LOCUS       NM_022060               3051 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 4, N-acyl phospholipase
            B (ABHD4), transcript variant 1, mRNA.
ACCESSION   NM_022060
VERSION     NM_022060.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3051)
  AUTHORS   Laszlo,Z.I., Lele,Z., Zoldi,M., Miczan,V., Mogor,F., Simon,G.M.,
            Mackie,K., Kacskovics,I., Cravatt,B.F. and Katona,I.
  TITLE     ABHD4-dependent developmental anoikis safeguards the embryonic
            brain
  JOURNAL   Nat Commun 11 (1), 4363 (2020)
   PUBMED   32868797
  REMARK    GeneRIF: ABHD4-dependent developmental anoikis safeguards the
            embryonic brain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3051)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3051)
  AUTHORS   Lee,H.C., Simon,G.M. and Cravatt,B.F.
  TITLE     ABHD4 regulates multiple classes of N-acyl phospholipids in the
            mammalian central nervous system
  JOURNAL   Biochemistry 54 (15), 2539-2549 (2015)
   PUBMED   25853435
REFERENCE   4  (bases 1 to 3051)
  AUTHORS   Simpson,C.D., Hurren,R., Kasimer,D., MacLean,N., Eberhard,Y.,
            Ketela,T., Moffat,J. and Schimmer,A.D.
  TITLE     A genome wide shRNA screen identifies alpha/beta hydrolase domain
            containing 4 (ABHD4) as a novel regulator of anoikis resistance
  JOURNAL   Apoptosis 17 (7), 666-678 (2012)
   PUBMED   22488300
  REMARK    GeneRIF: ABHD4 is a novel genetic regulator of anoikis sensitivity.
REFERENCE   5  (bases 1 to 3051)
  AUTHORS   Simon,G.M. and Cravatt,B.F.
  TITLE     Endocannabinoid biosynthesis proceeding through
            glycerophospho-N-acyl ethanolamine and a role for
            alpha/beta-hydrolase 4 in this pathway
  JOURNAL   J Biol Chem 281 (36), 26465-26472 (2006)
   PUBMED   16818490
  REMARK    GeneRIF: Lysophospholipase/phospholipase B (EC 3.1.1.5) specific
            for N-acyl phosphatidylethanolamine (NAPE) suggesting a role in the
            biosynthesis of N-acyl ethanolamines including the endocannabinoid
            anandamide.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243965.2.
            
            On Feb 1, 2021 this sequence version replaced NM_022060.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024779.1, AK022878.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000428304.7/ ENSP00000414558.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AC243965.2         186749-186778
            31-119              AC243965.2         190116-190204
            120-492             AC243965.2         191839-192211
            493-647             AC243965.2         192374-192528
            648-759             AC243965.2         194871-194982
            760-946             AC243965.2         198173-198359
            947-3051            AC243965.2         199308-201412
FEATURES             Location/Qualifiers
     source          1..3051
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q11.2"
     gene            1..3051
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /note="abhydrolase domain containing 4, N-acyl
                     phospholipase B"
                     /db_xref="GeneID:63874"
                     /db_xref="HGNC:HGNC:20154"
                     /db_xref="MIM:619728"
     exon            1..30
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     CDS             8..1036
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /note="isoform a is encoded by transcript variant 1;
                     abhydrolase domain-containing protein 4;
                     alpha/beta-hydrolase 4;
                     lyso-N-acylphosphatidylethanolamine lipase; alpha/beta
                     hydrolase domain-containing protein 4; protein ABHD4;
                     (Lyso)-N-acylphosphatidylethanolamine lipase"
                     /codon_start=1
                     /product="(Lyso)-N-acylphosphatidylethanolamine lipase
                     isoform a"
                     /protein_id="NP_071343.2"
                     /db_xref="CCDS:CCDS9572.1"
                     /db_xref="GeneID:63874"
                     /db_xref="HGNC:HGNC:20154"
                     /db_xref="MIM:619728"
                     /translation="MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFL
                     ARYVSLPNQNKIWTVTVSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDL
                     LGFGRSSRPAFPRDPEGAEDEFVTSIETWRETMGIPSMILLGHSLGGFLATSYSIKYP
                     DRVKHLILVDPWGFPLRPTNPSEIRAPPAWVKAVASVLGRSNPLAVLRVAGPWGPGLV
                     QRFRPDFKRKFADFFEDDTISEYIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHL
                     IRKDVPITMIYGSDTWIDTSTGKKVKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVV
                     EEICDSVD"
     exon            31..119
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     exon            120..492
