LOCUS       NM_002313               7560 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens actin binding LIM protein 1 (ABLIM1), transcript
            variant 1, mRNA.
ACCESSION   NM_002313 NM_006719
VERSION     NM_002313.7
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 7560)
  AUTHORS   Sibira,R., Vu,A., Giubellino,A. and Murugan,P.
  TITLE     Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case report
            with review of the literature
  JOURNAL   Diagn Pathol 19 (1), 133 (2024)
   PUBMED   39363234
  REMARK    GeneRIF: Spitz melanoma with MAP3K8::ABLIM1 rearrangement: a case
            report with review of the literature.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 7560)
  AUTHORS   He,Y., Shi,Q., Ling,Y., Guo,H., Fei,Y., Wu,R., Tang,C., Zhang,X.
            and Yao,L.
  TITLE     ABLIM1, a novel ubiquitin E3 ligase, promotes growth and metastasis
            of colorectal cancer through targeting IkBalpha ubiquitination and
            activating NF-kB signaling
  JOURNAL   Cell Death Differ 31 (2), 203-216 (2024)
   PUBMED   38228802
  REMARK    GeneRIF: ABLIM1, a novel ubiquitin E3 ligase, promotes growth and
            metastasis of colorectal cancer through targeting IkBalpha
            ubiquitination and activating NF-kB signaling.
REFERENCE   3  (bases 1 to 7560)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   4  (bases 1 to 7560)
  AUTHORS   Liu,D., Wang,X., Liu,Y., Li,C., Zhang,Z. and Lv,P.
  TITLE     Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and
            Serves as a Novel Prognostic Biomarker
  JOURNAL   Dis Markers 2022, 9516808 (2022)
   PUBMED   36583064
  REMARK    GeneRIF: Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma
            Progression and Serves as a Novel Prognostic Biomarker.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 7560)
  AUTHORS   Cho,N.H., Cheveralls,K.C., Brunner,A.D., Kim,K., Michaelis,A.C.,
            Raghavan,P., Kobayashi,H., Savy,L., Li,J.Y., Canaj,H., Kim,J.Y.S.,
            Stewart,E.M., Gnann,C., McCarthy,F., Cabrera,J.P., Brunetti,R.M.,
            Chhun,B.B., Dingle,G., Hein,M.Y., Huang,B., Mehta,S.B.,
            Weissman,J.S., Gomez-Sjoberg,R., Itzhak,D.N., Royer,L.A., Mann,M.
            and Leonetti,M.D.
  TITLE     OpenCell: Endogenous tagging for the cartography of human cellular
            organization
  JOURNAL   Science 375 (6585), eabi6983 (2022)
   PUBMED   35271311
REFERENCE   6  (bases 1 to 7560)
  AUTHORS   Wang,K.S., Liu,X., Aragam,N., Mullersman,J.E., Jian,X., Pan,Y. and
            Liu,Y.
  TITLE     Polymorphisms in ABLIM1 are associated with personality traits and
            alcohol dependence
  JOURNAL   J Mol Neurosci 46 (2), 265-271 (2012)
   PUBMED   21547531
  REMARK    GeneRIF: SNP rs727532 in ABLIM1 (10q25) had significant association
            in the multivariate test & strong associations with novelty
            seeking, harm avoidance, reward dependence and alcohol dependence
            in the COGA sample.
REFERENCE   7  (bases 1 to 7560)
  AUTHORS   Barrientos,T., Frank,D., Kuwahara,K., Bezprozvannaya,S.,
            Pipes,G.C., Bassel-Duby,R., Richardson,J.A., Katus,H.A., Olson,E.N.
            and Frey,N.
  TITLE     Two novel members of the ABLIM protein family, ABLIM-2 and -3,
            associate with STARS and directly bind F-actin
  JOURNAL   J Biol Chem 282 (11), 8393-8403 (2007)
   PUBMED   17194709
REFERENCE   8  (bases 1 to 7560)
  AUTHORS   Benzinger,A., Muster,N., Koch,H.B., Yates,J.R. 3rd and Hermeking,H.
