LOCUS       NM_001130111            1706 bp    mRNA    linear   PRI 13-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 17A, depalmitoylase
            (ABHD17A), transcript variant 2, mRNA.
ACCESSION   NM_001130111
VERSION     NM_001130111.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Zheng,S., Que,X., Wang,S., Zhou,Q., Xing,X., Chen,L., Hou,C.,
            Ma,J., An,P., Peng,Y., Yao,Y., Song,Q., Li,J., Zhang,P. and Pei,H.
  TITLE     ZDHHC5-mediated NLRP3 palmitoylation promotes NLRP3-NEK7
            interaction and inflammasome activation
  JOURNAL   Mol Cell 83 (24), 4570-4585 (2023)
   PUBMED   38092000
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   McClafferty,H., Runciman,H. and Shipston,M.J.
  TITLE     Site-specific deacylation by ABHD17a controls BK channel splice
            variant activity
  JOURNAL   J Biol Chem 295 (49), 16487-16496 (2020)
   PUBMED   32913120
  REMARK    GeneRIF: Site-specific deacylation by ABHD17a controls BK channel
            splice variant activity.
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Tortosa,E., Adolfs,Y., Fukata,M., Pasterkamp,R.J., Kapitein,L.C.
            and Hoogenraad,C.C.
  TITLE     Dynamic Palmitoylation Targets MAP6 to the Axon to Promote
            Microtubule Stabilization during Neuronal Polarization
  JOURNAL   Neuron 94 (4), 809-825 (2017)
   PUBMED   28521134
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Yokoi,N., Fukata,Y., Sekiya,A., Murakami,T., Kobayashi,K. and
            Fukata,M.
  TITLE     Identification of PSD-95 Depalmitoylating Enzymes
  JOURNAL   J Neurosci 36 (24), 6431-6444 (2016)
   PUBMED   27307232
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Lin,D.T. and Conibear,E.
  TITLE     ABHD17 proteins are novel protein depalmitoylases that regulate
            N-Ras palmitate turnover and subcellular localization
  JOURNAL   Elife 4, e11306 (2015)
   PUBMED   26701913
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1706)
  AUTHORS   Lambert,B., Vandeputte,J., Remacle,S., Bergiers,I., Simonis,N.,
            Twizere,J.C., Vidal,M. and Rezsohazy,R.
  TITLE     Protein interactions of the transcription factor Hoxa1
  JOURNAL   BMC Dev Biol 12, 29 (2012)
   PUBMED   23088713
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1706)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB025570.1, BC035961.1, BC020512.1 and AC012615.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001130111.1.
            
            Transcript Variant: This variant (2) is lacking an in-frame coding
            exon compared to transcript variant 1, resulting in a shorter
            isoform (2) missing an internal protein segment compared to isoform
            1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK289533.1, BC035961.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292577.12/ ENSP00000292577.6
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 DB025570.1         24-24
            2-1539              BC035961.1         1-1538
            1540-1540           BC020512.1         1630-1630
            1541-1706           AC012615.4         69257-69422         c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1706
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /note="abhydrolase domain containing 17A, depalmitoylase"
                     /db_xref="GeneID:81926"
                     /db_xref="HGNC:HGNC:28756"
                     /db_xref="MIM:617942"
     exon            1..145
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..715
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /inference="alignment:Splign:2.1.0"
     CDS             384..1316
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /EC_number="3.1.2.22"
                     /note="isoform 2 is encoded by transcript variant 2;
