LOCUS       NM_148912               1418 bp    mRNA    linear   PRI 20-DEC-2024
DEFINITION  Homo sapiens abhydrolase domain containing 11 (ABHD11), transcript
            variant 1, also known as A, mRNA.
ACCESSION   NM_148912
VERSION     NM_148912.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1418)
  AUTHORS   Yang,T., Tian,S., Zhao,J., Pei,M., Zhao,M. and Yang,X.
  TITLE     LncRNA ABHD11-AS1 activates EGFR signaling to promote cervical
            cancer progression by preventing FUS-mediated degradation of ABHD11
            mRNA
  JOURNAL   Cell Cycle 22 (23-24), 2538-2551 (2023)
   PUBMED   38146687
  REMARK    GeneRIF: LncRNA ABHD11-AS1 activates EGFR signaling to promote
            cervical cancer progression by preventing FUS-mediated degradation
            of ABHD11 mRNA.
REFERENCE   2  (bases 1 to 1418)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1418)
  AUTHORS   Luo,J., Jiang,Y., Wu,L., Zhuo,D., Zhang,S., Jiang,X., Sun,Y. and
            Huang,Y.
  TITLE     Long non-coding RNA ABHD11-AS1 promotes colorectal cancer
            progression and invasion through targeting the integrin subunit
            alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt
            signaling pathway
  JOURNAL   Aging (Albany NY) 13 (16), 20179-20191 (2021)
   PUBMED   34375304
  REMARK    GeneRIF: Long non-coding RNA ABHD11-AS1 promotes colorectal cancer
            progression and invasion through targeting the integrin subunit
            alpha 5/focal adhesion kinase/phosphoinositide 3 kinase/Akt
            signaling pathway.
REFERENCE   4  (bases 1 to 1418)
  AUTHORS   Bailey,P.S.J., Ortmann,B.M., Martinelli,A.W., Houghton,J.W.,
            Costa,A.S.H., Burr,S.P., Antrobus,R., Frezza,C. and Nathan,J.A.
  TITLE     ABHD11 maintains 2-oxoglutarate metabolism by preserving functional
            lipoylation of the 2-oxoglutarate dehydrogenase complex
  JOURNAL   Nat Commun 11 (1), 4046 (2020)
   PUBMED   32792488
  REMARK    GeneRIF: ABHD11 maintains 2-oxoglutarate metabolism by preserving
            functional lipoylation of the 2-oxoglutarate dehydrogenase complex.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1418)
  AUTHORS   Escoubet,J., Kenigsberg,M., Derock,M., Yaligara,V., Bock,M.D.,
            Roche,S., Massey,F., de Foucauld,H., Bettembourg,C., Olivier,A.,
            Berthemy,A., Capdevielle,J., Legoux,R., Perret,E., Buzy,A.,
            Chardenot,P., Destelle,V., Leroy,A., Cahours,C., Teixeira,S.,
            Juvet,P., Gauthier,P., Leguet,M., Rocheteau-Beaujouan,L.,
            Chatoux,M.A., Deshayes,W., Clement,M., Kabiri,M., Orsini,C.,
            Mikol,V., Didier,M. and Guillemot,J.C.
  TITLE     ABHD11, a new diacylglycerol lipase involved in weight gain
            regulation
  JOURNAL   PLoS One 15 (6), e0234780 (2020)
   PUBMED   32579589
  REMARK    GeneRIF: ABHD11, a new diacylglycerol lipase involved in weight
            gain regulation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1418)
  AUTHORS   He,D., Yue,Z., Liu,L., Fang,X., Chen,L. and Han,H.
  TITLE     Long noncoding RNA ABHD11-AS1 promote cells proliferation and
            invasion of colorectal cancer via regulating the miR-1254-WNT11
            pathway
  JOURNAL   J Cell Physiol 234 (7), 12070-12079 (2019)
   PUBMED   30537177
  REMARK    GeneRIF: that ABHD11-AS1 promotes CRC progression through the
            miR-1254-WNT11 pathway
REFERENCE   7  (bases 1 to 1418)
  AUTHORS   Arya,M., Srinivasan,M. and Rajasekharan,R.
