LOCUS       NM_001348989            4038 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily G member 2 (JR blood
            group) (ABCG2), transcript variant 7, mRNA.
ACCESSION   NM_001348989 XM_017008853
VERSION     NM_001348989.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4038)
  AUTHORS   Wu,C.P., Hung,C.Y., Murakami,M., Wu,Y.S., Chu,Y.H., Huang,Y.H.,
            Yu,J.S. and Ambudkar,S.V.
  TITLE     ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor
            MTX-211 in Cancer Cells
  JOURNAL   Int J Mol Sci 25 (10), 5160 (2024)
   PUBMED   38791198
  REMARK    GeneRIF: ABCG2 Mediates Resistance to the Dual EGFR and PI3K
            Inhibitor MTX-211 in Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4038)
  AUTHORS   Chen,S., Liu,Z., Wu,H., Wang,B., Ouyang,Y., Liu,J., Zheng,X.,
            Zhang,H., Li,X., Feng,X., Li,Y., Shen,Y., Zhang,H., Xiao,B., Yu,C.
            and Deng,W.
  TITLE     Adipocyte-rich microenvironment promotes chemoresistance via
            upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer
  JOURNAL   Int J Mol Med 53 (4) (2024)
   PUBMED   38426604
  REMARK    GeneRIF: Adipocyte-rich microenvironment promotes chemoresistance
            via upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 4038)
  AUTHORS   Raguz,M., Tarle,M., Muller,D., Tomasovic-Loncaric,C., Chudy,H.,
            Marinovic,T. and Chudy,D.
  TITLE     ABCG2 Expression as a Potential Survival Predictor in Human Gliomas
  JOURNAL   Int J Mol Sci 25 (6), 3116 (2024)
   PUBMED   38542090
  REMARK    GeneRIF: ABCG2 Expression as a Potential Survival Predictor in
            Human Gliomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4038)
  AUTHORS   Ajenu,E.O., Seideneck,A.M., Pandellapalli,E., Shinsky,E.M.,
            Humphries,C.L., Aparicio,N.L., Sharma,M., Marden,J.H. and
            Krasilnikova,M.M.
  TITLE     ABCG2 transporter reduces protein aggregation in cigarette smoke
            condensate-exposed A549 lung cancer cells
  JOURNAL   PLoS One 19 (3), e0297661 (2024)
   PUBMED   38442133
  REMARK    GeneRIF: ABCG2 transporter reduces protein aggregation in cigarette
            smoke condensate-exposed A549 lung cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4038)
  AUTHORS   Singh,H., Dhotre,K., Shyamveer, Choudhari,R., Verma,A.,
            Mahajan,S.D. and Ali,N.
  TITLE     ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity
  JOURNAL   Mol Genet Genomic Med 12 (3), e2362 (2024)
   PUBMED   38451012
  REMARK    GeneRIF: ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity.
REFERENCE   6  (bases 1 to 4038)
  AUTHORS   Ross,D.D., Yang,W., Abruzzo,L.V., Dalton,W.S., Schneider,E.,
            Lage,H., Dietel,M., Greenberger,L., Cole,S.P. and Doyle,L.A.
  TITLE     Atypical multidrug resistance: breast cancer resistance protein
            messenger RNA expression in mitoxantrone-selected cell lines
  JOURNAL   J Natl Cancer Inst 91 (5), 429-433 (1999)
   PUBMED   10070941
REFERENCE   7  (bases 1 to 4038)
  AUTHORS   Miyake,K., Mickley,L., Litman,T., Zhan,Z., Robey,R., Cristensen,B.,
            Brangi,M., Greenberger,L., Dean,M., Fojo,T. and Bates,S.E.
  TITLE     Molecular cloning of cDNAs which are highly overexpressed in
            mitoxantrone-resistant cells: demonstration of homology to ABC
            transport genes
  JOURNAL   Cancer Res 59 (1), 8-13 (1999)
   PUBMED   9892175
REFERENCE   8  (bases 1 to 4038)
  AUTHORS   Doyle,L.A., Yang,W., Abruzzo,L.V., Krogmann,T., Gao,Y., Rishi,A.K.
            and Ross,D.D.
  TITLE     A multidrug resistance transporter from human MCF-7 breast cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15665-15670 (1998)
   PUBMED   9861027
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
REFERENCE   9  (bases 1 to 4038)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
REFERENCE   10 (bases 1 to 4038)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097484.3 and AC084732.1.
