LOCUS       NM_001348985            4728 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily G member 2 (JR blood
            group) (ABCG2), transcript variant 3, mRNA.
ACCESSION   NM_001348985
VERSION     NM_001348985.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4728)
  AUTHORS   Wu,C.P., Hung,C.Y., Murakami,M., Wu,Y.S., Chu,Y.H., Huang,Y.H.,
            Yu,J.S. and Ambudkar,S.V.
  TITLE     ABCG2 Mediates Resistance to the Dual EGFR and PI3K Inhibitor
            MTX-211 in Cancer Cells
  JOURNAL   Int J Mol Sci 25 (10), 5160 (2024)
   PUBMED   38791198
  REMARK    GeneRIF: ABCG2 Mediates Resistance to the Dual EGFR and PI3K
            Inhibitor MTX-211 in Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4728)
  AUTHORS   Chen,S., Liu,Z., Wu,H., Wang,B., Ouyang,Y., Liu,J., Zheng,X.,
            Zhang,H., Li,X., Feng,X., Li,Y., Shen,Y., Zhang,H., Xiao,B., Yu,C.
            and Deng,W.
  TITLE     Adipocyte-rich microenvironment promotes chemoresistance via
            upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer
  JOURNAL   Int J Mol Med 53 (4) (2024)
   PUBMED   38426604
  REMARK    GeneRIF: Adipocyte-rich microenvironment promotes chemoresistance
            via upregulation of peroxisome proliferator-activated receptor
            gamma/ABCG2 in epithelial ovarian cancer.
REFERENCE   3  (bases 1 to 4728)
  AUTHORS   Raguz,M., Tarle,M., Muller,D., Tomasovic-Loncaric,C., Chudy,H.,
            Marinovic,T. and Chudy,D.
  TITLE     ABCG2 Expression as a Potential Survival Predictor in Human Gliomas
  JOURNAL   Int J Mol Sci 25 (6), 3116 (2024)
   PUBMED   38542090
  REMARK    GeneRIF: ABCG2 Expression as a Potential Survival Predictor in
            Human Gliomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4728)
  AUTHORS   Ajenu,E.O., Seideneck,A.M., Pandellapalli,E., Shinsky,E.M.,
            Humphries,C.L., Aparicio,N.L., Sharma,M., Marden,J.H. and
            Krasilnikova,M.M.
  TITLE     ABCG2 transporter reduces protein aggregation in cigarette smoke
            condensate-exposed A549 lung cancer cells
  JOURNAL   PLoS One 19 (3), e0297661 (2024)
   PUBMED   38442133
  REMARK    GeneRIF: ABCG2 transporter reduces protein aggregation in cigarette
            smoke condensate-exposed A549 lung cancer cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4728)
  AUTHORS   Singh,H., Dhotre,K., Shyamveer, Choudhari,R., Verma,A.,
            Mahajan,S.D. and Ali,N.
  TITLE     ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity
  JOURNAL   Mol Genet Genomic Med 12 (3), e2362 (2024)
   PUBMED   38451012
  REMARK    GeneRIF: ABCG2 polymorphisms and susceptibility to ARV-associated
            hepatotoxicity.
REFERENCE   6  (bases 1 to 4728)
  AUTHORS   Ross,D.D., Yang,W., Abruzzo,L.V., Dalton,W.S., Schneider,E.,
            Lage,H., Dietel,M., Greenberger,L., Cole,S.P. and Doyle,L.A.
  TITLE     Atypical multidrug resistance: breast cancer resistance protein
            messenger RNA expression in mitoxantrone-selected cell lines
  JOURNAL   J Natl Cancer Inst 91 (5), 429-433 (1999)
   PUBMED   10070941
REFERENCE   7  (bases 1 to 4728)
  AUTHORS   Miyake,K., Mickley,L., Litman,T., Zhan,Z., Robey,R., Cristensen,B.,
            Brangi,M., Greenberger,L., Dean,M., Fojo,T. and Bates,S.E.