                     abhydrolase domain-containing protein FAM108A1; family
                     with sequence similarity 108, member A1; alpha/beta
                     hydrolase domain-containing protein 17A; abhydrolase
                     domain-containing protein 17A; protein ABHD17A"
                     /codon_start=1
                     /product="alpha/beta hydrolase domain-containing protein
                     17A isoform 2"
                     /protein_id="NP_001123583.1"
                     /db_xref="CCDS:CCDS45902.1"
                     /db_xref="GeneID:81926"
                     /db_xref="HGNC:HGNC:28756"
                     /db_xref="MIM:617942"
                     /translation="MNGLSLSELCCLFCCPPCPGRIAAKLAFLPPEATYSLVPEPEPG
                     PGGAGAAPLGTLRASSGAPGRWKLHLTERADFQYSQRELDTIEVFPTKSARGNRVSCM
                     YVRCVPGARYTVLFSHGNAVDLGQMSSFYIGLGSRLHCNIFSYDYSGYGASSGRPSER
                     NLYADIDAAWQALRTRYGISPDSIILYGQSIGTVPTVDLASRYECAAVVLHSPLTSGM
                     RVAFPDTKKTYCFDAFPNIEKVSKITSPVLIIHGTEDEVIDFSHGLALYERCPKAVEP
                     LWVEGAGHNDIELYSQYLERLRRFISQELPSQRA"
     exon            716..910
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1090
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1706
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1521..1526
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /note="hexamer: ATTAAA"
     polyA_site      1540
                     /gene="ABHD17A"
                     /gene_synonym="C19orf27; FAM108A1"
                     /note="major polyA site"
ORIGIN      
        1 gaggctcact tccgtccgtg gggggagctg cggcggtggc ggtgcaggag gccgggcagg
       61 ggtgcggagg gaccgacgga cgcacgggcg ggcggccggg agccatggag cgcggccctg
      121 gggcccgggg gcgcgggccg gggtgggctt cccacggcac gacatggaga cctgtggttg
      181 cgaggctccc tggggctcgg cttggaccgc gatggggctg ggccctggcc tcctaacggg
      241 gctgctgtct ggggcggtag ctgggggggc gctctccccc ctgcccgcga ctcggagcac
      301 ccccacccct cccctgccgg gccaggccgg gcggcgttgt tggcgggggc cccggtggag
      361 gcccggcctg ggcggcgccc gccatgaatg ggctgtcgct gagtgagctc tgctgcctct
      421 tctgctgccc gccctgcccc ggccgcatcg ctgccaagct cgccttcctg ccgccggagg
      481 ccacctactc cctggtgcct gagcccgagc cggggcctgg tggggccggg gccgccccct
      541 tggggaccct gagagcctcc tcgggcgcac ccgggcgctg gaagctgcac ctgacggagc
      601 gtgccgactt ccagtacagc cagcgcgagc tggacaccat cgaggtcttc cccaccaaga
      661 gcgcccgcgg caaccgcgtc tcctgcatgt atgttcgctg cgtgcctggt gccaggtaca
      721 cggtcctctt ctcgcacggc aatgccgtgg acctgggcca gatgagcagc ttctacattg
      781 gcctgggctc ccgcctccac tgcaacatct tctcctacga ctactccggc tacggtgcca
      841 gctcgggcag gccttccgag aggaacctct atgccgacat cgacgccgcc tggcaggccc
      901 tgcgcaccag gtacggcatc agcccggaca gcatcatcct gtacgggcag agcatcggca
      961 cggtgcccac cgtggacctg gcctcgcgct acgagtgtgc cgcggtggtg ctgcactcgc
     1021 cgctcacctc gggcatgcgc gtcgccttcc ccgacaccaa gaagacctac tgcttcgacg
     1081 ccttccctaa catcgagaag gtgtccaaga tcacgtctcc cgtgctcatc atccacggca
     1141 cggaggacga ggtgatcgac ttctcgcacg ggctggcgct ctacgagcgc tgccccaagg
     1201 cggtggagcc gctgtgggtg gagggcgccg ggcacaacga catcgagctc tacagccagt
     1261 acctggagcg cctgcgtcgc ttcatctccc aggagctgcc cagccagcgc gcctagcggc
     1321 ggccccaacc ggccggacct cagcaataag gcggcccccg gacctcaccc cgcgccggcc
     1381 cccacccagg ggctgcatgt ggaccccccg ggcggcccag gggaccccgc cccgacccag
     1441 gggctgtgga cgatgtacag gcaacagagc tacgcactcc tttccttttg gaagcaagaa
     1501 gaaaatacgt gaaaacggaa attaaagatt taaaatttta gggctgctct ccttcctttc
     1561 atggctctgc tcactctctc gagcgctcag cgagctcgaa agggggccgg ggttcccagg
     1621 tttcgtccct gagtccctag gagagatcgg cacggacccc cttataggtt ttactctgcg
     1681 gaagtggggt gggtctctgt ctagtc
//
