LOCUS       NM_080622               1491 bp    mRNA    linear   PRI 08-DEC-2024
DEFINITION  Homo sapiens abhydrolase domain containing 16B (ABHD16B), mRNA.
ACCESSION   NM_080622
VERSION     NM_080622.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1491)
  AUTHORS   Narayanasamy,R., Rajasekharan,R. and Usharani,D.
  TITLE     Molecular insights on PS-PLA1 lipase activity of human ABHD16B
  JOURNAL   Biophys Chem 296, 106976 (2023)
   PUBMED   36841071
  REMARK    GeneRIF: Molecular insights on PS-PLA1 lipase activity of human
            ABHD16B.
REFERENCE   2  (bases 1 to 1491)
  AUTHORS   Shan,S., Xu,F., Bleyer,M., Becker,S., Melbaum,T., Wemheuer,W.,
            Hirschfeld,M., Wacker,C., Zhao,S., Schutz,E. and Brenig,B.
  TITLE     Association of alpha/beta-Hydrolase D16B with Bovine Conception
            Rate and Sperm Plasma Membrane Lipid Composition
  JOURNAL   Int J Mol Sci 21 (2), 627 (2020)
   PUBMED   31963602
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1491)
  AUTHORS   Eeles,R.A., Olama,A.A., Benlloch,S., Saunders,E.J.,
            Leongamornlert,D.A., Tymrakiewicz,M., Ghoussaini,M., Luccarini,C.,
            Dennis,J., Jugurnauth-Little,S., Dadaev,T., Neal,D.E., Hamdy,F.C.,
            Donovan,J.L., Muir,K., Giles,G.G., Severi,G., Wiklund,F.,
            Gronberg,H., Haiman,C.A., Schumacher,F., Henderson,B.E., Le
            Marchand,L., Lindstrom,S., Kraft,P., Hunter,D.J., Gapstur,S.,
            Chanock,S.J., Berndt,S.I., Albanes,D., Andriole,G., Schleutker,J.,
            Weischer,M., Canzian,F., Riboli,E., Key,T.J., Travis,R.C.,
            Campa,D., Ingles,S.A., John,E.M., Hayes,R.B., Pharoah,P.D.,
            Pashayan,N., Khaw,K.T., Stanford,J.L., Ostrander,E.A.,
            Signorello,L.B., Thibodeau,S.N., Schaid,D., Maier,C., Vogel,W.,
            Kibel,A.S., Cybulski,C., Lubinski,J., Cannon-Albright,L.,
            Brenner,H., Park,J.Y., Kaneva,R., Batra,J., Spurdle,A.B.,
            Clements,J.A., Teixeira,M.R., Dicks,E., Lee,A., Dunning,A.M.,
            Baynes,C., Conroy,D., Maranian,M.J., Ahmed,S., Govindasami,K.,
            Guy,M., Wilkinson,R.A., Sawyer,E.J., Morgan,A., Dearnaley,D.P.,
            Horwich,A., Huddart,R.A., Khoo,V.S., Parker,C.C., Van As,N.J.,
            Woodhouse,C.J., Thompson,A., Dudderidge,T., Ogden,C., Cooper,C.S.,
            Lophatananon,A., Cox,A., Southey,M.C., Hopper,J.L., English,D.R.,
            Aly,M., Adolfsson,J., Xu,J., Zheng,S.L., Yeager,M., Kaaks,R.,
            Diver,W.R., Gaudet,M.M., Stern,M.C., Corral,R., Joshi,A.D.,
            Shahabi,A., Wahlfors,T., Tammela,T.L., Auvinen,A., Virtamo,J.,
            Klarskov,P., Nordestgaard,B.G., Roder,M.A., Nielsen,S.F.,
            Bojesen,S.E., Siddiq,A., Fitzgerald,L.M., Kolb,S., Kwon,E.M.,
            Karyadi,D.M., Blot,W.J., Zheng,W., Cai,Q., McDonnell,S.K.,
            Rinckleb,A.E., Drake,B., Colditz,G., Wokolorczyk,D.,
            Stephenson,R.A., Teerlink,C., Muller,H., Rothenbacher,D.,
            Sellers,T.A., Lin,H.Y., Slavov,C., Mitev,V., Lose,F.,
            Srinivasan,S., Maia,S., Paulo,P., Lange,E., Cooney,K.A.,
            Antoniou,A.C., Vincent,D., Bacot,F., Tessier,D.C., Kote-Jarai,Z.
            and Easton,D.F.
  CONSRTM   COGS-Cancer Research UK GWAS-ELLIPSE (part of GAME-ON) Initiative;
            Australian Prostate Cancer Bioresource; UK Genetic Prostate Cancer
            Study Collaborators/British Association of Urological Surgeons'
            Section of Oncology; UK ProtecT (Prostate testing for cancer and
            Treatment) Study Collaborators; PRACTICAL (Prostate Cancer
            Association Group to Investigate Cancer-Associated Alterations in
            the Genome) Consortium
  TITLE     Identification of 23 new prostate cancer susceptibility loci using
            the iCOGS custom genotyping array
  JOURNAL   Nat Genet 45 (4), 385-391 (2013)
   PUBMED   23535732
REFERENCE   4  (bases 1 to 1491)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL118506.27.
