LOCUS       NM_001375753            6030 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens abl interactor 2 (ABI2), transcript variant 88, mRNA.
ACCESSION   NM_001375753
VERSION     NM_001375753.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6030)
  AUTHORS   Li,H., Liu,J., Lai,J., Su,X., Wang,X., Cao,J., Mao,S., Zhang,T. and
            Gu,Q.
  TITLE     The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties
            and tumorigenesis in HCC
  JOURNAL   J Transl Med 22 (1), 537 (2024)
   PUBMED   38844969
  REMARK    GeneRIF: The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like
            properties and tumorigenesis in HCC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6030)
  AUTHORS   Zhu,Q., Combs,M.E., Liu,J., Bai,X., Wang,W.B., Herring,L.E.,
            Liu,J., Locasale,J.W., Bowles,D.E., Gross,R.T., Pla,M.M., Mack,C.P.
            and Taylor,J.M.
  TITLE     GRAF1 integrates PINK1-Parkin signaling and actin dynamics to
            mediate cardiac mitochondrial homeostasis
  JOURNAL   Nat Commun 14 (1), 8187 (2023)
   PUBMED   38081847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6030)
  AUTHORS   Jensen,C.C., Clements,A.N., Liou,H., Ball,L.E., Bethard,J.R.,
            Langlais,P.R., Toth,R.K., Chauhan,S.S., Casillas,A.L., Daulat,S.R.,
            Kraft,A.S., Cress,A.E., Miranti,C.K., Mouneimne,G., Rogers,G.C. and
            Warfel,N.A.
  TITLE     PIM1 phosphorylates ABI2 to enhance actin dynamics and promote
            tumor invasion
  JOURNAL   J Cell Biol 222 (6) (2023)
   PUBMED   37042842
  REMARK    GeneRIF: PIM1 phosphorylates ABI2 to enhance actin dynamics and
            promote tumor invasion.
REFERENCE   4  (bases 1 to 6030)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6030)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6030)
  AUTHORS   Machado,R.D., Pauciulo,M.W., Fretwell,N., Veal,C., Thomson,J.R.,
            Vilarino Guell,C., Aldred,M., Brannon,C.A., Trembath,R.C. and
            Nichols,W.C.
  TITLE     A physical and transcript map based upon refinement of the critical
            interval for PPH1, a gene for familial primary pulmonary
            hypertension. The International PPH Consortium
  JOURNAL   Genomics 68 (2), 220-228 (2000)
   PUBMED   10964520
REFERENCE   7  (bases 1 to 6030)
  AUTHORS   Courtney,K.D., Grove,M., Vandongen,H., Vandongen,A., LaMantia,A.S.
            and Pendergast,A.M.
  TITLE     Localization and phosphorylation of Abl-interactor proteins, Abi-1
            and Abi-2, in the developing nervous system
  JOURNAL   Mol Cell Neurosci 16 (3), 244-257 (2000)
   PUBMED   10995551
REFERENCE   8  (bases 1 to 6030)
  AUTHORS   Juang,J.L. and Hoffmann,F.M.
  TITLE     Drosophila abelson interacting protein (dAbi) is a positive
            regulator of abelson tyrosine kinase activity
  JOURNAL   Oncogene 18 (37), 5138-5147 (1999)
   PUBMED   10498863
REFERENCE   9  (bases 1 to 6030)
  AUTHORS   Wang,B., Mysliwiec,T., Krainc,D., Jensen,R.A., Sonoda,G.,
            Testa,J.R., Golemis,E.A. and Kruh,G.D.
  TITLE     Identification of ArgBP1, an Arg protein tyrosine kinase binding
            protein that is the human homologue of a CNS-specific Xenopus gene
  JOURNAL   Oncogene 12 (9), 1921-1929 (1996)
   PUBMED   8649853
REFERENCE   10 (bases 1 to 6030)
  AUTHORS   Dai,Z. and Pendergast,A.M.
