LOCUS       NM_001130083            3725 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens actin binding LIM protein family member 2 (ABLIM2),
            transcript variant 1, mRNA.
ACCESSION   NM_001130083
VERSION     NM_001130083.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3725)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 3725)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 3725)
  AUTHORS   Barrientos,T., Frank,D., Kuwahara,K., Bezprozvannaya,S.,
            Pipes,G.C., Bassel-Duby,R., Richardson,J.A., Katus,H.A., Olson,E.N.
            and Frey,N.
  TITLE     Two novel members of the ABLIM protein family, ABLIM-2 and -3,
            associate with STARS and directly bind F-actin
  JOURNAL   J Biol Chem 282 (11), 8393-8403 (2007)
   PUBMED   17194709
REFERENCE   4  (bases 1 to 3725)
  AUTHORS   Klimov,E., Rud'ko,O., Rakhmanaliev,E. and Sulimova,G.
  TITLE     Genomic organisation and tissue specific expression of ABLIM2 gene
            in human, mouse and rat
  JOURNAL   Biochim Biophys Acta 1730 (1), 1-9 (2005)
   PUBMED   16005990
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067214.1, AJ748601.1, BE155865.1, AK094798.1, AK097003.1 and
            BQ267829.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001130083.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: HM005542.1, DQ413176.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000447017.7/ ENSP00000393511.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                BC067214.1         32-90
            60-1204             AJ748601.1         1-1145
            1205-1511           BE155865.1         295-601
            1512-2206           AK094798.1         763-1457
            2207-3723           AK097003.1         428-1944
            3724-3725           BQ267829.1         31-32               c
FEATURES             Location/Qualifiers
     source          1..3725
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p16.1"
     gene            1..3725
                     /gene="ABLIM2"
                     /note="actin binding LIM protein family member 2"
                     /db_xref="GeneID:84448"
                     /db_xref="HGNC:HGNC:19195"
                     /db_xref="MIM:612544"
     exon            1..134
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..2062
                     /gene="ABLIM2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     actin-binding LIM protein 2; abLIM-2; testis tissue
                     sperm-binding protein Li 35a"
                     /codon_start=1
                     /product="actin-binding LIM protein 2 isoform 1"
                     /protein_id="NP_001123555.1"
                     /db_xref="CCDS:CCDS47014.1"
                     /db_xref="GeneID:84448"
                     /db_xref="HGNC:HGNC:19195"
                     /db_xref="MIM:612544"
                     /translation="MSAVSQPQAAPSPLEKSPSTAILCNTCGNVCKGEVLRVQDKYFH
                     IKCFVCKACGCDLAEGGFFVRQGEYICTLDYQRLYGTRCFSCDQFIEGEVVSALGKTY
                     HPDCFVCAVCRLPFPPGDRVTFNGKECMCQKCSLPVSVGSSAHLSQGLRSCGGCGTEI
                     KNGQALVALDKHWHLGCFKCKSCGKLLNAEYISKDGLPYCEADYHAKFGIRCDSCEKY
                     ITGRVLEAGEKHYHPSCALCVRCGQMFAEGEEMYLQGSSIWHPACRQAARTEDRNKET
                     RTSSESIISVPASSTSGSPSRVIYAKLGGEILDYRDLAALPKSKAIYDIDRPDMISYS
