LOCUS       NM_001348987            4425 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily G member 2 (JR blood
            group) (ABCG2), transcript variant 5, mRNA.
ACCESSION   NM_001348987 XM_005263356
VERSION     NM_001348987.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4425)
  AUTHORS   Wu,C.P., Hung,C.Y., Murakami,M., Wu,Y.S., Chu,Y.H., Huang,Y.H.,
            Yu,J.S. and Ambudkar,S.V.
  TITLE     ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor
            MTX-211 in Cancer Cells
  JOURNAL   Int J Mol Sci 25 (10), 5160 (2024)
   PUBMED   38791198
  REMARK    GeneRIF: ABCG2 Mediates Resistance to the Dual EGFR and PI3K
            Inhibitor MTX-211 in Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4425)
  AUTHORS   Chen,S., Liu,Z., Wu,H., Wang,B., Ouyang,Y., Liu,J., Zheng,X.,
            Zhang,H., Li,X., Feng,X., Li,Y., Shen,Y., Zhang,H., Xiao,B., Yu,C.
            and Deng,W.
  TITLE     Adipocyte-rich microenvironment promotes chemoresistance via
            upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer
  JOURNAL   Int J Mol Med 53 (4) (2024)
   PUBMED   38426604
  REMARK    GeneRIF: Adipocyte-rich microenvironment promotes chemoresistance
            via upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 4425)
  AUTHORS   Raguz,M., Tarle,M., Muller,D., Tomasovic-Loncaric,C., Chudy,H.,
            Marinovic,T. and Chudy,D.
  TITLE     ABCG2 Expression as a Potential Survival Predictor in Human Gliomas
  JOURNAL   Int J Mol Sci 25 (6), 3116 (2024)
   PUBMED   38542090
  REMARK    GeneRIF: ABCG2 Expression as a Potential Survival Predictor in
            Human Gliomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4425)
  AUTHORS   Ajenu,E.O., Seideneck,A.M., Pandellapalli,E., Shinsky,E.M.,
            Humphries,C.L., Aparicio,N.L., Sharma,M., Marden,J.H. and
            Krasilnikova,M.M.
  TITLE     ABCG2 transporter reduces protein aggregation in cigarette smoke
            condensate-exposed A549 lung cancer cells
  JOURNAL   PLoS One 19 (3), e0297661 (2024)
   PUBMED   38442133
  REMARK    GeneRIF: ABCG2 transporter reduces protein aggregation in cigarette
            smoke condensate-exposed A549 lung cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4425)
  AUTHORS   Singh,H., Dhotre,K., Shyamveer, Choudhari,R., Verma,A.,
            Mahajan,S.D. and Ali,N.
  TITLE     ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity
  JOURNAL   Mol Genet Genomic Med 12 (3), e2362 (2024)
   PUBMED   38451012
  REMARK    GeneRIF: ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity.
REFERENCE   6  (bases 1 to 4425)
  AUTHORS   Ross,D.D., Yang,W., Abruzzo,L.V., Dalton,W.S., Schneider,E.,
            Lage,H., Dietel,M., Greenberger,L., Cole,S.P. and Doyle,L.A.
  TITLE     Atypical multidrug resistance: breast cancer resistance protein
            messenger RNA expression in mitoxantrone-selected cell lines
  JOURNAL   J Natl Cancer Inst 91 (5), 429-433 (1999)
   PUBMED   10070941
REFERENCE   7  (bases 1 to 4425)
  AUTHORS   Miyake,K., Mickley,L., Litman,T., Zhan,Z., Robey,R., Cristensen,B.,
            Brangi,M., Greenberger,L., Dean,M., Fojo,T. and Bates,S.E.
  TITLE     Molecular cloning of cDNAs which are highly overexpressed in
            mitoxantrone-resistant cells: demonstration of homology to ABC
            transport genes
  JOURNAL   Cancer Res 59 (1), 8-13 (1999)
   PUBMED   9892175
REFERENCE   8  (bases 1 to 4425)
  AUTHORS   Doyle,L.A., Yang,W., Abruzzo,L.V., Krogmann,T., Gao,Y., Rishi,A.K.
            and Ross,D.D.