            
            On Aug 14, 2020 this sequence version replaced NM_001348989.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            this protein functions as a xenobiotic transporter which may play a
            major role in multi-drug resistance. It likely serves as a cellular
            defense mechanism in response to mitoxantrone and anthracycline
            exposure. Significant expression of this protein has been observed
            in the placenta, which may suggest a potential role for this
            molecule in placenta tissue. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.3929866.1,
                                           SRR14038195.1973241.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-86                AC097484.3         66308-66393         c
            87-308              AC097484.3         46896-47117         c
            309-368             AC097484.3         39679-39738         c
            369-483             AC097484.3         38906-39020         c
            484-636             AC097484.3         38164-38316         c
            637-794             AC097484.3         28738-28895         c
            795-946             AC097484.3         25212-25363         c
            947-1048            AC097484.3         22060-22161         c
            1049-1299           AC097484.3         20406-20656         c
            1300-1382           AC097484.3         14287-14369         c
            1383-1472           AC097484.3         8333-8422           c
            1473-1597           AC097484.3         6427-6551           c
            1598-1752           AC097484.3         4556-4710           c
            1753-1842           AC097484.3         2623-2712           c
            1843-1925           AC097484.3         1680-1762           c
            1926-4038           AC084732.1         86594-88706
FEATURES             Location/Qualifiers
     source          1..4038
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..4038
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="ATP binding cassette subfamily G member 2 (JR blood
                     group)"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
     exon            1..86
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            87..308
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             106..2073
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /EC_number="7.6.2.2"
                     /note="isoform 1 is encoded by transcript variant 7;
                     breast cancer resistance protein; placenta specific MDR
                     protein; ABC transporter; ATP-binding cassette transporter
                     G2; mitoxantrone resistance-associated protein;
                     placenta-specific ATP-binding cassette transporter;
                     ATPbinding cassette transporter ABCG2; ATP binding
                     cassette subfamily G member 2 (Junior blood group); multi
                     drug resistance efflux transport ATP-binding cassette
                     sub-family G (WHITE) member 2; broad substrate specificity
                     ATP-binding cassette transporter ABCG2 isoform 1 (Junior
                     blood group); urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2 (Junior blood group)"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2 isoform 1"
                     /protein_id="NP_001335918.1"
                     /db_xref="CCDS:CCDS3628.1"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
                     /translation="MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICY
                     RVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGL
                     SGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER
                     INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDS
                     STANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGY
                     FESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAE
                     IYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNP
                     QASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVV
                     EKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFV
                     MMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLS
                     WLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPW
                     GLWKNHVALACMIVIFLTIAYLKLLFLKKYS"
     exon            309..368
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            369..483
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            484..636
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            637..794
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            795..946
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1048
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1049..1299
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1382
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1383..1472
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1473..1597
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1752
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1842
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..1925
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..4038
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2106..2111
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: CATAAA"
     polyA_site      2139
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2238..2243
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2260