  TITLE     Molecular cloning of cDNAs which are highly overexpressed in
            mitoxantrone-resistant cells: demonstration of homology to ABC
            transport genes
  JOURNAL   Cancer Res 59 (1), 8-13 (1999)
   PUBMED   9892175
REFERENCE   8  (bases 1 to 4728)
  AUTHORS   Doyle,L.A., Yang,W., Abruzzo,L.V., Krogmann,T., Gao,Y., Rishi,A.K.
            and Ross,D.D.
  TITLE     A multidrug resistance transporter from human MCF-7 breast cancer
            cells
  JOURNAL   Proc Natl Acad Sci U S A 95 (26), 15665-15670 (1998)
   PUBMED   9861027
  REMARK    Erratum:[Proc Natl Acad Sci U S A 1999 Mar 2;96(5):2569]
REFERENCE   9  (bases 1 to 4728)
  AUTHORS   Allikmets,R., Schriml,L.M., Hutchinson,A., Romano-Spica,V. and
            Dean,M.
  TITLE     A human placenta-specific ATP-binding cassette gene (ABCP) on
            chromosome 4q22 that is involved in multidrug resistance
  JOURNAL   Cancer Res 58 (23), 5337-5339 (1998)
   PUBMED   9850061
REFERENCE   10 (bases 1 to 4728)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC097484.3 and AC084732.1.
            
            Summary: The membrane-associated protein encoded by this gene is
            included in the superfamily of ATP-binding cassette (ABC)
            transporters. ABC proteins transport various molecules across
            extra- and intra-cellular membranes. ABC genes are divided into
            seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20,
            White). This protein is a member of the White subfamily.
            Alternatively referred to as a breast cancer resistance protein,
            this protein functions as a xenobiotic transporter which may play a
            major role in multi-drug resistance. It likely serves as a cellular
            defense mechanism in response to mitoxantrone and anthracycline
            exposure. Significant expression of this protein has been observed
            in the placenta, which may suggest a potential role for this
            molecule in placenta tissue. Multiple transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Apr 2012].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.270921.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-633               AC097484.3         138097-138729       c
            634-771             AC097484.3         118769-118906       c
            772-993             AC097484.3         46896-47117         c
            994-1053            AC097484.3         39679-39738         c
            1054-1168           AC097484.3         38906-39020         c
            1169-1321           AC097484.3         38164-38316         c
            1322-1479           AC097484.3         28738-28895         c
            1480-1631           AC097484.3         25212-25363         c
            1632-1733           AC097484.3         22060-22161         c
            1734-1984           AC097484.3         20406-20656         c
            1985-2067           AC097484.3         14287-14369         c
            2068-2157           AC097484.3         8333-8422           c
            2158-2282           AC097484.3         6427-6551           c
            2283-2437           AC097484.3         4556-4710           c
            2438-2527           AC097484.3         2623-2712           c
            2528-2610           AC097484.3         1680-1762           c
            2611-4728           AC084732.1         86594-88711
FEATURES             Location/Qualifiers
     source          1..4728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..4728