  TITLE     A multidrug resistance transporter from human MCF-7 breast cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15665-15670 (1998)
   PUBMED   9861027
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
REFERENCE   9  (bases 1 to 4425)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
REFERENCE   10 (bases 1 to 4425)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097484.3 and AC084732.1.
            
            On Feb 25, 2017 this sequence version replaced XM_005263356.3.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            this protein functions as a xenobiotic transporter which may play a
            major role in multi-drug resistance. It likely serves as a cellular
            defense mechanism in response to mitoxantrone and anthracycline
            exposure. Significant expression of this protein has been observed
            in the placenta, which may suggest a potential role for this
            molecule in placenta tissue. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.131402.1,
                                           SRR1660809.142079.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-474               AC097484.3         65489-65962         c
            475-696             AC097484.3         46896-47117         c
            697-756             AC097484.3         39679-39738         c
            757-871             AC097484.3         38906-39020         c
            872-1024            AC097484.3         38164-38316         c
            1025-1182           AC097484.3         28738-28895         c
            1183-1334           AC097484.3         25212-25363         c
            1335-1436           AC097484.3         22060-22161         c
            1437-1681           AC097484.3         20406-20650         c
            1682-1764           AC097484.3         14287-14369         c
            1765-1854           AC097484.3         8333-8422           c
            1855-1979           AC097484.3         6427-6551           c
            1980-2134           AC097484.3         4556-4710           c
            2135-2224           AC097484.3         2623-2712           c
            2225-2307           AC097484.3         1680-1762           c
            2308-4425           AC084732.1         86594-88711
FEATURES             Location/Qualifiers
     source          1..4425
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..4425
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="ATP binding cassette subfamily G member 2 (JR blood
                     group)"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
     exon            1..474
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..696
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             494..2455
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /EC_number="7.6.2.2"
                     /note="isoform 3 is encoded by transcript variant 5;
                     breast cancer resistance protein; placenta specific MDR
                     protein; ABC transporter; ATP-binding cassette transporter
                     G2; mitoxantrone resistance-associated protein;
                     placenta-specific ATP-binding cassette transporter;
                     ATPbinding cassette transporter ABCG2; ATP binding
                     cassette subfamily G member 2 (Junior blood group); multi
                     drug resistance efflux transport ATP-binding cassette
                     sub-family G (WHITE) member 2; broad substrate specificity
                     ATP-binding cassette transporter ABCG2 isoform 1 (Junior
                     blood group); urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2 (Junior blood group)"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2 isoform 3"
                     /protein_id="NP_001335916.1"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
                     /translation="MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICY
