LOCUS       NM_024527               2042 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens abhydrolase domain containing 8 (ABHD8), mRNA.
ACCESSION   NM_024527
VERSION     NM_024527.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2042)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2042)
  AUTHORS   Antoniou,A.C., Wang,X., Fredericksen,Z.S., McGuffog,L., Tarrell,R.,
            Sinilnikova,O.M., Healey,S., Morrison,J., Kartsonaki,C.,
            Lesnick,T., Ghoussaini,M., Barrowdale,D., Peock,S., Cook,M.,
            Oliver,C., Frost,D., Eccles,D., Evans,D.G., Eeles,R., Izatt,L.,
            Chu,C., Douglas,F., Paterson,J., Stoppa-Lyonnet,D., Houdayer,C.,
            Mazoyer,S., Giraud,S., Lasset,C., Remenieras,A., Caron,O.,
            Hardouin,A., Berthet,P., Hogervorst,F.B., Rookus,M.A., Jager,A.,
            van den Ouweland,A., Hoogerbrugge,N., van der Luijt,R.B.,
            Meijers-Heijboer,H., Gomez Garcia,E.B., Devilee,P., Vreeswijk,M.P.,
            Lubinski,J., Jakubowska,A., Gronwald,J., Huzarski,T., Byrski,T.,
            Gorski,B., Cybulski,C., Spurdle,A.B., Holland,H., Goldgar,D.E.,
            John,E.M., Hopper,J.L., Southey,M., Buys,S.S., Daly,M.B.,
            Terry,M.B., Schmutzler,R.K., Wappenschmidt,B., Engel,C., Meindl,A.,
            Preisler-Adams,S., Arnold,N., Niederacher,D., Sutter,C.,
            Domchek,S.M., Nathanson,K.L., Rebbeck,T., Blum,J.L., Piedmonte,M.,
            Rodriguez,G.C., Wakeley,K., Boggess,J.F., Basil,J., Blank,S.V.,
            Friedman,E., Kaufman,B., Laitman,Y., Milgrom,R., Andrulis,I.L.,
            Glendon,G., Ozcelik,H., Kirchhoff,T., Vijai,J., Gaudet,M.M.,
            Altshuler,D., Guiducci,C., Loman,N., Harbst,K., Rantala,J.,
            Ehrencrona,H., Gerdes,A.M., Thomassen,M., Sunde,L., Peterlongo,P.,
            Manoukian,S., Bonanni,B., Viel,A., Radice,P., Caldes,T., de la
            Hoya,M., Singer,C.F., Fink-Retter,A., Greene,M.H., Mai,P.L.,
            Loud,J.T., Guidugli,L., Lindor,N.M., Hansen,T.V., Nielsen,F.C.,
            Blanco,I., Lazaro,C., Garber,J., Ramus,S.J., Gayther,S.A.,
            Phelan,C., Narod,S., Szabo,C.I., Benitez,J., Osorio,A.,
            Nevanlinna,H., Heikkinen,T., Caligo,M.A., Beattie,M.S., Hamann,U.,
            Godwin,A.K., Montagna,M., Casella,C., Neuhausen,S.L., Karlan,B.Y.,
            Tung,N., Toland,A.E., Weitzel,J., Olopade,O., Simard,J., Soucy,P.,
            Rubinstein,W.S., Arason,A., Rennert,G., Martin,N.G.,
            Montgomery,G.W., Chang-Claude,J., Flesch-Janys,D., Brauch,H.,
            Severi,G., Baglietto,L., Cox,A., Cross,S.S., Miron,P., Gerty,S.M.,
            Tapper,W., Yannoukakos,D., Fountzilas,G., Fasching,P.A.,
            Beckmann,M.W., Dos Santos Silva,I., Peto,J., Lambrechts,D.,
            Paridaens,R., Rudiger,T., Forsti,A., Winqvist,R., Pylkas,K.,
            Diasio,R.B., Lee,A.M., Eckel-Passow,J., Vachon,C., Blows,F.,
            Driver,K., Dunning,A., Pharoah,P.P., Offit,K., Pankratz,V.S.,
            Hakonarson,H., Chenevix-Trench,G., Easton,D.F. and Couch,F.J.
  CONSRTM   EMBRACE; GEMO Study Collaborators; HEBON; kConFab; SWE-BRCA; MOD
            SQUAD; GENICA
  TITLE     A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation
            carriers and is associated with hormone receptor-negative breast
            cancer in the general population
  JOURNAL   Nat Genet 42 (10), 885-892 (2010)
   PUBMED   20852631
REFERENCE   3  (bases 1 to 2042)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA137174.1, DA357595.1 and BC039087.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024527.4.
