LOCUS       NM_138340               2029 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 3, phospholipase
            (ABHD3), transcript variant 1, mRNA.
ACCESSION   NM_138340
VERSION     NM_138340.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2029)
  AUTHORS   Demirkan,A., van Duijn,C.M., Ugocsai,P., Isaacs,A.,
            Pramstaller,P.P., Liebisch,G., Wilson,J.F., Johansson,A., Rudan,I.,
            Aulchenko,Y.S., Kirichenko,A.V., Janssens,A.C., Jansen,R.C.,
            Gnewuch,C., Domingues,F.S., Pattaro,C., Wild,S.H., Jonasson,I.,
            Polasek,O., Zorkoltseva,I.V., Hofman,A., Karssen,L.C.,
            Struchalin,M., Floyd,J., Igl,W., Biloglav,Z., Broer,L., Pfeufer,A.,
            Pichler,I., Campbell,S., Zaboli,G., Kolcic,I., Rivadeneira,F.,
            Huffman,J., Hastie,N.D., Uitterlinden,A., Franke,L., Franklin,C.S.,
            Vitart,V., Nelson,C.P., Preuss,M., Bis,J.C., O'Donnell,C.J.,
            Franceschini,N., Witteman,J.C., Axenovich,T., Oostra,B.A.,
            Meitinger,T., Hicks,A.A., Hayward,C., Wright,A.F., Gyllensten,U.,
            Campbell,H. and Schmitz,G.
  CONSRTM   DIAGRAM Consortium; CARDIoGRAM Consortium; CHARGE Consortium;
            EUROSPAN consortium
  TITLE     Genome-wide association study identifies novel loci associated with
            circulating phospho- and sphingolipid concentrations
  JOURNAL   PLoS Genet 8 (2), e1002490 (2012)
   PUBMED   22359512
REFERENCE   2  (bases 1 to 2029)
  AUTHORS   Long,J.Z., Cisar,J.S., Milliken,D., Niessen,S., Wang,C.,
            Trauger,S.A., Siuzdak,G. and Cravatt,B.F.
  TITLE     Metabolomics annotates ABHD3 as a physiologic regulator of
            medium-chain phospholipids
  JOURNAL   Nat Chem Biol 7 (11), 763-765 (2011)
   PUBMED   21926997
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2029)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Cloning and tissue distribution of three murine alpha/beta
            hydrolase fold protein cDNAs
  JOURNAL   Biochem Biophys Res Commun 292 (3), 617-625 (2002)
   PUBMED   11922611
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB126083.1 and BC021196.2.
            
            On Nov 23, 2018 this sequence version replaced NM_138340.4.
            
            Summary: This gene encodes a protein containing an alpha/beta
            hydrolase fold, which is a catalytic domain found in a very wide
            range of enzymes. The function of this protein has not been
            determined. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.1165180.1,
                                           SRR1163658.273732.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000289119.7/ ENSP00000289119.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-116               DB126083.1         32-147
            117-2029            BC021196.2         108-2020
FEATURES             Location/Qualifiers
     source          1..2029
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q11.2"
     gene            1..2029
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /note="abhydrolase domain containing 3, phospholipase"
                     /db_xref="GeneID:171586"
                     /db_xref="HGNC:HGNC:18718"
                     /db_xref="MIM:612197"
     exon            1..271
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1339
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /EC_number="3.1.1.4"
                     /EC_number="3.1.1.32"
                     /note="isoform 1 is encoded by transcript variant 1; lung
                     alpha/beta hydrolase 3; abhydrolase domain-containing
                     protein 3; alpha/beta hydrolase domain containing protein
                     3; phospholipase ABHD3"
                     /codon_start=1
                     /product="phospholipase ABHD3 isoform 1"
                     /protein_id="NP_612213.2"
                     /db_xref="CCDS:CCDS32802.1"
                     /db_xref="GeneID:171586"
