LOCUS       NM_152924               8424 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 2, acylglycerol lipase
            (ABHD2), transcript variant 2, mRNA.
ACCESSION   NM_152924
VERSION     NM_152924.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8424)
  AUTHORS   Lv,M.Y., Jin,L.L., Sang,X.Q., Shi,W.C., Qiang,L.X., Lin,Q.Y. and
            Jin,S.D.
  TITLE     Abhd2, a Candidate Gene Regulating Airway Remodeling in COPD via
            TGF-beta
  JOURNAL   Int J Chron Obstruct Pulmon Dis 19, 33-50 (2024)
   PUBMED   38197032
  REMARK    GeneRIF: Abhd2, a Candidate Gene Regulating Airway Remodeling in
            COPD via TGF-beta.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8424)
  AUTHORS   De Toni,L., Cosci,I., Sabovic,I., Di Nisio,A., Guidolin,D.,
            Pedrucci,F., Finocchi,F., Dall'Acqua,S., Foresta,C., Ferlin,A. and
            Garolla,A.
  TITLE     Membrane Cholesterol Inhibits Progesterone-Mediated Sperm Function
            through the Possible Involvement of ABHD2
  JOURNAL   Int J Mol Sci 24 (11), 9254 (2023)
   PUBMED   37298205
  REMARK    GeneRIF: Membrane Cholesterol Inhibits Progesterone-Mediated Sperm
            Function through the Possible Involvement of ABHD2.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8424)
  AUTHORS   Zhao,F., Jia,Z., Feng,Y., Li,Z. and Feng,J.
  TITLE     Circular RNA circ_0079593 enhances malignant melanoma progression
            by the regulation of the miR-573/ABHD2 axis
  JOURNAL   J Dermatol Sci 102 (1), 7-15 (2021)
   PUBMED   33648800
  REMARK    GeneRIF: Circular RNA circ_0079593 enhances malignant melanoma
            progression by the regulation of the miR-573/ABHD2 axis.
REFERENCE   4  (bases 1 to 8424)
  AUTHORS   Yun,B., Lee,H., Powell,R., Reisdorph,N., Ewing,H., Gelb,M.H.,
            Hsu,K.L., Cravatt,B.F. and Leslie,C.C.
  TITLE     Regulation of calcium release from the endoplasmic reticulum by the
            serine hydrolase ABHD2
  JOURNAL   Biochem Biophys Res Commun 490 (4), 1226-1231 (2017)
   PUBMED   28684316
REFERENCE   5  (bases 1 to 8424)
  AUTHORS   Persad,P.J., Heid,I.M., Weeks,D.E., Baird,P.N., de Jong,E.K.,
            Haines,J.L., Pericak-Vance,M.A. and Scott,W.K.
  CONSRTM   International Age-Related Macular Degeneration Genomics Consortium
            (IAMDGC)
  TITLE     Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related
            Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1
  JOURNAL   Invest Ophthalmol Vis Sci 58 (10), 4027-4038 (2017)
   PUBMED   28813576
  REMARK    GeneRIF: These results show that joint tests of main effects and
            gene-gene interaction reveal associations at some novel loci that
            were missed when considering main effects alone.
REFERENCE   6  (bases 1 to 8424)
  AUTHORS   Giambra,V., Cianci,R., Lolli,S., Mattioli,C., Tampella,G.,
            Cattalini,M., Kilic,S.S., Pandolfi,F., Plebani,A. and Frezza,D.
  TITLE     Allele *1 of HS1.2 enhancer associates with selective IgA
            deficiency and IgM concentration
  JOURNAL   J Immunol 183 (12), 8280-8285 (2009)
   PUBMED   20007591
  REMARK    GeneRIF: Patients with selective immunoglobulin (Ig)A deficiency
            have a highly significant increase of homozygousity of HS1.2 allele
            *1, with an increase of 2.6-fold; the HS1.2 polymorphism influences
            Ig seric production, but not IgG switch.
REFERENCE   7  (bases 1 to 8424)
  AUTHORS   Miyata,K., Nakayama,M., Mizuta,S., Hokimoto,S., Sugamura,K.,
            Oshima,S., Oike,Y., Sugiyama,S., Ogawa,H. and Yamamura,K.