                     PYISHSAGDRQSYGEGDQDDRSYKQCRTSSPSSTGSVSLGRYTPTSRSPQHYSRPAGT
                     VSVGTSSCLSLSQHPSPTSVFRHHYIPYFRGSESGRSTPSLSVLSDSKPPPSTYQQAP
                     RHFHVPDTGVKDNIYRKPPIYRQHAARRSDGEDGSLDQDNRKQKSSWLMLKGDADTRT
                     NSPDLDTQSLSHSSGTDRDPLQRMAGDSFHSRFPYSKSDPLPGHGKNGLDQRNANLAP
                     CGADPDASWGMREYKIYPYDSLIVTNRIRVKLPKDVDRTRLERHLSPEEFQEVFGMSI
                     EEFDRLALWKRNDLKKKALLF"
     exon            135..278
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            279..462
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            463..578
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            579..705
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            706..799
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            800..887
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            888..946
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1024
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1171
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1292
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1391
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1493
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1494..1547
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1600
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1601..1742
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1743..1804
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1805..1859
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1860..1867
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1948
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1949..3725
                     /gene="ABLIM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3704..3709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABLIM2"
                     /note="hexamer: AATAAA"
     polyA_site      3725
                     /gene="ABLIM2"
                     /note="major polyA site"
ORIGIN      
        1 gtgtgcgcaa ggagcgggcg cggagccggc gggcgggcgg aggatagcgc gggcgcggca
       61 cctgcgggcc cgagggtctg gctgtcgcag cgccgggccg ccccgactcc gagcggctgc
      121 tgagatgagt gcagtgtcgc agccccaggc tgctcccagc ccgctggaga agtcgcccag
      181 cacggcgatc ctgtgcaaca cgtgtgggaa tgtgtgcaag ggcgaggtgc tgcgggtgca
      241 ggacaagtac ttccacatca agtgcttcgt ctgtaaagca tgtggctgcg acctggccga
      301 gggcggcttc ttcgtgcggc agggcgagta catctgcacg ctggactacc agaggctcta
      361 cggcacccgc tgcttcagct gcgaccagtt cattgagggt gaggtggtgt cggcgctggg
      421 caagacctac caccccgact gcttcgtgtg tgccgtctgc cggctgccct tcccccccgg
      481 ggaccgagtg accttcaacg ggaaggaatg catgtgccag aagtgttccc tgcccgtatc
      541 ggtgggcagc agcgcgcacc tgtcccaggg cctccgaagt tgtgggggct gcggcacaga
      601 aatcaagaat ggccaggccc tggtagcctt ggacaagcac tggcacttgg gctgttttaa
      661 gtgcaagagc tgtgggaagc tcctgaatgc cgagtacatc agcaaggatg ggctgcccta
      721 ctgcgaagct gactatcacg ccaagttcgg catccgctgt gacagctgtg agaaatacat
      781 cacggggcgc gtgctggagg ccggagagaa gcactaccac ccttcctgcg cgctatgtgt
      841 caggtgcggc cagatgtttg cagaaggcga agagatgtat cttcaaggtt cctccatctg
      901 gcatccggcg tgtcgacaag cagccagaac tgaagacaga aacaaggaaa ccagaacttc
      961 ctcagagagc atcatttctg tccctgcttc cagcacctca gggtctccga gccgtgtgat
     1021 ttatgccaag cttggtggtg agatcctgga ctacagggac ttggcagccc ttcctaaaag
