LOCUS       NM_007314              12217 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase
            (ABL2), transcript variant b, mRNA.
ACCESSION   NM_007314
VERSION     NM_007314.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 12217)
  AUTHORS   Miao,Y. and Liu,J.
  TITLE     Tumor-suppressive action of miR-30a-5p in lung adenocarcinoma
            correlates with ABL2 inhibition and PI3K/AKT pathway inactivation
  JOURNAL   Clin Transl Oncol 26 (2), 398-413 (2024)
   PUBMED   37479901
  REMARK    GeneRIF: Tumor-suppressive action of miR-30a-5p in lung
            adenocarcinoma correlates with ABL2 inhibition and PI3K/AKT pathway
            inactivation.
REFERENCE   2  (bases 1 to 12217)
  AUTHORS   Kabirova,M., Reichenstein,M., Borovok,N., Sheinin,A., Gorobets,D.
            and Michaelevski,I.
  TITLE     Abl2 Kinase Differentially Regulates iGluRs Current Activity and
            Synaptic Localization
  JOURNAL   Cell Mol Neurobiol 43 (6), 2785-2799 (2023)
   PUBMED   36689065
  REMARK    GeneRIF: Abl2 Kinase Differentially Regulates iGluRs Current
            Activity and Synaptic Localization.
REFERENCE   3  (bases 1 to 12217)
  AUTHORS   Xu,J., Hao,Y., Gao,X., Wu,Y., Ding,Y. and Wang,B.
  TITLE     CircSLC7A6 promotes the progression of Wilms' tumor via
            microRNA-107/ ABL proto-oncogene 2 axis
  JOURNAL   Bioengineered 13 (1), 308-318 (2022)
   PUBMED   34787058
  REMARK    GeneRIF: CircSLC7A6 promotes the progression of Wilms' tumor via
            microRNA-107/ ABL proto-oncogene 2 axis.
REFERENCE   4  (bases 1 to 12217)
  AUTHORS   Wu,K., Wu,H., Lyu,W., Kim,Y., Furdui,C.M., Anderson,K.S. and
            Koleske,A.J.
  TITLE     Platelet-derived growth factor receptor beta activates Abl2 via
            direct binding and phosphorylation
  JOURNAL   J Biol Chem 297 (1), 100883 (2021)
   PUBMED   34144039
  REMARK    GeneRIF: Platelet-derived growth factor receptor beta activates
            Abl2 via direct binding and phosphorylation.
REFERENCE   5  (bases 1 to 12217)
  AUTHORS   Bianchi,C., Torsello,B., Angeloni,V., Bombelli,S., Soldi,M.,
            Invernizzi,L., Brambilla,P. and Perego,R.A.
  TITLE     Eight full-length abelson related gene (Arg) isoforms are
            constitutively expressed in caki-1 cell line and cell distribution
            of two isoforms has been analyzed after transfection
  JOURNAL   J Cell Biochem 105 (5), 1219-1227 (2008)
   PUBMED   18810762
REFERENCE   6  (bases 1 to 12217)
  AUTHORS   Perego,R.A., Corizzato,M., Bianchi,C., Eroini,B. and Bosari,S.
  TITLE     N- and C-terminal isoforms of Arg quantified by real-time PCR are
            specifically expressed in human normal and neoplastic cells, in
            neoplastic cell lines, and in HL-60 cell differentiation
  JOURNAL   Mol Carcinog 42 (4), 229-239 (2005)
   PUBMED   15765532
REFERENCE   7  (bases 1 to 12217)
  AUTHORS   Wang,B. and Kruh,G.D.
  TITLE     Subcellular localization of the Arg protein tyrosine kinase
  JOURNAL   Oncogene 13 (1), 193-197 (1996)
   PUBMED   8700546
REFERENCE   8  (bases 1 to 12217)
  AUTHORS   Muller,A.J., Pendergast,A.M., Havlik,M.H., Puil,L., Pawson,T. and
            Witte,O.N.
