LOCUS       NM_001042472            1960 bp    mRNA    linear   PRI 24-SEP-2024
DEFINITION  Homo sapiens abhydrolase domain containing 12, lysophospholipase
            (ABHD12), transcript variant 1, mRNA.
ACCESSION   NM_001042472
VERSION     NM_001042472.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1960)
  AUTHORS   Long,X., Xiong,W., Wang,X., Geng,J., Zhong,M., Huang,Y., Liu,M.,
            Bu,F., Cheng,J., Lu,Y. and Yuan,H.
  TITLE     Genotype-phenotype spectrum and correlation of PHARC Syndrome due
            to pathogenic ABHD12 variants
  JOURNAL   BMC Med Genomics 17 (1), 203 (2024)
   PUBMED   39123271
  REMARK    GeneRIF: Genotype-phenotype spectrum and correlation of PHARC
            Syndrome due to pathogenic ABHD12 variants.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1960)
  AUTHORS   Igelman,A.D., Ku,C., da Palma,M.M., Georgiou,M., Schiff,E.R.,
            Lam,B.L., Sankila,E.M., Ahn,J., Pyers,L., Vincent,A., Ferraz
            Sallum,J.M., Zein,W.M., Oh,J.K., Maldonado,R.S., Ryu,J.,
            Tsang,S.H., Gorin,M.B., Webster,A.R., Michaelides,M., Yang,P. and
            Pennesi,M.E.
  TITLE     Expanding the clinical phenotype in patients with disease causing
            variants associated with atypical Usher syndrome
  JOURNAL   Ophthalmic Genet 42 (6), 664-673 (2021)
   PUBMED   34223797
  REMARK    GeneRIF: Expanding the clinical phenotype in patients with disease
            causing variants associated with atypical Usher syndrome.
REFERENCE   3  (bases 1 to 1960)
  AUTHORS   Nguyen,X.T., Almushattat,H., Strubbe,I., Georgiou,M., Li,C.H.Z.,
            van Schooneveld,M.J., Joniau,I., De Baere,E., Florijn,R.J.,
            Bergen,A.A., Hoyng,C.B., Michaelides,M., Leroy,B.P. and Boon,C.J.F.
  TITLE     The Phenotypic Spectrum of Patients with PHARC Syndrome Due to
            Variants in ABHD12: An Ophthalmic Perspective
  JOURNAL   Genes (Basel) 12 (9), 1404 (2021)
   PUBMED   34573385
  REMARK    GeneRIF: The Phenotypic Spectrum of Patients with PHARC Syndrome
            Due to Variants in ABHD12: An Ophthalmic Perspective.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1960)
  AUTHORS   Singh,S., Joshi,A. and Kamat,S.S.
  TITLE     Mapping the Neuroanatomy of ABHD16A, ABHD12, and
            Lysophosphatidylserines Provides New Insights into the
            Pathophysiology of the Human Neurological Disorder PHARC
  JOURNAL   Biochemistry 59 (24), 2299-2311 (2020)
   PUBMED   32462874
  REMARK    GeneRIF: Mapping the Neuroanatomy of ABHD16A, ABHD12, and
            Lysophosphatidylserines Provides New Insights into the
            Pathophysiology of the Human Neurological Disorder PHARC.
REFERENCE   5  (bases 1 to 1960)
  AUTHORS   Jun,S., Kim,S.W., Lim,J.Y. and Park,S.J.
  TITLE     ABHD12 Knockdown Suppresses Breast Cancer Cell Proliferation,
            Migration and Invasion
  JOURNAL   Anticancer Res 40 (5), 2601-2611 (2020)
   PUBMED   32366405
  REMARK    GeneRIF: ABHD12 plays a crucial role in cell proliferation,
            migration, and invasion of breast cancer cells.
REFERENCE   6  (bases 1 to 1960)
  AUTHORS   Navia-Paldanius,D., Savinainen,J.R. and Laitinen,J.T.