                     RVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGL
                     SGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER
                     INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDS
                     STANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGY
                     FESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKEIIEPSKQDKPLIEKLAEIY
                     VNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNPQA
                     SIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVVEK
                     KLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFVMM
                     FTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLSWL
                     QYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPWGL
                     WKNHVALACMIVIFLTIAYLKLLFLKKYS"
     exon            697..756
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            757..871
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..1024
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1182
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1183..1334
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1436
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1681
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1764
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1765..1854
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1855..1979
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2134
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2135..2224
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2307
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..4425
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2488..2493
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: CATAAA"
     polyA_site      2521
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2620..2625
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2642
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2983..2988
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3008
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
     regulatory      3709..3714
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      3732
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      4399..4404
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      4420
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
ORIGIN      
        1 gtcagcgctg cctgagctcg tcccctggat gtccgggtct ccccaggcgg ccacccgccg
       61 gctcccatcg tgacctccag ccgcagcgcc tcccacgccg gccgccgcgc gaggggagcg
      121 ctcgggcgcg ccgggtgtgg ttgggggaag gggttgtgcc gcgcgcgggc tgcgtgctgt
      181 gcccactcaa aaggttccgg gcgcgcagga gggaagaggc agtgcccgcc actcccactg
      241 agattgagag acgcggcaag gaggcagcct gtggaggaac tgggtaggat ttaggaacgc
      301 accgtgcaca tgcttggtgg tcttgttaag tggaaactgc tgctttagag tttgtttgga
      361 aggtccgggt gactcatccc aacatttaca tccttaattg ttaaagcgct gcctccgagc
      421 gcacgcatcc tgagatcctg agcctttggt taagaccgag ctctattaag ctgaaaagat
      481 aaaaactctc cagatgtctt ccagtaatgt cgaagttttt atcccagtgt cacaaggaaa
      541 caccaatggc ttccccgcga cagcttccaa tgacctgaag gcatttactg aaggagctgt
      601 gttaagtttt cataacatct gctatcgagt aaaactgaag agtggctttc taccttgtcg
      661 aaaaccagtt gagaaagaaa tattatcgaa tatcaatggg atcatgaaac ctggtctcaa
      721 cgccatcctg ggacccacag gtggaggcaa atcttcgtta ttagatgtct tagctgcaag
      781 gaaagatcca agtggattat ctggagatgt tctgataaat ggagcaccgc gacctgccaa
      841 tttcaaatgt aattcaggtt acgtggtaca agatgatgtt gtgatgggca ctctgacggt
      901 gagagaaaac ttacagttct cagcagctct tcggcttgca acaactatga cgaatcatga
      961 aaaaaacgaa cggattaaca gggtcattca agagttaggt ctggataaag tggcagactc
     1021 caaggttgga actcagttta tccgtggtgt gtctggagga gaaagaaaaa ggactagtat
     1081 aggaatggag cttatcactg atccttccat cttgttcttg gatgagccta caactggctt
     1141 agactcaagc acagcaaatg ctgtcctttt gctcctgaaa aggatgtcta agcagggacg
     1201 aacaatcatc ttctccattc atcagcctcg atattccatc ttcaagttgt ttgatagcct