  TITLE     A limited set of SH2 domains binds BCR through a high-affinity
            phosphotyrosine-independent interaction
  JOURNAL   Mol Cell Biol 12 (11), 5087-5093 (1992)
   PUBMED   1383690
REFERENCE   9  (bases 1 to 12217)
  AUTHORS   Kruh,G.D., Perego,R., Miki,T. and Aaronson,S.A.
  TITLE     The complete coding sequence of arg defines the Abelson subfamily
            of cytoplasmic tyrosine kinases
  JOURNAL   Proc Natl Acad Sci U S A 87 (15), 5802-5806 (1990)
   PUBMED   2198571
REFERENCE   10 (bases 1 to 12217)
  AUTHORS   Kruh,G.D., King,C.R., Kraus,M.H., Popescu,N.C., Amsbaugh,S.C.,
            McBride,W.O. and Aaronson,S.A.
  TITLE     A novel human gene closely related to the abl proto-oncogene
  JOURNAL   Science 234 (4783), 1545-1548 (1986)
   PUBMED   3787260
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL512326.25, M35296.1,
            AL139132.16 and BQ014912.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_007314.3.
            
            Summary: This gene encodes a member of the Abelson family of
            nonreceptor tyrosine protein kinases. The protein is highly similar
            to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2
            and SH3 domains, and it plays a role in cytoskeletal rearrangements
            through its C-terminal F-actin- and microtubule-binding sequences.
            This gene is expressed in both normal and tumor cells, and is
            involved in translocation with the ets variant 6 gene in leukemia.
            Multiple alternatively spliced transcript variants encoding
            different protein isoforms have been found for this gene. [provided
            by RefSeq, Nov 2009].
            
            Transcript Variant: This variant (b) represents the longest
            transcript and encodes the longest isoform (b, also known as
            1BLCTL).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M35296.1, SRR1803615.145147.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000502732.6/ ENSP00000427562.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-160               AL512326.25        103930-104089       c
            161-3925            M35296.1           85-3849
            3926-12172          AL139132.16        133641-141887       c
            12173-12217         BQ014912.1         21-65               c
FEATURES             Location/Qualifiers
     source          1..12217
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q25.2"
     gene            1..12217
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /note="ABL proto-oncogene 2, non-receptor tyrosine kinase"
                     /db_xref="GeneID:27"
                     /db_xref="HGNC:HGNC:77"
                     /db_xref="MIM:164690"
     exon            1..437
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..3829
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /EC_number="2.7.10.2"
                     /note="isoform b is encoded by transcript variant b;
                     tyrosine-protein kinase ARG; abelson-related gene protein;
                     Abelson tyrosine-protein kinase 2; c-abl oncogene 2,