  TITLE     Abi-2, a novel SH3-containing protein interacts with the c-Abl
            tyrosine kinase and modulates c-Abl transforming activity
  JOURNAL   Genes Dev 9 (21), 2569-2582 (1995)
   PUBMED   7590236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080075.7 and AC018891.9.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.206482.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156670, SAMEA2159764
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC080075.7         35777-36014
            239-362             AC080075.7         58938-59061
            363-530             AC080075.7         74260-74427
            531-707             AC080075.7         87591-87767
            708-805             AC018891.9         1059-1156
            806-930             AC018891.9         5669-5793
            931-1089            AC018891.9         12589-12747
            1090-1263           AC018891.9         26921-27094
            1264-1356           AC018891.9         37190-37282
            1357-6030           AC018891.9         37509-42182
FEATURES             Location/Qualifiers
     source          1..6030
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.2"
     gene            1..6030
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="abl interactor 2"
                     /db_xref="GeneID:10152"
                     /db_xref="HGNC:HGNC:24011"
                     /db_xref="MIM:606442"
     exon            1..238
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            239..362
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            363..530
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             468..1436
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="isoform eeee is encoded by transcript variant 88;
                     abl-interacting protein 1 (SH3-containing protein); abl
                     binding protein 3; arg protein tyrosine kinase-binding
                     protein; abl-interactor protein 2b; abelson interactor 2;
                     arg-binding protein 1"
                     /codon_start=1
                     /product="abl interactor 2 isoform eeee"
                     /protein_id="NP_001362682.1"
                     /db_xref="GeneID:10152"
                     /db_xref="HGNC:HGNC:24011"
                     /db_xref="MIM:606442"
                     /translation="MLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNT
                     SRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKVSTQNMKMGGLPRTTPPTQKPP
                     SPPMSGKGTLGSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPGHPVQF
                     YSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSDTPPPPPPV
                     EEPVFDESPPPPPPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDK
                     EDELSFQEGAIIYVIKKNDDVLKTKQAESEQMDLSAIICTMLSCLD"
     exon            531..707
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            708..805
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            806..930
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1089
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1090..1263
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1356
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1357..6030
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6010..6015
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="hexamer: AATAAA"
     polyA_site      6030
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="major polyA site"
ORIGIN      
        1 ccttccgagt taccgccgcc gtcgccgccg ctcctcctct cccggtcctg ggtttccttg
       61 gcgctgcggc cgccgctccc tctgcgacct gtatgaggag gaggaggagg aggatgtgaa