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="ATP binding cassette subfamily G member 2 (JR blood
                     group)"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
     exon            1..633
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            634..771
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            772..993
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             791..2758
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /EC_number="7.6.2.2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     breast cancer resistance protein; placenta specific MDR
                     protein; ABC transporter; ATP-binding cassette transporter
                     G2; mitoxantrone resistance-associated protein;
                     placenta-specific ATP-binding cassette transporter;
                     ATPbinding cassette transporter ABCG2; ATP binding
                     cassette subfamily G member 2 (Junior blood group); multi
                     drug resistance efflux transport ATP-binding cassette
                     sub-family G (WHITE) member 2; broad substrate specificity
                     ATP-binding cassette transporter ABCG2 isoform 1 (Junior
                     blood group); urate exporter; ATP-binding cassette,
                     sub-family G (WHITE), member 2 (Junior blood group)"
                     /codon_start=1
                     /product="broad substrate specificity ATP-binding cassette
                     transporter ABCG2 isoform 1"
                     /protein_id="NP_001335914.1"
                     /db_xref="CCDS:CCDS3628.1"
                     /db_xref="GeneID:9429"
                     /db_xref="HGNC:HGNC:74"
                     /db_xref="MIM:603756"
                     /translation="MSSSNVEVFIPVSQGNTNGFPATASNDLKAFTEGAVLSFHNICY
                     RVKLKSGFLPCRKPVEKEILSNINGIMKPGLNAILGPTGGGKSSLLDVLAARKDPSGL
                     SGDVLINGAPRPANFKCNSGYVVQDDVVMGTLTVRENLQFSAALRLATTMTNHEKNER
                     INRVIQELGLDKVADSKVGTQFIRGVSGGERKRTSIGMELITDPSILFLDEPTTGLDS
                     STANAVLLLLKRMSKQGRTIIFSIHQPRYSIFKLFDSLTLLASGRLMFHGPAQEALGY
                     FESAGYHCEAYNNPADFFLDIINGDSTAVALNREEDFKATEIIEPSKQDKPLIEKLAE
                     IYVNSSFYKETKAELHQLSGGEKKKKITVFKEISYTTSFCHQLRWVSKRSFKNLLGNP
                     QASIAQIIVTVVLGLVIGAIYFGLKNDSTGIQNRAGVLFFLTTNQCFSSVSAVELFVV
                     EKKLFIHEYISGYYRVSSYFLGKLLSDLLPMRMLPSIIFTCIVYFMLGLKPKADAFFV
                     MMFTLMMVAYSASSMALAIAAGQSVVSVATLLMTICFVFMMIFSGLLVNLTTIASWLS
                     WLQYFSIPRYGFTALQHNEFLGQNFCPGLNATGNNPCNYATCTGEEYLVKQGIDLSPW
                     GLWKNHVALACMIVIFLTIAYLKLLFLKKYS"
     exon            994..1053
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1168
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1169..1321
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1479
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1480..1631
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1733
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1984
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2067
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2157
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2158..2282
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2283..2437
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2438..2527
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2528..2610
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..4728