                     /db_xref="HGNC:HGNC:18718"
                     /db_xref="MIM:612197"
                     /translation="MQRLAMDLRMLSRELSLYLEHQVRVGFFGSGVGLSLILGFSVAY
                     AFYYLSSIAKKPQLVTGGESFSRFLQDHCPVVTETYYPTVWCWEGRGQTLLRPFITSK
                     PPVQYRNELIKTADGGQISLDWFDNDNSTCYMDASTRPTILLLPGLTGTSKESYILHM
                     IHLSEELGYRCVVFNNRGVAGENLLTPRTYCCANTEDLETVIHHVHSLYPSAPFLAAG
                     VSMGGMLLLNYLGKIGSKTPLMAAATFSVGWNTFACSESLEKPLNWLLFNYYLTTCLQ
                     SSVNKHRHMFVKQVDMDHVMKAKSIREFDKRFTSVMFGYQTIDDYYTDASPSPRLKSV
                     GIPVLCLNSVDDVFSPSHAIPIETAKQNPNVALVLTSYGGHIGFLEGIWPRQSTYMDR
                     VFKQFVQAMVEHGHELS"
     exon            272..435
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            436..618
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            619..664
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            665..777
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            778..951
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            952..1000
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1001..1166
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..2029
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2009..2014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="ABHD3"
                     /gene_synonym="LABH3"
                     /note="major polyA site"
ORIGIN      
        1 actgtggtcg ggagtaggca gcggcgccgc gtccgctctc gcccgctctc gcccgctcgc
       61 cagccggctc tcctcccgcc gcaggacccg cgcgccgcgc tcgggggcca tgcagcgcct
      121 ggccatggac ctgcggatgt tgtcccggga gctctccctc tacctggaac accaagtccg
      181 ggtggggttc ttcggctcgg gggtgggctt atcccttatc ctgggcttca gcgtcgctta
      241 tgccttctac tacctgagca gcattgccaa gaaaccccag ttagtgaccg ggggtgagag
      301 tttcagccgc ttccttcaag accactgtcc cgtggttaca gaaacgtact acccgacggt
      361 ctggtgctgg gagggtcgag gacagaccct gcttagacct ttcatcactt cgaagccccc
      421 ggtgcagtac aggaatgaac ttattaaaac tgcagatgga ggacagattt cactggactg
      481 gtttgataat gataacagta cgtgttatat ggatgccagc accagaccta ctatcttatt
      541 gttgcctggc ctcacgggaa caagcaagga gtcatatatc cttcatatga tccatcttag
      601 tgaagaatta ggatacagat gtgtggtttt taacaacaga ggagtggcgg gggagaatct
      661 cttgacgcca aggacttatt gttgtgctaa cactgaagac ttggagacag ttattcacca
      721 tgtacacagc ctgtaccctt ctgctccttt cctggcagca ggggtttcaa tgggaggaat
      781 gctgcttcta aattacttgg gcaaaattgg gtccaaaacg cctttgatgg cagctgcaac
      841 tttttccgtt ggttggaaca ccttcgcttg ctcagagtca ttggaaaaac cactgaactg
      901 gctacttttt aattactatt tgacaacctg ccttcagtct tcagttaata agcaccgaca
      961 tatgtttgta aaacaagttg atatggatca tgtcatgaag gctaaatcca tcagagagtt
     1021 tgataagcga ttcacttcag tcatgtttgg ataccaaaca attgatgatt attatactga
     1081 tgccagtccg agtcctagac tgaagtcagt aggaattcca gtattgtgtc taaattctgt
     1141 ggatgatgtt ttctcaccca gtcatgctat tccaatagaa actgctaagc aaaatcctaa
     1201 tgttgctttg gtccttactt cttatggagg ccatattggt tttctggagg gaatctggcc
     1261 aagacagtcc acttacatgg atcgtgtctt caagcaattt gtgcaagcca tggttgagca
     1321 tggacatgaa ctctcttaac atgtagttct ttgggtgcat tttgtctgaa ccacaattgt
     1381 gaaggcagct cagcttagtg cacaaatttt aactgttgta tataaagcaa ataagccagc
     1441 agatgggtga agaggtccag aatgatatgc aaaaactact ttttagagaa acaaaacaac
     1501 tttgtagcaa caaattaaat atagtattag attgttactt acgtagattt tatttttact
     1561 atgccttacc aagtacatcc ttaaacaaag tagtatgtac atgaaattgc acttaaccaa
     1621 aactattgtg taaaacaaat tttaattcct cagggtttta atttaaacta gtattttttt
     1681 agattatttg ttttaggtga tttaatggta ctttaataac tactaagaaa tattggctat
     1741 ttcaatgtaa gttataaggt ggtacattcc taagggtatt tatagttgat gataacatga
     1801 aaactgaaat aagataaaat acaacgtgct aaatctttta tgtattctaa ctttaaaaga
     1861 caagtgcaac aaagttagac tgacttctat atgtgctctt ttactctgat aatattaaat
     1921 taggactaac ttatgtttta taatgattat aatttacatg cttattttta aaatagtata
     1981 tgtggacaca tatatatcat tatattaaaa taaattctac cattttaaa
//