            
            Summary: This gene is upstream of, and in a head-to-head
            orientation with the gene for the mitochondrial ribosomal protein
            L34. The predicted protein contains alpha/beta hydrolase fold and
            secretory lipase domains. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK021805.1, SRR3476690.934146.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247706.4/ ENSP00000247706.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-96                DA137174.1         49-144
            97-107              DA357595.1         134-144
            108-2042            BC039087.1         1-1935
FEATURES             Location/Qualifiers
     source          1..2042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..2042
                     /gene="ABHD8"
                     /note="abhydrolase domain containing 8"
                     /db_xref="GeneID:79575"
                     /db_xref="HGNC:HGNC:23759"
                     /db_xref="MIM:621036"
     exon            1..184
                     /gene="ABHD8"
                     /inference="alignment:Splign:2.1.0"
     exon            185..953
                     /gene="ABHD8"
                     /inference="alignment:Splign:2.1.0"
     CDS             193..1512
                     /gene="ABHD8"
                     /note="abhydrolase domain-containing protein 8; alpha/beta
                     hydrolase domain-containing protein 8"
                     /codon_start=1
                     /product="protein ABHD8"
                     /protein_id="NP_078803.4"
                     /db_xref="CCDS:CCDS12355.1"
                     /db_xref="GeneID:79575"
                     /db_xref="HGNC:HGNC:23759"
                     /db_xref="MIM:621036"
                     /translation="MLTGVTDGIFCCLLGTPPNAVGPLESVESSDGYTFVEVKPGRVL
                     RVKHAGPAPAAAPPPPSSASSDAAQGDLSGLVRCQRRITVYRNGRLLVENLGRAPRAD
                     LLHGQNGSGEPPAALEVELADPAGSDGRLAPGSAGSGSGSGSGGRRRRARRPKRTIHI
                     DCEKRITSCKGAQADVVLFFIHGVGGSLAIWKEQLDFFVRLGYEVVAPDLAGHGASSA
                     PQVAAAYTFYALAEDMRAIFKRYAKKRNVLIGHSYGVSFCTFLAHEYPDLVHKVIMIN
                     GGGPTALEPSFCSIFNMPTCVLHCLSPCLAWSFLKAGFARQGAKEKQLLKEGNAFNVS
                     SFVLRAMMSGQYWPEGDEVYHAELTVPVLLVHGMHDKFVPVEEDQRMAEILLLAFLKL
                     IDEGSHMVMLECPETVNTLLHEFLLWEPEPSPKALPEPLPAPPEDKK"
     exon            954..1124
                     /gene="ABHD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1341
                     /gene="ABHD8"
                     /inference="alignment:Splign:2.1.0"
     exon            1342..2042
                     /gene="ABHD8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2020..2025
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD8"
                     /note="hexamer: AATAAA"
     polyA_site      2042
                     /gene="ABHD8"
                     /note="major polyA site"
ORIGIN      
        1 aaagggccgg ctgtttcggc ggccgcggga tgcccctgcg ctgaccgcca ggggcaggtg
       61 cccgcccgcg tagacgcacc cggcctgacc ccgcgccacc atgtaaacgg cgccagcagg
      121 cggacgctgg cttctccgcc tgggacccct ccgccccgac ccgggccccg cggccctcga
      181 tgaggacaca ccatgctgac cggggtgacc gacggtatct tctgttgcct gctgggcacg
      241 ccccccaacg ccgtggggcc actggagagc gtcgagtcca gcgatggcta cacctttgta
      301 gaggtcaagc ccggccgcgt gctgcgggtg aagcatgcag gacccgcccc agccgctgcc
      361 ccacctccac catcatccgc atcctcggat gcagcccagg gggacctctc cggcttggtc
      421 cgctgtcagc gccggatcac cgtgtaccgc aatgggcggt tgctggtgga aaacctgggc
      481 cgagcccctc gagccgacct cctacacggg cagaatggct ctggggagcc gccggccgcc
      541 ctggaggtgg agctggcaga tccggcgggc agcgatggcc gcttggcccc cggcagcgca
      601 ggcagcggca gcggcagtgg cagtggtggg cggcggcggc gagccaggcg ccccaagagg
      661 accatccata ttgactgtga gaagcgcatc actagctgca aaggcgccca ggccgacgtg
      721 gtgctctttt tcatccatgg tgtcggcggt tccctggcca tctggaagga gcagctggac
      781 ttctttgtgc gcctaggcta tgaggtggtg gctcctgacc tggccggcca cggggccagc
      841 tctgcgcccc aggtggccgc agcctacacc ttctatgcgc tggctgagga catgcgagca
      901 atcttcaagc gctatgccaa gaagcgaaat gtgctcattg gccattccta cggtgtctct
      961 ttctgcacat tcctggcaca tgagtaccca gacctagtgc acaaggtgat catgatcaat
     1021 ggcgggggcc ctacggcgct ggagcccagc ttctgctcaa tcttcaacat gcccacctgc
     1081 gtcctgcact gcttgtcgcc ctgcctggcc tggagcttcc tcaaggccgg cttcgcccgc
     1141 caaggagcca aggagaagca gctgttaaag gagggcaacg ctttcaacgt gtcatccttc
     1201 gtactccggg ccatgatgag cggccagtac tggcccgagg gcgacgaggt ctaccacgcc
     1261 gagctcaccg tgcccgtcct gcttgtccac ggcatgcacg ataagtttgt gccggtggag
     1321 gaagaccagc gcatggccga gatcctgctc ctggcattcc tgaagctcat cgacgagggc
     1381 agccacatgg tgatgctgga atgccctgag acggtcaaca cgctgctcca cgaattcctg
     1441 ctctgggagc ccgagccctc gcccaaggct ctaccggagc cactgccggc gcctccagaa
     1501 gacaagaagt agccgctggg ccggcggggc atcgcttggt gagcacagcc gcagcaggag
     1561 gaggcccgag cctgcgccag gtctgcagcg cagaccacct gggcgggccg ttcgctccgg
     1621 tgggcggggc caggtcaggg agacgccccc aggctgcctg ggcggggcgt ggcatccgag
     1681 ggagcccagc ggacattccg ctctccgctt ccgtcccgcg gggcccatcg gcgttttggg
     1741 gccgcagccg ggaccctcac ggaagatgac cttgtacaga agctctccct caccttcccc
     1801 ccaacgccac ggccaaggca ggccccccac cccgctgtct tccgtgtcag ccgtgcttga
     1861 tcctgggacc cacgagcccc acagggaccc tcgaggcccc atcccgttat ccgagaccct
     1921 tcctaccccc cattcctcgg cgctgggagc tatttttgcc caaggggggg ggatgggggg
     1981 gctggcgcca ccgaacctgc acatctcaac ttgtaactca ataaacagaa gtgacaatcg
     2041 ga
//
