LOCUS       NM_021214               2361 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 17C, depalmitoylase
            (ABHD17C), mRNA.
ACCESSION   NM_021214 XM_051862 XM_937545
VERSION     NM_021214.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2361)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2361)
  AUTHORS   Tortosa,E., Adolfs,Y., Fukata,M., Pasterkamp,R.J., Kapitein,L.C.
            and Hoogenraad,C.C.
  TITLE     Dynamic Palmitoylation Targets MAP6 to the Axon to Promote
            Microtubule Stabilization during Neuronal Polarization
  JOURNAL   Neuron 94 (4), 809-825 (2017)
   PUBMED   28521134
REFERENCE   3  (bases 1 to 2361)
  AUTHORS   Yokoi,N., Fukata,Y., Sekiya,A., Murakami,T., Kobayashi,K. and
            Fukata,M.
  TITLE     Identification of PSD-95 Depalmitoylating Enzymes
  JOURNAL   J Neurosci 36 (24), 6431-6444 (2016)
   PUBMED   27307232
REFERENCE   4  (bases 1 to 2361)
  AUTHORS   Lin,D.T. and Conibear,E.
  TITLE     ABHD17 proteins are novel protein depalmitoylases that regulate
            N-Ras palmitate turnover and subcellular localization
  JOURNAL   Elife 4, e11306 (2015)
   PUBMED   26701913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2361)
  AUTHORS   Ovsyannikova,I.G., Kennedy,R.B., O'Byrne,M., Jacobson,R.M.,
            Pankratz,V.S. and Poland,G.A.
  TITLE     Genome-wide association study of antibody response to smallpox
            vaccine
  JOURNAL   Vaccine 30 (28), 4182-4189 (2012)
   PUBMED   22542470
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC023302.9, BC059401.1 and AL390079.1.
            
            On Nov 22, 2018 this sequence version replaced NM_021214.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059401.1, SRR1163655.259145.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000258884.5/ ENSP00000258884.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC023302.9         120083-120083       c
            2-162               AC023302.9         119922-120082       c
            163-2223            BC059401.1         132-2192
            2224-2361           AL390079.1         1844-1981
FEATURES             Location/Qualifiers
     source          1..2361
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q25.1"
     gene            1..2361
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /note="abhydrolase domain containing 17C, depalmitoylase"
                     /db_xref="GeneID:58489"
                     /db_xref="HGNC:HGNC:26925"
                     /db_xref="MIM:617944"
     exon            1..710
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..1110
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /EC_number="3.1.2.22"
                     /note="abhydrolase domain-containing protein FAM108C1;
                     abhydrolase domain-containing protein 17C; protein
                     ABHD17C; family with sequence similarity 108, member C1"
                     /codon_start=1
                     /product="alpha/beta hydrolase domain-containing protein
                     17C"
                     /protein_id="NP_067037.1"
                     /db_xref="CCDS:CCDS45323.1"
                     /db_xref="GeneID:58489"
                     /db_xref="HGNC:HGNC:26925"
                     /db_xref="MIM:617944"
                     /translation="MPEPGPRMNGFSLGELCWLFCCPPCPSRIAAKLAFLPPEPTYTV
                     LAPEQRGAGASAPAPAQATAAAAAAQPAPQQPEEGAGAGPGACSLHLSERADWQYSQR
                     ELDAVEVFFSRTARDNRLGCMFVRCAPSSRYTLLFSHGNAVDLGQMCSFYIGLGSRIN
                     CNIFSYDYSGYGVSSGKPSEKNLYADIDAAWQALRTRYGVSPENIILYGQSIGTVPTV
