LOCUS       NM_139166               2754 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens actin binding Rho activating protein (ABRA), mRNA.
ACCESSION   NM_139166
VERSION     NM_139166.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2754)
  AUTHORS   Li,B., Zhan,Y., Liang,Q., Xu,C., Zhou,X., Cai,H., Zheng,Y., Guo,Y.,
            Wang,L., Qiu,W., Cui,B., Lu,C., Qian,R., Zhou,P., Chen,H., Liu,Y.,
            Chen,S., Li,X. and Sun,N.
  TITLE     Isogenic human pluripotent stem cell disease models reveal ABRA
            deficiency underlies cTnT mutation-induced familial dilated
            cardiomyopathy
  JOURNAL   Protein Cell 13 (1), 65-71 (2022)
   PUBMED   33884582
  REMARK    GeneRIF: Isogenic human pluripotent stem cell disease models reveal
            ABRA deficiency underlies cTnT mutation-induced familial dilated
            cardiomyopathy.
REFERENCE   2  (bases 1 to 2754)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2754)
  AUTHORS   Reitzner,S.M., Norrbom,J., Sundberg,C.J. and Gidlund,E.K.
  TITLE     Expression of striated activator of rho-signaling in human skeletal
            muscle following acute exercise and long-term training
  JOURNAL   Physiol Rep 6 (5) (2018)
   PUBMED   29504288
  REMARK    GeneRIF: STARS expression is acutely upregulated following
            exercise, but there is no cumulative effect to long-term training.
REFERENCE   4  (bases 1 to 2754)
  AUTHORS   Russell,A.P., Wallace,M.A., Kalanon,M., Zacharewicz,E., Della
            Gatta,P.A., Garnham,A. and Lamon,S.
  TITLE     Striated muscle activator of Rho signalling (STARS) is reduced in
            ageing human skeletal muscle and targeted by miR-628-5p
  JOURNAL   Acta Physiol (Oxf) 220 (2), 263-274 (2017)
   PUBMED   27739650
  REMARK    GeneRIF: we established that miR-628-5p, a miRNA regulated by age
            and exercise, binds to the STARS 3'UTR to directly downregulate its
            transcription
REFERENCE   5  (bases 1 to 2754)
  AUTHORS   Furuya,Y., Denda,M., Sakane,K., Ogusu,T., Takahashi,S., Magari,M.,
            Kanayama,N., Morishita,R. and Tokumitsu,H.
  TITLE     Identification of striated muscle activator of Rho signaling
            (STARS) as a novel calmodulin target by a newly developed
            genome-wide screen
  JOURNAL   Cell Calcium 60 (1), 32-40 (2016)
   PUBMED   27132186
  REMARK    GeneRIF: These results suggest a connection between
            Ca(2+)-signaling via excitation-contraction coupling and the
            regulation of STARS-mediated gene expression in muscles.
REFERENCE   6  (bases 1 to 2754)
  AUTHORS   Lamon,S., Wallace,M.A., Leger,B. and Russell,A.P.
  TITLE     Regulation of STARS and its downstream targets suggest a novel
            pathway involved in human skeletal muscle hypertrophy and atrophy
  JOURNAL   J Physiol 587 (Pt 8), 1795-1803 (2009)
   PUBMED   19255118
  REMARK    GeneRIF: STARS signalling pathway is responsive to changes in
            skeletal muscle loading and appears to play a role in both human
            skeletal muscle hypertrophy and atrophy
REFERENCE   7  (bases 1 to 2754)
  AUTHORS   Kuwahara,K., Teg Pipes,G.C., McAnally,J., Richardson,J.A.,
            Hill,J.A., Bassel-Duby,R. and Olson,E.N.
  TITLE     Modulation of adverse cardiac remodeling by STARS, a mediator of
            MEF2 signaling and SRF activity
  JOURNAL   J Clin Invest 117 (5), 1324-1334 (2007)
   PUBMED   17415416
  REMARK    GeneRIF: Modulates the responsiveness of the heart to stress
            signaling by functioning as a cytoskeletal intermediary between
            human and transgenic myocyte enhancer factor-2 and serum response
            factor.