                     non-receptor tyrosine kinase; v-abl Abelson murine
                     leukemia viral oncogene homolog 2"
                     /codon_start=1
                     /product="tyrosine-protein kinase ABL2 isoform b"
                     /protein_id="NP_009298.1"
                     /db_xref="CCDS:CCDS30947.1"
                     /db_xref="GeneID:27"
                     /db_xref="HGNC:HGNC:77"
                     /db_xref="MIM:164690"
                     /translation="MGQQVGRVGEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTET
                     GFNIFTQHDHFASCVEDGFEGDKTGGSSPEALHRPYGCDVEPQALNEAIRWSSKENLL
                     GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVPSN
                     YITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVY
                     HYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSP
                     IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAA
                     VMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQ
                     ISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIK
                     WTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPE
                     GCPPKVYELMRACWKWSPADRPSFAETHQAFETMFHDSSISEEVAEELGRAASSSSVV
                     PYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSPALP
                     RKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKK
                     YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGT
                     AGGGWSGITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMA
                     MTLPRNCQRSKLQLERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRG
                     ATALPLRTPSGDLAITEKDPPGVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWP
                     SPAKAAPVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQGNKFKLLSEHQVTSSGDK
                     DRPRRVKPKCAPPPPPVMRLLQHPSICSDPTEEPTALTAGQSTSETQEGGKKAALGAV
                     PISGKAGRPVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEA
                     LLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELS
                     LQELQVSSAAAGVPGTNPVLNNLLSCVQEISDVVQR"
     exon            438..500
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            501..671
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            672..967
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            968..1240
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1325
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1326..1503
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1688
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1841
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1842..1931
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2105
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     exon            2106..12217
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      12116..12121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /note="hexamer: AATAAA"
     polyA_site      12159
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