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2601..2606
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2626
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
     regulatory      3327..3332
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      3350
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      4017..4022
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      4038
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
ORIGIN      
        1 gtgactgggc aacctgtgcg tcagcgtccc cggtgcttcg gcgctccggc cagtgacggc
       61 gaccaaaccc agctaggtca gacgagaaag ataaaaactc tccagatgtc ttccagtaat
      121 gtcgaagttt ttatcccagt gtcacaagga aacaccaatg gcttccccgc gacagcttcc
      181 aatgacctga aggcatttac tgaaggagct gtgttaagtt ttcataacat ctgctatcga
      241 gtaaaactga agagtggctt tctaccttgt cgaaaaccag ttgagaaaga aatattatcg
      301 aatatcaatg ggatcatgaa acctggtctc aacgccatcc tgggacccac aggtggaggc
      361 aaatcttcgt tattagatgt cttagctgca aggaaagatc caagtggatt atctggagat
      421 gttctgataa atggagcacc gcgacctgcc aatttcaaat gtaattcagg ttacgtggta
      481 caagatgatg ttgtgatggg cactctgacg gtgagagaaa acttacagtt ctcagcagct
      541 cttcggcttg caacaactat gacgaatcat gaaaaaaacg aacggattaa cagggtcatt
      601 caagagttag gtctggataa agtggcagac tccaaggttg gaactcagtt tatccgtggt
      661 gtgtctggag gagaaagaaa aaggactagt ataggaatgg agcttatcac tgatccttcc
      721 atcttgttct tggatgagcc tacaactggc ttagactcaa gcacagcaaa tgctgtcctt
      781 ttgctcctga aaaggatgtc taagcaggga cgaacaatca tcttctccat tcatcagcct
      841 cgatattcca tcttcaagtt gtttgatagc ctcaccttat tggcctcagg aagacttatg
      901 ttccacgggc ctgctcagga ggccttggga tactttgaat cagctggtta tcactgtgag
      961 gcctataata accctgcaga cttcttcttg gacatcatta atggagattc cactgctgtg
     1021 gcattaaaca gagaagaaga ctttaaagcc acagagatca tagagccttc caagcaggat
     1081 aagccactca tagaaaaatt agcggagatt tatgtcaact cctccttcta caaagagaca
     1141 aaagctgaat tacatcaact ttccgggggt gagaagaaga agaagatcac agtcttcaag
     1201 gagatcagct acaccacctc cttctgtcat caactcagat gggtttccaa gcgttcattc
     1261 aaaaacttgc tgggtaatcc ccaggcctct atagctcaga tcattgtcac agtcgtactg
     1321 ggactggtta taggtgccat ttactttggg ctaaaaaatg attctactgg aatccagaac
     1381 agagctgggg ttctcttctt cctgacgacc aaccagtgtt tcagcagtgt ttcagccgtg
     1441 gaactctttg tggtagagaa gaagctcttc atacatgaat acatcagcgg atactacaga
     1501 gtgtcatctt atttccttgg aaaactgtta tctgatttat tacccatgag gatgttacca
     1561 agtattatat ttacctgtat agtgtacttc atgttaggat tgaagccaaa ggcagatgcc
     1621 ttcttcgtta tgatgtttac ccttatgatg gtggcttatt cagccagttc catggcactg
     1681 gccatagcag caggtcagag tgtggtttct gtagcaacac ttctcatgac catctgtttt
     1741 gtgtttatga tgattttttc aggtctgttg gtcaatctca caaccattgc atcttggctg
     1801 tcatggcttc agtacttcag cattccacga tatggattta cggctttgca gcataatgaa
     1861 tttttgggac aaaacttctg cccaggactc aatgcaacag gaaacaatcc ttgtaactat
     1921 gcaacatgta ctggcgaaga atatttggta aagcagggca tcgatctctc accctggggc
     1981 ttgtggaaga atcacgtggc cttggcttgt atgattgtta ttttcctcac aattgcctac
     2041 ctgaaattgt tatttcttaa aaaatattct taaatttccc cttaattcag tatgatttat
     2101 cctcacataa aaaagaagca ctttgattga agtattcaat caagtttttt tgttgttttc
     2161 tgttcccttg ccatcacact gttgcacagc agcaattgtt ttaaagagat acatttttag
     2221 aaatcacaac aaactgaatt aaacatgaaa gaacccaaga catcatgtat cgcatattag
     2281 ttaatctcct cagacagtaa ccatggggaa gaaatctggt ctaatttatt aatctaaaaa
     2341 aggagaattg aattctggaa actcctgaca agttattact gtctctggca tttgtttcct
     2401 catctttaaa atgaataggt aggttagtag cccttcagtc ttaatacttt atgatgctat
     2461 ggtttgccat tatttaataa atgacaaatg tattaatgct atactggaaa tgtaaaattg
     2521 aaaatatgtt ggaaaaaaga ttctgtctta tagggtaaaa aaagccaccg tgatagaaaa
     2581 aaaatctttt tgataagcac attaaagtta atagaactta ctgatattcc tgtctagtgg
     2641 tataatatct caggaatctt ggctgagggt ttggaactgt gggtagagta gagggccagg
     2701 agtccagtaa tagaattctt gcaccatttc tggaacattc tagctctggg aggtcacgta
     2761 accttcttgg ggtagttcag tggtttagtg gtttataatc caggtgtgcg tcagaatcat
     2821 ctgaggaact ttgctaaaat acaaaaatct ggcctaagta gctccagatc taccttcata
     2881 aaggaatctg accactcctg gatttggtaa tttccaagtt ctgaaaattt tacttaggat
     2941 ttaataacta ttaacatctg tccctacata ggttttcttt cctacttata taccttatgt
     3001 tctcttcatt ctaaccttca tcagtaatag ggaaatgttt taattttatt tttttagttg
     3061 aagggtaatg taccaaaaaa tatagttcag tgaattaaaa tgaacacaca tgtgcaacca
     3121 tcaattcagg tcaagaaata gaagattgta gcacacaaaa gcctactcag ccattctccc
     3181 agtcactact tccttcctta cccctgggtt atttttgaaa tgacacttga tgtatttccc
     3241 tctgttgctg ttatgagaac attgctacag ccaagtgttg tgtttctgtg tgcataggtt
     3301 gatacttaat tatctcccca ctttttaata aacttttaat ttggaaataa ttttagattg
     3361 acagaaaagt tgcaaagata gtgaggaaag ttcctgtcta ctctttgctc agcttccctt
     3421 aatgttaaca ttttatatag caagatgcat ttgtcaaagc taacaagtta acattggtac
     3481 aatcactgtt aattaaactg cacacaatat tcagatttca ccacttttcc actaatattc
     3541 tttcattgtt ctaggattca attcaggaga ccacatttca tctagccctc ttttttaaaa
     3601 gtaaatactt ttcagcactt acaggagtta actgagctgg ggcatcatgg tgtatagacg
     3661 ccctgacact ggtcatcttg gaattcattt agtttgtcag tgggtgccct gacattctgt
     3721 cacaacatca atttgggaac atggcattat atttttatct ttgaactttt ttctttttgg
     3781 atgacatttg attaatgcgt catcttggaa cacattatct tttttcttgg ttatgtgatc
     3841 aggaagatta atcagttttt cctgttcttg gtataattcc tgcttttcac atacctgtcc
     3901 cttacagttc tctatatata cccttccctt attacacaga gagaaatatc tatctatact
     3961 ttttacacaa aatatacttc aaaagaaaca aaacagccac aattattaac tttttaaata
     4021 aatgagaatt taattata
//
