LOCUS       NM_018394               2604 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens abhydrolase domain containing 10, depalmitoylase
            (ABHD10), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_018394
VERSION     NM_018394.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Cao,Y., Qiu,T., Kathayat,R.S., Azizi,S.A., Thorne,A.K., Ahn,D.,
            Fukata,Y., Fukata,M., Rice,P.A. and Dickinson,B.C.
  TITLE     ABHD10 is an S-depalmitoylase affecting redox homeostasis through
            peroxiredoxin-5
  JOURNAL   Nat Chem Biol 15 (12), 1232-1240 (2019)
   PUBMED   31740833
REFERENCE   4  (bases 1 to 2604)
  AUTHORS   Ito,Y., Fukami,T., Yokoi,T. and Nakajima,M.
  TITLE     An orphan esterase ABHD10 modulates probenecid acyl glucuronidation
            in human liver
  JOURNAL   Drug Metab Dispos 42 (12), 2109-2116 (2014)
   PUBMED   25217485
  REMARK    GeneRIF: Which potently inhibited ABHD10 activity.
REFERENCE   5  (bases 1 to 2604)
  AUTHORS   Zuhl,A.M., Mohr,J.T., Bachovchin,D.A., Niessen,S., Hsu,K.L.,
            Berlin,J.M., Dochnahl,M., Lopez-Alberca,M.P., Fu,G.C. and
            Cravatt,B.F.
  TITLE     Competitive activity-based protein profiling identifies
            aza-beta-lactams as a versatile chemotype for serine hydrolase
            inhibition
  JOURNAL   J Am Chem Soc 134 (11), 5068-5071 (2012)
   PUBMED   22400490
REFERENCE   6  (bases 1 to 2604)
  AUTHORS   Iwamura,A., Fukami,T., Higuchi,R., Nakajima,M. and Yokoi,T.
  TITLE     Human alpha/beta hydrolase domain containing 10 (ABHD10) is
            responsible enzyme for deglucuronidation of mycophenolic acid
            acyl-glucuronide in liver
  JOURNAL   J Biol Chem 287 (12), 9240-9249 (2012)
   PUBMED   22294686
  REMARK    GeneRIF: ABHD10 is responsible for deglucuronidation of
            mycophenolic acid acyl-glucuronide in liver.
REFERENCE   7  (bases 1 to 2604)
  AUTHORS   Fukami,T. and Yokoi,T.
  TITLE     The emerging role of human esterases
  JOURNAL   Drug Metab Pharmacokinet 27 (5), 466-477 (2012)
   PUBMED   22813719
  REMARK    Review article
REFERENCE   8  (bases 1 to 2604)
  AUTHORS   Li,Q., Vande Velde,C., Israelson,A., Xie,J., Bailey,A.O.,
            Dong,M.Q., Chun,S.J., Roy,T., Winer,L., Yates,J.R., Capaldi,R.A.,
            Cleveland,D.W. and Miller,T.M.
  TITLE     ALS-linked mutant superoxide dismutase 1 (SOD1) alters
            mitochondrial protein composition and decreases protein import
  JOURNAL   Proc Natl Acad Sci U S A 107 (49), 21146-21151 (2010)
   PUBMED   21078990
  REMARK    GeneRIF: mitochondrial localization of rat Abhd10
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB453330.1, BC014516.2,
            AL713726.1 and CA427297.1.
            
            On Nov 22, 2018 this sequence version replaced NM_018394.3.
            
            Summary: This gene encodes a mitochondrially-localized enzyme that
            acts in liver cells as a hydrolase. The encoded protein removes
            glucuronide from mycophenolic acid acyl-glucuronide. There is a
            pseudogene for this gene on chromosome 6. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Jan
            2013].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.113640.1,
                                           SRR1660803.88508.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 21078990; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000273359.8/
                                                  ENSP00000273359.3
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                DB453330.1         46-56
            12-1207             BC014516.2         1-1196
            1208-2599           AL713726.1         956-2347
            2600-2604           CA427297.1         18-22               c
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.2"
     gene            1..2604
                     /gene="ABHD10"
                     /note="abhydrolase domain containing 10, depalmitoylase"
                     /db_xref="GeneID:55347"
                     /db_xref="HGNC:HGNC:25656"
                     /db_xref="MIM:618756"
     exon            1..178
                     /gene="ABHD10"
                     /inference="alignment:Splign:2.1.0"
     CDS             37..957
                     /gene="ABHD10"
                     /EC_number="3.1.2.22"
                     /EC_number="3.1.1.93"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; abhydrolase domain-containing protein 10,
                     mitochondrial; mycophenolic acid acyl-glucuronide
                     esterase, mitochondrial; alpha/beta hydrolase
                     domain-containing protein 10, mitochondrial; acyl-protein
                     thioesterase ABHD10; palmitoyl-protein thioesterase
                     ABHD10, mitochondrial"
                     /codon_start=1
