LOCUS       NM_014945               4439 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens actin binding LIM protein family member 3 (ABLIM3),
            transcript variant 2, mRNA.
ACCESSION   NM_014945 XM_376434
VERSION     NM_014945.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4439)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4439)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4439)
  AUTHORS   Hasson,S.A., Kane,L.A., Yamano,K., Huang,C.H., Sliter,D.A.,
            Buehler,E., Wang,C., Heman-Ackah,S.M., Hessa,T., Guha,R.,
            Martin,S.E. and Youle,R.J.
  TITLE     High-content genome-wide RNAi screens identify regulators of parkin
            upstream of mitophagy
  JOURNAL   Nature 504 (7479), 291-295 (2013)
   PUBMED   24270810
REFERENCE   4  (bases 1 to 4439)
  AUTHORS   Cao,J., Shen,Y., Zhu,L., Xu,Y., Zhou,Y., Wu,Z., Li,Y., Yan,X. and
            Zhu,X.
  TITLE     miR-129-3p controls cilia assembly by regulating CP110 and actin
            dynamics
  JOURNAL   Nat Cell Biol 14 (7), 697-706 (2012)
   PUBMED   22684256
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4439)
  AUTHORS   Ruau,D., Dudley,J.T., Chen,R., Phillips,N.G., Swan,G.E.,
            Lazzeroni,L.C., Clark,J.D., Butte,A.J. and Angst,M.S.
  TITLE     Integrative approach to pain genetics identifies pain sensitivity
            loci across diseases
  JOURNAL   PLoS Comput Biol 8 (6), e1002538 (2012)
   PUBMED   22685391
REFERENCE   6  (bases 1 to 4439)
  AUTHORS   Matsuda,M., Yamashita,J.K., Tsukita,S. and Furuse,M.
  TITLE     abLIM3 is a novel component of adherens junctions with
            actin-binding activity
  JOURNAL   Eur J Cell Biol 89 (11), 807-816 (2010)
   PUBMED   20709423
REFERENCE   7  (bases 1 to 4439)
  AUTHORS   Barrientos,T., Frank,D., Kuwahara,K., Bezprozvannaya,S.,
            Pipes,G.C., Bassel-Duby,R., Richardson,J.A., Katus,H.A., Olson,E.N.
            and Frey,N.
  TITLE     Two novel members of the ABLIM protein family, ABLIM-2 and -3,
            associate with STARS and directly bind F-actin
  JOURNAL   J Biol Chem 282 (11), 8393-8403 (2007)
   PUBMED   17194709
REFERENCE   8  (bases 1 to 4439)
  AUTHORS   Krupp,M., Weinmann,A., Galle,P.R. and Teufel,A.
  TITLE     Actin binding LIM protein 3 (abLIM3)
  JOURNAL   Int J Mol Med 17 (1), 129-133 (2006)
   PUBMED   16328021
  REMARK    GeneRIF: Results characterize a third member of the actin binding
            LIM protein subgroup, actin binding LIM protein 3.
REFERENCE   9  (bases 1 to 4439)
  AUTHORS   Zheng,B., Wen,J.K., Han,M. and Zhou,A.R.
  TITLE     hhLIM protein is involved in cardiac hypertrophy
  JOURNAL   Biochim Biophys Acta 1690 (1), 1-10 (2004)
   PUBMED   15337165
REFERENCE   10 (bases 1 to 4439)
  AUTHORS   Yamada,S., Ohira,M., Horie,H., Ando,K., Takayasu,H., Suzuki,Y.,
            Sugano,S., Hirata,T., Goto,T., Matsunaga,T., Hiyama,E., Hayashi,Y.,
            Ando,H., Suita,S., Kaneko,M., Sasaki,F., Hashizume,K., Ohnuma,N.
            and Nakagawara,A.
  TITLE     Expression profiling and differential screening between
            hepatoblastomas and the corresponding normal livers: identification
            of high expression of the PLK1 oncogene as a poor-prognostic
            indicator of hepatoblastomas
  JOURNAL   Oncogene 23 (35), 5901-5911 (2004)
   PUBMED   15221005
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BP285049.1, BC001665.2,
            AK289736.1, AK225769.1 and AC012613.7.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 27, 2020 this sequence version replaced NM_014945.4.
