LOCUS       NM_017832               1901 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens actin binding transcription modulator (ABITRAM),
            transcript variant 1, mRNA.
ACCESSION   NM_017832
VERSION     NM_017832.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1901)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1901)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1901)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   4  (bases 1 to 1901)
  AUTHORS   Derlig,K., Ehrhardt,T., Giessl,A., Brandstatter,J.H., Enz,R. and
            Dahlhaus,R.
  TITLE     Simiate is an Actin binding protein involved in filopodia dynamics
            and arborization of neurons
  JOURNAL   Front Cell Neurosci 8, 99 (2014)
   PUBMED   24782708
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1901)
  AUTHORS   Derlig,K., Giessl,A., Brandstatter,J.H., Enz,R. and Dahlhaus,R.
  TITLE     Identification and characterisation of Simiate, a novel protein
            linked to the fragile X syndrome
  JOURNAL   PLoS One 8 (12), e83007 (2013)
   PUBMED   24349419
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1901)
  AUTHORS   Ahn,J., Chung,K.S., Kim,D.U., Won,M., Kim,L., Kim,K.S., Nam,M.,
            Choi,S.J., Kim,H.C., Yoon,M., Chae,S.K. and Hoe,K.L.
  TITLE     Systematic identification of hepatocellular proteins interacting
            with NS5A of the hepatitis C virus
  JOURNAL   J Biochem Mol Biol 37 (6), 741-748 (2004)
   PUBMED   15607035
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC015795.1 and AK000464.1.
            
            On Nov 22, 2018 this sequence version replaced NM_017832.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.281482.1, BC015795.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322940.11/ ENSP00000363753.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BC015795.1         220-228
            10-1901             AK000464.1         1-1892
FEATURES             Location/Qualifiers
     source          1..1901
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q31.3"
     gene            1..1901
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /note="actin binding transcription modulator"
                     /db_xref="GeneID:54942"
                     /db_xref="HGNC:HGNC:1364"
                     /db_xref="MIM:620392"
     exon            1..166
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /inference="alignment:Splign:2.1.0"
     CDS             88..633
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein FAM206A; protein Simiate; family with sequence
                     similarity 206 member A; protein Abitram"
                     /codon_start=1
                     /product="protein Abitram isoform 1"
                     /protein_id="NP_060302.1"
                     /db_xref="CCDS:CCDS6774.1"
                     /db_xref="GeneID:54942"
                     /db_xref="HGNC:HGNC:1364"
                     /db_xref="MIM:620392"
                     /translation="MATEPEAAEPVVPSLVDRYFTRWYKPDVKGKFCEDHCILQHSNR
                     ICVITLAESHPVLQSGKTIKSISYQISTNCSRLQNKVSGKFKRGAQFLTELAPLCKIY
                     CSDGEEYTVSSCVRGRLMEVNENILHKPSILQEKPSTEGYIAVVLPKFEESKSITEGL
                     LTQKQYEEVMVKRINATTATS"
     exon            167..218
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /inference="alignment:Splign:2.1.0"
     exon            219..348
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /inference="alignment:Splign:2.1.0"
     exon            349..425
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /inference="alignment:Splign:2.1.0"
     exon            426..495
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /inference="alignment:Splign:2.1.0"
     exon            496..1901
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /note="hexamer: AATATA"
     polyA_site      1901
                     /gene="ABITRAM"
                     /gene_synonym="C9orf6; CG-8; FAM206A; Simiate"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgccgga agagcacgcc cagtccgggc tgcgcggagg aagcgctggg gtcccggagg
       61 gcgggggtgg cggcgccgga ggtcgccatg gctaccgagc ccgaagccgc ggagccggtg
      121 gtgccttcgc tcgtggatcg atacttcact cgctggtaca aaccggatgt caaaggaaaa
      181 ttttgtgagg accactgtat actacagcac tctaaccgaa tatgtgtcat cacattggca
      241 gaatctcatc cagttcttca aagtggaaaa acaattaaaa gcatttccta tcagatcagt
      301 accaactgta gcagacttca gaacaaggtc tctgggaaat ttaagcgggg ggcacagttt
      361 ctaacagagc ttgcacctct ctgtaagatt tactgctcag atggtgaaga atatactgtg
      421 tctagttgtg ttagaggacg tttgatggaa gtgaatgaaa acatcctcca taagccatct
      481 attcttcaag aaaagccatc tactgaaggc tacattgcag ttgtgttacc caaatttgaa
      541 gaaagtaaaa gcataacaga agggttactg acacaaaaac aatatgaaga agtcatggtg
      601 aaacgcatta atgccacaac agctacgtca tgaggattga catggaacaa aaagcaaagt
      661 gggattcttg ttacctggcc taaaccatca gggtactaaa ggagaagaac cagtatatgt
      721 aaagcatacc taacagccag ccatatgcag gggaggccta gtgcttcact tagttttccc
      781 tctctgtctt cataatgagc cttggttccc atttgtctac agcctgccag atctggcctg
      841 cccatgtact cacactgttc tcttgcatct ctctaacaac tggcatgcaa ggcatgtttt
      901 tctgattaaa aacaaacaaa gctctttgaa gaagatttag aaaatacaga agagttttaa
      961 gtagccaagt aaaaataatt tacccatcat cccataatcc agaagtaaat acatttgacc
     1021 cttgagcaac ataggtttga actgcaaggg tccacttatg catggactat tttcaactat
     1081 aaacgagtca aaaatatatc attaaccaaa cacgaaaccc acttatagag caggttcata
     1141 tactcaggtt ccaaagggcc aactgcagga cttgagttct cacgtatgga tttgggtata
     1201 tgtggaagtt cctggaacca atcccctatg taaaccaagg gataactact acattttaac
     1261 ctacttctgt ttgaacatat ggtatggtta ttgcttttgc ctcgttttcc taacagtttg
     1321 aagtttaaaa aaacctaacc cacctttctt acccagtctt ctataatgtg cctaccaaaa
     1381 agcctagtcc tagcccatct gcctcaactc ctctcccttt taggttgtag ggaagaggcc
     1441 ggagtgtaga gtatattata tcttctgtcc cccttatgcc aacaagatgg ccttcccctc
     1501 tgaaacaaag taaaactgca acactgtgac ttcttaaatg agggatatgt gaaaaggcta
     1561 tgaaaaatac aaaggctttc ctaggaaatg tgttataatg cagcgggaag ctaattcttg
     1621 aaatatgcac attatagtta ctcagtctca catactctag ttactggcaa agaagttact
     1681 gagaatatgt cattcaaagg cataggggcc tttgaatgga acaaatgctt tcacatcatt
     1741 taaagtaaaa aaaaacctcc aacaactgtg aatttatagt ttaagagtga tttacactga
     1801 atttcaaata aaaggactat aaaacgtgtt atttttctgt aagggctata acatacatgt
     1861 caatatcact gtttttaaat aaaatatact tttatacaga a
//
