LOCUS       NM_198147               3492 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens abhydrolase domain containing 15 (ABHD15), mRNA.
ACCESSION   NM_198147 XM_057674
VERSION     NM_198147.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3492)
  AUTHORS   Huang,G., Guo,X., Guo,J., Zhang,P., Liang,W., Bai,C. and Zhang,Y.
  TITLE     ABHD15 promotes cell viability, glycolysis, and inhibits apoptosis
            in cardiomyocytes under hypoxia
  JOURNAL   Nutr Metab Cardiovasc Dis 31 (2), 681-690 (2021)
   PUBMED   33257193
  REMARK    GeneRIF: ABHD15 promotes cell viability, glycolysis, and inhibits
            apoptosis in cardiomyocytes under hypoxia.
REFERENCE   2  (bases 1 to 3492)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3492)
  AUTHORS   Xia,W., Pessentheiner,A.R., Hofer,D.C., Amor,M., Schreiber,R.,
            Schoiswohl,G., Eichmann,T.O., Walenta,E., Itariu,B., Prager,G.,
            Hackl,H., Stulnig,T., Kratky,D., Rulicke,T. and Bogner-Strauss,J.G.
  TITLE     Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by
            Altering PDE3B Stability and Contributes to Insulin Resistance
  JOURNAL   Cell Rep 23 (7), 1948-1961 (2018)
   PUBMED   29768196
  REMARK    GeneRIF: ABHD15 associates with and stabilizes phosphodiesterase 3B
            (PDE3B).
REFERENCE   4  (bases 1 to 3492)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   5  (bases 1 to 3492)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104564.11, BC012476.1 and AK056717.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198147.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012476.1, SRR1660803.195085.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000307201.5/ ENSP00000302657.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AC104564.11        154473-154485
            14-929              BC012476.1         1-916
            930-1070            AK056717.1         430-570
            1071-1071           AC104564.11        158542-158542
            1072-2626           BC012476.1         1059-2613
            2627-2774           AK056717.1         2127-2274
            2775-3084           BC012476.1         2762-3071
            3085-3085           AC104564.11        160556-160556
            3086-3378           BC012476.1         3073-3365
            3379-3492           AC104564.11        160850-160963
FEATURES             Location/Qualifiers
     source          1..3492
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..3492
                     /gene="ABHD15"
                     /note="abhydrolase domain containing 15"
                     /db_xref="GeneID:116236"
                     /db_xref="HGNC:HGNC:26971"
                     /db_xref="MIM:619894"
     exon            1..952
                     /gene="ABHD15"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..1478
                     /gene="ABHD15"
                     /EC_number="3.1.1.-"
                     /note="abhydrolase domain-containing protein 15;
                     alpha/beta hydrolase domain-containing protein 15; protein
                     ABHD15"
                     /codon_start=1
                     /product="protein ABHD15 precursor"
                     /protein_id="NP_937790.2"
                     /db_xref="CCDS:CCDS32602.1"
                     /db_xref="GeneID:116236"
                     /db_xref="HGNC:HGNC:26971"
                     /db_xref="MIM:619894"
                     /translation="MPPWGAALALILAVLALLGLLGPRLRGPWGRAVGERTLPGAQDR
                     DDGEEADGGGPADQFSDGREPLPGGCSLVCKPSALAQCLLRALRRSEALEAGPRSWFS
                     GPHLQTLCHFVLPVAPGPELAREYLQLADDGLVALDWVVGPCVRGRRITSAGGLPAVL
                     LVIPNAWGRLTRNVLGLCLLALERGYYPVIFHRRGHHGCPLVSPRLQPFGDPSDLKEA
                     VTYIRFRHPAAPLFAVSEGSGSALLLSYLGECGSSSYVTGAACISPVLRCREWFEAGL
                     PWPYERGFLLHQKIALSRYATALEDTVDTSRLFRSRSLREFEEALFCHTKSFPISWDT
                     YWDRNDPLRDVDEAAVPVLCICSADDPVCGPPDHTLTTELFHSNPYFFLLLSRHGGHC
                     GFLRQEPLPAWSHEVILESFRALTEFFRTEERIKGLSRHRASFLGGRRRGGALQRREV
                     SSSSNLEEIFNWKRSYTR"
     exon            953..3492
                     /gene="ABHD15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2723..2728
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD15"
                     /note="hexamer: ATTAAA"
     polyA_site      2746
                     /gene="ABHD15"
                     /note="major polyA site"
     polyA_site      2779
                     /gene="ABHD15"
     regulatory      3471..3476
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD15"