  TITLE     Human alpha beta hydrolase domain containing protein 11 and its
            yeast homolog are lipid hydrolases
  JOURNAL   Biochem Biophys Res Commun 487 (4), 875-880 (2017)
   PUBMED   28465236
  REMARK    GeneRIF: The results demonstrate that human ABHD11 and its yeast
            homolog YGR031W have a pivotal role in the lipid metabolism.
REFERENCE   8  (bases 1 to 1418)
  AUTHORS   Yang,Y., Shao,Y., Zhu,M., Li,Q., Yang,F., Lu,X., Xu,C., Xiao,B.,
            Sun,Y. and Guo,J.
  TITLE     Using gastric juice lncRNA-ABHD11-AS1 as a novel type of biomarker
            in the screening of gastric cancer
  JOURNAL   Tumour Biol 37 (1), 1183-1188 (2016)
   PUBMED   26280398
  REMARK    GeneRIF: ABHD11-AS1 is expressed in gastric cancer tissues and may
            have a role as a biological marker
REFERENCE   9  (bases 1 to 1418)
  AUTHORS   Wiedl,T., Arni,S., Roschitzki,B., Grossmann,J., Collaud,S.,
            Soltermann,A., Hillinger,S., Aebersold,R. and Weder,W.
  TITLE     Activity-based proteomics: identification of ABHD11 and ESD
            activities as potential biomarkers for human lung adenocarcinoma
  JOURNAL   J Proteomics 74 (10), 1884-1894 (2011)
   PUBMED   21596165
  REMARK    GeneRIF: Abhydrolase domain-containing protein 11 and Esterase D
            predict the development of distant metastases and the presence of
            aggressive lung adenocarcinomas.
REFERENCE   10 (bases 1 to 1418)
  AUTHORS   Merla,G., Ucla,C., Guipponi,M. and Reymond,A.
  TITLE     Identification of additional transcripts in the Williams-Beuren
            syndrome critical region
  JOURNAL   Hum Genet 110 (5), 429-438 (2002)
   PUBMED   12073013
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC073846.6.
            
            On Aug 10, 2020 this sequence version replaced NM_148912.3.
            
            Summary: This gene encodes a protein containing an alpha/beta
            hydrolase fold domain. This gene is deleted in Williams syndrome, a
            multisystem developmental disorder caused by the deletion of
            contiguous genes at 7q11.23. [provided by RefSeq, Mar 2016].
            
            Transcript Variant: This variant (1, also known as A) encodes
            isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067750.1, AF412030.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG   :: upstream AUG and CDS
                                                  extension is not conserved
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000222800.8/
                                                  ENSP00000222800.4
            RefSeq Select criteria             :: based on manual assertion,
                                                  conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC073846.6         28142-28298
            158-293             AC073846.6         28481-28616
            294-467             AC073846.6         29209-29382
            468-638             AC073846.6         29553-29723
            639-820             AC073846.6         29834-30015
            821-1418            AC073846.6         30253-30850
FEATURES             Location/Qualifiers
     source          1..1418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q11.23"
     gene            1..1418
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /note="abhydrolase domain containing 11"
                     /db_xref="GeneID:83451"
                     /db_xref="HGNC:HGNC:16407"
                     /db_xref="MIM:621050"
     exon            1..157
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..953
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /EC_number="3.1.1.116"
                     /note="isoform 1 is encoded by transcript variant 1, also
