LOCUS       NM_001316331            1836 bp    mRNA    linear   PRI 15-SEP-2020
DEFINITION  Homo sapiens ABHD14A-ACY1 readthrough (ABHD14A-ACY1), mRNA.
ACCESSION   NM_001316331
VERSION     NM_001316331.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1836)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS ONE 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK298086.1 and AC115284.4.
            
            On Jun 2, 2019 this sequence version replaced NM_001316331.1.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring abhydrolase domain containing
            14A (ABHD14A) and aminoacylase 1 (ACY1) genes on chromosome 3. The
            read-through transcript encodes a protein that shares sequence
            identity with the downstream gene product but its N-terminal region
            is distinct due to the use of an alternate start codon relative to
            the upstream gene. [provided by RefSeq, Oct 2015].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK298086.1, SRR1660809.133634.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 95, 25864
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1239              AK298086.1         15-1253
            1240-1240           AC115284.4         69241-69241
            1241-1822           AK298086.1         1255-1836
            1823-1836           AC115284.4         71071-71084
FEATURES             Location/Qualifiers
     source          1..1836
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.2"
     gene            1..1836
                     /gene="ABHD14A-ACY1"
                     /note="ABHD14A-ACY1 readthrough"
                     /db_xref="GeneID:100526760"
                     /db_xref="HGNC:HGNC:38856"
     exon            1..141
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            142..353
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     CDS             218..1714
                     /gene="ABHD14A-ACY1"
                     /note="ABHD14A-ACY1 readthrough (non-protein coding)"
                     /codon_start=1
                     /product="ABHD14A-ACY1 readthrough (NMD candidate)"
                     /protein_id="NP_001303260.1"
                     /db_xref="GeneID:100526760"
                     /db_xref="HGNC:HGNC:38856"
                     /translation="MWGCQAPLSRLPASGETPMSQSWLVSPLATRPSFTARCSHSTRH
                     TGWRWCCFMERPLTLTRGSSWAHCSYCHRGATGPWPLTFQLTTRSAMTSKGPEEEHPS
                     VTLFRQYLRIRTVQPKPDYGAAVAFFEETARQLGLGCQKVEVAPGYVVTVLTWPGTNP
                     TLSSILLNSHTDVVPVFKEHWSHDPFEAFKDSEGYIYARGAQDMKCVSIQYLEAVRRL
                     KVEGHRFPRTIHMTFVPDEEVGGHQGMELFVQRPEFHALRAGFALDEGIANPTDAFTV
                     FYSERSPWWVRVTSTGRPGHASRFMEDTAAEKLHKVVNSILAFREKEWQRLQSNPHLK
                     EGSVTSVNLTKLEGGVAYNVIPATMSASFDFRVAPDVDFKAFEEQLQSWCQAAGEGVT
                     LEFAQKWMHPQVTPTDDSNPWWAAFSRVCKDMNLTLEPEIMPAATDNRYIRAVGVPAL
                     GFSPMNRTPVLLHDHDERLHEAVFLRGVDIYTRLLPALASVPALPSDS"
     exon            354..469
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..581
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            582..646
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..751
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            752..846
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..923
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1013
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1014..1070
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1071..1144
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1194
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1339
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1340..1408
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1488
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1489..1549
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1836
                     /gene="ABHD14A-ACY1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1794..1799
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD14A-ACY1"
                     /note="hexamer: AATAAA"
     polyA_site      1836
                     /gene="ABHD14A-ACY1"
                     /note="major polyA site"
ORIGIN      
        1 gcaggcgcgc cgagatggcc gcgctcctgg ccgcctagag ccggagcggc ccgcggagct
       61 gcggaggcag ccatggtcgg ggcgctgtgc ggctgctggt tccgcctggg cggggcccgc
      121 ccgctcatcc cgttgggccc gactgtggta cagacctcca tgagccggtc ccaggtagcc
      181 ctgctgggcc tgagtctgct gctcatgctc ctactgtatg tggggctgcc aggcccccct
      241 gagcagactt cctgcctctg gggagacccc aatgtcacag tcctggctgg tctcacccct
      301 ggcaactcgc ccatctttta ccgcgaggtg ctcccactca accaggcaca cagggtggag
      361 gtggtgctgc ttcatggaaa ggcctttaac tctcacacgt gggagcagct gggcacactg
      421 cagctactgt cacagagggg ctaccgggcc gtggcccttg accttccagc tcaccacgcg
      481 cagcgccatg accagcaagg gtcccgagga ggagcaccca tcggtgacgc tcttccgcca
      541 gtacctgcgt atccgcactg tccagcccaa gcctgactat ggagctgctg tggctttctt
      601 tgaggagaca gcccgccagc tgggcctggg ctgtcagaaa gtagaggtgg cacctggcta
      661 tgtggtgacc gtgttgacct ggccaggcac caaccctaca ctctcctcca tcttgctcaa
      721 ctcccacacg gatgtggtgc ctgtcttcaa ggaacattgg agtcacgacc cctttgaggc
      781 cttcaaggat tctgagggct acatctatgc caggggtgcc caggacatga agtgcgtcag
      841 catccagtac ctggaagctg tgaggaggct gaaggtggag ggccaccggt tccccagaac
      901 catccacatg acctttgtgc ctgatgagga ggttgggggt caccaaggca tggagctgtt
      961 cgtgcagcgg cctgagttcc acgccctgag ggcaggcttt gccctggatg agggcatagc
     1021 caatcccact gatgccttca ctgtctttta tagtgagcgg agtccctggt gggtgcgggt
     1081 taccagcact gggaggccag gccatgcctc acgcttcatg gaggacacag cagcagagaa
     1141 gctgcacaag gttgtaaact ccatcctggc attccgggag aaggaatggc agaggctgca
     1201 gtcaaacccc cacctgaaag aggggtccgt gacctccgtg aacctgacta agctagaggg
     1261 tggcgtggcc tataacgtga tacctgccac catgagcgcc agctttgact tccgtgtggc
     1321 accggatgtg gacttcaagg cttttgagga gcagctgcag agctggtgcc aggcagctgg
     1381 cgagggggtc accctagagt ttgctcagaa gtggatgcac ccccaagtga cacctactga
     1441 tgactcaaac ccttggtggg cagcttttag ccgggtctgc aaggatatga acctcactct
     1501 ggagcctgag atcatgcctg ctgccactga caaccgctat atccgcgcgg tgggggtccc
     1561 agctctaggc ttctcaccca tgaaccgcac acctgtgctg ctgcacgacc acgatgaacg
     1621 gctgcatgag gctgtgttcc tccgtggggt ggacatatat acacgcctgc tgcctgccct
     1681 tgccagtgtg cctgccctgc ccagtgacag ctgagccctg gaactcctaa acctttgccc
     1741 ctggggcttc catcccaacc agtgccaagg acctcctctt cccccttcca aataataaag
     1801 tctatggaca gggctgtctc tgaagtacta acacaa
//
