LOCUS       NM_001375670            6567 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens abl interactor 2 (ABI2), transcript variant 15, mRNA.
ACCESSION   NM_001375670 XM_005246217
VERSION     NM_001375670.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6567)
  AUTHORS   Li,H., Liu,J., Lai,J., Su,X., Wang,X., Cao,J., Mao,S., Zhang,T. and
            Gu,Q.
  TITLE     The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like properties
            and tumorigenesis in HCC
  JOURNAL   J Transl Med 22 (1), 537 (2024)
   PUBMED   38844969
  REMARK    GeneRIF: The HHEX-ABI2/SLC17A9 axis induces cancer stem cell-like
            properties and tumorigenesis in HCC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6567)
  AUTHORS   Zhu,Q., Combs,M.E., Liu,J., Bai,X., Wang,W.B., Herring,L.E.,
            Liu,J., Locasale,J.W., Bowles,D.E., Gross,R.T., Pla,M.M., Mack,C.P.
            and Taylor,J.M.
  TITLE     GRAF1 integrates PINK1-Parkin signaling and actin dynamics to
            mediate cardiac mitochondrial homeostasis
  JOURNAL   Nat Commun 14 (1), 8187 (2023)
   PUBMED   38081847
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6567)
  AUTHORS   Jensen,C.C., Clements,A.N., Liou,H., Ball,L.E., Bethard,J.R.,
            Langlais,P.R., Toth,R.K., Chauhan,S.S., Casillas,A.L., Daulat,S.R.,
            Kraft,A.S., Cress,A.E., Miranti,C.K., Mouneimne,G., Rogers,G.C. and
            Warfel,N.A.
  TITLE     PIM1 phosphorylates ABI2 to enhance actin dynamics and promote
            tumor invasion
  JOURNAL   J Cell Biol 222 (6) (2023)
   PUBMED   37042842
  REMARK    GeneRIF: PIM1 phosphorylates ABI2 to enhance actin dynamics and
            promote tumor invasion.
REFERENCE   4  (bases 1 to 6567)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 6567)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   6  (bases 1 to 6567)
  AUTHORS   Machado,R.D., Pauciulo,M.W., Fretwell,N., Veal,C., Thomson,J.R.,
            Vilarino Guell,C., Aldred,M., Brannon,C.A., Trembath,R.C. and
            Nichols,W.C.
  TITLE     A physical and transcript map based upon refinement of the critical
            interval for PPH1, a gene for familial primary pulmonary
            hypertension. The International PPH Consortium
  JOURNAL   Genomics 68 (2), 220-228 (2000)
   PUBMED   10964520
REFERENCE   7  (bases 1 to 6567)
  AUTHORS   Courtney,K.D., Grove,M., Vandongen,H., Vandongen,A., LaMantia,A.S.
            and Pendergast,A.M.
  TITLE     Localization and phosphorylation of Abl-interactor proteins, Abi-1
            and Abi-2, in the developing nervous system
  JOURNAL   Mol Cell Neurosci 16 (3), 244-257 (2000)
   PUBMED   10995551
REFERENCE   8  (bases 1 to 6567)
  AUTHORS   Juang,J.L. and Hoffmann,F.M.
  TITLE     Drosophila abelson interacting protein (dAbi) is a positive
            regulator of abelson tyrosine kinase activity
  JOURNAL   Oncogene 18 (37), 5138-5147 (1999)
   PUBMED   10498863
REFERENCE   9  (bases 1 to 6567)
  AUTHORS   Wang,B., Mysliwiec,T., Krainc,D., Jensen,R.A., Sonoda,G.,
            Testa,J.R., Golemis,E.A. and Kruh,G.D.
  TITLE     Identification of ArgBP1, an Arg protein tyrosine kinase binding
            protein that is the human homologue of a CNS-specific Xenopus gene
  JOURNAL   Oncogene 12 (9), 1921-1929 (1996)
   PUBMED   8649853
REFERENCE   10 (bases 1 to 6567)
  AUTHORS   Dai,Z. and Pendergast,A.M.
