LOCUS       NM_004827               4206 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily G member 2 (JR blood
            group) (ABCG2), transcript variant 1, mRNA.
ACCESSION   NM_004827
VERSION     NM_004827.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4206)
  AUTHORS   Wu,C.P., Hung,C.Y., Murakami,M., Wu,Y.S., Chu,Y.H., Huang,Y.H.,
            Yu,J.S. and Ambudkar,S.V.
  TITLE     ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor
            MTX-211 in Cancer Cells
  JOURNAL   Int J Mol Sci 25 (10), 5160 (2024)
   PUBMED   38791198
  REMARK    GeneRIF: ABCG2 Mediates Resistance to the Dual EGFR and PI3K
            Inhibitor MTX-211 in Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4206)
  AUTHORS   Chen,S., Liu,Z., Wu,H., Wang,B., Ouyang,Y., Liu,J., Zheng,X.,
            Zhang,H., Li,X., Feng,X., Li,Y., Shen,Y., Zhang,H., Xiao,B., Yu,C.
            and Deng,W.
  TITLE     Adipocyte-rich microenvironment promotes chemoresistance via
            upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer
  JOURNAL   Int J Mol Med 53 (4) (2024)
   PUBMED   38426604
  REMARK    GeneRIF: Adipocyte-rich microenvironment promotes chemoresistance
            via upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 4206)
  AUTHORS   Raguz,M., Tarle,M., Muller,D., Tomasovic-Loncaric,C., Chudy,H.,
            Marinovic,T. and Chudy,D.
  TITLE     ABCG2 Expression as a Potential Survival Predictor in Human Gliomas
  JOURNAL   Int J Mol Sci 25 (6), 3116 (2024)
   PUBMED   38542090
  REMARK    GeneRIF: ABCG2 Expression as a Potential Survival Predictor in
            Human Gliomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4206)
  AUTHORS   Ajenu,E.O., Seideneck,A.M., Pandellapalli,E., Shinsky,E.M.,
            Humphries,C.L., Aparicio,N.L., Sharma,M., Marden,J.H. and
            Krasilnikova,M.M.
  TITLE     ABCG2 transporter reduces protein aggregation in cigarette smoke
            condensate-exposed A549 lung cancer cells
  JOURNAL   PLoS One 19 (3), e0297661 (2024)
   PUBMED   38442133
  REMARK    GeneRIF: ABCG2 transporter reduces protein aggregation in cigarette
            smoke condensate-exposed A549 lung cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4206)
  AUTHORS   Singh,H., Dhotre,K., Shyamveer, Choudhari,R., Verma,A.,
            Mahajan,S.D. and Ali,N.
  TITLE     ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity
  JOURNAL   Mol Genet Genomic Med 12 (3), e2362 (2024)
   PUBMED   38451012
  REMARK    GeneRIF: ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity.
REFERENCE   6  (bases 1 to 4206)
  AUTHORS   Ross,D.D., Yang,W., Abruzzo,L.V., Dalton,W.S., Schneider,E.,
            Lage,H., Dietel,M., Greenberger,L., Cole,S.P. and Doyle,L.A.
  TITLE     Atypical multidrug resistance: breast cancer resistance protein
            messenger RNA expression in mitoxantrone-selected cell lines
  JOURNAL   J Natl Cancer Inst 91 (5), 429-433 (1999)
   PUBMED   10070941
REFERENCE   7  (bases 1 to 4206)
  AUTHORS   Miyake,K., Mickley,L., Litman,T., Zhan,Z., Robey,R., Cristensen,B.,
            Brangi,M., Greenberger,L., Dean,M., Fojo,T. and Bates,S.E.
  TITLE     Molecular cloning of cDNAs which are highly overexpressed in
            mitoxantrone-resistant cells: demonstration of homology to ABC
            transport genes
  JOURNAL   Cancer Res 59 (1), 8-13 (1999)
   PUBMED   9892175
REFERENCE   8  (bases 1 to 4206)
  AUTHORS   Doyle,L.A., Yang,W., Abruzzo,L.V., Krogmann,T., Gao,Y., Rishi,A.K.
            and Ross,D.D.