  TITLE     Elevated mature macrophage expression of human ABHD2 gene in
            vulnerable plaque
  JOURNAL   Biochem Biophys Res Commun 365 (2), 207-213 (2008)
   PUBMED   17980156
  REMARK    GeneRIF: Our results showed that the ABHD2 was expressed in
            atherosclerotic lesions, and that the ABHD2 expression was
            significantly higher in the patients with UA than with SA.
REFERENCE   8  (bases 1 to 8424)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   9  (bases 1 to 8424)
  AUTHORS   Edgar,A.J. and Polak,J.M.
  TITLE     Cloning and tissue distribution of three murine alpha/beta
            hydrolase fold protein cDNAs
  JOURNAL   Biochem Biophys Res Commun 292 (3), 617-625 (2002)
   PUBMED   11922611
REFERENCE   10 (bases 1 to 8424)
  AUTHORS   Rapiejko,P.J., George,S.T. and Malbon,C.C.
  TITLE     Primary structure of a human protein which bears structural
            similarities to members of the rhodopsin/beta-adrenergic receptor
            family
  JOURNAL   Nucleic Acids Res 16 (17), 8721 (1988)
   PUBMED   2843827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC090052.1, AC124068.6 and
            AI916724.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152924.4.
            
            Summary: This gene encodes a protein containing an alpha/beta
            hydrolase fold, which is a catalytic domain found in a wide range
            of enzymes. The encoded protein is an acylglycerol lipase that
            catalyzes the hydrolysis of endocannabinoid arachidonoylglycerol
            from the cell membrane. This leads to activation of the sperm
            calcium channel CatSper, which results in sperm activation.
            Alternative splicing of this gene results in two transcript
            variants encoding the same protein. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (2) lacks four consecutive exons
            within the 5' UTR, as compared to variant 1. Both variants encode
            the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.5465.1,
                                           SRR1660809.151306.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000352732.10/ ENSP00000268129.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1820              BC090052.1         41-1860
            1821-8393           AC124068.6         29331-35903
            8394-8424           AI916724.1         32-62               c
FEATURES             Location/Qualifiers
     source          1..8424
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q26.1"
     gene            1..8424
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /note="abhydrolase domain containing 2, acylglycerol
                     lipase"
                     /db_xref="GeneID:11057"
                     /db_xref="HGNC:HGNC:18717"
                     /db_xref="MIM:612196"
     exon            1..108
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            109..208
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            209..408
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1492
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /EC_number="3.1.1.79"
                     /EC_number="3.1.1.23"
                     /EC_number="3.1.1.6"