     regulatory      12189..12194
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /note="hexamer: AATAAA"
     polyA_site      12217
                     /gene="ABL2"
                     /gene_synonym="ABLL; ARG"
                     /note="major polyA site"
ORIGIN      
        1 ggtttaaaga tggcggcggc ggtggcggcg gcggcggcgg cggcgttggg ggcgcggagc
       61 cgcgacagga ggagggaaaa gcagaatctg tgagtcgcct ggaggcagcg cggcggctgc
      121 cgtgaggagg ccgggtgcgg agccgccggt ggcccagcca ctcagggcca gggcctgggc
      181 tgggagggag agaccggagc agcgccagga gcccgaggcc ggagccgagg aggaatgtga
      241 ccaggggtcg gcgggggcgc gggagtacgc gagagcaggg atggggcagc aggtgggccg
      301 cgtcggggaa gctccggggc tccagcagcc tcagccccgc gggatccggg gcagcagtgc
      361 agccaggccc tccggccgca ggcgggaccc ggcggggcgc accacagaga ccggcttcaa
      421 tatcttcacc cagcatgatc actttgccag ctgtgtggag gatggatttg agggagacaa
      481 gactggaggc agtagtccag aagctttgca tcgtccctat ggttgtgatg ttgaacccca
      541 ggcactaaat gaggctatca ggtggagctc caaggagaac ttgctcggag ccactgagag
      601 tgaccctaat ctcttcgttg cactttatga ttttgtagca agtggtgata acacactcag
      661 catcactaaa ggtgaaaagc tacgagtcct tggttacaac cagaatggtg agtggagtga
      721 agttcgctct aagaatgggc agggctgggt gccaagcaac tacatcaccc cagtgaacag
      781 cctggaaaaa cactcctggt accatggacc tgtgtcacgc agtgcagctg agtatctgct
      841 cagcagtcta atcaatggca gcttcctggt gcgagaaagt gagagtagcc ctgggcagct
      901 gtccatctcg ctcaggtacg agggacgtgt gtatcactac aggatcaata ccactgcaga
      961 tggcaaggtg tatgtgactg ctgagagccg cttcagcacc ttggcagagc ttgtacacca
     1021 tcactccaca gtggctgatg ggctggtgac aacattacac tacccagcac ccaagtgtaa
     1081 taagcctaca gtctatggtg tgtcccccat ccacgacaaa tgggaaatgg agcgaacaga
     1141 tattaccatg aagcacaaac ttgggggcgg tcagtatgga gaggtttacg ttggcgtctg
     1201 gaagaaatac agccttacag ttgctgtgaa aacattgaag gaagatacca tggaggtaga
     1261 agaattcctg aaagaagctg cagtaatgaa ggaaatcaag catcctaatc tggtacaact
     1321 tttaggtgtg tgtactttgg agccaccatt ttacattgtg actgaataca tgccatacgg
     1381 gaatttgctg gattacctcc gagaatgcaa ccgagaagag gtgactgcag ttgtgctgct
     1441 ctacatggcc actcagattt cttctgcaat ggagtactta gagaagaaga atttcatcca
     1501 tagagatctt gcagctcgta actgcctagt gggagaaaac catgtggtaa aagtggctga
     1561 ctttggctta agtagattga tgactggaga cacttatact gctcatgctg gagccaaatt
     1621 tcctattaag tggacagcac cagagagtct tgcctacaat accttctcaa ttaaatctga
     1681 cgtctgggct tttggggtat tgttgtggga aattgctacc tatggaatgt caccatatcc
     1741 aggtattgac ctgtctcagg tctatgacct actagaaaaa ggatatcgaa tggaacagcc
     1801 tgagggatgc ccccctaagg tttatgaact tatgagagca tgctggaagt ggagccctgc
     1861 cgataggccc tcttttgctg aaacacacca agcttttgaa accatgttcc atgactccag
     1921 catttctgaa gaggtagctg aggagcttgg gagagccgcc tcctcgtcat ctgttgttcc
     1981 atacctgccc cggctaccta tacttccttc caagactcgg acactgaaga aacaggtgga
     2041 gaacaaggag aacattgaag gggcacaaga tgccacagaa aattctgctt ccagtttagc
     2101 accagggttc atcagaggtg cacaggcctc tagtggatcc ccagcactgc ctcgaaagca
     2161 aagagacaag tcacccagca gcctcttgga agatgccaaa gagacatgct tcaccaggga
     2221 taggaagggg ggcttcttca gctccttcat gaagaagaga aatgctccta caccccccaa