                     /note="hexamer: AATAAA"
     polyA_site      3492
                     /gene="ABHD15"
                     /note="major polyA site"
ORIGIN      
        1 gggcaaagcg cggagctcgc cgagtagacg gccccgccgc ccgctgcccg ccggggctct
       61 ccagcttcgc catgccgccg tggggcgccg ccctcgcgct catcttggcc gtgctcgccc
      121 ttctcggcct gctcggcccg cggctccggg gaccctgggg gcgcgccgtc ggagagagga
      181 ccctgccggg ggcccaagac cgagacgacg gggaggaggc ggacggcgga ggcccggcgg
      241 accagttcag cgacgggcgc gagccactgc cgggagggtg cagccttgtt tgcaagccgt
      301 cggccctggc ccagtgcctg ctgcgcgccc tgcggcgctc agaggcgctg gaggccggcc
      361 cgcgctcctg gttctccggg ccccacctgc agaccctctg ccacttcgtc ctgcccgtag
      421 cgcctgggcc tgagctggcc cgggagtacc tgcagttggc ggacgatggg ctagtggccc
      481 tggactgggt ggtaggacct tgtgttcggg gccgccggat caccagcgcc gggggccttc
      541 ctgcggtgct tctggtgatc cccaatgcgt ggggtcgcct cacccgcaac gtgctcggcc
      601 tttgcttgct cgccctggag cgcggctact acccggtcat cttccatcgc cgcggccacc
      661 acggttgccc actggtcagc ccccggctgc agcctttcgg ggacccgtcc gacctcaagg
      721 aggcggtcac atacatccgc ttccgacacc cggcggcgcc gctgttcgcg gtgagcgaag
      781 gctcgggctc ggcgctgctc ctgtcctacc tgggcgagtg cggctcctcc agctacgtga
      841 caggcgccgc ctgcatctcg cccgtgctgc gctgccgaga gtggttcgag gccggcctgc
      901 cctggcccta cgagcggggc tttctgctcc accagaagat cgccctcagc aggtatgcca
      961 cagccctgga ggacactgtg gacaccagca gactgttcag gagccgttcc cttcgagagt
     1021 ttgaggaggc tctcttctgc cacaccaaaa gcttccccat cagctgggat acctactggg
     1081 accgcaacga cccgctccgg gatgtcgatg aggcagccgt gcctgtgctg tgtatctgca
     1141 gtgctgacga ccccgtgtgt ggacccccag accacactct gacaactgaa ctcttccaca
     1201 gcaaccccta cttcttcctc ctgctcagtc gccacggagg ccactgtggc ttcctgcgcc
     1261 aggagccctt gccagcctgg agccatgagg tcatcttgga gtccttccgg gccttgactg
     1321 agttcttccg aacggaggag aggattaaag ggctgagcag gcacagagct tccttccttg
     1381 ggggccgtcg tcgtggggga gccttgcaga ggcgggaagt ctcttcctct tccaacctgg
     1441 aggagatctt taactggaag cgatcataca caaggtgaaa gacctggcct gagaaccccc
     1501 aagtcctgca aagaaaaaca gagctgggca agggggagtc ctggaaagat ggggcggact
     1561 gaacagaggg agctccagct ctgtgctcct cattcagtcc ctctctctta aattggtgcc
     1621 ttgaaagaga aggaacgtcc tgcgagcctg cactcacttc atcctcagca gaactcctgc
     1681 ctggcctctg ctcaacatat ccctactcat ccggtcagca gcggcgcgtt ccagtcactg
     1741 tcacctgtca ctgacatcac aagccaaagg atagcacttt ttcaatccat ggactcagga
     1801 gaaaatgccc tcttactggc agtggctaga gggatgagac gtttgtgtat gtcactgggc
     1861 agtgaccccg attctcaagc tggagccatt tgatgtcatg aggacaggat gtttgtgtct
     1921 cggccccact tccctcattt gctctgtggt tgtggcgccc tgctttgacc gaatgctctg
     1981 gcaactgcgg cagcaggctt gtgtgtgtga gaagggcggc agaggcagtg gggctggctc
     2041 gctgagggct gagcaggtag agaatgtgaa tgtccatctc aaggaatgcg aagttccaat
     2101 ctctcagagg agctctgcaa gtctcagcta ggaatggggc tgatctggcc cccaagcctc
     2161 actggagaga tcccaagggt attttacaaa taggaagcgc tctcatgcag gatctgaggg
     2221 ctttgctaga ccatggttca aggagtcaga atcttggcta ccctacatgc tccctctggc
     2281 accatttcag gggattactc cagagagctg cagccagaac tgtttatctc ctgagatatg
     2341 gactttctct aagtcaggaa aagcacaaac ctcataactt aggtgttttc tggttggttg
     2401 ctcccttttc tgatcctact actggcctct ccctttccag agccaggaga cacatctggg
     2461 accagaggaa acaaaagcac caagaggttg actagagctg accagtgatt tacaaatatt
     2521 tcatattcca atgcttcgtc tgctcaatta ttcaaaaggc catccctgta aaggcagaaa
     2581 agcttcctct tagatctggc cactcagcaa ataagtgggt atttggtttt atgaagaata
     2641 atgctgagga ctagagatat agtatatcag agataatata tagtatacag gttgatctaa
     2701 atattctggt ttggattagg caattaaaat ttttttggca acaggacata tgtttccatg
     2761 tgttgctaag attcaaaaac tttgccctga agttttattt taatcgtcat tgagaaagag
     2821 ggctcctgtt ctgacctcaa aaacagcaaa gctgttgtaa agaagagagc tgcttatacg
     2881 aaaacccaca ttccaagact tggtataagg tattcctgag gccttgattt caggtttgga
     2941 taatcttgcc ccagattcta gatcttgttc ttctagatca aatcagaaga aactttgaaa
     3001 taactccaag aatctgcact gaaatgtaga cagcactcga taatctaagg gacattatct
     3061 tgttgtgaaa aattatctcc ctcctggctg ggagcggtgg cacacaccta taatctcagc
     3121 actttgggag gccgaggtgg gtggatcacg aggtcaggag atcgagacca tcctggctaa
     3181 cacagtgaaa cctcatctct actaaaaata caaaaaatta gccgggcgtg gtagcgggtg
     3241 cctgtaatcc cagttactca ggaggctgag gcaggagaat ggcgtgaacc cgggaggcgg
     3301 agcttgcagt gagctgagat cgcaccactg cactccagcc tgggcgacag agtaagactg
     3361 tgtttcaaaa aaaaaaaaga aaagaaaaat tatctccctt ctccccactt cttgtttctc
     3421 ctcctccata ttcctcatct gacgttcttt tgccgtttct aagcaggata aataaaaagg
     3481 aactgaaatt aa
//
