LOCUS       NM_001146314            1657 bp    mRNA    linear   PRI 17-DEC-2024
DEFINITION  Homo sapiens abhydrolase domain containing 14B (ABHD14B),
            transcript variant 2, mRNA.
ACCESSION   NM_001146314
VERSION     NM_001146314.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1657)
  AUTHORS   Rajendran,A., Soory,A., Khandelwal,N., Ratnaparkhi,G. and
            Kamat,S.S.
  TITLE     A multi-omics analysis reveals that the lysine deacetylase ABHD14B
            influences glucose metabolism in mammals
  JOURNAL   J Biol Chem 298 (7), 102128 (2022)
   PUBMED   35700823
REFERENCE   2  (bases 1 to 1657)
  AUTHORS   Rajendran,A., Vaidya,K., Mendoza,J., Bridwell-Rabb,J. and
            Kamat,S.S.
  TITLE     Functional Annotation of ABHD14B, an Orphan Serine Hydrolase Enzyme
  JOURNAL   Biochemistry 59 (2), 183-196 (2020)
   PUBMED   31478652
  REMARK    GeneRIF: ABHD14B is a lysine deacetylase that transfers an acetyl
            group on a lysine residue to coenzyme A.
REFERENCE   3  (bases 1 to 1657)
  AUTHORS   Gonzalez-Begne,M., Lu,B., Han,X., Hagen,F.K., Hand,A.R.,
            Melvin,J.E. and Yates,J.R.
  TITLE     Proteomic analysis of human parotid gland exosomes by
            multidimensional protein identification technology (MudPIT)
  JOURNAL   J Proteome Res 8 (3), 1304-1314 (2009)
   PUBMED   19199708
REFERENCE   4  (bases 1 to 1657)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 1657)
  AUTHORS   Padmanabhan,B., Kuzuhara,T., Adachi,N. and Horikoshi,M.
  TITLE     The crystal structure of CCG1/TAF(II)250-interacting factor B (CIB)
  JOURNAL   J Biol Chem 279 (10), 9615-9624 (2004)
   PUBMED   14672934
REFERENCE   6  (bases 1 to 1657)
  AUTHORS   Padmanabhan,B., Kuzuhara,T., Mizuno,H. and Horikoshi,M.
  TITLE     Purification, crystallization and preliminary X-ray
            crystallographic analysis of human CCG1-interacting factor B
  JOURNAL   Acta Crystallogr D Biol Crystallogr 56 (Pt 11), 1479-1481 (2000)
   PUBMED   11053859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096073.1 and BC056411.1.
            
            On Aug 11, 2020 this sequence version replaced NM_001146314.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056411.1, SRR14038196.2292565.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2153932, SAMEA2153980
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361143.10/ ENSP00000354841.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AK096073.1         582-599
            19-1657             BC056411.1         1-1639
FEATURES             Location/Qualifiers
     source          1..1657
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..1657
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /note="abhydrolase domain containing 14B"
                     /db_xref="GeneID:84836"
                     /db_xref="HGNC:HGNC:28235"
                     /db_xref="MIM:621040"
     exon            1..85
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /inference="alignment:Splign:2.1.0"
     exon            86..324
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..746
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /EC_number="3.-.-.-"
                     /note="isoform 1 is encoded by transcript variant 2; cell
                     cycle gene 1-interacting factor B; abhydrolase
                     domain-containing protein 14B; CCG1-interacting factor B;
                     alpha/beta hydrolase domain-containing protein 14B;