                     /note="isoform 1 is encoded by transcript variant 2; lung
                     alpha/beta hydrolase 2; alpha/beta hydrolase domain
                     containing protein 2; abhydrolase domain-containing
                     protein 2; protein PHPS1-2; testicular tissue protein Li
                     6; acetylesterase; 2-arachidonoylglycerol hydrolase;
                     monoacylglycerol lipase ABHD2; progesterone-sensitive
                     lipase"
                     /codon_start=1
                     /product="monoacylglycerol lipase ABHD2 isoform 1"
                     /protein_id="NP_690888.1"
                     /db_xref="CCDS:CCDS10348.1"
                     /db_xref="GeneID:11057"
                     /db_xref="HGNC:HGNC:18717"
                     /db_xref="MIM:612196"
                     /translation="MNAMLETPELPAVFDGVKLAAVAAVLYVIVRCLNLKSPTAPPDL
                     YFQDSGLSRFLLKSCPLLTKEYIPPLIWGKSGHIQTALYGKMGRVRSPHPYGHRKFIT
                     MSDGATSTFDLFEPLAEHCVGDDITMVICPGIANHSEKQYIRTFVDYAQKNGYRCAVL
                     NHLGALPNIELTSPRMFTYGCTWEFGAMVNYIKKTYPLTQLVVVGFSLGGNIVCKYLG
                     ETQANQEKVLCCVSVCQGYSALRAQETFMQWDQCRRFYNFLMADNMKKIILSHRQALF
                     GDHVKKPQSLEDTDLSRLYTATSLMQIDDNVMRKFHGYNSLKEYYEEESCMRYLHRIY
                     VPLMLVNAADDPLVHESLLTIPKSLSEKRENVMFVLPLHGGHLGFFEGSVLFPEPLTW
                     MDKLVVEYANAICQWERNKLQCSDTEQVEADLE"
     exon            409..584
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            585..752
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            753..936
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1029
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1030..1140
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1210
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1295
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1296..8424
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1797..1802
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /note="hexamer: ATTAAA"
     polyA_site      1820
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
     regulatory      8406..8411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /note="hexamer: AATAAA"
     polyA_site      8407
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
     polyA_site      8424
                     /gene="ABHD2"
                     /gene_synonym="HS1-2; LABH2; PHPS1-2"
                     /note="major polyA site"
ORIGIN      
        1 gcactggcca ggggttccgg ctgtatatcc atgagcgccg ctggcagccg gggagctgca
       61 ggaaccagac tgggggcgag ctgagcacct gtagtcaatc acacgcagct tttaggtttg
      121 tttgaataag agatctgacc tgaccggccc aactgtacaa ctcttcaagg aaaattcgta
      181 tttgcagtgg gaagaataag taacattgat caagatgaat gccatgctgg agactcccga
      241 actcccagcc gtgtttgatg gagtgaagct ggctgcagtg gctgctgtgc tgtacgtgat
      301 cgtccggtgt ttgaacctga agagccccac agccccacct gacctctact tccaggactc
      361 ggggctctca cgctttctgc tcaagtcctg tcctcttctg accaaagaat acattccacc
      421 gttgatctgg gggaaaagtg gacacatcca gacagccttg tatgggaaga tgggaagggt
      481 gaggtcgcca catccttatg ggcaccggaa gttcatcact atgtctgatg gagccacttc
      541 tacattcgac ctcttcgagc ccttggctga gcactgtgtt ggagatgata tcaccatggt
      601 catctgccct ggaattgcca atcacagcga gaagcaatac atccgcactt tcgttgacta