     2281 acgcagcagc tccttccgag aaatggagaa tcagccccat aagaaatacg aactcacggg
     2341 taacttctca tctgttgctt ctctacagca tgctgatggg ttctctttca ctcctgccca
     2401 gcaagaggcg aatctggtgc cacccaagtg ctatgggggg agctttgcac agaggaacct
     2461 ctgtaatgac gacggtggtg ggggtggggg cagtggcact gctgggggtg ggtggtctgg
     2521 catcacaggc ttctttacac cacgcttaat caaaaagaca ctgggcttac gagcaggtaa
     2581 acccacagcc agtgatgaca cttccaagcc ttttccaagg tcaaactcta catcttccat
     2641 gtcctcaggg cttccagagc aggataggat ggcaatgacc cttcccagga actgccagag
     2701 gtccaaactc cagctggaaa ggacagtgtc cacctcttct cagccagaag agaatgtgga
     2761 cagggccaat gacatgcttc caaaaaaatc agaggaaagt gctgctccaa gcagggagag
     2821 accaaaagcc aagttattgc ccagaggagc cacagctctt cctctcagaa caccctctgg
     2881 ggatctagcc attacagaga aggaccctcc aggggtggga gtggctggag tggcagctgc
     2941 ccccaagggt aaagagaaga atggtggggc acgacttggg atggctggag ttccagagga
     3001 tggagagcag ccgggctggc cttctccagc caaggctgcc cccgtcctcc caaccactca
     3061 caaccacaaa gtgccagtcc ttatctcacc cactctgaaa cacactccag ctgacgtgca
     3121 gctcattggc acagactctc aggggaataa attcaagctc ttatctgagc atcaggtcac
     3181 atcctctgga gacaaggacc gaccccgacg ggtaaaacca aagtgtgccc cacccccacc
     3241 accagtgatg agactactgc agcatccgtc catctgctca gaccctacag aagagccaac
     3301 tgccctaact gcaggacagt ccacatcaga aacacaggaa ggaggaaaga aggcagctct
     3361 gggcgcagtg cccatcagtg ggaaagctgg gaggccagtg atgcctccac ctcaagtgcc
     3421 tctgcccaca tcttccatct cgccagccaa aatggccaat ggcacagcag gtactaaagt
     3481 ggctctgaga aaaaccaaac aggccgctga gaaaatctca gcagacaaaa tcagcaaaga
     3541 ggccctgctg gaatgtgctg acctactgtc cagtgcactc acggaacctg tgcccaacag
     3601 ccagctggta gacactggac accagctgct tgactactgc tcaggctatg tggactgcat
     3661 ccctcaaact cgcaacaaat ttgccttccg agaggctgtg agcaaactgg aactcagcct
     3721 gcaggagcta caggtttctt cagcagctgc tggtgtgccc gggacaaacc ctgtccttaa
     3781 taacttattg tcatgtgtac aggaaatcag tgatgtggtg cagaggtagc cactgttagc
     3841 ctggtgggaa aatgcacaca tttctgaggg gagagggaaa aggacttgtt ttcctgtgtt
     3901 cttgttttca gaaaatgaaa gactcatact tgagtgtgtt tatgtgaagt acctcagatc
     3961 cctgagttct cacgtttaca gtttcatctc aaaaataaga agcaaaccac ataagtatag
     4021 gagaggtaaa ttaagtgggg gcaaggcagt agtggacagg gttggaaact gcactggaaa
     4081 atagggaaca tgtgtatgtc ataaggaagg caatgcagcc catccctacc tggaatgctg
     4141 ggaagtgcta ggcagggctg ctctcagcaa gactgcagca gctgcaccca gacctggggc
     4201 tctggtaggt actaatggtg attatgctcc aatttaccta atgaatttgg tgggacagca
     4261 gaaaagaaag ctgggaatgt accaagagaa atttttgttc agggctgttg gaagtagctg
     4321 ttagccttgc ttccacaagg ccattgctgc tgtaataaga actgcaaatc agagtgctac
     4381 aacataaaac tgggaaatat ggccctatct gaatgcctct gtcctatttt ccgctggtgt
     4441 atcagttagt gcaggaagta aagaatgctg gaaagttgaa tcagaaattg aaaaccttct
     4501 aaaatcttac acagattagc agaagtcact tctcccagtc tggtatatta tttcataatg
     4561 gaccaggatc ggcttcctgc ctgttggtgg ctatctgtaa accataagta caggggtctc
     4621 cctagtggtt cttctctgtc ttttgctggg caggctgtct tcctttattc ctggtagcat
     4681 tcagagcatt aaccagtgtt gattttgaaa atagtagtcc ctacaggttc tcacaaagga