  TITLE     A multidrug resistance transporter from human MCF-7 breast cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15665-15670 (1998)
   PUBMED   9861027
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
REFERENCE   9  (bases 1 to 4206)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
REFERENCE   10 (bases 1 to 4206)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI598784.1, BC021281.2 and
            BC092408.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_004827.2.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            this protein functions as a xenobiotic transporter which may play a
            major role in multi-drug resistance. It likely serves as a cellular
            defense mechanism in response to mitoxantrone and anthracycline
            exposure. Significant expression of this protein has been observed
            in the placenta, which may suggest a potential role for this
            molecule in placenta tissue. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.118989.1,
                                           SRR14038191.4108211.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000237612.8/ ENSP00000237612.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               BI598784.1         279-617
            340-2305            BC021281.2         560-2525
            2306-4206           BC092408.1         2371-4271
FEATURES             Location/Qualifiers
     source          1..4206
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..4206
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="ATP binding cassette subfamily G member 2 (JR blood
                     group)"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
     exon            1..254
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            255..476
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             274..2241
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /EC_number="7.6.2.2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     breast cancer resistance protein; placenta specific MDR
                     protein; ABC transporter; ATP-binding cassette transporter
                     G2; mitoxantrone resistance-associated protein;
                     placenta-specific ATP-binding cassette transporter;
                     ATPbinding cassette transporter ABCG2; ATP binding
                     cassette subfamily G member 2 (Junior blood group); multi
                     drug resistance efflux transport ATP-binding cassette
                     sub-family G (WHITE) member 2; broad substrate specificity
                     ATP-binding cassette transporter ABCG2 isoform 1 (Junior
                     blood group); urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2 (Junior blood group)"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2 isoform 1"
                     /protein_id="NP_004818.2"
                     /db_xref="CCDS:CCDS3628.1"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
                     /translation="MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICY
                     RVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGL
                     SGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER
                     INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDS
                     STANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGY
                     FESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAE
                     IYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNP
                     QASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVV
                     EKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFV
                     MMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLS
                     WLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPW
                     GLWKNHVALACMIVIFLTIAYLKLLFLKKYS"
     exon            477..536
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            537..651
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..804
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            805..962
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            963..1114
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1115..1216
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1467
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1550
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1640
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..1765
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..1920
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..2010
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2093
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2094..4206
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2274..2279
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: CATAAA"
     polyA_site      2307
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2406..2411
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2428
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2769..2774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2794
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
     regulatory      3495..3500
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      3518
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      4185..4190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      4206