  TITLE     Targeted proteomic analysis of 14-3-3 sigma, a p53 effector
            commonly silenced in cancer
  JOURNAL   Mol Cell Proteomics 4 (6), 785-795 (2005)
   PUBMED   15778465
REFERENCE   9  (bases 1 to 7560)
  AUTHORS   Kim,A.C., Peters,L.L., Knoll,J.H., Van Huffel,C., Ciciotte,S.L.,
            Kleyn,P.W. and Chishti,A.H.
  TITLE     Limatin (LIMAB1), an actin-binding LIM protein, maps to mouse
            chromosome 19 and human chromosome 10q25, a region frequently
            deleted in human cancers
  JOURNAL   Genomics 46 (2), 291-293 (1997)
   PUBMED   9417918
REFERENCE   10 (bases 1 to 7560)
  AUTHORS   Roof,D.J., Hayes,A., Adamian,M., Chishti,A.H. and Li,T.
  TITLE     Molecular characterization of abLIM, a novel actin-binding and
            double zinc finger protein
  JOURNAL   J Cell Biol 138 (3), 575-588 (1997)
   PUBMED   9245787
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF005654.2, AL354873.19 and
            AL133384.12.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_002313.6.
            
            Summary: This gene encodes a LIM zinc-binding domain-containing
            protein that binds to actin filaments and mediates interactions
            between actin and cytoplasmic targets. Alternatively spliced
            transcript variants encoding different isoforms have been
            identified. [provided by RefSeq, Jun 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF005654.2 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000533213.7/ ENSP00000433629.3
            RefSeq Select criteria :: based on manual assertion, conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-779               AF005654.2         24-802
            780-780             AL354873.19        7508-7508           c
            781-1570            AF005654.2         804-1593
            1571-1571           AL133384.12        55932-55932         c
            1572-1668           AF005654.2         1595-1691
            1669-1669           AL133384.12        54127-54127         c
            1670-1670           AL133384.12        50523-50523         c
            1671-2424           AF005654.2         1694-2447
            2425-7560           AL133384.12        33615-38750         c
FEATURES             Location/Qualifiers
     source          1..7560
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q25.3"
     gene            1..7560
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /note="actin binding LIM protein 1"
                     /db_xref="GeneID:3983"
                     /db_xref="HGNC:HGNC:78"
                     /db_xref="MIM:602330"
     exon            1..319
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..2412
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /note="isoform a is encoded by transcript variant 1;
                     actin-binding double-zinc-finger protein; actin-binding
                     LIM protein family member 1"
                     /codon_start=1
                     /product="actin-binding LIM protein 1 isoform a"
                     /protein_id="NP_002304.3"
                     /db_xref="CCDS:CCDS7590.1"