  TITLE     Abi-2, a novel SH3-containing protein interacts with the c-Abl
            tyrosine kinase and modulates c-Abl transforming activity
  JOURNAL   Genes Dev 9 (21), 2569-2582 (1995)
   PUBMED   7590236
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC080075.7 and AC018891.9.
            
            On Oct 31, 2019 this sequence version replaced XM_005246217.2.
            
            Transcript Variant: This variant (15) encodes the longest isoform
            (j).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.124267.1,
                                           SRR1803617.205780.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2145743
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261018.12/ ENSP00000261018.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-238               AC080075.7         35777-36014
            239-406             AC080075.7         74260-74427
            407-583             AC080075.7         87591-87767
            584-601             AC080075.7         89572-89589
            602-699             AC018891.9         1059-1156
            700-846             AC018891.9         4713-4859
            847-971             AC018891.9         5669-5793
            972-1154            AC018891.9         6798-6980
            1155-1313           AC018891.9         12589-12747
            1314-1400           AC018891.9         21298-21384
            1401-1574           AC018891.9         26921-27094
            1575-6567           AC018891.9         37190-42182
FEATURES             Location/Qualifiers
     source          1..6567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2q33.2"
     gene            1..6567
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="abl interactor 2"
                     /db_xref="GeneID:10152"
                     /db_xref="HGNC:HGNC:24011"
                     /db_xref="MIM:606442"
     exon            1..238
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             122..1750
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="isoform j is encoded by transcript variant 15;
                     abl-interacting protein 1 (SH3-containing protein); abl
                     binding protein 3; arg protein tyrosine kinase-binding
                     protein; abl-interactor protein 2b; abelson interactor 2;
                     arg-binding protein 1"
                     /codon_start=1
                     /product="abl interactor 2 isoform j"
                     /protein_id="NP_001362599.1"
                     /db_xref="CCDS:CCDS92932.1"
                     /db_xref="GeneID:10152"
                     /db_xref="HGNC:HGNC:24011"
                     /db_xref="MIM:606442"
                     /translation="MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQ
                     RALEETKAYTTQSLASVAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKE
                     KVARREIGILTTNKNTSRTHKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWLLRFK
                     VSTQNMKMGGLPRTTPPTQKPPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPT
                     RNMAPSQQSPVRTASVNQRNRTYSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTP
                     SPPSVFPAPAGSAGTPPLPATSASAPAPLVPATVPSSTAPDAAAGGAQTLADGFTSPT
                     PPVVSSTPPTGHPVQFYSMNRPASRHTPPTIGGSLPYRRPPSITSQTSLQNQMNGGPF
                     YSQNPVSLAPPPPSILQVTPQLPLMGFVARVQENISDTPPPPPPVEEPVFDESPPPPP
                     PPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIY
                     VIKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE"
     exon            239..406
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            407..583
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..601
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            602..699
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            700..846
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..971
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1154
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1313
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1400
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1574
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..6567
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6547..6552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="hexamer: AATAAA"
     polyA_site      6567
                     /gene="ABI2"
                     /gene_synonym="ABI-2; ABI2B; AblBP3; AIP-1; AIP1; argBP1;
                     argBPIA; argBPIB; SSH3BP2"
                     /note="major polyA site"
ORIGIN      
        1 ccttccgagt taccgccgcc gtcgccgccg ctcctcctct cccggtcctg ggtttccttg
       61 gcgctgcggc cgccgctccc tctgcgacct gtatgaggag gaggaggagg aggatgtgaa
      121 gatggcggag ctgcagatgc tgctggaaga ggaaatcccg gggggccgcc gggccctctt
      181 cgacagctac acaaatctgg aacgggtggc cgattactgc gagaacaact acatacagtc
      241 agcagataag cagagagccc tagaagaaac caaagcctac accacccaat ccttagcaag
      301 tgttgcctat ctgataaaca ccttggccaa caatgtcctg cagatgctgg atatccaggc
      361 atcccagcta cgaaggatgg aatcttcaat caatcatatt tcacaaacag ttgatattca
      421 taaagagaaa gttgcaagaa gagaaattgg tattttgact accaataaaa acacttcaag
      481 gacacataag attattgctc cagccaacct tgaacgacca gttcgttata ttagaaaacc
      541 tattgactat acaattctag atgatattgg acatggagta aagtggttgc ttagatttaa
      601 ggtgagtacc cagaacatga agatgggtgg gctgccgcgt acaacacctc caactcagaa
      661 gccccctagt ccccctatgt cagggaaagg gacacttggg cggcactccc cctatcgcac
      721 actggagcca gtgcgtcctc cagtggtacc aaatgattac gtacctagcc caacccgtaa
      781 tatggctccc tcgcagcaga gccctgtgag gacagcttct gtgaatcaaa gaaatcgaac
      841 ttacagcagc agtgggagta gtggagggag ccacccaagt agtcggagca gcagtcgaga
      901 gaacagtgga agtggtagtg tgggggttcc tattgctgtt cctactccat ctcctcccag
      961 tgtctttcca gcccctgctg gctctgctgg cactcctccc cttcctgcta cttctgcatc
     1021 tgcccctgct cctcttgttc ctgctactgt cccttcctcc actgccccag acgctgctgc
     1081 tgggggtgcc cagacccttg ctgatggctt cacttctcca actccccctg ttgtttcttc
     1141 cactccccct acaggtcatc ctgtacagtt ctacagcatg aataggcctg cctctcgcca
     1201 tactccccca acaatagggg gctcgttgcc ctatagacgc cctccttcca ttacttcaca
     1261 aacaagcctt cagaatcaga tgaatggagg acctttttat agccagaatc cagtatctct
     1321 tgctcctcct cctccctcca tcctacaggt aactcctcag ttacctttaa tgggatttgt
     1381 ggccagagtc caagaaaata tttcagatac accacctcca ccgccacctg tggaagaacc