            
            On Nov 26, 2019 this sequence version replaced NM_080622.3.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC031949.1, ERR279855.305.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000369916.5/ ENSP00000358932.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1491              AL118506.27        2446-3936
FEATURES             Location/Qualifiers
     source          1..1491
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q13.33"
     gene            1..1491
                     /gene="ABHD16B"
                     /gene_synonym="C20orf135; dJ591C20.1"
                     /note="abhydrolase domain containing 16B"
                     /db_xref="GeneID:140701"
                     /db_xref="HGNC:HGNC:16128"
                     /db_xref="MIM:620190"
     exon            1..1491
                     /gene="ABHD16B"
                     /gene_synonym="C20orf135; dJ591C20.1"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1453
                     /gene="ABHD16B"
                     /gene_synonym="C20orf135; dJ591C20.1"
                     /EC_number="3.1.1.111"
                     /note="abhydrolase domain-containing protein 16B; protein
                     ABHD16B; alpha/beta hydrolase domain-containing protein
                     16B"
                     /codon_start=1
                     /product="ABHD16B"
                     /protein_id="NP_542189.1"
                     /db_xref="CCDS:CCDS13539.1"
                     /db_xref="GeneID:140701"
                     /db_xref="HGNC:HGNC:16128"
                     /db_xref="MIM:620190"
                     /translation="MCVICFVKALVRVFKIYLTASYTYPFRGWPVAFRWDDVRAVGRS
                     SSHRALTCAAAAAGVWLLRDETLGGDALGRPPRGARSQAQCLLQQLRELPGQLASYAL
                     AHSLGRWLVYPGSVSLMTRALLPLLQQGQERLVERYHGRRAKLVACDGNEIDTMFMDR
                     RQHPGSHVHGPRLVICCEGNAGFYEMGCLSAPLEAGYSVLGWNHPGFGSSTGVPFPQH
                     DANAMDVVVEYALHRLHFPPAHLVVYGWSVGGFTATWATMTYPELGALVLDATFDDLV
                     PLALKVMPHSWKGLVVRTVREHFNLNVAEQLCCYPGPVLLLRRTQDDVVSTSGRLRPL
                     SPGDVEGNRGNELLLRLLEHRYPVVMAREGRAVVTRWLRAGSLAQEAAFYARYRVDED
                     WCLALLRSYRARCEEELEGEEALGPHGPAFPWLVGQGLSSRRRRRLALFLARKHLKNV
                     EATHFSPLEPEEFQLPWRL"
ORIGIN      
        1 gcggcgatcc cggcccagcg gctgggcgtt agggccaccg ctcatgtgcg tcatctgctt
       61 cgtgaaggcg ctggtgcgcg tgttcaagat ctacctgacc gccagctaca cctacccatt
      121 ccgcggctgg cccgtggcct tccgctggga tgacgtgcgc gccgtgggcc ggagcagcag
      181 ccaccgggcg ctgacctgcg cggcagccgc ggcgggcgtg tggttgctgc gggacgagac
      241 gctgggcggg gatgcgctgg ggcggcctcc acgtggggcg cgcagccagg cgcagtgcct
      301 cttgcagcag ctccgcgagc tgcccggcca gctcgctagc tacgcgctgg cccactcgct
      361 gggccgctgg ctcgtgtacc ccggctccgt gtccctgatg acgcgcgcgc tgctgccgct
      421 gctgcagcag ggccaagagc gcctcgtgga gcgctaccac ggccggcgcg ccaagctggt
      481 ggcctgtgac ggcaacgaga tcgacactat gttcatggac cgccgccagc acccgggcag
      541 ccacgtgcac gggccgcgcc tcgtcatctg ctgcgaaggc aacgcgggct tctacgagat
      601 gggctgtctg tctgcaccgc tcgaggccgg ctactccgtg ctgggctgga accaccccgg
      661 cttcggcagc agcactggcg tgcccttccc tcagcacgac gccaacgcca tggacgtggt
      721 ggtcgagtac gcactgcacc gcctgcactt cccgcccgcg cacctggtgg tctacggctg
      781 gtctgttggc ggcttcacgg ccacctgggc caccatgacc tacccggagc tgggtgcact
      841 ggtgctggac gccaccttcg acgaccttgt gccgctggcg ctgaaggtca tgccccacag
      901 ttggaagggg ctggtggtgc gcaccgtgcg cgagcacttc aacctcaacg tggccgagca
      961 gctgtgctgc tacccggggc cggtgctgct gctccgacgc acgcaggatg acgtggtcag
     1021 cacttcgggc cgcctgcgcc ccctgtcacc tggtgacgtg gagggcaacc ggggcaatga
     1081 gctgctgctg cgcctgctgg agcaccgcta ccccgtcgtg atggcgcgag agggccgcgc
     1141 cgtcgtcacc cgctggctgc gcgctggcag cttggcgcag gaggccgcct tctatgcacg
     1201 ctaccgcgtg gacgaggact ggtgcctggc gctgctgcgc tcctaccgtg cacgctgcga
     1261 agaggagctg gagggcgagg aggccctggg gccacacgga cccgccttcc catggctggt
     1321 gggccagggc ctgagctcgc ggcggcgccg gcgcctcgca ctgttcctgg ctcggaagca
     1381 cctcaagaac gtggaggcga ctcacttcag ccctctggag cctgaggagt ttcagttgcc
     1441 ctggcggctg taacctatat gccccagtgg gggatcacgc acttgaactc c
//