     1081 taaggccatc tatgacatcg accgccccga catgatctcc tactcaccct acatcagcca
     1141 ctctgcaggg gacaggcaga gctacggcga gggggatcag gatgaccggt cctacaagca
     1201 gtgtcggacc tccagcccaa gctccactgg gtcggttagc ctcgggcgct acactccgac
     1261 ctcacggtca ccacagcact acagccgtcc agctggtact gtgagtgtgg gtaccagtag
     1321 ctgcctctcc ctgtcccaac acccaagccc tacatccgtg ttcagacatc attacatccc
     1381 ctacttccga ggcagtgaaa gtggccggag cacccccagc ctctccgtgc tctctgacag
     1441 caagccgccc ccctccacct accagcaggc acctcgccac ttccacgtcc cagacactgg
     1501 cgtaaaagat aacatctata ggaaaccccc tatctacaga cagcatgctg ccaggcgatc
     1561 ggatggggag gatggaagct tggaccagga taacaggaag cagaagagca gctggctgat
     1621 gctcaagggg gatgcagaca caaggaccaa ttctccagac ctggacaccc agtccttgtc
     1681 ccacagcagc gggaccgaca gagaccctct ccaaaggatg gcaggggaca gctttcactc
     1741 acgattcccc tattccaaat ctgaccctct cccaggacat ggaaagaatg gcttggacca
     1801 gcggaatgcc aatctggccc cctgtggagc agacccggat gccagctggg gcatgcgaga
     1861 atacaagatc tatccgtatg actccctcat cgtcacaaac cgaattcgcg tgaaactgcc
     1921 caaagacgtg gaccggacga gactggagag acacttgtcg cccgaggagt tccaggaagt
     1981 gtttgggatg agcatcgagg agtttgaccg cctggccctc tggaagagga atgaccttaa
     2041 gaagaaagcc cttttgttct gacggctgcc agcctgcccc actggtgtgt gccgggcgcc
     2101 gaggccaggg gcccctggcg agaaccgcac acacccctcc cacacacctt gctctggctt
     2161 ctctgtgtcc atggggtggg cgggaggggg tcccccagca ggtgcggccc ctgcacctgc
     2221 cggcgacact cctgccggta gtttagggcc gagacggcta gcttcacgcc acccttcccc
     2281 gctgtggctt ggtgtcaggg agaggctgta gagtggctgt gtcgggcatc agatggagca
     2341 cacaggtggc tgcagcccag cccaccttcc cagcgttctc gaggtgccct ggccccggtg
     2401 ctgggcacgt gggggacaga ggtggccggg acgtgagctg tgaggcttgt tgatgatggt
     2461 tgctgacacc atcatcgggg gtgggcacac ggcccttcgg agcctgggca gcctggcctc
     2521 acaggcagac tcgcagacgg ggcagtgagc gtctgggaca gtgccaagag tggggtgtgt
     2581 gatttttgca ggcgtctgtg atgggtctct ttagggacaa atgtcaacaa gggacaagac
     2641 agggcacctt ccgccagcgc ccctccatgc gctgcgttcc tcctccagat cgacccctag
     2701 atgcctacac aatatcttta aagtaacaca gaagttttta ttttattaaa aagtatagcc
     2761 tacttaaacg cgagatgaca tatatagagt ttaattttac ggtccctccg caggggagcg
     2821 gcctccagcc ttattctcca ccgctcggat ctgtgtggtt tcagtctgtt cttggtgtgg
     2881 tcctcataca cagagctccc tgtctagttt cttttctttt tcttttttct ttttctcgtc
     2941 acacaggtaa ccttaaagac agacccctct aaagaacgct ttgtaaatac atgtgaggta
     3001 tagccaccac tgttttcctt gctgttattt ttccaagtct tggggagaaa acatcctcct
     3061 ctgatggcca aagccctgga atcaagggtt tccacgtacc ctgcctaata cccgacgtag
     3121 ctcttgatgc accgtccttg tgctgtggct ggcggtgtct cagcctgaaa cataaacccc
     3181 acatgcccca ggagcgatgt gctccctgaa acagacaacc acacgctgtt ggggagagaa
     3241 ggatggagat aggatggaga taggatggag atgtggctct tctcatcttt gaagccagca
     3301 gggcatcccg gagcaggagg ctggccgggc tccccaagcg aaggcgttgg tgtctgtcat
     3361 taggtgtgtg ttagggtgca gcaccggccg tcacaggatg ctgataagcg cgctgagagg
     3421 tggatgaaac accaaagtct gtttccccgt ccgcagtggg tgttgcctct ttgtgtgtgt
     3481 cccgatgttc ctgcctgtga gtcggcctta ctccgtttcc ttagcgccca tgacacgcca
     3541 agtcccgttt cgcactcggc ttctcacccg cccagctcgg ctagggaggg ggagttttta
     3601 gcacctaata tgcttcctgc cattgcgcaa tctgagcctg agcaactgga aacccccatt
     3661 tctcattagt gcaatgtcat atctgatccc aggaagcctg gaaaataaaa gacgatgcat
     3721 tataa
//
