LOCUS       NM_001025780            3065 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 17B, depalmitoylase
            (ABHD17B), transcript variant 2, mRNA.
ACCESSION   NM_001025780
VERSION     NM_001025780.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3065)
  AUTHORS   Remsberg,J.R., Suciu,R.M., Zambetti,N.A., Hanigan,T.W.,
            Firestone,A.J., Inguva,A., Long,A., Ngo,N., Lum,K.M., Henry,C.L.,
            Richardson,S.K., Predovic,M., Huang,B., Dix,M.M., Howell,A.R.,
            Niphakis,M.J., Shannon,K. and Cravatt,B.F.
  TITLE     ABHD17 regulation of plasma membrane palmitoylation and
            N-Ras-dependent cancer growth
  JOURNAL   Nat Chem Biol 17 (8), 856-864 (2021)
   PUBMED   33927411
  REMARK    GeneRIF: ABHD17 regulation of plasma membrane palmitoylation and
            N-Ras-dependent cancer growth.
REFERENCE   2  (bases 1 to 3065)
  AUTHORS   Tortosa,E., Adolfs,Y., Fukata,M., Pasterkamp,R.J., Kapitein,L.C.
            and Hoogenraad,C.C.
  TITLE     Dynamic Palmitoylation Targets MAP6 to the Axon to Promote
            Microtubule Stabilization during Neuronal Polarization
  JOURNAL   Neuron 94 (4), 809-825 (2017)
   PUBMED   28521134
REFERENCE   3  (bases 1 to 3065)
  AUTHORS   Yokoi,N., Fukata,Y., Sekiya,A., Murakami,T., Kobayashi,K. and
            Fukata,M.
  TITLE     Identification of PSD-95 Depalmitoylating Enzymes
  JOURNAL   J Neurosci 36 (24), 6431-6444 (2016)
   PUBMED   27307232
REFERENCE   4  (bases 1 to 3065)
  AUTHORS   Lin,D.T. and Conibear,E.
  TITLE     ABHD17 proteins are novel protein depalmitoylases that regulate
            N-Ras palmitate turnover and subcellular localization
  JOURNAL   Elife 4, e11306 (2015)
   PUBMED   26701913
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3065)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 3065)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL138751.18 and AL671309.6.
            
            On Feb 27, 2020 this sequence version replaced NM_001025780.2.
            
            Transcript Variant: This variant (2) differs in the 3' UTR and
            coding sequence compared to variant 1. The resulting isoform (2)
            has a shorter and distinct C-terminus compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC044576.1, GQ900982.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000333421.7/ ENSP00000330222.6
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-560               AL138751.18        38531-39090         c
            561-1030            AL138751.18        2511-2980           c
            1031-1210           AL671309.6         113956-114135       c
            1211-3065           AL671309.6         109025-110879       c
FEATURES             Location/Qualifiers
     source          1..3065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.13"
     gene            1..3065
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /note="abhydrolase domain containing 17B, depalmitoylase"
                     /db_xref="GeneID:51104"
                     /db_xref="HGNC:HGNC:24278"
                     /db_xref="MIM:617943"
     exon            1..560
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /inference="alignment:Splign:2.1.0"
     exon            561..1030
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /inference="alignment:Splign:2.1.0"
     CDS             564..1430
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /EC_number="3.1.2.22"
                     /note="isoform 2 is encoded by transcript variant 2;
                     abhydrolase domain-containing protein FAM108B1; family
                     with sequence similarity 108, member B1; alpha/beta
                     hydrolase domain-containing protein 17B; abhydrolase
                     domain-containing protein 17B; protein ABHD17B; epididymis
                     secretory sperm binding protein"
                     /codon_start=1
                     /product="alpha/beta hydrolase domain-containing protein
                     17B isoform 2"
                     /protein_id="NP_001020951.1"
                     /db_xref="CCDS:CCDS35043.1"
                     /db_xref="GeneID:51104"
                     /db_xref="HGNC:HGNC:24278"
                     /db_xref="MIM:617943"
                     /translation="MNNLSFSELCCLFCCPPCPGKIASKLAFLPPDPTYTLMCDESGS
                     RWTLHLSERADWQYSSREKDAIECFMTRTSKGNRIACMFVRCSPNAKYTLLFSHGNAV
                     DLGQMSSFYIGLGSRINCNIFSYDYSGYGASSGKPTEKNLYADIEAAWLALRTRYGIR