                     known as A; Williams Beuren syndrome chromosome region 21;
                     abhydrolase domain-containing protein 11; alpha/beta
                     hydrolase domain-containing protein 11; protein ABHD11;
                     sn-1-specific diacylglycerol lipase ABHD11"
                     /codon_start=1
                     /product="sn-1-specific diacylglycerol lipase ABHD11
                     isoform 1"
                     /protein_id="NP_683710.2"
                     /db_xref="CCDS:CCDS5558.2"
                     /db_xref="GeneID:83451"
                     /db_xref="HGNC:HGNC:16407"
                     /db_xref="MIM:621050"
                     /translation="MLRWTRAWRLPREGLGPHGPSFARVPVAPSSSSGGRGGAEPRPL
                     PLSYRLLDGEAALPAVVFLHGLFGSKTNFNSIAKILAQQTGRRVLTVDARNHGDSPHS
                     PDMSYEIMSQDLQDLLPQLGLVPCVVVGHSMGGKTAMLLALQRPELVERLIAVDISPV
                     ESTGVSHFATYVAAMRAINIADELPRSRARKLADEQLSSVIQDMAVRQHLLTNLVEVD
                     GRFVWRVNLDALTQHLDKILAFPQRQESYLGPTLFLLGGNSQFVHPSHHPEIMRLFPR
                     AQMQTVPNAGHWIHADRPQDFIAAIRGFLV"
     exon            158..293
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /inference="alignment:Splign:2.1.0"
     exon            294..467
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /inference="alignment:Splign:2.1.0"
     exon            468..638
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /inference="alignment:Splign:2.1.0"
     exon            639..820
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /inference="alignment:Splign:2.1.0"
     exon            821..1418
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1398..1403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /note="hexamer: AATAAA"
     polyA_site      1418
                     /gene="ABHD11"
                     /gene_synonym="PP1226; WBSCR21"
                     /note="major polyA site"
ORIGIN      
        1 gtgagatgcg agccggccaa cagcttgcaa gcatgctccg ctggacccga gcctggaggc
       61 tcccgcgtga gggactcggc ccccacggcc ctagcttcgc gagggtgcct gtcgcaccca
      121 gcagcagcag cggcggccga gggggcgccg agccgaggcc gcttccgctt tcctacaggc
      181 ttctggacgg ggaggcagcc ctcccggccg tcgtcttttt gcacgggctc ttcggcagca
      241 aaactaactt caactccatc gccaagatct tggcccagca gacaggccgt agggtgctga
      301 cggtggatgc tcgtaaccac ggtgacagcc cccacagccc agacatgagc tacgagatca
      361 tgagccagga cctgcaggac cttctgcccc agctgggcct ggtgccctgc gtcgtcgttg
      421 gccacagcat gggaggaaag acagccatgc tgctggcact acagaggcca gagctggtgg
      481 aacgtctcat tgctgtagat atcagcccag tggaaagcac aggtgtctcc cactttgcaa
      541 cctatgtggc agccatgagg gccatcaaca tcgcagatga gctgccccgc tcccgtgccc
      601 gaaaactggc ggatgaacag ctcagttctg tcatccagga catggccgtg cggcagcacc
      661 tgctcactaa cctggtagag gtagacgggc gcttcgtgtg gagggtgaac ttggatgccc
      721 tgacccagca cctagacaag atcttggctt tcccacagag gcaggagtcc tacctcgggc
      781 caacactctt tctccttggt ggaaactccc agttcgtgca tcccagccac caccctgaga
      841 ttatgcggct cttccctcgg gcccagatgc agacggtgcc gaacgctggc cactggatcc
      901 acgctgaccg cccacaggac ttcatagctg ccatccgagg cttcctggtc taagagttgc
      961 tggcaagaag atggccgggc gtggtggctc atgcctgtaa ttccagcact ttgggaggct
     1021 aaggcgggag gatgacttga ggccaggagt tggagaccag cctggccaac atggtgaaac
     1081 cctgtctcta ctaaaaatac aaaaattagc ctggcgtggt ggtgcacacc tgtaatccca
     1141 gctactctgg aggctgaggc aggagaatca cttgaaccct ggaggcagag gttgcaatga
     1201 gccgagatca caccactaca ctccagccta ggcaacagag caagactctg tctcaaaaaa
     1261 aacaaaacaa aaaggaggca caaaacccca ggcttcaagt ctctgcagcc tgctccacat
     1321 ttgggcacag aaggactcag acaggcactg tgtgggcacg aggttttaca ggggtggtca
     1381 gacctcaggc tttaatgaat aaagacacta ctcccaaa
//