                     epididymis secretory protein Li 299; protein ABHD14B;
                     epididymis secretory sperm binding protein; putative
                     protein-lysine deacylase ABHD14B;
                     CCG1/TAFII250-interacting factor B"
                     /codon_start=1
                     /product="putative protein-lysine deacylase ABHD14B
                     isoform 1"
                     /protein_id="NP_001139786.1"
                     /db_xref="CCDS:CCDS2842.1"
                     /db_xref="GeneID:84836"
                     /db_xref="HGNC:HGNC:28235"
                     /db_xref="MIM:621040"
                     /translation="MAASVEQREGTIQVQGQALFFREALPGSGQARFSVLLLHGIRFS
                     SETWQNLGTLHRLAQAGYRAVAIDLPGLGHSKEAAAPAPIGELAPGSFLAAVVDALEL
                     GPPVVISPSLSGMYSLPFLTAPGSQLPGFVPVAPICTDKINAANYASVKTPALIVYGD
                     QDPMGQTSFEHLKQLPNHRVLIMKGAGHPCYLDKPEEWHTGLLDFLQGLQ"
     exon            325..566
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /inference="alignment:Splign:2.1.0"
     exon            567..1657
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1638..1643
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /note="hexamer: AATAAA"
     polyA_site      1657
                     /gene="ABHD14B"
                     /gene_synonym="CIB; HEL-S-299"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcccag cgttcctcct ccggccccag gtcaccgcca gcacgcgcct gcttcccgtc
       61 tgcgcgagtc cacgcagctc cccaggccct tcaccagcac agcagcagca ggcatggcag
      121 caagcgtgga gcagcgcgag ggcaccatcc aggtgcaggg ccaggccctc ttcttccgag
      181 aggccctgcc cggcagtggg caggctcgct tctctgtact gctgctgcat ggtattcgct
      241 tctcctccga gacctggcag aacctgggta cactgcacag gctggcccag gctggctacc
      301 gggctgtggc cattgacctg ccaggtctgg ggcactccaa ggaagcagca gcccctgccc
      361 ctattgggga gctggcccct ggcagcttcc tggcggctgt ggtggatgcc ttggagctgg
      421 gccccccggt tgtgatcagt ccatcactga gtggcatgta ctccctgccc ttcctcacgg
      481 cccctggctc ccagctcccg ggctttgtgc cagtggcccc catctgcact gacaaaatca
      541 atgctgccaa ctatgccagt gtgaagactc cagctctgat tgtatatgga gaccaggacc
      601 ccatgggtca gaccagcttt gagcacctga agcagctgcc caaccaccgg gtgctgatca
      661 tgaagggggc ggggcacccc tgttacctgg acaaaccaga ggagtggcat acagggctgc
      721 tggacttcct gcaggggctc cagtgaagcc cagcactgct gcagggggtg ggctgcctgc
      781 ctgctctgag ctctctcttg cacgctctct cttctctccc aggctctggc tcatgcacat
      841 gcaacaggtg cgtctgtcta tatgtctggg ttcttgtctt ttgtggtctg tttgtctttt
      901 ctacctcttt ctcttgcagt gatagactga gggggtaaaa tcaagagaaa aaactctcag
      961 gaatcaagga acataatcct gtggagggta atccattaca tgagcttctc ctgttcttcc
     1021 actttcctgc ctggctttca ctccttcccc tgctctgccc agcctttccc tcccacccac
     1081 tcctccttct gcaaatgccc tgaaggccag cccttacccc aacacccact tccccacctc
     1141 cttaggcccc agatacatac atgcccacat gcacgcttac atgtttagag ccatccttgt
     1201 ttccaaatat gacccttcgc ttgagggcaa ctgcataggt acatctaact ctggactggc
     1261 atgcacattg tcatgtgcag ctttgcatat acacacatgc atacatgagc ctccacacaa
     1321 gcacttgcac acatgtggac tcctaaccat gctaacctca ctggctggga aggtggggac
     1381 cccatgggcc agcccttgca ggaggccctt ttgcaaggct tagggtgtgg ccagccctga
     1441 aagctacttg gacacaggtt tcagctggcc ccagcccaga agtgaccccc agaaagggag
     1501 ggccaccgct ttgccccctg cttttaccct tccttctggg tgctctacac ctcaggttac
     1561 caggcctgag gcatctcagc caagcttgtt tcctgctctg aggcttgtgg ggtgggagcc
     1621 agagtggagg tcggtgaaat aaagtgatgc aattaga
//