                     /db_xref="GeneID:3983"
                     /db_xref="HGNC:HGNC:78"
                     /db_xref="MIM:602330"
                     /translation="MPAFLGLKCLGKLCSSEKSKVTSSERTSARGSNRKRLIVEDRRV
                     SGTSFTAHRRATITHLLYLCPKDYCPRGRVCNSVDPFVAHPQDPHHPSEKPVIHCHKC
                     GEPCKGEVLRVQTKHFHIKCFTCKVCGCDLAQGGFFIKNGEYLCTLDYQRMYGTRCHG
                     CGEFVEGEVVTALGKTYHPNCFACTICKRPFPPGDRVTFNGRDCLCQLCAQPMSSSPK
                     ETTFSSNCAGCGRDIKNGQALLALDKQWHLGCFKCKSCGKVLTGEYISKDGAPYCEKD
                     YQGLFGVKCEACHQFITGKVLEAGDKHYHPSCARCSRCNQMFTEGEEMYLQGSTVWHP
                     DCKQSTKTEEKLRPTRTSSESIYSRPGSSIPGSPGHTIYAKVDNEILDYKDLAAIPKV
                     KAIYDIERPDLITYEPFYTSGYDDKQERQSLGESPRTLSPTPSAEGYQDVRDRMIHRS
                     TSQGSINSPVYSRHSYTPTTSRSPQHFHRPGNEPSSGRNSPLPYRPDSRPLTPTYAQA
                     PKHFHVPDQGINIYRKPPIYKQHAALAAQSKSSEDIIKFSKFPAAQAPDPSETPKIET
                     DHWPGPPSFAVVGPDMKRRSSGREEDDEELLRRRQLQEEQLMKLNSGLGQLILKEEME
                     KESRERSSLLASRYDSPINSASHIPSSKTASLPGYGRNGLHRPVSTDFAQYNSYGDVS
                     GGVRDYQTLPDGHMPAMRMDRGVSMPNMLEPKIFPYEMLMVTNRGRNKILREVDRTRL
                     ERHLAPEVFREIFGMSIQEFDRLPLWRRNDMKKKAKLF"
     exon            320..454
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            455..638
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            639..748
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            749..875
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            876..969
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1057
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1116
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1117..1194
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1350
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1386
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1387..1516
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1621
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1622..1669
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1810
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1811..1902
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1903..2008
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2073
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2074..2134
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2142
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2143..2217
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2218..2298
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     exon            2299..7560
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7536..7541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /note="hexamer: AATAAA"
     polyA_site      7560
                     /gene="ABLIM1"
                     /gene_synonym="ABLIM; abLIM-1; LIMAB1; LIMATIN"
                     /note="major polyA site"
ORIGIN      
        1 agagagaatt gtggggcagc accgctcctt gggtccccac tccccatttc tcattgcttg
       61 gaaatccatg ccaagatgcc tgccttcctt ggtctaaagt gtctggggaa attgtgcagc