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2791..2796
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: CATAAA"
     polyA_site      2824
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      2923..2928
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      2945
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      3286..3291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: ATTAAA"
     polyA_site      3311
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
     regulatory      4012..4017
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      4035
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="major polyA site"
     regulatory      4702..4707
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
                     /note="hexamer: AATAAA"
     polyA_site      4723
                     /gene="ABCG2"
                     /gene_synonym="ABC15; ABCP; BCRP; BCRP1; BMDP; CD338;
                     CDw338; CDw388; EST157481; GOUT1; MRX; MXR; MXR-1; MXR1;
                     UAQTL1"
ORIGIN      
        1 ttacatcagg gttaaaaaag cacaggaagt ttacgcacag agcaaagcca tttgctagaa
       61 ttggttttta tccttccatt tcgaaaataa agttgctgtt tgtgttggag atgctgtcat
      121 cagaattccg cggcacaaag agaaagatac aaaaatatct ctctgacatg taactttccc
      181 ccttcttcta gccccttgct aggaatgcca gaagaggatc ccacgctgac tggaaccatt
      241 aggtcttttg tttgaatccc agtgatcgag aaagaaatgt ggttcataat cagctagtag
      301 tggagaaaaa aggaacccaa ggagatagga gagctgttaa tttcactcgg gacatttcct
      361 cgaggctagt ttactcggaa agcctcaatg ttccctggta gctgcaggat ctactttggg
      421 ggctgccaag tttcctctct cattctttct cctgccccaa gagcaggcag gaaggaaagt
      481 tcctggactg atactcgtct gtttagtagg cgtgggtcct ggttgaagtc tgtctaggaa
      541 aactcctaag tgtagaaatc ttcttcgtat taccactgtc tctgcactga gatttgggct
      601 gctttgcttc cagcgtcaca catcataact gagtgcagta ccggtttgac tgtatcttca
      661 agttaagaga attgctgtat tccccaaaat atcttggtca tttgaaagta aagagttctc
      721 ggccgggcac agtggctcac gcctgtaatc ccagcacttc agaaggcaaa gaaagataaa
      781 aactctccag atgtcttcca gtaatgtcga agtttttatc ccagtgtcac aaggaaacac
      841 caatggcttc cccgcgacag cttccaatga cctgaaggca tttactgaag gagctgtgtt
      901 aagttttcat aacatctgct atcgagtaaa actgaagagt ggctttctac cttgtcgaaa
      961 accagttgag aaagaaatat tatcgaatat caatgggatc atgaaacctg gtctcaacgc
     1021 catcctggga cccacaggtg gaggcaaatc ttcgttatta gatgtcttag ctgcaaggaa
     1081 agatccaagt ggattatctg gagatgttct gataaatgga gcaccgcgac ctgccaattt
     1141 caaatgtaat tcaggttacg tggtacaaga tgatgttgtg atgggcactc tgacggtgag
     1201 agaaaactta cagttctcag cagctcttcg gcttgcaaca actatgacga atcatgaaaa
     1261 aaacgaacgg attaacaggg tcattcaaga gttaggtctg gataaagtgg cagactccaa
     1321 ggttggaact cagtttatcc gtggtgtgtc tggaggagaa agaaaaagga ctagtatagg
     1381 aatggagctt atcactgatc cttccatctt gttcttggat gagcctacaa ctggcttaga
     1441 ctcaagcaca gcaaatgctg tccttttgct cctgaaaagg atgtctaagc agggacgaac
     1501 aatcatcttc tccattcatc agcctcgata ttccatcttc aagttgtttg atagcctcac
     1561 cttattggcc tcaggaagac ttatgttcca cgggcctgct caggaggcct tgggatactt
     1621 tgaatcagct ggttatcact gtgaggccta taataaccct gcagacttct tcttggacat
     1681 cattaatgga gattccactg ctgtggcatt aaacagagaa gaagacttta aagccacaga
     1741 gatcatagag ccttccaagc aggataagcc actcatagaa aaattagcgg agatttatgt
     1801 caactcctcc ttctacaaag agacaaaagc tgaattacat caactttccg ggggtgagaa
     1861 gaagaagaag atcacagtct tcaaggagat cagctacacc acctccttct gtcatcaact