      661 cgcccagaaa aatggctatc ggtgcgccgt gctgaaccac ctgggtgccc tgcccaacat
      721 tgaattgacc tcgccacgca tgttcaccta tggctgcacg tgggaatttg gagccatggt
      781 gaactacatc aagaagacat atcccctgac ccagctggtc gtcgtgggct tcagcctggg
      841 tggtaacatt gtgtgcaaat acttggggga gactcaggca aaccaagaga aggtcctgtg
      901 ctgcgtcagc gtgtgccagg ggtacagtgc actgagggcc caggaaacct tcatgcaatg
      961 ggatcagtgc cggcggttct acaacttcct catggctgac aacatgaaga agatcatcct
     1021 ctcgcacagg caagctcttt ttggagacca tgttaagaaa ccccagagcc tggaagacac
     1081 ggacttgagc cggctctaca cagcaacatc cctgatgcag attgatgaca atgtgatgag
     1141 gaagtttcac ggctataact ccctgaagga atactatgag gaagaaagtt gcatgcggta
     1201 cctgcacagg atttatgttc ctctcatgct ggttaatgca gctgacgatc cgttggtgca
     1261 tgaaagtctt ctaaccattc caaaatctct ttcagagaaa cgagagaacg tcatgtttgt
     1321 gctgcctctg catgggggcc acttgggctt ctttgagggc tctgtgctgt tccccgagcc
     1381 cctgacatgg atggataagc tggtggtgga gtacgccaac gccatttgcc aatgggagcg
     1441 taacaagttg cagtgctctg acacggagca ggtggaggcc gacctggagt gaggcctccg
     1501 gactctggca cgctccagca gccctcctct ggaagctgcg tcccctcacc ccctgtttca
     1561 ggtctcccat ctccctcagt gacctggatc tgacctcaca ccatcagcag ggggcaccca
     1621 ccatgcacac ctgtctcgga gtaggcagct cttcctggga gctccaggct atttttgtgc
     1681 ttagttactg gttttctcca ttgcattgtt aggcatggtg acaagtgaca gagttcttgc
     1741 cctctgtcca gtttcagcat ctggttgctt ttaagccaag tacatctagt ttccctatta
     1801 aaaatgtgtc tgaatagcga ttttgctttg ccaccaaaag gcttttccct gagaacagtg
     1861 aaggatgtat gtcattttgt ggtggttgta tgtgtcctta catagacctt aaaaagagct
     1921 cacccttcca ggccaatgct gaagacacag ctccgcttgg gagcctgaga acccaggctt
     1981 cccaggccag agtgtggctt cttaaacggc aaaggaaatt cctttgagtc acaagccaag
     2041 ttttcgccct gtctcctgag accatttccc tacgctttgc tgctgctgag agttacgtga
     2101 ggcacttgtt aaaaattcag cctcccaggt ccctcccctc ggagaggctg attcactggg
     2161 tctgggaagg agcctgggga ttttaatttt tcacaagtgc cccagatgat tctcatcacc
     2221 aagcaaattt tggaaatgct gttcaacagc gcccttaaat tggaaacatc tttgcagctc
     2281 gttttattga aattcataat caggggtgtc ctctagctcc cacggtctcc agagcagcaa
     2341 ggccggctat ggagctgccg tcgtgtgacc acagtgtgat gtctcagaag ggctctgggt
     2401 gggctgagca tctgggctgt gccctggctc tgcttttcac cctggacaaa gtcgctgtgg
     2461 acttcaattt cttcacctct aaaatggggg acttggacca ggtagattgc tgagctcact
     2521 accaggttca aagttcaatg acaaactcag tttactgagg tttgagagaa catccctcca
     2581 ggggagcctg ggagctgctc tcccagtcta agcatgtaga tatcatcgtt tgccttttgt
     2641 gtgtgtgtgt cccttatttg ataaaaagat gttttgagtt gttttttttt taagcactca
     2701 cttgtaattt tagtttttaa acccaagtcc ctctaacttt gcctttgata ccaaacaatt
     2761 caaaagttgg atctgagttt ggagaaagat atttccaacc taagtgggta ttattttgaa
     2821 accagatttt taatttaata gcctatattt gtagtctgtt ggataggtgt ttccaaagtg
     2881 tgtcttctca agtgaaaacg caactctagg tttcaagtac tccttttctc cgatcctgtg
     2941 gtacttgaat atccaaaaac cctgcacttt gaacaatcag ctgttgctat ctggaactaa
     3001 acagaactat gagtaaaatt gcctggatac tttaaaaaga tatttttcct ccttcatctc
     3061 ctttgactcc aggacagact ggaatataag tagtgggtct gcatggatgt ttcagggatc
     3121 aaaggagcca cctgggcgcc tgagtgccaa ccctcagggc cacaggtggg tgtggtttgg
     3181 gcacgggtcc aagtgactgt gacgggaccc gtgggcatgg gtccaggtct gtaacctgaa