      121 tctgagaaaa gcaaagtcac ctcatctgag agaaccagtg ccaggggctc gaacagaaag
      181 agactgattg ttgaggaccg gagggtctct gggacctcct tcaccgctca taggcgtgcc
      241 actatcactc atttgctgta tctctgtccc aaggactact gcccacgtgg gcgtgtatgt
      301 aacagcgttg atccttttgt ggcccaccct caggaccctc accacccatc agagaagcct
      361 gtcattcact gccataaatg tggggagcct tgcaagggtg aagtgcttcg ggtccagacc
      421 aaacatttcc acatcaagtg tttcacctgc aaagtgtgtg gctgtgacct ggcacaaggg
      481 ggcttcttca taaagaacgg agagtatctc tgcaccctgg actaccagcg gatgtacggg
      541 acacgctgcc atggctgtgg ggagttcgtg gagggcgaag tggtgactgc tctgggcaag
      601 acctaccatc ccaattgctt tgcttgtact atctgcaagc gcccgtttcc acccggagac
      661 cgagtcacat tcaatgggag agactgcctt tgtcaactct gtgcacagcc gatgtcgtcc
      721 agtccgaaag aaaccacctt ctccagcaat tgtgccggct gcggaagaga tatcaagaat
      781 gggcaggcgc tgctggcgct ggataagcag tggcacttgg ggtgctttaa atgcaagtcc
      841 tgcgggaagg tcctcaccgg ggagtacatc agcaaggatg gtgctccgta ctgtgaaaag
      901 gactaccagg gactctttgg ggtgaaatgt gaggcgtgtc accagtttat cacagggaaa
      961 gtcctggagg caggtgacaa acattaccac cccagctgtg cacgatgcag cagatgcaac
     1021 cagatgttca cagaaggaga ggaaatgtat cttcaaggct ccaccgtttg gcatcccgac
     1081 tgtaagcaat ctacgaagac cgaggaaaag ctgcggccta ccaggacatc ctcggaaagt
     1141 atttattcta ggccaggctc cagtattcct ggctcaccag gtcatactat ctatgcaaaa
     1201 gtagacaatg agatcctgga ttacaaggat ttagcagcca ttccgaaggt caaggcaatt
     1261 tatgacattg aacgtccaga tcttattacc tatgagcctt tctacacttc gggctatgat
     1321 gacaaacagg agagacagag ccttggagag tctccgagga ctttgtctcc tactccatca
     1381 gcagaagggt accaggatgt tcgggatcgg atgatccatc ggtccacgag ccagggctcc
     1441 atcaactccc ctgtgtacag ccgccacagc tacactccaa ccacgtcccg ctctccccag
     1501 catttccaca gacctggcaa tgagccgtcc agcggccgga actcccctct cccttaccgg
     1561 ccagacagcc gccctctaac tccaacttac gctcaggccc ctaaacattt ccatgttcca
     1621 gatcaaggaa tcaacattta ccgaaagcca cccatctaca aacagcatgc tgccttggca
     1681 gcccagagca agtcctcaga agatatcatc aagttttcca agttcccagc agcccaggca
     1741 ccagacccca gcgagacacc aaagattgag acggaccact ggcctggtcc cccctcattt
     1801 gctgtcgtag gacctgacat gaaacgcaga tctagtggca gagaggaaga tgatgaggaa
     1861 cttctgagac gtcggcagct tcaagaagag caattaatga agcttaactc aggcctggga
     1921 cagttgatct tgaaagaaga gatggagaaa gagagccggg aaaggtcatc tctgttagcc
     1981 agtcgctacg attctcccat caactcagct tcacatattc catcatctaa aactgcatct
     2041 ctccctggct atggaagaaa tgggcttcac cggcctgttt ctaccgactt cgctcagtat
     2101 aacagctatg gggatgtcag cgggggagtg cgagattacc agacactccc agatggccac
     2161 atgcctgcaa tgagaatgga ccgaggagtg tctatgccca acatgttgga accaaagata
     2221 tttccatatg aaatgctcat ggtgaccaac agagggcgaa acaaaatcct cagagaggtg
     2281 gacagaacca ggctggagcg ccacttagcc cctgaagtgt ttcgggaaat ctttggaatg
     2341 tccatacagg agtttgacag gttacctctt tggagacgca acgacatgaa gaaaaaagca
     2401 aaactcttct aagtcccact cgtgaatggc aattagagaa aggactgaca gtggcggtgc
     2461 cccataggat gtcatattga ggcccaaact tgattggaga atttgcaaac taccgtcgct
     2521 cagcaacacc aaaaagagaa agtctggtta aaacaccatg agtcaaatgt cgggccagcc
     2581 aacagtaaca cttgccaaga agcatggcgt agaaatttct atgttccgaa acacagagta