     4741 atgaatcctg ttctgataca gttcccctgc atactgacat actggccaag gacttgagca
     4801 gctgtgtatt tttctttatc aactaaaata ccagggagat ggtcttttct tgaaacccag
     4861 tggcctgtat gtgactgaga ggaaaagctg gcttggtcct aatggctgtt tctctgtacc
     4921 tttcccttcc cttaccacct taagcccaat ccaggtagag aatagggaga ggcattctcc
     4981 tctctatgga tttgaagtga atcaccccca cattattctc acatgctttt cttctctcac
     5041 atattcctcc ctactccccc acccaatcat tgtgcttatt tgtacagatc ttattgggaa
     5101 tattctttat ttattttgtc atttcacttc tattttaaga atgcataatt gaaggagtag
     5161 tcattttcag ggagcaccag gtagaccctg ggaacctaat gacttaatcc ttaaatatgt
     5221 tttgcccttg aaaaataggc cttttccttc cttccttagt tataattgtg gaagctaatt
     5281 aggatggcat ggaagtgaat ctaatgagtt aggtattatt aatgttcttg gtatcgggtc
     5341 taattccagt tactgcttca ttctcttttt aaagctttat gaatacttcc cccatcctcc
     5401 ccaaggagag ctcaatacac acatattttt attttattct ctcaaaggaa tattagctta
     5461 ggaagatagg aattcaacat tgagcactga gttttcttct ggctctgtca ttgatacact
     5521 gtcaaaccac agcctcatct cttaatctat ttaattaagg taacagtaca tgttctcaag
     5581 ggtgttgcaa gtaagtgtgc agctatccct tggagagcct ctctggaaag ctcttttagt
     5641 gcagtgttgt tatgctgaat tgttttccat tatcttattt gctgagtaga aaatattaat
     5701 gaaattaaga attgttgaga ttatatgaat tgggctagaa tactaagggg aaaactatgt
     5761 tttgaataga gtttggcatt tttgaccaag aacaaaattg agttttcatt ggaaagaaag
     5821 gaaaccttga ttcttaccat tgctgctcca aaggaggccc aggttaagag gattagagga
     5881 gacacgcggt gctgggcatt cctggcaggt gttgggtgat ccccgcagta tgtcacctgc
     5941 agttgcagca caggcagcta gtgattgggt tcatctcctc ctagtggttg gaagagaact
     6001 cagatgtaaa aaccagcggt ccttctccca ccttctttcc tgccattctt gctcatcata
     6061 catgtccgta aacttgaaga actcgtttta gcagctagcc ttttaaggtc gaggatggga
     6121 aagctaaaac tgtagaatat tattatgctg ctttttaggt ttatccctgt tgttgtggga
     6181 tgcaagttaa gggattgtaa ttgtttttca gggttttttt gttttttgtt ttttaagcaa
     6241 gggctctatt ttcccttgag agttctggaa ctaagccttg gagaaacact actgagtgta
     6301 tttaggctcc ctggttttct tgcccaacaa caatctgaag ggtagggggt gggggctgtg
     6361 tcttactcag gggcagcacc tagctgtctt gcctacagtg ggtgcacgat atataaatgg
     6421 aattgatttt tgtcaacact gtcaagagtg gcattgacta ttggagcata ccccgtccac
     6481 atgatgcttg aactatgtaa cttcaggggt tgagggctca aggttcaggt taaagaggca
     6541 ctgtcaactt actatacaag cataatttag gtttttcctt tttctacttg aaaaggacca
     6601 gcttaaacac aaacccttat gtaaattaaa aggtttgaat ccaaagcaga gagaactgct
     6661 tctggaaaag tgtagtttaa ttttaactat tctaaaagca atgagcaaag gcccttgtcc
     6721 aaggcgttga cagttttcta aagtggttat gctgtatatc tggatgcatg cctttgggct
     6781 gccactgctt gattcctttc atgtacagat aatattactt cagtttagat ttcccacttt
     6841 aaaatgcagt gatttgtgtt gaatacatct tgattgtgct ttacctaaag tattttctta
     6901 aaaggctttg tgtaaaattt aaatgtatat attttcctgt agacttccat catgattttc
     6961 agagattagc cttaaaaaat ttggccctaa gaaattcatt cagtgttttt ctagatgacc
     7021 tctgtacata gaggtcatta tagtggagac cctttaccag cagcatttta agatttaaat
     7081 tagatagaaa gtttcttagg attcaactga aaattggcta gtaaaatatg tcccaggtaa
     7141 taaagcatgc tgactttgct aaggcactgc ccatttttat ttaactaaag tcatggagat
     7201 tttgagttta aaggatgcag tatagatagt ggtttagtgt ttaggctcta atgccagtct