     1261 caccttattg gcctcaggaa gacttatgtt ccacgggcct gctcaggagg ccttgggata
     1321 ctttgaatca gctggttatc actgtgaggc ctataataac cctgcagact tcttcttgga
     1381 catcattaat ggagattcca ctgctgtggc attaaacaga gaagaagact ttaaagagat
     1441 catagagcct tccaagcagg ataagccact catagaaaaa ttagcggaga tttatgtcaa
     1501 ctcctccttc tacaaagaga caaaagctga attacatcaa ctttccgggg gtgagaagaa
     1561 gaagaagatc acagtcttca aggagatcag ctacaccacc tccttctgtc atcaactcag
     1621 atgggtttcc aagcgttcat tcaaaaactt gctgggtaat ccccaggcct ctatagctca
     1681 gatcattgtc acagtcgtac tgggactggt tataggtgcc atttactttg ggctaaaaaa
     1741 tgattctact ggaatccaga acagagctgg ggttctcttc ttcctgacga ccaaccagtg
     1801 tttcagcagt gtttcagccg tggaactctt tgtggtagag aagaagctct tcatacatga
     1861 atacatcagc ggatactaca gagtgtcatc ttatttcctt ggaaaactgt tatctgattt
     1921 attacccatg aggatgttac caagtattat atttacctgt atagtgtact tcatgttagg
     1981 attgaagcca aaggcagatg ccttcttcgt tatgatgttt acccttatga tggtggctta
     2041 ttcagccagt tccatggcac tggccatagc agcaggtcag agtgtggttt ctgtagcaac
     2101 acttctcatg accatctgtt ttgtgtttat gatgattttt tcaggtctgt tggtcaatct
     2161 cacaaccatt gcatcttggc tgtcatggct tcagtacttc agcattccac gatatggatt
     2221 tacggctttg cagcataatg aatttttggg acaaaacttc tgcccaggac tcaatgcaac
     2281 aggaaacaat ccttgtaact atgcaacatg tactggcgaa gaatatttgg taaagcaggg
     2341 catcgatctc tcaccctggg gcttgtggaa gaatcacgtg gccttggctt gtatgattgt
     2401 tattttcctc acaattgcct acctgaaatt gttatttctt aaaaaatatt cttaaatttc
     2461 cccttaattc agtatgattt atcctcacat aaaaaagaag cactttgatt gaagtattca
     2521 atcaagtttt tttgttgttt tctgttccct tgccatcaca ctgttgcaca gcagcaattg
     2581 ttttaaagag atacattttt agaaatcaca acaaactgaa ttaaacatga aagaacccaa
     2641 gacatcatgt atcgcatatt agttaatctc ctcagacagt aaccatgggg aagaaatctg
     2701 gtctaattta ttaatctaaa aaaggagaat tgaattctgg aaactcctga caagttatta
     2761 ctgtctctgg catttgtttc ctcatcttta aaatgaatag gtaggttagt agcccttcag
     2821 tcttaatact ttatgatgct atggtttgcc attatttaat aaatgacaaa tgtattaatg
     2881 ctatactgga aatgtaaaat tgaaaatatg ttggaaaaaa gattctgtct tatagggtaa
     2941 aaaaagccac cgtgatagaa aaaaaatctt tttgataagc acattaaagt taatagaact
     3001 tactgatatt cctgtctagt ggtataatat ctcaggaatc ttggctgagg gtttggaact
     3061 gtgggtagag tagagggcca ggagtccagt aatagaattc ttgcaccatt tctggaacat
     3121 tctagctctg ggaggtcacg taaccttctt ggggtagttc agtggtttag tggtttataa
     3181 tccaggtgtg cgtcagaatc atctgaggaa ctttgctaaa atacaaaaat ctggcctaag
     3241 tagctccaga tctaccttca taaaggaatc tgaccactcc tggatttggt aatttccaag
     3301 ttctgaaaat tttacttagg atttaataac tattaacatc tgtccctaca taggttttct
     3361 ttcctactta tataccttat gttctcttca ttctaacctt catcagtaat agggaaatgt
     3421 tttaatttta tttttttagt tgaagggtaa tgtaccaaaa aatatagttc agtgaattaa
     3481 aatgaacaca catgtgcaac catcaattca ggtcaagaaa tagaagattg tagcacacaa
     3541 aagcctactc agccattctc ccagtcacta cttccttcct tacccctggg ttatttttga
     3601 aatgacactt gatgtatttc cctctgttgc tgttatgaga acattgctac agccaagtgt
     3661 tgtgtttctg tgtgcatagg ttgatactta attatctccc cactttttaa taaactttta
     3721 atttggaaat aattttagat tgacagaaaa gttgcaaaga tagtgaggaa agttcctgtc
     3781 tactctttgc tcagcttccc ttaatgttaa cattttatat agcaagatgc atttgtcaaa
     3841 gctaacaagt taacattggt acaatcactg ttaattaaac tgcacacaat attcagattt
     3901 caccactttt ccactaatat tctttcattg ttctaggatt caattcagga gaccacattt
     3961 catctagccc tcttttttaa aagtaaatac ttttcagcac ttacaggagt taactgagct
     4021 ggggcatcat ggtgtataga cgccctgaca ctggtcatct tggaattcat ttagtttgtc
     4081 agtgggtgcc ctgacattct gtcacaacat caatttggga acatggcatt atatttttat
     4141 ctttgaactt ttttcttttt ggatgacatt tgattaatgc gtcatcttgg aacacattat
     4201 cttttttctt ggttatgtga tcaggaagat taatcagttt ttcctgttct tggtataatt
     4261 cctgcttttc acatacctgt cccttacagt tctctatata tacccttccc ttattacaca
     4321 gagagaaata tctatctata ctttttacac aaaatatact tcaaaagaaa caaaacagcc
     4381 acaattatta actttttaaa taaatgagaa tttaattata tccta
//
