou,T.Y. and Chen,M.Y.
  TITLE     Human Costars Family Protein ABRACL Modulates Actin Dynamics and
            Cell Migration and Associates with Tumorigenic Growth
  JOURNAL   Int J Mol Sci 22 (4), 2037 (2021)
   PUBMED   33670794
  REMARK    GeneRIF: Human Costars Family Protein ABRACL Modulates Actin
            Dynamics and Cell Migration and Associates with Tumorigenic Growth.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 782)
  AUTHORS   Lin,J., Zhou,T. and Wang,J.
  TITLE     Solution structure of the human HSPC280 protein
  JOURNAL   Protein Sci 20 (1), 216-223 (2011)
   PUBMED   21082705
  REMARK    GeneRIF: Solution structure of the human HSPC280 protein
            Erratum:[Protein Sci. 2011 Sep;20(9):1644]
REFERENCE   5  (bases 1 to 782)
  AUTHORS   Pang,T.L., Chen,F.C., Weng,Y.L., Liao,H.C., Yi,Y.H., Ho,C.L.,
            Lin,C.H. and Chen,M.Y.
  TITLE     Costars, a Dictyostelium protein similar to the C-terminal domain
            of STARS, regulates the actin cytoskeleton and motility
  JOURNAL   J Cell Sci 123 (Pt 21), 3745-3755 (2010)
   PUBMED   20940261
REFERENCE   6  (bases 1 to 782)
  AUTHORS   Molina,H., Bunkenborg,J., Reddy,G.H., Muthusamy,B., Scheel,P.J. and
            Pandey,A.
  TITLE     A proteomic analysis of human hemodialysis fluid
  JOURNAL   Mol Cell Proteomics 4 (5), 637-650 (2005)
   PUBMED   15723814
REFERENCE   7  (bases 1 to 782)
  AUTHORS   Gevaert,K., Goethals,M., Martens,L., Van Damme,J., Staes,A.,
            Thomas,G.R. and Vandekerckhove,J.
  TITLE     Exploring proteomes and analyzing protein processing by mass
            spectrometric identification of sorted N-terminal peptides
  JOURNAL   Nat Biotechnol 21 (5), 566-569 (2003)
   PUBMED   12665801
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG563686.1 and AF116682.1.
            
            On Nov 23, 2018 this sequence version replaced NM_021243.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163657.36065.1,
                                           SRR1163658.170877.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367660.4/ ENSP00000356632.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                BG563686.1         65-103
            40-782              AF116682.1         38-780
FEATURES             Location/Qualifiers
     source          1..782
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q24.1"
     gene            1..782
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /note="ABRA C-terminal like"
                     /db_xref="GeneID:58527"
                     /db_xref="HGNC:HGNC:21230"
     exon            1..131
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /inference="alignment:Splign:2.1.0"
     exon            132..198
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..383
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /note="ABRA C-terminal-like protein"
                     /codon_start=1
                     /product="costars family protein ABRACL"
                     /protein_id="NP_067066.1"
                     /db_xref="CCDS:CCDS43509.1"
                     /db_xref="GeneID:58527"
                     /db_xref="HGNC:HGNC:21230"
                     /translation="MNVDHEVNLLVEEIHRLGSKNADGKLSVKFGVLFRDDKCANLFE
                     ALVGTLKAAKRRKIVTYPGELLLQGVHDDVDIILLQD"
     exon            199..782
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /inference="alignment:Splign:2.1.0"
     regulatory      755..760
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /note="hexamer: AATAAA"
     polyA_site      782
                     /gene="ABRACL"
                     /gene_synonym="C6orf115; Costars; HSPC280; PRO2013"
                     /note="major polyA site"
ORIGIN      
        1 acagccgtct ttctctttgc ctcagccact tccttccttg gcctcaccct ccccagtgca
       61 ctgaagaagg taaccgggtc cagacccacg cggcgccagt tctccggcgg gaaggaaaac
      121 cgcgcagaga ggcagcaatg aatgtggatc acgaggttaa cctcttagtg gaggaaattc
      181 atcgtttggg ttcaaaaaat gctgatggaa agttaagcgt gaaatttggg gtcctcttcc
      241 gtgatgataa atgtgccaac ctctttgaag cattggtagg aactcttaaa gctgcaaaac
      301 gaaggaagat tgtaacatat ccaggagagc tgcttctgca aggtgttcat gatgatgttg
      361 acattatatt actgcaagat taatgtggtt tacatatctt tatgtactgc cattttttgt
      421 ttctggtaaa ctggaatata aagtgaaaga acaaacattt gaacatactt aatgtatttt
      481 tatagaactt tgtaaacgaa aggagattca tgttttagaa gtctgtcctt ttttatatct
      541 tgaaagaaaa tctatgtatg atgctataaa ataaatccta ttatttttct caggaatctg
      601 gttaggaatt gcaggcaatg agattttttg cggggcaggg atgggaatgt ttgttcataa
      661 ataattagac attttctata gatatttgac attctgcgaa agcaacaagc aaactgaaga
      721 ccaactccta tgagaaatat tatgatgttt atgtaataaa gacatgtaac tgtcttaaat
      781 tt
//