     7261 aaaaggcaag tcatttaacc ttgggagcct cagtttcctc actgtaaaac agggataata
     7321 atagtaacta cctcagggtt gttgtaagga ttaaatgaga tgatatttgt aagatactta
     7381 gctcaagtgc ctggcacaca atgagcacac tctataaatg ttctactact actattatta
     7441 acacctagtc tagggatgca cagcagaatc ccctagggtt aaaaaacaaa acaaaacaaa
     7501 caaaaaaaac tgacggaata gccccactcc agatcagaat tcccagtggg ctggggtctc
     7561 ggccagtgta ttctccagta atctcgccag gtgtttgaaa cacccagtgc tatctgaaaa
     7621 ctatcagtac cccaaccctt tggtttatag attaagaaac tagcagaaga tggttaaatt
     7681 acttgcctat tgtctcagaa cggttaatta gtggcggagc caaggctaga attcaagtct
     7741 cttgacttta tggttgtggg gtctttccac catacctgct gccatgtgag acactgcaaa
     7801 aaagtggctc agaccgacaa tcagcctgtg tggtgctgca cactttctaa agcacatgct
     7861 cctgacactt tgaccttaag gggcttgaat gtggagtaat gggaacacaa gccaagcaag
     7921 cactcagtag aattcagtca tttaaaaaat tcaatggggt cattcttttg gacagacctc
     7981 agcaacacag caatgtgcac tttgtagtaa agaaatacca acttgagttt ttaaaaaacc
     8041 tagttagtcc tacattccct tttctttaaa aaaactttat tgttcacatt attttaatga
     8101 ctatgagata atgtatatga cagcactttg agaaaatatc aactgtaata taactataag
     8161 gttgtagtat tgtctgttta aaagataaga cagttgattc aatgtggatg gaccctgtgg
     8221 ggtacctgaa aatgtagata cgtaagaatc acctctgtca tttatcacat ttagaaatat
     8281 gaaactgctt aacaggtatg agcaggtata gcaagtgttt gctaaagttg tagttcagag
     8341 ctgaattact tcaggaaact agggaccaac tttttggttt aattccgatc tttaaaaagt
     8401 aagaatgtgt actcactcca gaacacagaa gctcttccaa ggaccttgac tcaagaagga
     8461 tgaggtcctc ttactcttct ccatttatcc actatatgct tggccattta tcctaaatgt
     8521 ggtgggaaca gacttgttat ctgttgatgt tgacagtgtc ttttttaacc tatgtcctgc
     8581 atagttttgt taggtttaca gggggaggtg gatggccata aaaccagtgc actttgggaa
     8641 ttacttttct aggatttcct accagttata aatgacattg acatttgtca tctttttttt
     8701 ctttttctaa aaagaatagc tgaatttaat tcacctatta taaaatactc aaaagtaaat
     8761 tgccttggtg gccacttctg aattatagct acatttcatt atgacccctt ctgctccctt
     8821 ccattttgct actgatgtca ttcttgttat caggctgtgc ccctaccagg agttcatatt
     8881 gggttgacag ggttatctat atttttgttc ttgatttttg agtttcatca tcttgcatta
     8941 aattgttcca cctggatttg gggttcatct ctgtgcccta aggatctgct atgaccaatc
     9001 ctctttttgt aggtgggtct ctggcttaag tattgatagg cttcagcggt ttgtgtctct
     9061 gtcttagctt gtatcaagcc agtagtagct cacttccttt gtaaattcct gcttcagtct
     9121 gggatccgta ggagtatgtg agaacttctg aaacgtctcc aactcttaac agtcaagata
     9181 tctatatcat ttggatagag ttctggtttt ccaactacta gacttaaaga aattctggcc
     9241 gggtgcggtg gctcacgcct gtaatcccag cactttgggg ggctgaggcg ggtggatcac
     9301 gaggtcagga gattgagacc atcctggcta acacggtgaa accccacctc tactaaaaat
     9361 acaaaaactt agctgggcgt ggtggcgggc gcctgtagtc ccagctactg gggaggctga
     9421 ggcaggagaa tggcgtgaac ccaggaggcg gagcttgcag tgagcccaga tcgcgccact
     9481 gcactccagc ctgggtgaca gtgagactcc gtctcaaaaa aaaaaaaaaa aaaaaaaaaa
     9541 aaaaaaaaaa gaaattctaa tgcaaagctt gctttttttt tcttttttcc agcaagccag
     9601 tagtaatagt tattgttact tgctctgttc agcacaactg tagttcactt gaacttcact
     9661 gtcattccct acgctcctct cttactgaga agcatgggtg ggattcaggg ctgtgggaca