REFERENCE   8  (bases 1 to 2754)
  AUTHORS   Kuwahara,K., Barrientos,T., Pipes,G.C., Li,S. and Olson,E.N.
  TITLE     Muscle-specific signaling mechanism that links actin dynamics to
            serum response factor
  JOURNAL   Mol Cell Biol 25 (8), 3173-3181 (2005)
   PUBMED   15798203
  REMARK    GeneRIF: STARS activates serum response factor by inducing the
            nuclear translocation of myocardin-related transcription factors .
REFERENCE   9  (bases 1 to 2754)
  AUTHORS   Arai,A., Spencer,J.A. and Olson,E.N.
  TITLE     STARS, a striated muscle activator of Rho signaling and serum
            response factor-dependent transcription
  JOURNAL   J Biol Chem 277 (27), 24453-24459 (2002)
   PUBMED   11983702
REFERENCE   10 (bases 1 to 2754)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL832152.1 and BC105103.1.
            
            On Nov 23, 2018 this sequence version replaced NM_139166.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL832152.1, AL833422.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000311955.4/ ENSP00000311436.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-446               AL832152.1         2-447
            447-1224            BC105103.1         435-1212
            1225-2754           AL832152.1         1226-2755
FEATURES             Location/Qualifiers
     source          1..2754
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q23.1"
     gene            1..2754
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /note="actin binding Rho activating protein"
                     /db_xref="GeneID:137735"
                     /db_xref="HGNC:HGNC:30655"
                     /db_xref="MIM:609747"
     exon            1..722
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..1200
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /note="striated muscle activator of Rho-dependent
                     signaling"
                     /codon_start=1
                     /product="actin-binding Rho-activating protein"
                     /protein_id="NP_631905.1"
                     /db_xref="CCDS:CCDS6305.1"
                     /db_xref="GeneID:137735"
                     /db_xref="HGNC:HGNC:30655"
                     /db_xref="MIM:609747"
                     /translation="MAPGEKESGEGPAKSALRKIRTATLVISLARGWQQWANENSIRQ
                     AQEPTGWLPGGTQDSPQAPKPITPPTSHQKAQSAPKSPPRLPEGHGDGQSSEKAPEVS
                     HIKKKEVSKTVVSKTYERGGDVSHLSHRYERDAGVLEPGQPENDIDRILHSHGSPTRR
                     RKCANLVSELTKGWRVMEQEEPTWRSDSVDTEDSGYGGEAEERPEQDGVQVAVVRIKR
                     PLPSQVNRFTEKLNCKAQQKYSPVGNLKGRWQQWADEHIQSQKLNPFSEEFDYELAMS
                     TRLHKGDEGYGRPKEGTKTAERAKRAEEHIYREMMDMCFIICTMARHRRDGKIQVTFG
                     DLFDRYVRISDKVVGILMRARKHGLVDFEGEMLWQGRDDHVVITLLK"
     exon            723..2754
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1303..1308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /note="hexamer: ATTAAA"
     polyA_site      1323
                     /gene="ABRA"
                     /gene_synonym="STARS"
     regulatory      2734..2739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /note="hexamer: AATAAA"
     polyA_site      2754
                     /gene="ABRA"
                     /gene_synonym="STARS"
                     /note="major polyA site"
ORIGIN      
        1 acactcattt tagccagtgt ccaggctatc agcagagaaa gacaggtggg cagcatggct