     3241 gaagttgttt tctgacaatc accaaatcat ccgaatgaca tcaaaagcag cccttatctc
     3301 agagactgag atttctgtgg tctcaacttc gctttggtat aatttctggc actcaccagc
     3361 ctctatcatt atgactttcc ccccagtgta ttatttctct aataggtttc cttttcacgt
     3421 tcttttagca cagactggca ctttaccctc tcagtttgga agttagcccc tctcctctgt
     3481 tacttttccc ttcacccaac tacagctgtg atctagaaca ttcatagtca tatttctgct
     3541 actactacct tcatttatca agacttttta tgagaatagg taaaccaagc aataacttcc
     3601 taggactgaa tcaccacccc agaagagcga gaggctcctt tcatatgcct gaggccacac
     3661 cccttaacct gttctgacaa aatagtggct ggcccatgta ccagctccat tcagaaattc
     3721 aggaagagaa aagacagccc tgttgtcaca caaaccggtg tgggggaggg tggagcctgg
     3781 tctgcacggc agtcctggtg gcccctgtgg aggacaggca gggctggcag catagccttt
     3841 gttgccacac aaccggaatt tgctccccca ggactgtggg agccagtgtc ccagctgaaa
     3901 tctttttagt gtgtggctct gaatggcact cacattccat tttggctcac atgaaactaa
     3961 ctgaagccct ttgttcaagc ttcaggctct taggcatgga aatgagaatg tgactgtggc
     4021 tgtcttacag gaaaattctt gtttgtccct gaatgagagc acagaggcat tgaattcaca
     4081 gagctgcaaa cttgcctgat aaatgaggga gtggcagttt atagataggt catctttttt
     4141 ccttcctcca ggtgtccttg cctttcttcc caaagtcatt catttctgat gagtatatga
     4201 atccccctct tgctagtaag gttctatttg ggctaaaaca aggctgaatt tttaaagagt
     4261 atttgaatat attttagaat caaattgagg ctataaattg catcaatctg gacaattcca
     4321 ttgcaggaat aatatgttaa aaaccaatgg ggagaagcac ccacatctct cctgtagcac
     4381 tccgtgtctc ataagcaatt tgaagacact tacaagtaac tgattccagt caaattagga
     4441 ttaactgact caaaaaatgg tgtcaagttt ctttaatgtt tttatgttag aagtgagttt
     4501 aacagacttg aagaaaactg ttatcttttc ctgctgtgag tttacacaaa tgattccaga
     4561 gcagaatgaa agcagaaagc tgttggttac aatattcttt taacctctct gcagcatttt
     4621 acacttactg ggaaccttat gattcaccgt aagagtggaa atatacctga gttcgtgtcc
     4681 taatggtctc taattcacat tggatcgtgg gcaaatcacc tcacctctct gagcctgttc
     4741 cctcctctta gaccatctct aagaccactt catctattta cacatcattt gcttgaacat
     4801 tgctgaacat ctgcgtgaac ttggcctctc cagcccttgc aggtggaaac agctgtgtca
     4861 aggctcaagg ctcacgctga ggggacttgg agggaggggg cttctgcatt aagctttcct
     4921 ggtgaagacc cttgatcttg tccaaagccc tgtgtctttg actggcttct cttcagagtc
     4981 cccgttgtca tcgtaagacc cttgctgttt ggagggtggt cttgtgactg tggcagctgc
     5041 tggccgctgg aatgaggagc ctatctccat cctccagtgt gactcaggca gagcattgag
     5101 aattcccagg gcagaaatcc ttcctgctca ggctttcatt ctaaaactac agtcttcatt
     5161 aaagctgaac tttctgggta gctgagctta tatgcccggc atctgaatga gagctctctt
     5221 tgtaactgtg tgacttgaga tctagtttgc cagctcctgg gaaacaatac atgtgttctt
     5281 gtttgtgttt gctcagcaag cagatgtctg agatgtaaga agcttttctt ttcctgtggc
     5341 attgattctg acttagagct gaagtaaaag atcactgaaa catcacgtca agttgaagtc
     5401 actcataggt ctttgtcctt taggcaggac aggagagtca ttaagaagca tttcactgta
     5461 gcattctatc acaatatcat ctggaattgt tttctttgcc cagaaagcct taacttgcct
     5521 ctagagaatc cctggtatta caacgatatt gcggcattag aattccaact cttctgctgt
     5581 ggaagtttga agcgaagctg cagcaaaacc agagaatttc ctcaagtggc ctgtaggctc
     5641 cttgttatct tatgccccca cccctccctc aacaatatga gtgatccaga actggcccaa
     5701 acacctcagc tctggtccct ttttgccctt cttggcctta ctctgttgtt caaagccact
     5761 ttggattgct tggatgcttc gaacagccat gaaaagtagc ctgcctgtgg catttagagg