                     /product="palmitoyl-protein thioesterase ABHD10,
                     mitochondrial isoform 1 precursor"
                     /protein_id="NP_060864.1"
                     /db_xref="CCDS:CCDS2963.1"
                     /db_xref="GeneID:55347"
                     /db_xref="HGNC:HGNC:25656"
                     /db_xref="MIM:618756"
                     /translation="MAVARLAAVAAWVPCRSWGWAAVPFGPHRGLSVLLARIPQRAPR
                     WLPACRQKTSLSFLNRPDLPNLAYKKLKGKSPGIIFIPGYLSYMNGTKALAIEEFCKS
                     LGHACIRFDYSGVGSSDGNSEESTLGKWRKDVLSIIDDLADGPQILVGSSLGGWLMLH
                     AAIARPEKVVALIGVATAADTLVTKFNQLPVELKKEVEMKGVWSMPSKYSEEGVYNVQ
                     YSFIKEAEHHCLLHSPIPVNCPIRLLHGMKDDIVPWHTSMQVADRVLSTDVDVILRKH
                     SDHRMREKADIQLLVYTIDDLIDKLSTIVN"
     exon            179..362
                     /gene="ABHD10"
                     /inference="alignment:Splign:2.1.0"
     exon            363..474
                     /gene="ABHD10"
                     /inference="alignment:Splign:2.1.0"
     exon            475..612
                     /gene="ABHD10"
                     /inference="alignment:Splign:2.1.0"
     exon            613..2604
                     /gene="ABHD10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2576..2581
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABHD10"
                     /note="hexamer: AATAAA"
     polyA_site      2604
                     /gene="ABHD10"
                     /note="major polyA site"
ORIGIN      
        1 agtgggacac tgcagggtgc ggggacaact acgaagatgg cggttgcgcg cttggcagct
       61 gtggcggcct gggtaccttg tcggagctgg ggctgggcag ccgtcccctt cggtccccac
      121 cgtggcctca gcgtgctgct tgcacggata cctcagcggg cgccacggtg gctcccagct
      181 tgtagacaaa agacgtcact ctcattcctt aatcgaccag accttccaaa cctggcttat
      241 aagaagctaa aaggcaaaag tccaggaatt atcttcatcc ctggctatct ttcttatatg
      301 aatggtacaa aagcgttggc gattgaggag ttttgcaaat ctctaggtca cgcctgcata
      361 aggtttgatt actcaggagt tggaagttca gatggtaact cagaggaaag cacactgggg
      421 aaatggagaa aagatgttct ttctataatt gatgacttag ctgatgggcc acagattctt
      481 gttggatcta gccttggagg gtggcttatg cttcatgctg caattgcacg accagagaag
      541 gtcgtggctc ttattggtgt agctacagct gcagatacct tagtgacaaa gtttaatcag
      601 cttcctgttg agctaaaaaa ggaagtagag atgaaaggtg tgtggagcat gccatcaaaa
      661 tactctgaag aaggagttta taacgttcag tacagtttca ttaaagaagc tgaacatcac
      721 tgcttgttac atagcccaat tcctgtgaac tgccccataa gattgctcca tggcatgaag
      781 gatgacattg taccttggca tacatcaatg caggttgccg atcgagtact cagcacagat
      841 gtggatgtca tcctccgaaa acacagtgat caccgaatga gggaaaaagc agacattcaa
      901 cttcttgttt acactattga tgacttaatt gataagctct caactatagt taactagtat
      961 cacatgttta gttggtatgt aaactaatgt atccagaaga ttggaagagg gataagaaat
     1021 gaaagatcct gatactttag gtttttccct ttcctctatt ttgtaaatat aagatgagta
     1081 ttatttaatg atgtatttgc ataagtaatg caaattgtga agaaggacca gctgctgttt
     1141 agaaaatttt ctccttcctt ctgtccttga ttttttttca ttaaagtatt tccttttttt
     1201 aattcaagaa aagtttacct ttcttatgct tatgttagct atgccagctc ttaattgcat
     1261 ccttttctaa ttaggattat taataaagcg tgaatatttt gttttttatt atagacagaa
     1321 atttgtaaca ttacttctga tttgaaaatg caattcacaa aatataggga aatttttatt
     1381 gaagtaaatt tgaaatgatg gagaaatttc agaagcataa taaagttcac aataaggata
     1441 atactttata taatgtataa agtatatata atataatata tatgttatat aaactgcaca
     1501 ttatattcaa acttaaaatt gagctttttt tttaaaggcc caaaattgta cagtgataca
     1561 aggagctatt tctaaaattt ggcttatgta taatatattt aaatggggaa tttcatctaa
     1621 aacaatgatg tagtattttt aatattctga ttggtaaaat taaagaggaa attaatcttt
     1681 atatattatt tcttgcagaa acattcatta ttttattaat attgccctaa gtacaactag
     1741 gcaagtgatt gccacctaaa tcagaagacg ttctaaagtc agtaagaaag tgtgaaatgc
     1801 tagtataaag gttatttttt ttctttccta aataactaaa gtgaggtgta gattgagcct
     1861 tgatattatt tagttaatgt tttttattaa ttaattttgg ctggacttta tttagcttga
     1921 ttaggttatt atctgtcaaa ccttttaagt tgacaacatg actcatatat atacatgtgt
     1981 ataagatgag catgtgtcga agacttattc gactcattaa tgaggaaacc agcagatagt
     2041 aaacctggtt caaagtacaa ttcaagaaac tgagtattta tgggcattga agaaaaaatg
     2101 ttgagataaa attgctgtgc agaaaaaagt gttaatgaag ccgacctgac tacttaacct
     2161 tagagacctg ctttacaagg ttggcccttg attggcatct gggaacttgg agttcagggg
     2221 gcttccacca ttcccagaac tgatcaaagt agcttactat atctaaactg taaaacaata
     2281 tagtttctcc tgaacacctg ctttccttct gggagtctgg aattttggta tgtgccaggc
     2341 agagactacc tttgtgacca gctcccagta aaaaccccag gcactcagtc tctaacaagc
     2401 ttttctggtt gacagtgttt cacaagtgct gttacaactg gttgctggga gaattaagct
     2461 catcctctgt gattccactg gcggaggatt cttggaagct tgcacttagt ttcccctgac
     2521 ttcaccccat gtgtcttttt tcctttgctg attttgtttt gtatcctttc actgtaataa
     2581 atcatggccg tgagcagaac tgta
//