       61 ccgggcgaaa aggaaagcgg ggagggccca gccaagagcg ccctccggaa gatacgcaca
      121 gccaccctgg tcatcagctt ggcccgaggt tggcagcagt gggcgaatga gaacagcatc
      181 aggcaggccc aggagcctac aggctggctg ccgggaggga cccaggactc acctcaagct
      241 cctaaaccaa tcacaccccc tacttcacac cagaaagctc agagtgcccc aaagtcgcca
      301 ccccgcctgc cagaaggaca tggagatgga caaagctcag agaaagcccc tgaggtttct
      361 cacatcaaaa agaaagaggt gtccaaaacg gtggtcagca agacttatga gagaggaggg
      421 gacgtgagcc acctcagcca caggtacgag agggatgctg gtgtgcttga acctgggcag
      481 ccagagaatg acattgacag aatcctccac agccacggct ccccaacgcg gaggagaaaa
      541 tgtgccaacc tggtgtctga gctaaccaag ggctggagag tgatggagca ggaggagccc
      601 acatggagga gtgacagcgt agacacagag gacagcggct atggaggaga ggctgaggag
      661 aggcccgagc aggatggagt gcaggtggct gtggtcagga tcaagcgccc cttgccctcc
      721 caggtaaaca gatttacaga gaaactcaac tgcaaagccc aacagaaata tagcccagtg
      781 ggcaacttga aagggagatg gcagcagtgg gctgatgaac acatacaatc ccagaagctc
      841 aatcctttca gtgaagagtt tgattacgag ctggccatgt ccacccgcct acacaaagga
      901 gatgagggct atggccgccc caaagaagga accaaaactg ctgaaagggc caagcgtgct
      961 gaggagcaca tctacaggga aatgatggac atgtgcttca ttatctgcac aatggctcgc
     1021 cacagacgag atggcaagat ccaggttact tttggagatc tctttgacag atacgttcgt
     1081 atttcagata aagtagtggg cattctcatg cgtgccagga aacatggact ggtagacttt
     1141 gaaggagaga tgctatggca aggccgagat gaccatgttg tgattacgct actcaagtga
     1201 accttcaaaa acaaaagcca aatttggccc actatggtct taatgctaaa tgctcatgta
     1261 ggtaaaatga aaatgcaaac tctctgtaat aagttagtaa atattaaaca atttttacat
     1321 aaacgacttt ctggcattct atttctatct agaatgagga attttggaga ttttgagaag
     1381 gcacaaagca tttcagaaag cacatagaat gttaatgtat aataatagta ttaatagttg
     1441 aaattccaca gggtgttttt gtttttgttt tgagacagat tctctttatg tcaccaaagc
     1501 tggtctttta actcctggcc tcaagtgatc ctctcacctc agcctcccaa gtagctggga
     1561 ttataggcat gagcaacagc acccagccac ttgtatattt taggcaaaat atttagctag
     1621 tcattgtaga aactactata gatttttaat taaacattac atctaagaag aatgctgact
     1681 tgagataaat atcagtagaa catataataa tgtgtcttta tttggaaaaa agaaaatacc
     1741 attaagtttg gtaaaactaa acttaaaatt ttttcagaag cttgactttg tattattgtt
     1801 tatatcatag catcacttac aaaacaagca catatataaa aagttgtcaa gatgttgctg
     1861 aaattgttga agttcctctg tgggcttgga ttctaacagg tttccagtaa gagttcacct
     1921 tcctcttgtt tgatttcagc aaatcacata aaaacagaca cttcctgtct tagtaccaac
     1981 aaaggaaggc acaccctcac taaaagtaga gcagaggtga gagattcaga tttacttgcc
     2041 tttgtaggac ttcttggaga agtttattgt ttcattacat gtcagcatat aacgagtcaa
     2101 gctgcttgca ttaacatcaa tgcaatgata tgtatttctc caacaatgga gaaatacaga
     2161 aaatctatga agtggaatgt tcagtattag aaaaatccca tagaatcatt ggtgaattaa
     2221 aaacagattt gagacagttt aatgttcctc atactgtaac aaagaaaact ttatgaaatg
     2281 tttaagtcat aaaactgcaa tattagttct gccaaagtaa aaaatataca atgatgatgg
     2341 caaggagaaa atcattggac attaatgtgc ctatgtgatc ttaaaaacaa atggaatgga
     2401 atgtgagatt gcaattctta ctggattcaa tgaaattact aaaatgcatt gatagtatag
     2461 cactttggtg ttaaatgtaa aaattaatgt ctaaatatga tacctcaaaa taataggtat
     2521 tagactgcta taagaattat atttgttttc atgtatgagt ctctttcaaa ctgaaggttc
     2581 tggtatctta agaaagtatg cgtattttgt ttccataccg tatttataaa gctataagtt
     2641 aatgaccaat atttctaagt aggatttcat gtaagatgca cacttctatt acaagtgaaa
     2701 cctacgccaa atgttaaaga caaatagcat aagaataaaa gatgttttct tgta
//