            
            Summary: This gene encodes a member of the actin-binding LIM
            (abLIM) family of proteins. These proteins are characterized by an
            N-terminal LIM domain and a C-terminal dematin-like domain. The
            encoded protein interacts with actin filaments and may be a
            component of adherens junctions in several cell types. A variant of
            this gene may be associated with pain sensitivity in male human
            patients. [provided by RefSeq, Sep 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB020650.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2148874
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000309868.12/ ENSP00000310309.7
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-571               BP285049.1         11-581
            572-1137            BC001665.2         598-1163
            1138-2581           AK289736.1         915-2358
            2582-4336           AK225769.1         2814-4568
            4337-4439           AC012613.7         104602-104704       c
FEATURES             Location/Qualifiers
     source          1..4439
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..4439
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /note="actin binding LIM protein family member 3"
                     /db_xref="GeneID:22885"
                     /db_xref="HGNC:HGNC:29132"
                     /db_xref="MIM:611305"
     exon            1..162
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            163..262
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..2301
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /note="isoform 1 is encoded by transcript variant 2;
                     abLIM-3"
                     /codon_start=1
                     /product="actin-binding LIM protein 3 isoform 1"
                     /protein_id="NP_055760.1"
                     /db_xref="CCDS:CCDS4294.1"
                     /db_xref="GeneID:22885"
                     /db_xref="HGNC:HGNC:29132"
                     /db_xref="MIM:611305"
                     /translation="MNTSIPYQQNPYNPRGSSNVIQCYRCGDTCKGEVVRVHNNHFHI
                     RCFTCQVCGCGLAQSGFFFKNQEYICTQDYQQLYGTRCDSCRDFITGEVISALGRTYH
                     PKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSKPIKIRGPSHCAGCKEEIKH
                     GQSLLALDKQWHVSCFKCQTCSVILTGEYISKDGVPYCESDYHAQFGIKCETCDRYIS
                     GRVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWHPICKQAARAEKKLKHRRT
                     SETSISPPGSSIGSPNRVICAKVDNEILNYKDLAALPKVKSIYEVQRPDLISYEPHSR
                     YMSDEMLERCGYGESLGTLSPYSQDIYENLDLRQRRASSPGYIDSPTYSRQGMSPTFS
                     RSPHHYYRSGPESGRSSPYHSQLDVRSSTPTSYQAPKHFHIPAGDSNIYRKPPIYKRH
                     GDLSTATKSKTSEDISQTSKYSPIYSPDPYYASESEYWTYHGSPKVPRARRFSSGGEE
                     DDFDRSMHKLQSGIGRLILKEEMKARSSSYADPWTPPRSSTSSREALHTAGYEMSLNG
                     SPRSHYLADSDPLISKSASLPAYRRNGLHRTPSADLFHYDSMNAVNWGMREYKIYPYE
                     LLLVTTRGRNRLPKDVDRTRLERHLSQEEFYQVFGMTISEFDRLALWKRNELKKQARL
                     F"
     exon            263..400
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            401..584
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            585..697
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            698..824
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            825..918
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1006