  TITLE     Biochemical and pharmacological characterization of human
            alpha/beta-hydrolase domain containing 6 (ABHD6) and 12 (ABHD12)
  JOURNAL   J Lipid Res 53 (11), 2413-2424 (2012)
   PUBMED   22969151
  REMARK    GeneRIF: Data show that the three hydrolases are genuine MAG
            lipases; medium-chain saturated MAGs were the best substrates for
            hABHD6 and hMAGL, whereas hABHD12 preferred the 1 (3)- and
            2-isomers of arachidonoylglycerol.
REFERENCE   7  (bases 1 to 1960)
  AUTHORS   Eisenberger,T., Slim,R., Mansour,A., Nauck,M., Nurnberg,G.,
            Nurnberg,P., Decker,C., Dafinger,C., Ebermann,I., Bergmann,C. and
            Bolz,H.J.
  TITLE     Targeted next-generation sequencing identifies a homozygous
            nonsense mutation in ABHD12, the gene underlying PHARC, in a family
            clinically diagnosed with Usher syndrome type 3
  JOURNAL   Orphanet J Rare Dis 7, 59 (2012)
   PUBMED   22938382
  REMARK    GeneRIF: After the identification of the ABHD12 mutation in this
            family, one patient underwent neurological examination which
            revealed ataxia, but no polyneuropathy
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1960)
  AUTHORS   Chambers,J.C., Zhang,W., Sehmi,J., Li,X., Wass,M.N., Van der
            Harst,P., Holm,H., Sanna,S., Kavousi,M., Baumeister,S.E.,
            Coin,L.J., Deng,G., Gieger,C., Heard-Costa,N.L., Hottenga,J.J.,
            Kuhnel,B., Kumar,V., Lagou,V., Liang,L., Luan,J., Vidal,P.M., Mateo
            Leach,I., O'Reilly,P.F., Peden,J.F., Rahmioglu,N., Soininen,P.,
            Speliotes,E.K., Yuan,X., Thorleifsson,G., Alizadeh,B.Z.,
            Atwood,L.D., Borecki,I.B., Brown,M.J., Charoen,P., Cucca,F.,
            Das,D., de Geus,E.J., Dixon,A.L., Doring,A., Ehret,G.,
            Eyjolfsson,G.I., Farrall,M., Forouhi,N.G., Friedrich,N.,
            Goessling,W., Gudbjartsson,D.F., Harris,T.B., Hartikainen,A.L.,
            Heath,S., Hirschfield,G.M., Hofman,A., Homuth,G., Hypponen,E.,
            Janssen,H.L., Johnson,T., Kangas,A.J., Kema,I.P., Kuhn,J.P.,
            Lai,S., Lathrop,M., Lerch,M.M., Li,Y., Liang,T.J., Lin,J.P.,
            Loos,R.J., Martin,N.G., Moffatt,M.F., Montgomery,G.W., Munroe,P.B.,
            Musunuru,K., Nakamura,Y., O'Donnell,C.J., Olafsson,I.,
            Penninx,B.W., Pouta,A., Prins,B.P., Prokopenko,I., Puls,R.,
            Ruokonen,A., Savolainen,M.J., Schlessinger,D., Schouten,J.N.,
            Seedorf,U., Sen-Chowdhry,S., Siminovitch,K.A., Smit,J.H.,
            Spector,T.D., Tan,W., Teslovich,T.M., Tukiainen,T.,
            Uitterlinden,A.G., Van der Klauw,M.M., Vasan,R.S., Wallace,C.,
            Wallaschofski,H., Wichmann,H.E., Willemsen,G., Wurtz,P., Xu,C.,
            Yerges-Armstrong,L.M., Abecasis,G.R., Ahmadi,K.R., Boomsma,D.I.,
            Caulfield,M., Cookson,W.O., van Duijn,C.M., Froguel,P., Matsuda,K.,
            McCarthy,M.I., Meisinger,C., Mooser,V., Pietilainen,K.H.,
            Schumann,G., Snieder,H., Sternberg,M.J., Stolk,R.P., Thomas,H.C.,
            Thorsteinsdottir,U., Uda,M., Waeber,G., Wareham,N.J.,
            Waterworth,D.M., Watkins,H., Whitfield,J.B., Witteman,J.C.,
            Wolffenbuttel,B.H., Fox,C.S., Ala-Korpela,M., Stefansson,K.,
            Vollenweider,P., Volzke,H., Schadt,E.E., Scott,J., Jarvelin,M.R.,
            Elliott,P. and Kooner,J.S.