     1441 agtctttgat gagtctcccc cacctcctcc tcctccagaa gattacgaag aggaggaagc
     1501 tgctgtggtt gagtatagtg atccttatgc tgaagaggac ccaccgtggg ctccacgttc
     1561 ttacttggaa aaggttgtgg caatttatga ctatacaaaa gacaaggaag atgagctgtc
     1621 ctttcaggaa ggagccatta tttatgtcat caagaagaat gacgatggtt ggtatgaggg
     1681 agttatgaat ggagtgactg ggctttttcc tgggaattac gttgagtcta tcatgcatta
     1741 ttctgagtaa agctcagcag ggctgtgctt gcctcacagg aatagtcagg tcttcccaga
     1801 ttatctgaag gccctgggga ttccactcca gtaaagtaga atgaaggata caaatgataa
     1861 aaattacact tttttttttg gtttattccc cagtattaaa aacaaagcaa gctgagtctg
     1921 aacaaatgga tctttctgcc atcatttgta caatgctgag ctgtctggat tgaaataaaa
     1981 tgaccatttt tatgtatgtc aaaggtataa cagcataact gtgtagccaa aacaaaatca
     2041 gattaagact gattcagaaa aatctgggat ctttctcagg aatactgtat acccttggga
     2101 tttctcctcc tgcagaatct gtggcattgg atgttcttca ttgcctgtgc taaggggtta
     2161 acctcatggc ccagtgggta ccctagcccc ttcttttctt ccacttgtat gaagaggagg
     2221 gaaccaacat ttaaatacca cacttaacca tttttacaat tatttcagat ggcttttttc
     2281 ctctgtgaca ctgtaaattc tgcattctct cagcacttga gtgcaccaaa cgagtgaatg
     2341 ctgaactcac ttgcatccct tcatgtttct gtttgtggat tataaggatg atgaaatgtg
     2401 aaagtctccc aacactctga gggtggtgaa cgattgccac ccgtttgatt ttaatgtgct
     2461 gctgcatgag actgcattgt tgctaatggc cagtgtaccc agatgtgaag tgtggtaggc
     2521 tggttcatat gtggaggtgg gtgtgtgaag ctagacacga aggtccctaa ggttctgaag
     2581 agacttgaac tgtggaaatg ctcttagcag gcatcccgaa cccctgcttc ggtgctgttt
     2641 tgaggagtag gatcttggag ttcagaccaa ctatgactat catttccttc actatctaga
     2701 aaaacgctat tctactttgg aagagaatag tagttatttt caagtctcct gacagtcact
     2761 gggagtacaa ggtttgctaa tgtgctctct ggacgttatt aatggccagt attagttgct
     2821 gctgtattac tgactcgctt agctgtagaa agggtaatac tctcctgatt ttgtatgatt
     2881 ggactcttaa gtagctgctg ttagtcagaa ttaaaaccca tctcagacta agaatataat
     2941 gaataagatt aataggccaa aatatgtatc taatcacatt gataaaaatt aatataactg
     3001 acacaataaa acacatttcc cccatctgta caataaatac agcttcaaat tcagtggagt
     3061 ctgtagggca gataacttta atcatcacta ctgtagtcag tataagaaat gctgaaaaaa
     3121 atccaggagg gcttgtctct ttgtgggtgg tcactgtgat gttgggccag ctcctgttca
     3181 ggtccagagc tgctaacgtg ggttctactc agtcccagtg acttggccag aatagagctt
     3241 tgccaggtaa ctgccctgtg ctaggtgaaa ggggaaaagc agtagctgga tatatttcaa
     3301 atgaggtttt gaacaagttc agaaagtgga acttgattga aaagtgaaca agtgtagtag
     3361 tgtgtgagaa aattcagatg gtgtcggatg cagaagttaa tattccactt aatgttatct
     3421 gagcattaaa aatcatcagc atttaactga gaccccacta tagagtttcc ttatcaagac
     3481 tttttggttt taaagttgtt tttaatgcat tgcaagttac aatagctatt ttgcttttag
     3541 atttttccca gcactttgta tttattagct ttcattaact tgcctccagt atacattcca
     3601 cttcgtgctt ttcttaggtc atttctacat cccttattcc ttgttttcct gcagtgtaat
     3661 ggccctgaat gtcctctgag ccttcagctc cattatggac ccaaactaga ctatacttgg
     3721 ataagttaag ctcttcttcg tgtactggtc tataattaga aaaactgttt taaattagat
     3781 gttcccatta tttatttaaa cagctttttg ctgagaaagc ttagtggatt aatgaggcag
     3841 agggtgtttt gaaatccaat aaatagttcc cacaggctgg gtgtggtggc ttatgcctgt
     3901 aatcccagca ctttcggagg ccgaggtggg tggatcatga ggtcaataaa ttgagaccat
     3961 cctggccaac atggtgaaac cccatctcta ctaaaaacac aaaaattagc tgggcgtggt