                     PENVIIYGQSIGTVPSVDLAARYESAAVILHSPLTSGMRVAFPDTKKTYCFDAFPNID
                     KISKITSPVLIIHGTEDEVIDFSHGLALFERCQRPVEPLWVEGAGHNDVELYGQYLER
                     LKQFVSQELVNL"
     exon            1031..1210
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..3065
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /note="hexamer: AGTAAA"
     polyA_site      3065
                     /gene="ABHD17B"
                     /gene_synonym="C9orf77; CGI-67; FAM108B1"
                     /note="major polyA site"
ORIGIN      
        1 agtcagtggc caactcctgg ctcagtgggg attgtgctcg tcccctccgt tcccctccag
       61 tcttcctccc gctaccggaa cgagcctcgc gcttggcagg ctgaggagga gcaaagaaag
      121 caggattaaa gagaaggaag acctggctag gtctgggtgg cgtctgcagt gccagaaagg
      181 gaggcggtgg cggcggcggc tgcgaccacg gccgcgcggg acgtgaggcc cgagagcaac
      241 cgacgggcag cggcggccgc tccagcgccc cgcaccgggg ccgttagtca gcagaacgcg
      301 agctcttgtg gaggagcagg gccggcgcga ggcgagactc gggagcgtga gcggggcccc
      361 tggggcgccg ccgtccttct tcgccccggc gccgggggct gtagccctgg tccccgctcc
      421 tctgtcgggc cagtctgcag gcggagagag tcggacggcg cccggagcgc ggatctcgcc
      481 ttgtggagga cagcgcgtcg gctgcggttc tctctcgacc ccttctgccc ggcgcttcgg
      541 cccgggccgc tcaggtgcag agcatgaata atctttcatt tagtgagcta tgttgcctct
      601 tctgctgtcc accttgtcca gggaagattg cttcaaaatt agcgtttttg ccacctgatc
      661 caacttacac actgatgtgt gatgaaagcg gaagccgttg gactttacat ctgtctgaac
      721 gagcagactg gcagtattct tctagagaaa aagatgctat tgagtgtttc atgactagaa
      781 ccagtaaagg caacagaatt gcttgtatgt ttgtacgttg ttcacccaat gcgaaataca
      841 ctttactctt ctcacatgga aatgctgttg atcttggtca aatgagcagc ttttacatag
      901 gactaggatc acggattaat tgtaatatat tctcatatga ttattctgga tatggtgcca
      961 gttccgggaa acccacagag aagaacctct atgcagacat tgaagctgct tggcttgctc
     1021 ttaggacaag atatggcatt cgccctgaaa atgtgattat atatggccaa agtataggga
     1081 cagtaccgtc tgtggatctt gctgctcgat atgagagtgc tgctgttatt cttcattctc
     1141 ctctgacttc gggaatgcga gttgcctttc ctgataccaa gaagacctac tgttttgatg
     1201 cattcccaaa cattgacaaa atctctaaga taacctctcc agtattaata attcatggga
     1261 ctgaagatga agtcattgac ttttcacatg gcctcgcatt gtttgaacgt tgccaaagac
     1321 ctgtggagcc tctctgggtt gaaggagcag gtcacaatga tgtggaactt tatggacagt
     1381 atcttgaaag gttgaaacag tttgtgtcac aggaactggt aaatttgtaa aatattctgt
     1441 aaatttgcta ctgggttttc ctttcttgct gaactgcact ctttggtaaa taacataaaa
     1501 cctgaaggtt ttgtttgcaa atcatgtcag ttgccttcat aaatgtacag gtaatgattt
     1561 gttaacagac ttaatgaagg ttttaattac cagaactaaa aactggaaat aacagtaccg
     1621 tgcagtcagg ctgtgtaatt tatatttttt ctgtgaattt ttttttaaca tcaagatgag
     1681 tactgtatga gattttaatt ctataaaatc aaatgctgta aaagtattgc caaatgcttt
     1741 tgcatactag aaacaaattt ataaatattt ttaaaacatc tcaatatatt aaatcttatc
     1801 ctggaataca actgtaatat tttgaaaaaa gctatgtatc taaagcaatt taagtactca
     1861 taatggaatg aactgtaaaa gagatttaaa accatgcaag ttcactagaa ttaacctaaa
     1921 ccctgttgta cagggataga ggtttaaagt tattttattg taaaatacat tgaattttct
     1981 gtatactctg attacataca tttatccttt aaaaaagatg taaatcttaa tttttatgcc
     2041 atctattaat ttaccaatga gttaccttgt aaatgagaag tcatgatagc actgaatttt
     2101 aactagtttt gacttctaag tttggtactg tgaggcaagt acttaaaatt ttcatgctgg
     2161 ttacttaaaa ggcatttaga gatttcaaga atgattttgt atacgatgtt ttaaattttg
     2221 actgatctca tagtcttcat agaattgcag tagtcttcat tgtatgaaat cccgaaagtc
     2281 catgagttga tcttaaagac cactaacaga ctggctatca gatccctttt cactttggct
     2341 atttttttca ttttttgaga tggagtcttg ctgtgtcact gaggctggag tgcagtggcg
     2401 cgatcttgat tcactgcaac ctctgcctcc cgggatcaag tgattctcct gcctcagcct
     2461 cctgagtagc tggtattaca gatgcttgcc accacgcctg gctaattttt gtatttttag
     2521 tagagacagg gttttgccat gttgatcagg ctggtcttga actcctgacc tcatgatctg
     2581 cccttggcct cccaaagtgt cggaattaca ggcatgagcc actgcgcctg gcccacttta
     2641 gctattttta aaaataggac ctattgtttt ggattactat ctgagaattt catggattca
     2701 ctcctgggta taggagataa gaatacgttt aattcataac ttttatatta accaatatag
     2761 taaaaaaata aagctcacac atacaaaaac taagttgcct ttccttgaat gaaccctgtc
     2821 tgaataaaac aatgaaaaat aaaaataaaa ttaatggtat gtagtctaat ttgtaaatga
     2881 atgaatatgg aaataataca cactgtggat atattttaag gccttatgta gttttaattg
     2941 ttctgctcgt tccgtggtta tgtttaagac tatagtatat gactctcttc aaagtatatc
     3001 aagtattgtg aatgctttgg ttcagatgtg tcaaattaac agtaaaacaa caaatatacc
     3061 actga
//