  CONSRTM   Alcohol Genome-wide Association (AlcGen) Consortium; Diabetes
            Genetics Replication and Meta-analyses (DIAGRAM+) Study; Genetic
            Investigation of Anthropometric Traits (GIANT) Consortium; Global
            Lipids Genetics Consortium; Genetics of Liver Disease (GOLD)
            Consortium; International Consortium for Blood Pressure
            (ICBP-GWAS); Meta-analyses of Glucose and Insulin-Related Traits
            Consortium (MAGIC)
  TITLE     Genome-wide association study identifies loci influencing
            concentrations of liver enzymes in plasma
  JOURNAL   Nat Genet 43 (11), 1131-1138 (2011)
   PUBMED   22001757
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1960)
  AUTHORS   Fiskerstrand,T., H'mida-Ben Brahim,D., Johansson,S., M'zahem,A.,
            Haukanes,B.I., Drouot,N., Zimmermann,J., Cole,A.J., Vedeler,C.,
            Bredrup,C., Assoum,M., Tazir,M., Klockgether,T., Hamri,A.,
            Steen,V.M., Boman,H., Bindoff,L.A., Koenig,M. and Knappskog,P.M.
  TITLE     Mutations in ABHD12 cause the neurodegenerative disease PHARC: An
            inborn error of endocannabinoid metabolism
  JOURNAL   Am J Hum Genet 87 (3), 410-417 (2010)
   PUBMED   20797687
  REMARK    GeneRIF: Mutations in the ABHD12 gene cause polyneuropathy, hearing
            loss, ataxia, retinitis pigmentosa, and cataract disease.
REFERENCE   10 (bases 1 to 1960)
  AUTHORS   Deloukas,P., Matthews,L.H., Ashurst,J., Burton,J., Gilbert,J.G.,
            Jones,M., Stavrides,G., Almeida,J.P., Babbage,A.K., Bagguley,C.L.,
            Bailey,J., Barlow,K.F., Bates,K.N., Beard,L.M., Beare,D.M.,
            Beasley,O.P., Bird,C.P., Blakey,S.E., Bridgeman,A.M., Brown,A.J.,
            Buck,D., Burrill,W., Butler,A.P., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M., Clark,G., Clark,L.N., Clark,S.Y.,
            Clee,C.M., Clegg,S., Cobley,V.E., Collier,R.E., Connor,R.,
            Corby,N.R., Coulson,A., Coville,G.J., Deadman,R., Dhami,P.,
            Dunn,M., Ellington,A.G., Frankland,J.A., Fraser,A., French,L.,
            Garner,P., Grafham,D.V., Griffiths,C., Griffiths,M.N., Gwilliam,R.,
            Hall,R.E., Hammond,S., Harley,J.L., Heath,P.D., Ho,S., Holden,J.L.,
            Howden,P.J., Huckle,E., Hunt,A.R., Hunt,S.E., Jekosch,K.,
            Johnson,C.M., Johnson,D., Kay,M.P., Kimberley,A.M., King,A.,
            Knights,A., Laird,G.K., Lawlor,S., Lehvaslaiho,M.H., Leversha,M.,
            Lloyd,C., Lloyd,D.M., Lovell,J.D., Marsh,V.L., Martin,S.L.,
            McConnachie,L.J., McLay,K., McMurray,A.A., Milne,S., Mistry,D.,
            Moore,M.J., Mullikin,J.C., Nickerson,T., Oliver,K., Parker,A.,
            Patel,R., Pearce,T.A., Peck,A.I., Phillimore,B.J.,
            Prathalingam,S.R., Plumb,R.W., Ramsay,H., Rice,C.M., Ross,M.T.,
            Scott,C.E., Sehra,H.K., Shownkeen,R., Sims,S., Skuce,C.D.,
            Smith,M.L., Soderlund,C., Steward,C.A., Sulston,J.E., Swann,M.,
            Sycamore,N., Taylor,R., Tee,L., Thomas,D.W., Thorpe,A., Tracey,A.,
            Tromans,A.C., Vaudin,M., Wall,M., Wallis,J.M., Whitehead,S.L.,
            Whittaker,P., Willey,D.L., Williams,L., Williams,S.A., Wilming,L.,
            Wray,P.W., Hubbard,T., Durbin,R.M., Bentley,D.R., Beck,S. and
            Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 20
  JOURNAL   Nature 414 (6866), 865-871 (2001)
   PUBMED   11780052
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ961739.1, AK075023.1 and
            BQ672998.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001042472.2.