      121 gatggcggag ctgcagatgc tgctggaaga ggaaatcccg gggggccgcc gggccctctt
      181 cgacagctac acaaatctgg aacgggtggc cgattactgc gagaacaact acatacagag
      241 atggggtctt ggtatgtcat gcaggctgga atgcagtggt gtgatcatag ctcactgcag
      301 ccttgaactc ctgtgctcaa gtgatcatcc tgcctcagtc tctcagtagt ctgggactac
      361 agtcagcaga taagcagaga gccctagaag aaaccaaagc ctacaccacc caatccttag
      421 caagtgttgc ctatctgata aacaccttgg ccaacaatgt cctgcagatg ctggatatcc
      481 aggcatccca gctacgaagg atggaatctt caatcaatca tatttcacaa acagttgata
      541 ttcataaaga gaaagttgca agaagagaaa ttggtatttt gactaccaat aaaaacactt
      601 caaggacaca taagattatt gctccagcca accttgaacg accagttcgt tatattagaa
      661 aacctattga ctatacaatt ctagatgata ttggacatgg agtaaaggtg agtacccaga
      721 acatgaagat gggtgggctg ccgcgtacaa cacctccaac tcagaagccc cctagtcccc
      781 ctatgtcagg gaaagggaca cttggcagca gtgggagtag tggagggagc cacccaagta
      841 gtcggagcag cagtcgagag aacagtggaa gtggtagtgt gggggttcct attgctgttc
      901 ctactccatc tcctcccagt gtctttccag gtcatcctgt acagttctac agcatgaata
      961 ggcctgcctc tcgccatact cccccaacaa tagggggctc gttgccctat agacgccctc
     1021 cttccattac ttcacaaaca agccttcaga atcagatgaa tggaggacct ttttatagcc
     1081 agaatccagt ttcagataca ccacctccac cgccacctgt ggaagaacca gtctttgatg
     1141 agtctccccc acctcctcct cctccagaag attacgaaga ggaggaagct gctgtggttg
     1201 agtatagtga tccttatgct gaagaggacc caccgtgggc tccacgttct tacttggaaa
     1261 aggttgtggc aatttatgac tatacaaaag acaaggaaga tgagctgtcc tttcaggaag
     1321 gagccattat ttatgtcatc aagaagaatg acgatgtatt aaaaacaaag caagctgagt
     1381 ctgaacaaat ggatctttct gccatcattt gtacaatgct gagctgtctg gattgaaata
     1441 aaatgaccat ttttatgtat gtcaaaggta taacagcata actgtgtagc caaaacaaaa
     1501 tcagattaag actgattcag aaaaatctgg gatctttctc aggaatactg tatacccttg
     1561 ggatttctcc tcctgcagaa tctgtggcat tggatgttct tcattgcctg tgctaagggg
     1621 ttaacctcat ggcccagtgg gtaccctagc cccttctttt cttccacttg tatgaagagg
     1681 agggaaccaa catttaaata ccacacttaa ccatttttac aattatttca gatggctttt
     1741 ttcctctgtg acactgtaaa ttctgcattc tctcagcact tgagtgcacc aaacgagtga
     1801 atgctgaact cacttgcatc ccttcatgtt tctgtttgtg gattataagg atgatgaaat
     1861 gtgaaagtct cccaacactc tgagggtggt gaacgattgc cacccgtttg attttaatgt
     1921 gctgctgcat gagactgcat tgttgctaat ggccagtgta cccagatgtg aagtgtggta
     1981 ggctggttca tatgtggagg tgggtgtgtg aagctagaca cgaaggtccc taaggttctg
     2041 aagagacttg aactgtggaa atgctcttag caggcatccc gaacccctgc ttcggtgctg
     2101 ttttgaggag taggatcttg gagttcagac caactatgac tatcatttcc ttcactatct
     2161 agaaaaacgc tattctactt tggaagagaa tagtagttat tttcaagtct cctgacagtc
     2221 actgggagta caaggtttgc taatgtgctc tctggacgtt attaatggcc agtattagtt
     2281 gctgctgtat tactgactcg cttagctgta gaaagggtaa tactctcctg attttgtatg
     2341 attggactct taagtagctg ctgttagtca gaattaaaac ccatctcaga ctaagaatat
     2401 aatgaataag attaataggc caaaatatgt atctaatcac attgataaaa attaatataa
     2461 ctgacacaat aaaacacatt tcccccatct gtacaataaa tacagcttca aattcagtgg
     2521 agtctgtagg gcagataact ttaatcatca ctactgtagt cagtataaga aatgctgaaa
     2581 aaaatccagg agggcttgtc tctttgtggg tggtcactgt gatgttgggc cagctcctgt
     2641 tcaggtccag agctgctaac gtgggttcta ctcagtccca gtgacttggc cagaatagag
     2701 ctttgccagg taactgccct gtgctaggtg aaaggggaaa agcagtagct ggatatattt
     2761 caaatgaggt tttgaacaag ttcagaaagt ggaacttgat tgaaaagtga acaagtgtag
     2821 tagtgtgtga gaaaattcag atggtgtcgg atgcagaagt taatattcca cttaatgtta
     2881 tctgagcatt aaaaatcatc agcatttaac tgagacccca ctatagagtt tccttatcaa
     2941 gactttttgg ttttaaagtt gtttttaatg cattgcaagt tacaatagct attttgcttt
     3001 tagatttttc ccagcacttt gtatttatta gctttcatta acttgcctcc agtatacatt