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     exon            493..647
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     exon            648..759
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     exon            760..946
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     exon            947..3051
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /note="hexamer: AATAAA"
     polyA_site      2447
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /note="major polyA site"
     regulatory      2932..2937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /note="hexamer: TATAAA"
     polyA_site      2951
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
     regulatory      3026..3031
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
                     /note="hexamer: AATAAA"
     polyA_site      3051
                     /gene="ABHD4"
                     /gene_synonym="ABH4"
ORIGIN      
        1 gtttactatg gccgatgatc tggagcagca gtctcaaggc tggctgagta gctggctgcc
       61 cacgtggcgc cccacttcca tgtctcagct gaagaatgtg gaagccagga tcctccagtg
      121 tctccagaat aagttcctgg ccagatatgt atccctccca aaccagaata agatctggac
      181 ggtgactgtg agccccgagc aaaacgaccg cacccccttg gtgatggtgc atggttttgg
      241 gggcggcgtg ggtctctgga tcctcaacat ggactcactg agtgcccgcc gcacactgca
      301 caccttcgat ctgcttggct tcgggcgaag ctcaaggcca gcattcccaa gggacccgga
      361 gggggctgag gatgagtttg tgacatcgat agagacatgg cgggagacca tggggatccc
      421 cagcatgatc ctcctggggc acagtttggg aggattcctg gccacttctt actcaatcaa
      481 gtaccctgat agagttaaac acctcatcct ggtggaccca tggggctttc ccctccgacc
      541 aactaacccc agtgagatcc gtgcaccccc agcctgggtc aaagccgtgg catctgtcct
      601 aggacgttcc aatccattgg ctgttcttcg agtagctggg ccctgggggc ctggtctggt
      661 gcagcgattc cggccggact tcaaacgcaa gtttgcagac ttctttgaag atgataccat
      721 atcagagtat atttaccact gcaacgcaca gaatcccagt ggtgagacag cattcaaagc
      781 catgatggag tcctttggct gggcccggcg ccctatgctg gagcgaattc acttgattcg
      841 aaaagatgtg cctatcacta tgatctacgg gtccgacacc tggatagata ccagtacggg
      901 aaaaaaggtg aagatgcagc ggccggattc ctatgtccga gacatggaga ttaagggtgc
      961 ctcccaccat gtctatgctg accagccaca catcttcaat gctgtggtgg aggagatctg
     1021 cgactcagtt gattgagctg ctctctgaag aggaagagga gaaagccaga gagtcactct
     1081 tacctccctg tctgcttact cacccactct gtcctttcct caccaactaa catgtgccag
     1141 ccaggcagag tcttgtgctg ttcccagaac aggacgacag tgaaaagaac actcttgacc
     1201 ctacactgaa ggctgaaggc agaagccaca agaggccttg agtgccaccc ccagggaaga
     1261 acataaaggg ttgcacaatg ccacccatcc actccttgcc aagtgttacc cagatggtgg
     1321 aggatgtgaa gggattgcac caagccacat tcactctctc tgtggccttt cttcctctgg
     1381 gcaaagaagg gcttccagtg gcctttcctc actctgtagt gtttgtgggg ataggttcca
     1441 tgcaagaaca ccttcctcct ccatccccca cttcacccca tcccatacca gttccatcca
     1501 gggtctgctt aactgccaag agcaggtcct ggagttccct tcacctgcag agtccttttc
     1561 atgacctagg aggtcttatt caaagccctc attgacagag gaggaaacag gccaaggcag
     1621 gacatggctg gaccatggtg atacagctct gtgtgattca agttctggca gagcttgtaa
     1681 ggctagagcc caggtctgcc gacaccctgt gcttgttgca cacttgattt gctaaggctg
     1741 gagacaggca ccattgccat ggggctggtc ctagtcactg gccgaggata agcccgtccc
     1801 tgtcccacat tctagcccca ctatgcgggg gtgctgttgt cctgcctgtg tctcatcccc
     1861 ggctgcctaa gctagggaca ctcaagtgct tccttccttg ccccatcttc ctcccaactg
     1921 gaggcctctg agcctcccct gtgccttggg ccctgaagcc ccatatgtag tatagagcaa
     1981 aggtggctcc tggtgaagag agggtggaaa ggcccttcag ccccagggcc atgtctgggt
     2041 tctccatgcc catcagtctc tgcagtttct ctacctgccc ccagagctga ggccatctgc
     2101 aagcccctgc ccatggccca atggggagcc tccagccaca agttccctgt ccttatcagc
     2161 cactgggtgg ttcccactgc atgaccctct atccctgcca tctgtcccca tggtttccag
     2221 ctcaatccac ccctgaccca tctgtcagct ttttcccagg gagccgtttc aggggttctg
     2281 ggcagtaggc tgggcctggc ctcagaacct ggtggctcct gcctgctcct tcacttttgt
     2341 aaaaccatcc ccttcaccag aatggtatta actcctggtg ctttgtacta ctggtccagc
     2401 tgccctgggc tccttttcta tattaataaa gaaacgagta aaaattaccg gtggggatga
     2461 tgtttaaaat tgctctgatc actggtggtg ctgaattcgc aacagcctgt gtgatgcctg
     2521 agagaaggga gtcctgaggg ttgcctgcct acccacgact ccttctcctt ttagtgtggc
     2581 gtttgcccgc tagacccagc ccagagtcca ggtcagcaca ggccctctca gccaaccact
     2641 catgacaaat gaggagtcga gatccacagt gtggatgggg caagccccag ttcacagtag
     2701 agaggtggaa cttagtactt cctgctgccc attagacacc ctttcttcct aagttcaagg
     2761 gaagcccaca catgtactgc tccctgcatc ctgctctaac ttcctctcat cctctggatc
     2821 tcagctcaaa tattccttat gcagagatgc cttcccctga ttccctaaac tagactcgga
     2881 cccctctgtt ctgcatctct gtggcatatc atctgcccct tttgtaaaac ttataaactt
     2941 gtggttactt gtttagcgtc tctttcctcc ccagaccata agcaacataa agacaaaggg
     3001 tacatctagc acatagttcg tgttcaataa atgtttgttt tcatcatgcc a
//