            
            Summary: This gene encodes an enzyme that catalyzes the hydrolysis
            of 2-arachidonoyl glycerol (2-AG), the main endocannabinoid lipid
            transmitter that acts on cannabinoid receptors, CB1 and CB2. The
            endocannabinoid system is involved in a wide range of physiological
            processes, including neurotransmission, mood, appetite, pain
            appreciation, addiction behavior, and inflammation. Mutations in
            this gene are associated with the neurodegenerative disease, PHARC
            (polyneuropathy, hearing loss, ataxia, retinitis pigmentosa, and
            cataract), resulting from an inborn error of endocannabinoid
            metabolism. Alternatively spliced transcript variants encoding
            different isoforms have been noted for this gene.[provided by
            RefSeq, Jan 2011].
            
            Transcript Variant: This variant (1) represents the predominant
            transcript and encodes the shorter isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.136703.1,
                                           SRR1163655.66924.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339157.10/ ENSP00000341408.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-576               BQ961739.1         148-723
            577-1199            AK075023.1         455-1077
            1200-1675           BQ672998.1         230-705
            1676-1960           AK075023.1         1554-1838
FEATURES             Location/Qualifiers
     source          1..1960
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20p11.21"
     gene            1..1960
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /note="abhydrolase domain containing 12,
                     lysophospholipase"
                     /db_xref="GeneID:26090"
                     /db_xref="HGNC:HGNC:15868"
                     /db_xref="MIM:613599"
     exon            1..323
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     CDS             133..1329
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /EC_number="3.1.1.23"
                     /note="isoform a is encoded by transcript variant 1;
                     monoacylglycerol lipase ABHD12; abhydrolase
                     domain-containing protein 12; 2-arachidonoylglycerol
                     hydrolase ABHD12; oxidized phosphatidylserine lipase
                     ABHD12; lysophosphatidylserine lipase ABHD12"
                     /codon_start=1
                     /product="lysophosphatidylserine lipase ABHD12 isoform a"
                     /protein_id="NP_001035937.1"
                     /db_xref="CCDS:CCDS42857.1"
                     /db_xref="GeneID:26090"
                     /db_xref="HGNC:HGNC:15868"
                     /db_xref="MIM:613599"
                     /translation="MRKRTEPVALEHERCAAAGSSSSGSAAAALDADCRLKQNLRLTG
                     PAAAEPRCAADAGMKRALGRRKGVWLRLRKILFCVLGLYIAIPFLIKLCPGIQAKLIF
                     LNFVRVPYFIDLKKPQDQGLNHTCNYYLQPEEDVTIGVWHTVPAVWWKNAQGKDQMWY
                     EDALASSHPIILYLHGNAGTRGGDHRVELYKVLSSLGYHVVTFDYRGWGDSVGTPSER
                     GMTYDALHVFDWIKARSGDNPVYIWGHSLGTGVATNLVRRLCERETPPDALILESPFT
                     NIREEAKSHPFSVIYRYFPGFDWFFLDPITSSGIKFANDENVKHISCPLLILHAEDDP
                     VVPFQLGRKLYSIAAPARSFRDFKVQFVPFHSDLGYRHKYIYKSPELPRILREFLGKS
                     EPEHQH"
     exon            324..448
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            449..554