     4021 ggcgcacacc tgtagtccca gctacttggg aggctgaggc aggagaatca ctggaacctg
     4081 ggaggcagag gttgcagtga gccgagattg tgccactgca ctccagcctg gtgacagagc
     4141 gagactccat caaaaaaaaa aaaaaaaagt tcccacagct caccactaca gaagcaggga
     4201 agacaactat gcagaaaaca gagttagtgg cggtcagcag gaatgcagct ggtcttttgg
     4261 acccctacgg gatgggggca gtgcagaaga cactggtgaa gtcctttata ctgaagacct
     4321 gtggttggga gcaggggtag tccatgggtc tgctgatttt ttttccctat ttagtactaa
     4381 tgtgtgtgtg atctttgttt tacaaacagt accttttggg ttttctgcat attttataat
     4441 ttttgtacag ttttgaattc tatagattgt cttggaagga tactgtgtga tgggtcaggc
     4501 acacagtaat tggagacttt taatgtatgt aatatttcat agattgcatg ctattaatca
     4561 tctgtgaggg tagtattttt tgttttattg taagtttccc tcttttttta taaattaaaa
     4621 gatggttggt attaggaatt tcaaatgaat gcagaaaatc ttacatgctg tgtactatta
     4681 atattataac agacgatcca agtccaaaat ctgaccaata aagcaaccat tttatcaaga
     4741 tagagggatt ctaatgggag aggggattct tccctcctga agtttgtgtg tccagtcccc
     4801 ttaaaaaaaa tgaatagttg tcttttcttg tcatattaat actcgaaagt ccatggtggt
     4861 attaatgaaa gtacacttta ttgttgcctt tgaacttacg gccaaggcaa taaatcagaa
     4921 acaaaaatag tgccaatgtg tcaaaatcga catctgagag attcagcctc ccatttggaa
     4981 taaatatgaa tcttctaagc tatcttgttt aatattttcc atcatttagc tacttcctat
     5041 ctccctcaga ggcgcctgct gttcccattt tagagttgac agtggcctgc taattttgct
     5101 atgttcctaa aagttactgg gtgtgagaca ttttcatccc ctcctttttc ctactgctgg
     5161 tgtttattat ccagctagac aatattttat gcatatttac cgtgatgtct ggaccgtacc
     5221 tgtgctcctt ggcagtttat gttgaagata actaaagatt tttctctttg ggaggcatca
     5281 aaatgatggt agtttgcttt tatcttttta tgttcatttt cttttagtag gtgacctttc
     5341 tgcattaaga actgttttta tcttttacta ccttttcttt tctcctttgt ggagacagca
     5401 tgacatgtcc tgaaggtcac ctttgccttt gaaaaaggtt tgatggagga attcacaggt
     5461 gactgacaag tctttgaaaa gaatgggatc tgctcacttc tggtcttttt ggccgggaac
     5521 tcctgattgg tgttaaggtg gtaatttccc ccatataaga tttagaatca ctgagtttga
     5581 gctagatgaa atttttaaaa tttctggttg tctcattaga ctgatgaggt gagttttctt
     5641 cttcatatga acagctagtt aataacagca gagttctcac tcagtgctca gtacttaatt
     5701 ttccactgca ccacaactgt cttaactaaa tgtgctgtat ttttctttaa aagttaagag
     5761 ttctatttgg tgttttcagg aatatacgtg aaaagacatg ccatgttttg gtaaatacca
     5821 tcagagttgt gtaaaggcgt gtactaagtg caatcttaat ttgtggaaat aatcttcatt
     5881 tacccctcct aaaactacac tcagtataaa cactttccca taaggtgtgt gcagtaaaaa
     5941 tgttatatta ctccaacact ggcaggagca cagcacagca gccttattgg agagagcctt
     6001 ataaaagtga ttaaatggag gcattgagct cattaccttt aagtttactt tgtgctgacc
     6061 tttgttcctg ttttgagaat ctcatataat tattaaaaaa aaaaaacaat taaaacgaaa
     6121 cggcggggcc tagctgtgta taaatgatcc ttgctgaata tcttaaggtt ttttgtaaga
     6181 aaaaagaaaa accaacaaaa aaagcttatt ttcacattaa aatgaaacct cttttgcaac
     6241 ttaagaattc tatggaaaag cagtttttat catattttgt gtccatgcac catttttctt
     6301 aaaatggctt acaaaaaaga atgtaaacaa tttgtgatct ggccagttgt acttttagct
     6361 cccagaggga gagttggtgg tattatgagt tgagtaaaaa ccatccaggg gaacttgagg
     6421 gagcagtctg ttgccagtaa tgttccttgt gtgccattaa accacctcca gatgagtgga
     6481 ggaacatcac tttttaattt tttaattgta tttggaattg ttgccgtgta ctaagaactt
     6541 gacctaaata aaatcccaca aagtata
//