     5821 ccaagcaatt gacagaaagg gtttcttcta cctctgttat ctaagcagag ggaagtaaac
     5881 ctctcaccgc cccccacccc tcactgcccc cgattaccct agaattgctt tcgccaaatt
     5941 gtagttgaag ctaaggaagg ggaatctggc ccctgctggg agagggaact ggaatgccac
     6001 acaaggcaag gcctgcttcc ttccttcccc tctgctgctg ctgcctcgga acgctgcagc
     6061 ccaggcttcc tcccacagtg gcccttggaa gcaggccgca gagtagacag ctgctccttt
     6121 tggaagagtc agtcccctgt gttttctgaa ctgtttttcc tagcatgtat gtgggtagag
     6181 ctttcatgca tctctagtaa taataagctg aaattagttt tttttttaat tctccaattt
     6241 aaaactttta attaaaaagt aaattttaat gtcgaaaatg caaacttggg gagggcagaa
     6301 agatcacaca caaggctgtc acttcatact tgcaggattg cacagcagcc gggcagaggc
     6361 gctcctcact tcccagatgg ggcggcgggc agcagagacg cacctcactt cctagacagt
     6421 gcggcagcca ggcacaggca cacctcactt cccagacagt tgggcggcca ggcaagcgct
     6481 cctcacttcc cagatggggc ggctcccggg aagcggggct cctcacttcc cagacagggt
     6541 ggccaggcag aggtgctcct cacttcccag aacaattctt tatgaatttg ataaaggact
     6601 gaagtgcaac tgaaagctgc tagtgatgat ctggtaatat acaatttgtc cagtagccag
     6661 tttgttttta ttgtgttttc taaccataag agatcattaa aggcaaagcc tgtatgacgc
     6721 tgtacacaca caaaaaaatg gtcaccgcag gccatactac caatgaaatg gtaggtaaac
     6781 aaatcttctg gtcaagagaa aaaaaaaaga aatagcactc tgcatgcttt gctctacaag
     6841 acgaatttcc ctagaaagaa tccaatgaag gccgggcata gtggctcact cctgtaatcc
     6901 cagcactttg gaggccgagg cgggtagatc acctgaggtt aggagttcaa gaccagcctg
     6961 gccaacatgg tgaaacccct tctctactaa aaatgcaaaa attagctggg tgtggtggcg
     7021 ggcgcctgta atcccagcta ctcgggaggc tgaggtggga gaattgcttg aacccaggag
     7081 acggaggttg cagtgagccg agatcacgcc tctgcactcc agcctgggca acaagagtga
     7141 gactccgtct ccaaaaaaag aaaaggaatc cagtgaaaat ggctgcaatt acaacaagaa
     7201 gtgaaggaag aagactggtg acatctctga aggatgcagt tgaggttgat ccaggtttat
     7261 ccgaatatgc tacctttctg agccttaaac cttcatctct caggtgttga tttgcttctg
     7321 atagcttcat catttctccc tgaagtcttt tacactcttc tgttagtttc cttgtttcag
     7381 tatcatgaag tgaagcactg tgtggttgtg gcgtgggccc gtcttgctta gatgcattca
     7441 gtgggacagc tttgctgggt tccatgtcat tcaatttatc attttcattg gggatctcca
     7501 tttggaatcc attaattcat gaggttttgc ctcattccac acagcttcca tatctgaagt
     7561 gtttagtgga gcaaaaattg taccataaac ttgtgtttac tcttttcatt cggatcatag
     7621 tcaaagggct gtagcattac tgaaacagtc acagttgacc ctgggtcaat aattccactg
     7681 ttgggcctca cacagtaccg gtgaggcacg gtagtcttca ctttgaaaca cacttttcta
     7741 tccgatggat ttcgcaattt aagatttgta gtgactacat ctgtgaaggg gcctttgaat
     7801 ttgaggtcta tgggcgggtc gaggaccagg atctgctcgt gcttcgccgt ggccccggag
     7861 gcagacgcca ttggagagac agcgcagagc agggggcggc ttgctcgctg ggggcggggg
     7921 acgatggcga gaggggaggg ggagcgagtt cgcatctctc cttttcctgg ttagactctg
     7981 ttcaaccaca ttcttatgtt ggcagatctg cttccagatt gatttttaga gcaccatcac
     8041 tttcacattc ctgattctga ttttgttttg ttttgtttgg gttttctgaa acttaaaatg
     8101 ctgccccgaa aatactatat ttttgagttt gtgttctgaa agcctccgtg ctgctggatc
     8161 tttgggggga aatacaggat ccttcagcac tgaggtgttt aagatttgca actagcaatg
     8221 caattttttc taaatatggg gatatttacc tttattaaga aattatacta aacattgatg
     8281 tccttgatca ttttatgttc tcatattact tttgattcta ctatgattgt gtggtggtga
     8341 acaaagatca ttacaaacaa aaactgtaat tttgttatat ttgattcaat ggaatttacc
     8401 taaaaaataa agactaaaaa tgtg
//