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            555..674
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            675..705
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            706..751
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            752..881
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            882..919
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            920..999
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1082
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1161
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1162..1289
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1960
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1940..1945
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /note="hexamer: AATAAA"
     polyA_site      1960
                     /gene="ABHD12"
                     /gene_synonym="ABHD12A; BEM46L2; C20orf22; dJ965G21.2;
                     hABHD12; PHARC"
                     /note="major polyA site"
ORIGIN      
        1 gcagcggcct gggctgggat gtgaggagcg gcgggttccg ggctccgggc tctgggtggc
       61 ggcggctgtg agcggcggca ctgcggcgca ggccagcggg cgccgtcggc ggctggccct
      121 gtcggccgcg ggatgaggaa gcggaccgag cccgtcgcct tggagcatga gcgctgcgcc
      181 gccgcgggct cgtcctcctc cggctcggcc gccgcggcgc tggacgccga ctgccgcctg
      241 aagcagaacc tacgcctgac gggcccggcg gcggctgagc cgcgctgcgc agccgacgcg
      301 ggaatgaagc gggcgctggg caggcgaaag ggcgtgtggt tgcgcctgag gaagatactt
      361 ttctgtgttt tggggttgta cattgccatt ccatttctca tcaaactatg tcctggaata
      421 caggccaaac tgattttctt gaatttcgta agagttccct atttcattga tttgaaaaaa
      481 ccacaggatc aaggtttgaa tcacacgtgt aactactacc tgcagccaga ggaagacgtg
      541 accattggag tctggcacac cgtccctgca gtctggtgga agaacgccca aggcaaagac
      601 cagatgtggt atgaggatgc cttggcttcc agccacccta tcattctgta cctgcatggg
      661 aacgcaggta ccagaggagg cgaccaccgc gtggagcttt acaaggtgct gagttccctt
      721 ggttaccatg tggtcacctt tgactacaga ggttggggtg actcagtggg aacgccatct
      781 gagcggggca tgacctatga cgcactccac gtttttgact ggatcaaagc aagaagtggt
      841 gacaaccccg tgtacatctg gggccactct ctgggcactg gcgtggcgac aaatctggtg
      901 cggcgcctct gtgagcgaga gacgcctcca gatgccctta tattggaatc tccattcact
      961 aatatccgcg aagaagctaa gagccatcca ttttcagtga tatatcgata cttccctggg
     1021 tttgactggt tcttccttga tcctattaca agtagtggaa ttaaatttgc aaatgatgaa
     1081 aacgtgaagc acatctcctg tcccctgctc atcctgcacg ctgaggacga cccggtggtg
     1141 cccttccagc ttggcagaaa gctctatagc atcgccgcac cagctcgaag cttccgagat
     1201 ttcaaagttc agtttgtgcc ctttcattca gaccttggct acaggcacaa atacatttac
     1261 aagagccctg agctgccacg gatactgagg gaattcctgg ggaagtcgga gcctgagcac
     1321 cagcactgag cctggccgtg ggaaggaagc atgaagacct ctgccctcct cccgttttcc
     1381 tccagtcagc agcccggtat cctgaagccc cggggggccg gcacctgcaa tgctcaggag
     1441 cccagctcgc acctggagag cacctcagat cccaggcggg gaggcccctg caggcctgca
     1501 gtgcccggag gcctgagcat ggctgtgtgg aaagcgtggg tggcaggcat gtggctctcc
     1561 ttgccgcccc tcaacctgag atcttgttgg gagacttaat ggcagcaggc agccatcact
     1621 gcctgcttga tgctgcactg agctggacag ggggagtccg ggcaggggac tcttggggct
     1681 cgggaccatg ctgagctttt tggcaccacc cacagagaac gtggggtcca ggttctttct
     1741 gcaccttccc agcacatgca gaatgactcc agtggttcca tcgtcccctc ctgccctgtg
     1801 tacctgcttg cctttctcag ctgccccacc tcccctgggc tggcccactc acccacagtg
     1861 gaagtgcccg ggatctgcac ttcctcccct ttcacctacc tgtacaccta acctggcctt
     1921 agactgagct ttatttaaga ataaaatcgt ggtggtggtc
//