     1921 cagatgggtt tccaagcgtt cattcaaaaa cttgctgggt aatccccagg cctctatagc
     1981 tcagatcatt gtcacagtcg tactgggact ggttataggt gccatttact ttgggctaaa
     2041 aaatgattct actggaatcc agaacagagc tggggttctc ttcttcctga cgaccaacca
     2101 gtgtttcagc agtgtttcag ccgtggaact ctttgtggta gagaagaagc tcttcataca
     2161 tgaatacatc agcggatact acagagtgtc atcttatttc cttggaaaac tgttatctga
     2221 tttattaccc atgaggatgt taccaagtat tatatttacc tgtatagtgt acttcatgtt
     2281 aggattgaag ccaaaggcag atgccttctt cgttatgatg tttaccctta tgatggtggc
     2341 ttattcagcc agttccatgg cactggccat agcagcaggt cagagtgtgg tttctgtagc
     2401 aacacttctc atgaccatct gttttgtgtt tatgatgatt ttttcaggtc tgttggtcaa
     2461 tctcacaacc attgcatctt ggctgtcatg gcttcagtac ttcagcattc cacgatatgg
     2521 atttacggct ttgcagcata atgaattttt gggacaaaac ttctgcccag gactcaatgc
     2581 aacaggaaac aatccttgta actatgcaac atgtactggc gaagaatatt tggtaaagca
     2641 gggcatcgat ctctcaccct ggggcttgtg gaagaatcac gtggccttgg cttgtatgat
     2701 tgttattttc ctcacaattg cctacctgaa attgttattt cttaaaaaat attcttaaat
     2761 ttccccttaa ttcagtatga tttatcctca cataaaaaag aagcactttg attgaagtat
     2821 tcaatcaagt ttttttgttg ttttctgttc ccttgccatc acactgttgc acagcagcaa
     2881 ttgttttaaa gagatacatt tttagaaatc acaacaaact gaattaaaca tgaaagaacc
     2941 caagacatca tgtatcgcat attagttaat ctcctcagac agtaaccatg gggaagaaat
     3001 ctggtctaat ttattaatct aaaaaaggag aattgaattc tggaaactcc tgacaagtta
     3061 ttactgtctc tggcatttgt ttcctcatct ttaaaatgaa taggtaggtt agtagccctt
     3121 cagtcttaat actttatgat gctatggttt gccattattt aataaatgac aaatgtatta
     3181 atgctatact ggaaatgtaa aattgaaaat atgttggaaa aaagattctg tcttataggg
     3241 taaaaaaagc caccgtgata gaaaaaaaat ctttttgata agcacattaa agttaataga
     3301 acttactgat attcctgtct agtggtataa tatctcagga atcttggctg agggtttgga
     3361 actgtgggta gagtagaggg ccaggagtcc agtaatagaa ttcttgcacc atttctggaa
     3421 cattctagct ctgggaggtc acgtaacctt cttggggtag ttcagtggtt tagtggttta
     3481 taatccaggt gtgcgtcaga atcatctgag gaactttgct aaaatacaaa aatctggcct
     3541 aagtagctcc agatctacct tcataaagga atctgaccac tcctggattt ggtaatttcc
     3601 aagttctgaa aattttactt aggatttaat aactattaac atctgtccct acataggttt
     3661 tctttcctac ttatatacct tatgttctct tcattctaac cttcatcagt aatagggaaa
     3721 tgttttaatt ttattttttt agttgaaggg taatgtacca aaaaatatag ttcagtgaat
     3781 taaaatgaac acacatgtgc aaccatcaat tcaggtcaag aaatagaaga ttgtagcaca
     3841 caaaagccta ctcagccatt ctcccagtca ctacttcctt ccttacccct gggttatttt
     3901 tgaaatgaca cttgatgtat ttccctctgt tgctgttatg agaacattgc tacagccaag
     3961 tgttgtgttt ctgtgtgcat aggttgatac ttaattatct ccccactttt taataaactt
     4021 ttaatttgga aataatttta gattgacaga aaagttgcaa agatagtgag gaaagttcct
     4081 gtctactctt tgctcagctt cccttaatgt taacatttta tatagcaaga tgcatttgtc
     4141 aaagctaaca agttaacatt ggtacaatca ctgttaatta aactgcacac aatattcaga
     4201 tttcaccact tttccactaa tattctttca ttgttctagg attcaattca ggagaccaca
     4261 tttcatctag ccctcttttt taaaagtaaa tacttttcag cacttacagg agttaactga
     4321 gctggggcat catggtgtat agacgccctg acactggtca tcttggaatt catttagttt
     4381 gtcagtgggt gccctgacat tctgtcacaa catcaatttg ggaacatggc attatatttt
     4441 tatctttgaa cttttttctt tttggatgac atttgattaa tgcgtcatct tggaacacat
     4501 tatctttttt cttggttatg tgatcaggaa gattaatcag tttttcctgt tcttggtata
     4561 attcctgctt ttcacatacc tgtcccttac agttctctat atataccctt cccttattac
     4621 acagagagaa atatctatct atacttttta cacaaaatat acttcaaaag aaacaaaaca
     4681 gccacaatta ttaacttttt aaataaatga gaatttaatt atatccta
//