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1065
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1137
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1138..1293
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1294..1323
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1453
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1454..1552
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1553..1600
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1735
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1736..1800
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1801..1948
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..1978
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            1979..2037
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2098
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            2099..2106
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2187
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     exon            2188..4439
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4309..4314
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /note="hexamer: CATAAA"
     polyA_site      4336
                     /gene="ABLIM3"
                     /gene_synonym="HMFN1661"
                     /note="major polyA site"
ORIGIN      
        1 gccccctgcg ctgccaaccc gcgagcccgc atcatggatg tcgagctccc ctatttcgca
       61 ttgctagccc tggaattcga gaccccagac gaggaccagg attcatgaaa tcagtcgcag
      121 gggccggggc aggggcctct ggctcccgac actggccgag aggtgatgag tgaggttcga
      181 agaacggaag atttaaaaag cagccggggc ctccgtattg aatgaaagac ccagtgcaaa
      241 gacatcacca tgaacactag cattccttat cagcagaatc cttacaatcc acggggcagc
      301 tccaatgtca tccagtgcta ccgctgtgga gacacctgca aaggggaagt ggtccgcgtg
      361 cacaacaacc acttccacat cagatgcttc acctgtcaag tatgtggctg tggcctggcc
      421 cagtcaggct tcttcttcaa gaaccaggag tacatctgca cccaggacta ccagcaactc
      481 tatggcaccc gctgtgacag ctgccgggac ttcatcacag gcgaagtcat ctcggccctg
      541 ggccgcactt accaccccaa gtgcttcgtg tgcagcttgt gcaggaagcc tttccccatt
      601 ggagacaagg tgaccttcag cggtaaagaa tgtgtgtgcc aaacgtgctc ccagtccatg
      661 gccagcagta agcccatcaa gattcgtgga ccaagccact gtgccgggtg caaggaggag
      721 atcaagcacg gccagtcact cctggctctg gacaagcagt ggcacgtcag ctgcttcaag
      781 tgccagacct gcagcgtcat cctcaccggg gagtatatca gcaaggatgg tgttccatac
      841 tgtgagtccg actaccatgc ccagtttggc attaaatgtg agacttgtga ccgatacatc
      901 agtggcagag tcttggaggc aggagggaag cactaccacc caacctgtgc caggtgtgta
      961 cgctgccacc agatgttcac cgaaggagag gaaatgtacc tcacaggttc cgaggtttgg
     1021 caccccatct gcaaacaggc agcccgggca gagaagaagt taaagcatag acggacatct
     1081 gaaacctcca tctcaccccc tggatccagc attgggtcac ccaaccgagt catctgcgct
     1141 aaagtggata atgagatcct taattacaaa gacctggcgg ctctccccaa ggttaagtct
     1201 atctacgagg tacaacgccc cgacctcatt tcctatgagc ctcattccag atacatgtcc
     1261 gacgagatgc tggagagatg tggctatgga gagtcgctgg gaacattatc tccctactcc
     1321 caggacatct acgagaacct ggacctccgg cagagacggg cctccagccc ggggtacata
     1381 gactccccca cctacagccg gcagggcatg tcccccacct tctcccgctc acctcaccac
     1441 tactaccgct ctgggcccga gagtggccgg agctctccat accatagcca gttagatgtg
     1501 aggtcctcca ctccaacctc ttaccaggct cccaagcact ttcacatccc agctggagac
     1561 agtaacatct accggaaacc cccgatctac aaacggcatg gtgatttgtc tacagcaacc
     1621 aagagcaaaa caagtgaaga catcagccag acctccaagt acagtcccat ctactcgcca