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
ORIGIN      
        1 agtgcccgcc actcccactg agattgagag acgcggcaag gaggcagcct gtggaggaac
       61 tgggtaggat ttaggaacgc accgtgcaca tgcttggtgg tcttgttaag tggaaactgc
      121 tgctttagag tttgtttgga aggtccgggt gactcatccc aacatttaca tccttaattg
      181 ttaaagcgct gcctccgagc gcacgcatcc tgagatcctg agcctttggt taagaccgag
      241 ctctattaag ctgaaaagat aaaaactctc cagatgtctt ccagtaatgt cgaagttttt
      301 atcccagtgt cacaaggaaa caccaatggc ttccccgcga cagcttccaa tgacctgaag
      361 gcatttactg aaggagctgt gttaagtttt cataacatct gctatcgagt aaaactgaag
      421 agtggctttc taccttgtcg aaaaccagtt gagaaagaaa tattatcgaa tatcaatggg
      481 atcatgaaac ctggtctcaa cgccatcctg ggacccacag gtggaggcaa atcttcgtta
      541 ttagatgtct tagctgcaag gaaagatcca agtggattat ctggagatgt tctgataaat
      601 ggagcaccgc gacctgccaa tttcaaatgt aattcaggtt acgtggtaca agatgatgtt
      661 gtgatgggca ctctgacggt gagagaaaac ttacagttct cagcagctct tcggcttgca
      721 acaactatga cgaatcatga aaaaaacgaa cggattaaca gggtcattca agagttaggt
      781 ctggataaag tggcagactc caaggttgga actcagttta tccgtggtgt gtctggagga
      841 gaaagaaaaa ggactagtat aggaatggag cttatcactg atccttccat cttgttcttg
      901 gatgagccta caactggctt agactcaagc acagcaaatg ctgtcctttt gctcctgaaa
      961 aggatgtcta agcagggacg aacaatcatc ttctccattc atcagcctcg atattccatc
     1021 ttcaagttgt ttgatagcct caccttattg gcctcaggaa gacttatgtt ccacgggcct
     1081 gctcaggagg ccttgggata ctttgaatca gctggttatc actgtgaggc ctataataac
     1141 cctgcagact tcttcttgga catcattaat ggagattcca ctgctgtggc attaaacaga
     1201 gaagaagact ttaaagccac agagatcata gagccttcca agcaggataa gccactcata
     1261 gaaaaattag cggagattta tgtcaactcc tccttctaca aagagacaaa agctgaatta
     1321 catcaacttt ccgggggtga gaagaagaag aagatcacag tcttcaagga gatcagctac
     1381 accacctcct tctgtcatca actcagatgg gtttccaagc gttcattcaa aaacttgctg
     1441 ggtaatcccc aggcctctat agctcagatc attgtcacag tcgtactggg actggttata
     1501 ggtgccattt actttgggct aaaaaatgat tctactggaa tccagaacag agctggggtt
     1561 ctcttcttcc tgacgaccaa ccagtgtttc agcagtgttt cagccgtgga actctttgtg
     1621 gtagagaaga agctcttcat acatgaatac atcagcggat actacagagt gtcatcttat
     1681 ttccttggaa aactgttatc tgatttatta cccatgagga tgttaccaag tattatattt
     1741 acctgtatag tgtacttcat gttaggattg aagccaaagg cagatgcctt cttcgttatg
     1801 atgtttaccc ttatgatggt ggcttattca gccagttcca tggcactggc catagcagca
     1861 ggtcagagtg tggtttctgt agcaacactt ctcatgacca tctgttttgt gtttatgatg
     1921 attttttcag gtctgttggt caatctcaca accattgcat cttggctgtc atggcttcag
     1981 tacttcagca ttccacgata tggatttacg gctttgcagc ataatgaatt tttgggacaa
     2041 aacttctgcc caggactcaa tgcaacagga aacaatcctt gtaactatgc aacatgtact
     2101 ggcgaagaat atttggtaaa gcagggcatc gatctctcac cctggggctt gtggaagaat
     2161 cacgtggcct tggcttgtat gattgttatt ttcctcacaa ttgcctacct gaaattgtta
     2221 tttcttaaaa aatattctta aatttcccct taattcagta tgatttatcc tcacataaaa
     2281 aagaagcact ttgattgaag tattcaatca agtttttttg ttgttttctg ttcccttgcc
     2341 atcacactgt tgcacagcag caattgtttt aaagagatac atttttagaa atcacaacaa
     2401 actgaattaa acatgaaaga acccaagaca tcatgtatcg catattagtt aatctcctca
     2461 gacagtaacc atggggaaga aatctggtct aatttattaa tctaaaaaag gagaattgaa
     2521 ttctggaaac tcctgacaag ttattactgt ctctggcatt tgtttcctca tctttaaaat
     2581 gaataggtag gttagtagcc cttcagtctt aatactttat gatgctatgg tttgccatta
     2641 tttaataaat gacaaatgta ttaatgctat actggaaatg taaaattgaa aatatgttgg
     2701 aaaaaagatt ctgtcttata gggtaaaaaa agccaccgtg atagaaaaaa aatctttttg
     2761 ataagcacat taaagttaat agaacttact gatattcctg tctagtggta taatatctca
     2821 ggaatcttgg ctgagggttt ggaactgtgg gtagagtaga gggccaggag tccagtaata
     2881 gaattcttgc accatttctg gaacattcta gctctgggag gtcacgtaac cttcttgggg
     2941 tagttcagtg gtttagtggt ttataatcca ggtgtgcgtc agaatcatct gaggaacttt
     3001 gctaaaatac aaaaatctgg cctaagtagc tccagatcta ccttcataaa ggaatctgac
     3061 cactcctgga tttggtaatt tccaagttct gaaaatttta cttaggattt aataactatt
     3121 aacatctgtc cctacatagg ttttctttcc tacttatata ccttatgttc tcttcattct
     3181 aaccttcatc agtaataggg aaatgtttta attttatttt tttagttgaa gggtaatgta
     3241 ccaaaaaata tagttcagtg aattaaaatg aacacacatg tgcaaccatc aattcaggtc
     3301 aagaaataga agattgtagc acacaaaagc ctactcagcc attctcccag tcactacttc
     3361 cttccttacc cctgggttat ttttgaaatg acacttgatg tatttccctc tgttgctgtt
     3421 atgagaacat tgctacagcc aagtgttgtg tttctgtgtg cataggttga tacttaatta
     3481 tctccccact ttttaataaa cttttaattt ggaaataatt ttagattgac agaaaagttg
     3541 caaagatagt gaggaaagtt cctgtctact ctttgctcag cttcccttaa tgttaacatt
     3601 ttatatagca agatgcattt gtcaaagcta acaagttaac attggtacaa tcactgttaa
     3661 ttaaactgca cacaatattc agatttcacc acttttccac taatattctt tcattgttct
     3721 aggattcaat tcaggagacc acatttcatc tagccctctt ttttaaaagt aaatactttt
     3781 cagcacttac aggagttaac tgagctgggg catcatggtg tatagacgcc ctgacactgg
     3841 tcatcttgga attcatttag tttgtcagtg ggtgccctga cattctgtca caacatcaat
     3901 ttgggaacat ggcattatat ttttatcttt gaactttttt ctttttggat gacatttgat
     3961 taatgcgtca tcttggaaca cattatcttt tttcttggtt atgtgatcag gaagattaat
     4021 cagtttttcc tgttcttggt ataattcctg cttttcacat acctgtccct tacagttctc
     4081 tatatatacc cttcccttat tacacagaga gaaatatcta tctatacttt ttacacaaaa
     4141 tatacttcaa aagaaacaaa acagccacaa ttattaactt tttaaataaa tgagaattta
     4201 attata
//