     9721 agctacagcc tactctggag cactcacccc catgactcag tccagcctgt ctcttgggaa
     9781 gtttattgca atgtgcagac ggatgaattt ctgcttttca tgccacctct ctgaggtatg
     9841 tattctatct tgagtatgta caagatgata ccttttggct gggcacagtg gctcgtgcct
     9901 gtaatcccag cactttggga gaccaagatg ggcggatcac ttgaggtcag gagtttgaga
     9961 ccagcctggc caacatggtg aaaccccgtc tctactaaaa atataaaaat tagccgggcg
    10021 tagtacatgc ctgtaatccc agctactccc gaggctgagg cagaattgct tgaacccagg
    10081 aggcggaggt tgcagtgagc tgagatcgcg ccgctgcact ccagcctaag tgacagagtg
    10141 agacacgtta agaagaaaaa aaaaaaaaag gataccttca tttctgactc aatatcctag
    10201 atccaaagga caggaaatta gggaaggctt caccctgtgg gatcaagata agaagatccc
    10261 atacttcttc ccaggtaagg aggcctgtgg caggtcatga ttcaaagctg acttggaatg
    10321 gcagaaactg ctgagaggcc acccttggag atttgtgcct tcaaagatgg gtttcatgag
    10381 tctcagagag gaaaagactt gtcagctggg ttgattttgc atgattattg aactagagct
    10441 ggtagacacg agcttctcag atggcagtgg ccagatcctc catctgtgag aatccgccac
    10501 ttgaagtggt ttcctgagag tgttcacttg gcagttgctg cgtttctcaa gcccacctgg
    10561 cgaggtctcg ccggaccctt ccctccaagt gcacttactt cttcatcccc atgtacatct
    10621 ctaactttga aattgtttac ctctcctaca aaaatcttac cttttgacct gagcagagta
    10681 gcaaagccct gttcactctg agggagcagc tggcgtgttg aaggggaaag gccaggcaca
    10741 gcactgtcct cagaccacac catatttgga gcagaattgt gatacatgtc atctgtgtct
    10801 attctggaag gttctttgtt catcactgta ctcgcatcag caaattttca gggtcctacc
    10861 tgtcactcca ggctactgag ctgaaccctc agaagctgag gtctccgagc atgctaagta
    10921 accttttaga aaagctggag gcaaactgtc gaatgctagc aggctttatg aaaggaaaca
    10981 taaggagttt gtgtagtcag aacttgctta aatttgcttc ggaattaggc accataaact
    11041 ttagttggag aatgggactt aaattttcac atatatgtat acttaatttt cagcaattat
    11101 gacacaataa aaagaatatg caaatttatt gttgtttcag aaggttttgc aggactggga
    11161 acgctttagt gtcatcaaca gtaaacctca gatactgttc tgcacagttc agaagtacca
    11221 taccaggtat tgtgagtggc aagaacgcca ggggacagag atgcttctgg tagatgaggg
    11281 ccagagaaac cagctctcct ccattttgac agcaatttct cactgtggcc atttggcctc
    11341 cattatgttt tgagaggaat ttcttgagat cttgagaaat caccatgatt aggccaattg
    11401 tcaatcagta ttcagaaact agaaaggaac aatgagatac ttgtttatgg ttctttaggg
    11461 catatgtttg aaaaccctct catctcagat ctgtatagct ggtgtgtgtt tgtgtccata
    11521 aatacacgtg cattgctgtc gtgcccatta agaaaggggg agtaagtaaa agaggaatcg
    11581 ctcagatctt tccttggatg aacagcagtg gcgtggttgg tgtgttgact gtgaacaggc
    11641 tgacttagct gttgatgtat actcagaacc tccatctcct cccagaccct gcacttttcc
    11701 ttctctgcag tctgattctc taatgactgt cactggacaa accccagttt tatgctcgct
    11761 tagtaaaaat aagtttaaac atttcatggt ggttgacaga actttgtccc caaacatgcg
    11821 gattcaattc tttaaaactc gttgaacgtt tataccaaag gtcccgcccc gcaggtgtgt
    11881 atgtggtgca cagagggtga ggtttggagc atcgggcact gtgtgcattg ctaaggggac
    11941 atagtgagac aatgtgggat ttaactaaaa acacatcaat tgtgtgtcac attaccagtg
    12001 ttgtcaggta tttgttctta attgttattg taatatattt tcagttgttt ttctaattta
    12061 attctctccg tctgttgtct gactgtgaac tgctaacagt gttaaacttg atgtaaataa
    12121 atgaggccct tgaaagggac tgctttctct gtcttctcac aaggtttgcc aagttgtgtt
    12181 ctgttttaaa taaaggttgc aatattttat tggcaaa
//
