LOCUS       NP_078803                439 aa            linear   PRI 27-MAR-2025
DEFINITION  protein ABHD8 [Homo sapiens].
ACCESSION   NP_078803
VERSION     NP_078803.4
DBSOURCE    REFSEQ: accession NM_024527.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 439)
  AUTHORS   Yang,S., Li,M., Lian,G., Wu,Y., Cui,J. and Wang,L.
  TITLE     ABHD8 antagonizes inflammation by facilitating chaperone-mediated
            autophagy-mediated degradation of NLRP3
  JOURNAL   Autophagy 21 (2), 338-351 (2025)
   PUBMED   39225180
REFERENCE   2  (residues 1 to 439)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (residues 1 to 439)
  AUTHORS   Antoniou,A.C., Wang,X., Fredericksen,Z.S., McGuffog,L., Tarrell,R.,
            Sinilnikova,O.M., Healey,S., Morrison,J., Kartsonaki,C.,
            Lesnick,T., Ghoussaini,M., Barrowdale,D., Peock,S., Cook,M.,
            Oliver,C., Frost,D., Eccles,D., Evans,D.G., Eeles,R., Izatt,L.,
            Chu,C., Douglas,F., Paterson,J., Stoppa-Lyonnet,D., Houdayer,C.,
            Mazoyer,S., Giraud,S., Lasset,C., Remenieras,A., Caron,O.,
            Hardouin,A., Berthet,P., Hogervorst,F.B., Rookus,M.A., Jager,A.,
            van den Ouweland,A., Hoogerbrugge,N., van der Luijt,R.B.,
            Meijers-Heijboer,H., Gomez Garcia,E.B., Devilee,P., Vreeswijk,M.P.,
            Lubinski,J., Jakubowska,A., Gronwald,J., Huzarski,T., Byrski,T.,
            Gorski,B., Cybulski,C., Spurdle,A.B., Holland,H., Goldgar,D.E.,
            John,E.M., Hopper,J.L., Southey,M., Buys,S.S., Daly,M.B.,
            Terry,M.B., Schmutzler,R.K., Wappenschmidt,B., Engel,C., Meindl,A.,
            Preisler-Adams,S., Arnold,N., Niederacher,D., Sutter,C.,
            Domchek,S.M., Nathanson,K.L., Rebbeck,T., Blum,J.L., Piedmonte,M.,
            Rodriguez,G.C., Wakeley,K., Boggess,J.F., Basil,J., Blank,S.V.,
            Friedman,E., Kaufman,B., Laitman,Y., Milgrom,R., Andrulis,I.L.,
            Glendon,G., Ozcelik,H., Kirchhoff,T., Vijai,J., Gaudet,M.M.,
            Altshuler,D., Guiducci,C., Loman,N., Harbst,K., Rantala,J.,
            Ehrencrona,H., Gerdes,A.M., Thomassen,M., Sunde,L., Peterlongo,P.,
            Manoukian,S., Bonanni,B., Viel,A., Radice,P., Caldes,T., de la
            Hoya,M., Singer,C.F., Fink-Retter,A., Greene,M.H., Mai,P.L.,
            Loud,J.T., Guidugli,L., Lindor,N.M., Hansen,T.V., Nielsen,F.C.,
            Blanco,I., Lazaro,C., Garber,J., Ramus,S.J., Gayther,S.A.,
            Phelan,C., Narod,S., Szabo,C.I., Benitez,J., Osorio,A.,
            Nevanlinna,H., Heikkinen,T., Caligo,M.A., Beattie,M.S., Hamann,U.,
            Godwin,A.K., Montagna,M., Casella,C., Neuhausen,S.L., Karlan,B.Y.,
            Tung,N., Toland,A.E., Weitzel,J., Olopade,O., Simard,J., Soucy,P.,
            Rubinstein,W.S., Arason,A., Rennert,G., Martin,N.G.,
            Montgomery,G.W., Chang-Claude,J., Flesch-Janys,D., Brauch,H.,
            Severi,G., Baglietto,L., Cox,A., Cross,S.S., Miron,P., Gerty,S.M.,
            Tapper,W., Yannoukakos,D., Fountzilas,G., Fasching,P.A.,
            Beckmann,M.W., Dos Santos Silva,I., Peto,J., Lambrechts,D.,
            Paridaens,R., Rudiger,T., Forsti,A., Winqvist,R., Pylkas,K.,
            Diasio,R.B., Lee,A.M., Eckel-Passow,J., Vachon,C., Blows,F.,
            Driver,K., Dunning,A., Pharoah,P.P., Offit,K., Pankratz,V.S.,
            Hakonarson,H., Chenevix-Trench,G., Easton,D.F. and Couch,F.J.