     2641 gtgtccacat gtgagctttt cacattacct tatgtataca acaggagctg cgttgttttc
     2701 ttctttttct tttcctttat ctgttgtcca acaacagtgc tgactgtccg gataagagct
     2761 ggcaagtgcc cttaggatgc cgcatgggaa aaatcggtta tcataatttc aaagtataaa
     2821 tatatttatt aagtagcgct gcggctaaga aggaagagtg aggggtctgt ccatggggtg
     2881 gcagtgattt cacacccgcc tttcttgaat ggcttcgtgt tactcagccg tgccctggca
     2941 ggaatggaac tccatcaggg aacagggcag ctctgtttga atggggtgaa aaacagcaaa
     3001 attaattctt agcaagctcc ttgttctcta ctgttcaccg ggacctggct ggcaaatgac
     3061 ttagctatta gtatatttaa aaactgttca aaagcaaaag agaaggaaca ggaatgaaag
     3121 gaaaccttcc cttaactctt tctgcttccc atagcaggtc tggttcctgc tccccgccta
     3181 ggacaggagc tgtctggagc tccacctttg caaagaaagg aaaaacacaa attgccccca
     3241 gattggccca gtggcatgcc attaggtgat tttgcatagg ggccatatca ttcatggcca
     3301 aaaaaaacca aaaagcaaaa aacaaaaaca agtcccatgt cctactgact ctagttcttc
     3361 cagtcgttat cctctgctgt ctctctggca tcctatgaat cagatcaagc ccatgctgtt
     3421 gttggttttt aaggtttctt tcaataatag gctaaggaaa gacatgtttt tctcttttaa
     3481 atctctgcaa ctccaaagta gactccttcg aacgtattta atttggcctt ttcagctttc
     3541 ttcttgccca gctctgtcga attcatgggt gtgtgtgcac atgttggttt cactcaccca
     3601 gagtaatttt gtgagcatgc atgtgctttt taatttctgc ttgaatgttt gtcctgctgt
     3661 gttgcagctt ctaaagacat tgtcaccgag tgtgtgtgac tcaaagatca agagtgaggc
     3721 taaactgcga ccccaacatc acttccttca tggaaaggtg ttggcgctga tgtagctcat
     3781 ggaaggatca gactgggaac cacagaggaa ggatgaggtg ggatgtggag gtcagagcat
     3841 ctcacgagag tccctcaggc tctgcaacac tagattcgaa tatgagccta gggtttcccc
     3901 aacacgtgcg tgcatatgaa accacatcat gattcccgac gtgagttaga tgagggagag
     3961 tttgtgtaac tccacaccca ggagggtaag ccactttatt atcatgcttt ggggctgtgc
     4021 ttaagaattt aagctctgtt ttaaagccga agaagaaaac atttgaattt accttcatat
     4081 gccactaaga acaaaagctc tgaagttctt cctgctggca ccaaatatta ggattacaag
     4141 ctgtctctct gacaccagtg gtaaaaaagc aagtagaata gtttctgagt ctgtgttgca
     4201 gcctctgaca cgtggctcac cgctgtcatt tgggggatgg aatgaacagt cactgttcta
     4261 tagcatcctc ctgtgctctt acctaaggaa tctaaattgt cctagccttc cattgctatg
     4321 cactgaatga ggactactct cgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg
     4381 tgtgtgtgtg ttggatctac taacatgttt agcaaatggc tctgacaggg tggccatgag
     4441 cagatgagac cagctcttgc ttggttggaa gccacactgc agtttgcagt ttagcctttg
     4501 gtgtctcagt ggcttcttgc ttattccatg ctttttctat cccatcctct ctctgtgccc
     4561 tcctgcaatg gcagccttgg cacaatgcct gggtgtcctc atccttgctt tactctggaa
     4621 agtgtgggga tggagaggat ggtgcatttc cagtgcttcc ttacctgtca ataacaatgg
     4681 tggccacctg ggtcccagca cttggctggt ggagagattt ttttcattat ggagctaata
     4741 aagggtccct acgttttaca ttgattaatg aattatcacc cagacatgtg cagatgaaat
     4801 gtcaatataa gaaaaatcaa ggtatttggg aaacatgggc ataatcaggt agttttgcta
     4861 aaattcctct tccttggtct acataaagaa gacatgggtc tgtcatagaa tggggacatt
     4921 agactgaaaa ctgggacaac ccccttcctt attttataga gactaggagt taaggggcct
     4981 gcctaagatt gcagtgataa agaactgaac cctaaatcag ctcccactaa tgaaaccctg
     5041 ctttccttgt atcttttaaa ctcagttctg catccaactt gagaagaaaa aaagcttctt