     3061 ccacttcgtg cttttcttag gtcatttcta catcccttat tccttgtttt cctgcagtgt
     3121 aatggccctg aatgtcctct gagccttcag ctccattatg gacccaaact agactatact
     3181 tggataagtt aagctcttct tcgtgtactg gtctataatt agaaaaactg ttttaaatta
     3241 gatgttccca ttatttattt aaacagcttt ttgctgagaa agcttagtgg attaatgagg
     3301 cagagggtgt tttgaaatcc aataaatagt tcccacaggc tgggtgtggt ggcttatgcc
     3361 tgtaatccca gcactttcgg aggccgaggt gggtggatca tgaggtcaat aaattgagac
     3421 catcctggcc aacatggtga aaccccatct ctactaaaaa cacaaaaatt agctgggcgt
     3481 ggtggcgcac acctgtagtc ccagctactt gggaggctga ggcaggagaa tcactggaac
     3541 ctgggaggca gaggttgcag tgagccgaga ttgtgccact gcactccagc ctggtgacag
     3601 agcgagactc catcaaaaaa aaaaaaaaaa agttcccaca gctcaccact acagaagcag
     3661 ggaagacaac tatgcagaaa acagagttag tggcggtcag caggaatgca gctggtcttt
     3721 tggaccccta cgggatgggg gcagtgcaga agacactggt gaagtccttt atactgaaga
     3781 cctgtggttg ggagcagggg tagtccatgg gtctgctgat tttttttccc tatttagtac
     3841 taatgtgtgt gtgatctttg ttttacaaac agtacctttt gggttttctg catattttat
     3901 aatttttgta cagttttgaa ttctatagat tgtcttggaa ggatactgtg tgatgggtca
     3961 ggcacacagt aattggagac ttttaatgta tgtaatattt catagattgc atgctattaa
     4021 tcatctgtga gggtagtatt ttttgtttta ttgtaagttt ccctcttttt ttataaatta
     4081 aaagatggtt ggtattagga atttcaaatg aatgcagaaa atcttacatg ctgtgtacta
     4141 ttaatattat aacagacgat ccaagtccaa aatctgacca ataaagcaac cattttatca
     4201 agatagaggg attctaatgg gagaggggat tcttccctcc tgaagtttgt gtgtccagtc
     4261 cccttaaaaa aaatgaatag ttgtcttttc ttgtcatatt aatactcgaa agtccatggt
     4321 ggtattaatg aaagtacact ttattgttgc ctttgaactt acggccaagg caataaatca
     4381 gaaacaaaaa tagtgccaat gtgtcaaaat cgacatctga gagattcagc ctcccatttg
     4441 gaataaatat gaatcttcta agctatcttg tttaatattt tccatcattt agctacttcc
     4501 tatctccctc agaggcgcct gctgttccca ttttagagtt gacagtggcc tgctaatttt
     4561 gctatgttcc taaaagttac tgggtgtgag acattttcat cccctccttt ttcctactgc
     4621 tggtgtttat tatccagcta gacaatattt tatgcatatt taccgtgatg tctggaccgt
     4681 acctgtgctc cttggcagtt tatgttgaag ataactaaag atttttctct ttgggaggca
     4741 tcaaaatgat ggtagtttgc ttttatcttt ttatgttcat tttcttttag taggtgacct
     4801 ttctgcatta agaactgttt ttatctttta ctaccttttc ttttctcctt tgtggagaca
     4861 gcatgacatg tcctgaaggt cacctttgcc tttgaaaaag gtttgatgga ggaattcaca
     4921 ggtgactgac aagtctttga aaagaatggg atctgctcac ttctggtctt tttggccggg
     4981 aactcctgat tggtgttaag gtggtaattt cccccatata agatttagaa tcactgagtt
     5041 tgagctagat gaaattttta aaatttctgg ttgtctcatt agactgatga ggtgagtttt
     5101 cttcttcata tgaacagcta gttaataaca gcagagttct cactcagtgc tcagtactta
     5161 attttccact gcaccacaac tgtcttaact aaatgtgctg tatttttctt taaaagttaa
     5221 gagttctatt tggtgttttc aggaatatac gtgaaaagac atgccatgtt ttggtaaata
     5281 ccatcagagt tgtgtaaagg cgtgtactaa gtgcaatctt aatttgtgga aataatcttc
     5341 atttacccct cctaaaacta cactcagtat aaacactttc ccataaggtg tgtgcagtaa
     5401 aaatgttata ttactccaac actggcagga gcacagcaca gcagccttat tggagagagc
     5461 cttataaaag tgattaaatg gaggcattga gctcattacc tttaagttta ctttgtgctg
     5521 acctttgttc ctgttttgag aatctcatat aattattaaa aaaaaaaaac aattaaaacg
     5581 aaacggcggg gcctagctgt gtataaatga tccttgctga atatcttaag gttttttgta
     5641 agaaaaaaga aaaaccaaca aaaaaagctt attttcacat taaaatgaaa cctcttttgc
     5701 aacttaagaa ttctatggaa aagcagtttt tatcatattt tgtgtccatg caccattttt
     5761 cttaaaatgg cttacaaaaa agaatgtaaa caatttgtga tctggccagt tgtactttta
     5821 gctcccagag ggagagttgg tggtattatg agttgagtaa aaaccatcca ggggaacttg
     5881 agggagcagt ctgttgccag taatgttcct tgtgtgccat taaaccacct ccagatgagt
     5941 ggaggaacat cactttttaa ttttttaatt gtatttggaa ttgttgccgt gtactaagaa
     6001 cttgacctaa ataaaatccc acaaagtata
//