  CONSRTM   EMBRACE; GEMO Study Collaborators; HEBON; kConFab; SWE-BRCA; MOD
            SQUAD; GENICA
  TITLE     A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation
            carriers and is associated with hormone receptor-negative breast
            cancer in the general population
  JOURNAL   Nat Genet 42 (10), 885-892 (2010)
   PUBMED   20852631
REFERENCE   4  (residues 1 to 439)
  AUTHORS   Kang,D., Oh,S., Ahn,S.M., Lee,B.H. and Moon,M.H.
  TITLE     Proteomic analysis of exosomes from human neural stem cells by flow
            field-flow fractionation and nanoflow liquid chromatography-tandem
            mass spectrometry
  JOURNAL   J Proteome Res 7 (8), 3475-3480 (2008)
   PUBMED   18570454
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA137174.1, DA357595.1 and BC039087.1.
            
            On Apr 23, 2007 this sequence version replaced NP_078803.3.
            
            Summary: This gene is upstream of, and in a head-to-head
            orientation with the gene for the mitochondrial ribosomal protein
            L34. The predicted protein contains alpha/beta hydrolase fold and
            secretory lipase domains. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK021805.1, SRR3476690.934146.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000247706.4/ ENSP00000247706.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..439
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     Protein         1..439
                     /product="protein ABHD8"
                     /note="abhydrolase domain-containing protein 8; alpha/beta
                     hydrolase domain-containing protein 8"
                     /calculated_mol_wt=47200
     Region          49..70
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96I13.1)"
     Region          124..156
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q96I13.1)"
     Region          171..416
                     /region_name="MenH"
                     /note="2-succinyl-6-hydroxy-2,
                     4-cyclohexadiene-1-carboxylate synthase MenH and related
                     esterases, alpha/beta hydrolase fold [Coenzyme transport
                     and metabolism, General function prediction only];
                     COG0596"
                     /db_xref="CDD:440361"
     CDS             1..439
                     /gene="ABHD8"
                     /coded_by="NM_024527.5:193..1512"
                     /db_xref="CCDS:CCDS12355.1"
                     /db_xref="GeneID:79575"
                     /db_xref="HGNC:HGNC:23759"
                     /db_xref="MIM:621036"
ORIGIN      
        1 mltgvtdgif ccllgtppna vgplesvess dgytfvevkp grvlrvkhag papaaapppp
       61 ssassdaaqg dlsglvrcqr ritvyrngrl lvenlgrapr adllhgqngs geppaaleve
      121 ladpagsdgr lapgsagsgs gsgsggrrrr arrpkrtihi dcekritsck gaqadvvlff
      181 ihgvggslai wkeqldffvr lgyevvapdl aghgassapq vaaaytfyal aedmraifkr
      241 yakkrnvlig hsygvsfctf laheypdlvh kvimingggp talepsfcsi fnmptcvlhc
      301 lspclawsfl kagfarqgak ekqllkegna fnvssfvlra mmsgqywpeg devyhaeltv
      361 pvllvhgmhd kfvpveedqr maeilllafl klidegshmv mlecpetvnt llhefllwep
      421 epspkalpep lpappedkk
//