                     DLASRYECAAVILHSPLMSGLRVAFPDTRKTYCFDAFPSIDKISKVTSPVLVIHGTED
                     EVIDFSHGLAMYERCPRAVEPLWVEGAGHNDIELYAQYLERLKQFISHELPNS"
     exon            711..890
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /inference="alignment:Splign:2.1.0"
     exon            891..2361
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2339..2344
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /note="hexamer: AATAAA"
     polyA_site      2361
                     /gene="ABHD17C"
                     /gene_synonym="FAM108C1"
                     /note="major polyA site"
ORIGIN      
        1 gggctgcagc cgccctccgc gctcgcctgc cagctccctc gccgcgcgtc cgtcctccgt
       61 cctcccgggc cagccagcca gccagccagc cgggccggcg gcgggcacca ggccgtcccg
      121 atgcccgagc caggccccag gatgaacggc ttctcgctgg gtgagctgtg ctggctcttc
      181 tgctgcccgc cctgcccgag ccgcatcgcc gccaagctgg ccttcctgcc gcccgagccc
      241 acctacacgg tgctggcgcc ggagcagcgc ggcgccggcg cgtccgcccc ggccccggcc
      301 caggctaccg ccgccgccgc cgcggcccag ccggcaccgc agcagcccga ggagggcgcg
      361 ggcgcggggc ccggtgcgtg cagcctgcac ctcagcgagc gcgccgactg gcagtactcg
      421 cagcgcgagc tggacgccgt cgaggtcttc ttctcgcgca cggcccggga caaccggctc
      481 ggctgcatgt tcgtgcgctg cgcgccctcc agccgctaca cgctgctctt ctcgcacggc
      541 aacgccgtgg acctgggcca gatgtgcagc ttctacattg gcctcggctc ccgcatcaac
      601 tgcaacatct tctcctacga ctactcggga tacggcgtca gctcgggcaa gccctccgag
      661 aagaacctct acgccgacat cgacgccgcg tggcaggcgc tgcgcacccg gtatggcgtg
      721 agtcccgaga acattatcct ctatggtcag agcattggga ctgtccccac ggtagacttg
      781 gcctcgaggt atgaatgcgc agcggtaatt ctccattccc ctctgatgtc tggtttgcgt
      841 gtggcttttc cggataccag gaaaacatac tgctttgatg ctttccccag cattgacaag
      901 atatctaaag tcacctctcc tgtgttggtc attcatggta cagaggatga ggtcatcgat
      961 ttctcccatg gcctagcgat gtacgagcgc tgtccccgag ccgtggagcc cctttgggtt
     1021 gaaggggctg ggcataatga catagagctt tatgcacaat acctagaaag actaaaacag
     1081 ttcatatctc acgaacttcc taattcctga agacaacaac ttgatcttac ctcatttact
     1141 gtgaacagaa gagtcctctg ttttgcacat gctttaactg ggtagctgta aaggcttgat
     1201 aaccatgaag aagtgcccaa cctttagggt gttctaatca aagagctgat gaaatctcag
     1261 tcttttgtat ctagaggtgg ttctgctaat tcacacaaca cgttaaactg aacagtcgtg
     1321 attcccagct tcattacctt gcaggaatgg gaatgagagc tgaatgtagg gacaattttc
     1381 tagtgctgta taaagtagcc tcgcatctgt ttctcaacct tatccatcat ttctgacatt
     1441 catgcaggac ttgccctgtt gccaccaatg ttctcggtat ttcacatgca gctctctttc
     1501 tgccactgga tacatgggtt caatccattt gtgaagctgt gatagtgtaa ctggaaagct
     1561 agtgtggtga aaattccttt attatttttt gttaacatgc tgatctttcc cggacaaatg
     1621 aactgaaggg taatttactg gaactctcgt gtacagcttc atcaactgta accatataaa
     1681 tataactgga atattcttaa acaaaaagaa actaggggtt tttttaagtg taaatttatt
     1741 actagccaac agagttttac tattttgatt gtctggttgg tttaacaaag agcctagctg
     1801 actttccttc tgtaaagtcc tccttgtagg cttttttaaa gtactgtaca tatttgcaat
     1861 cacattgtgc atagattctt aatggtagat atgatttctt ttgtcaggct acaacaatga
     1921 actgcagatt ccttgtttgt aatgtaaatg attgaataca ttttgttaat atgtttttat
     1981 tcctatgttt tgctattaaa aattttataa catttccaag acaaaaattc caagtttatg
     2041 ctttgaagaa tttatgtaat taaaatttca ctaaactaat ctttttagtt taggaattat
     2101 ttgggttttg acactggaag ttgcgccaaa taagcatcag aaataggaga tgcttaacat
     2161 tgctatacta cttgtgttgg ttaggggttt ggatttgggg gttctttggt tttaattttt
     2221 ttttccacat ttaaaagcct taaatgtact gtaagcctca gatcgttgta caactggact
     2281 gcggttgatt gccagtttgt gtactgttgc ttggatgcgg cacagtggtt ggtaatggaa
     2341 taaaggatgc atggatcaga a
//