     5101 tccatatcaa gtaccatatg agttcattta aactgcacct tgcagaaatg cattgccaga
     5161 aagcaccagt agcctcctat ctgcaagcag agtagtgctc tgctctgggg aggggtcatt
     5221 ggaaaccata atgcagagtg ggccccctac tccatttccc agcaaaaggc tccagctgga
     5281 gggatgggtt gtggggcaac ctggttcctg ctaactgcca gattgaatgt gtgggctaga
     5341 atgcctgcac atttagttaa actgggctca gcatgcttgt cctcaaaatg tccatcctgg
     5401 tcacagcaca caagatggct attggtctgc ttttacccta ccctgtacta tacatgaaaa
     5461 ttccagttat taacacactc aaactggtgg agcttgttca ccctaggaag gggattgtat
     5521 atatggcagg cttccctggt gccgatgtaa agggctacat ttgggaacat ttgacttcct
     5581 tgggactctt aagtgcataa tgatggcatg aagtaaaagg ggcctcaatg atgataggaa
     5641 aatcagttct tttaaaattt cttcaagaaa atccaggcta tcacatagtc tttctgtgtg
     5701 acttattagg agataggaag agcattggga aacttgcaca gctagctatg catctacatt
     5761 ttggtttggg gttagttatg aaatgttctt aatatgacgt gttcaataac ttcacataaa
     5821 cttcctgttc tccaaaacct caaagagata gagttaatga gttgttgttt ttttttaaat
     5881 gggggtagtt ttctatctgt catgggctct agcatctact ccgctaccca attctgtcat
     5941 ctccaagctg agtttcctct tctgaggcag aggctggagc agttcttttt cagttctcat
     6001 cctctccatc ccaatccagt atatcaatca actctaactc ggagacgtct agctggcaat
     6061 gtttctaaaa ctttcactgg atttctttag acattgaagc aaacattttt ttctaagaat
     6121 tgcttctcag atgatgatat caaatgtata tgcttttgca agtttgaaaa gttcaaatta
     6181 accacttttg actaggtaag tctttctaaa aaccatttaa agctaactgg gtcttagcat
     6241 cctcctgtgt atggaagaga caggtgaccg ctccaggttg ggtgctcaca gaaccctttt
     6301 cctgactctc atggaagatg gtggaaggaa aatagactgt ctcatcaacc ctcctgtgtc
     6361 ctctgaagca atctcagttt ttattaacca cctcttctgt gtttctggta gctatttaac
     6421 ctgtatttaa tctgtacttc ctatgccagc ctcaatttta tttgattttt acaattattc
     6481 tcttctaacc aatgaagtgt ttgtcagtat gccccaaagc ttgctctttt gtgctccctt
     6541 ttgaataact ttctatccag aaaaagagat tatttgggac ttgagatttg cagtgatacc
     6601 aacttatagc aatgatgtac tttaagggaa ctacccaact atgttgtgat agaagaaaga
     6661 gaaaccttca ctttggcatt tttttttaat cactgtttat ttttctgttt gcggcccagg
     6721 aagcagtggg aggtggtggc agatatgctt tgcatatgga ttgttatgtt tttatttggg
     6781 caagtttaat catggaaaac tcaaaaagaa ggggggaaat ggtcagttta agccaaaaga
     6841 aactttctaa acaatgtata ggtacacagc aaaattaaac aaatccaaca atttctgaag
     6901 cttagtgtaa ttgagtggtg gttgttattc aataaaatta ttcccaaaag tgtttctcct
     6961 aagagtgcag ttcccatgag tcacttcctg aacccattga ccaaaggtgg acagagacaa
     7021 tcctgtagac cttgacattc agaaagatgt gagctgctta ctgatcatat atgcatacgt
     7081 ttctttacag cagaggaaac cattgtccac aaaactgatg ttcttttggg gttttatgta
     7141 cagacttgtc caatcatgtg tgtggttcct gcgagttgct gatgactccg cattgaagct
     7201 ctctgagttc tttgatttta agttgggttt atggaatttt ttcaaatgtt ggaaggtgtg
     7261 tggttcttcc tgccctccct ccccttttgg aaatatgaaa gcaaatgttt agaagaattc
     7321 cttttgaaaa gctgtgtcgt gttccctgtg aaactgagca ggtgtgtgtt ggcgcgctaa
     7381 gtgccacatg cttgtgtgta gaggaggagg tggccctgcc ggctccgcgc tgctgtgcct
     7441 gtgatcccta cctgctcccc gctcctgttg ccagcagcac tcactgcact cctttgtcat
     7501 atactctgca tcactgtcat actcacaact tcgtgaataa agttgtgtgc tttattcgta
//