     1681 gacccctact atgcttcgga gtctgagtac tggacctacc atgggtcccc caaagtgccc
     1741 cgagccagaa ggttctcgtc tggaggagag gaggatgatt ttgaccgcag catgcacaag
     1801 ctccaaagtg gaattggccg gctgattctg aaggaagaaa tgaaggcccg gtcgagctcc
     1861 tatgcagatc cctggacccc tccccggagc tccaccagca gccgggaagc cctgcacaca
     1921 gctggctatg agatgtccct caatggctcc cctcggtcgc actacctggc tgacagtgat
     1981 cctctcatct ccaaatctgc ctccctgcct gcctaccgaa gaaatgggct gcacaggaca
     2041 cccagcgcag acctcttcca ctacgacagc atgaacgcag tcaactgggg catgcgagag
     2101 tacaagatct acccttatga actgctgctg gtgactacaa gaggaagaaa ccgactgccc
     2161 aaggatgtag acaggacccg tttagagcgc cacctgtccc aggaagagtt ctaccaagtc
     2221 tttggcatga ccatctctga gtttgaccgg ctggccctct ggaagaggaa tgaactgaag
     2281 aagcaagccc ggctgttcta ggcagaggct ctataaatat atatgcattt atataaagat
     2341 atatgtaaaa tctctctact gaagctcggt ataatcctct cttgtgtaat gggacacact
     2401 gcctgccatg agacttgctt ttctgtactg tcaggcaagc ccacgtcatc gagatatttt
     2461 tatgctcctt actttctctt ttctaagtgc tgtgggatct gggaagggat ttgaggggac
     2521 tctgtccttt tattggggat cctttttata ctgaaacatc tgtcctaact tgagtgcccc
     2581 aaggtccaac tctctttcct aaagaaggtg cctgaagaag tctctcttct ctctgcttcg
     2641 tggccccttt cttaaatttc tagggctgat gctgaccatg tggtttccac accttattgg
     2701 ccccagaggg gccctcccat gggaagatct gcagcagtct ccccaaatca gtgagcacct
     2761 ttgagcgccc acgaagaact ttctcaacac ccccaattag gagctcagtg ctctcttggg
     2821 gcaatgcagt taaaagggtg agcctcaaat ctagtcatta caccagtcaa cagaagtgga
     2881 cagggcctag gcctctcctc agctccttaa ccctcctcct tctgccctgg attgtaacct
     2941 ctcccttgtc caaatctagg attcctggta ggaaaaggaa aaggcccttc ccttccctcc
     3001 accacttcca actggcccct ttgcctgacc tggacttgga gaaccagagg aaaagagagg
     3061 gagcggaagt gggagatgga gcagggcacc tgttagaatc agagctgcag gatttcttgg
     3121 gaccctcctc tctccctcac tgctcccagc acctcctgac ccttccctct ttcaaggaga
     3181 agcccatgat tgcagcttgt attctttagc cttattacaa tctatgtgcc tgacaactca
     3241 acacaccgca gggctaatgt tcccaccaga gctccaactg aacaaccaga cagacaactc
     3301 tcatcatcct ccagagagaa aataggccgt gtctcaaaga aaggttcttg gtctatgcct
     3361 ctggtctgtg ggctggcagg gcaaccatac catacccccg ccagtcctcg gctcctgctg
     3421 caaagttggc catgtttcac agggaaactt ttggaagagt ggctgcttat gagattccaa
     3481 aatgaagtgt tggccaacac cgctcatggc catcctggat tttcccagtg gcttcccttc
     3541 ctgctcgcct ccctgaacag gggagaaagc ttaacctctc ttctcctctc caaacctttc
     3601 accttgaatg ggtaatgttt ggtgggggct gttccttctt ggagaagcct tgagtcggac
     3661 cattttgaga tcatggagga aggatgaaga agtgaaaatg acaataatga ctctcaagag
     3721 gctggcgatg tgacatggca aatgtagaac tgacttaaat tgaacaaacc ctcactgagc
     3781 acctctgatg ttgagcacct gctgaatact gagcactgaa tgggggaggg ggaggggagc
     3841 acggggtgag tcaacctggg actcggtctc agggatatgc ctaccaatag cgggtatcgt
     3901 aaggcatgta cccaaacata acggatgtaa ggcagaaagt gatcggagaa ggaatgagaa
     3961 agtgtgcgtg atgttaatga aaagtcatat gcagctagag cagacccagg aaagctttct
     4021 ggaagagatt gcatctgagg aaattcagga aggatctttg tagattgggg ggagattcta
     4081 aattgaaggg gtgatggggt gaggggccag agggaagtct gctgtgttct catgtaggat
     4141 gtcagccctc cctgcaactt ctctttttgg ccaatgtctt ttcactttcc tgacccttta
     4201 gaatcatccc cagccagacg caatcatgga agttgcctta ttgtcactgg ttaagaactt
     4261 ggcgagattg aagggctttt gttattgttg ttggatattt ttgtttccca taaaagcaca
     4321 tcatttcaac cctaaacctg tgtgcttctg ttgtttcttg tgtgggagtg gaaatgactg
     4381 acatgggaag aggctgaacc ctgcacattt ttcaaaatga aagcaccaaa acagcagcc
//
