LOCUS       NM_207628               3060 bp    mRNA    linear   PRI 03-DEC-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily G member 1 (ABCG1),
            transcript variant 6, mRNA.
ACCESSION   NM_207628
VERSION     NM_207628.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3060)
  AUTHORS   Yazdi,M.K., Alavi,M.S. and Roohbakhsh,A.
  TITLE     The role of ATP-binding cassette transporter G1 (ABCG1) in
            Alzheimer's disease: A review of the mechanisms
  JOURNAL   Basic Clin Pharmacol Toxicol 134 (4), 423-438 (2024)
   PUBMED   38275217
  REMARK    GeneRIF: The role of ATP-binding cassette transporter G1 (ABCG1) in
            Alzheimer's disease: A review of the mechanisms.
            Review article
REFERENCE   2  (bases 1 to 3060)
  AUTHORS   Zeng,G.G., Lei,Q., Jiang,W.L., Zhang,X.X., Nie,L., Gong,X. and
            Zheng,K.
  TITLE     A new perspective on the current and future development potential
            of ABCG1
  JOURNAL   Curr Probl Cardiol 49 (1 Pt C), 102161 (2024)
   PUBMED   37875209
  REMARK    GeneRIF: A new perspective on the current and future development
            potential of ABCG1.
            Review article
REFERENCE   3  (bases 1 to 3060)
  AUTHORS   Li,X., Shao,X., Kou,M., Wang,X., Ma,H., Grundberg,E., Bazzano,L.A.,
            Smith,S.R., Bray,G.A., Sacks,F.M. and Qi,L.
  TITLE     DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat
            Distribution in Response to Dietary Interventions: The POUNDS Lost
            Trial
  JOURNAL   Diabetes Care 46 (12), 2201-2207 (2023)
   PUBMED   37770056
  REMARK    GeneRIF: DNA Methylation at ABCG1 and Long-term Changes in
            Adiposity and Fat Distribution in Response to Dietary
            Interventions: The POUNDS Lost Trial.
REFERENCE   4  (bases 1 to 3060)
  AUTHORS   Jin,J., Zhao,X., Zhu,C., Li,M., Wang,J., Fan,Y., Liu,C., Shen,C.
            and Yang,R.
  TITLE     Hypomethylation of ABCG1 in peripheral blood as a potential marker
            for the detection of coronary heart disease
  JOURNAL   Clin Epigenetics 15 (1), 120 (2023)
   PUBMED   37507725
  REMARK    GeneRIF: Hypomethylation of ABCG1 in peripheral blood as a
            potential marker for the detection of coronary heart disease.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3060)
  AUTHORS   Zhou,W., Sun,J., Huai,C., Liu,Y., Chen,L., Yi,Z., Lv,Q., Song,C.,
            Zhu,W., Liu,C., Weng,S., Wu,H., Sun,Y., Zhang,R., Wu,L., Li,M.,
            Zhu,J., Zhang,Y., Wei,M., Guo,Y., Huang,S., Zhang,N., Shen,R.,
            Zhang,Y., Du,H., Huang,H., He,L., Sun,X., Shen,L. and Qin,S.
  TITLE     Multi-omics analysis identifies rare variation in leptin/PPAR gene
            sets and hypermethylation of ABCG1 contribute to
            antipsychotics-induced metabolic syndromes
  JOURNAL   Mol Psychiatry 27 (12), 5195-5205 (2022)
   PUBMED   36065016
  REMARK    GeneRIF: Multi-omics analysis identifies rare variation in
            leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to
            antipsychotics-induced metabolic syndromes.
REFERENCE   6  (bases 1 to 3060)
  AUTHORS   Venkateswaran,A., Repa,J.J., Lobaccaro,J.M., Bronson,A.,
            Mangelsdorf,D.J. and Edwards,P.A.
  TITLE     Human white/murine ABC8 mRNA levels are highly induced in
            lipid-loaded macrophages. A transcriptional role for specific
            oxysterols
  JOURNAL   J Biol Chem 275 (19), 14700-14707 (2000)
   PUBMED   10799558
REFERENCE   7  (bases 1 to 3060)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
REFERENCE   8  (bases 1 to 3060)
  AUTHORS   Croop,J.M., Tiller,G.E., Fletcher,J.A., Lux,M.L., Raab,E.,
            Goldenson,D., Son,D., Arciniegas,S. and Wu,R.L.
  TITLE     Isolation and characterization of a mammalian homolog of the
            Drosophila white gene
  JOURNAL   Gene 185 (1), 77-85 (1997)
   PUBMED   9034316
REFERENCE   9  (bases 1 to 3060)
  AUTHORS   Savary,S., Denizot,F., Luciani,M., Mattei,M. and Chimini,G.
  TITLE     Molecular cloning of a mammalian ABC transporter homologous to
            Drosophila white gene
  JOURNAL   Mamm Genome 7 (9), 673-676 (1996)
   PUBMED   8703120
REFERENCE   10 (bases 1 to 3060)
  AUTHORS   Chen,H., Rossier,C., Lalioti,M.D., Lynn,A., Chakravarti,A.,
            Perrin,G. and Antonarakis,S.E.
  TITLE     Cloning of the cDNA for a human homologue of the Drosophila white
            gene and mapping to chromosome 21q22.3
  JOURNAL   Am J Hum Genet 59 (1), 66-75 (1996)
   PUBMED   8659545
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF323661.1, BC029158.1 and
            X91249.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the White subfamily. It is involved in
            macrophage cholesterol and phospholipids transport, and may
            regulate cellular lipid homeostasis in other cell types. Six
            alternative splice variants have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (6) differs in the 5' end-region
            compared to variant 1, which includes a part of the coding region.
            The resulting isoform (6) has a distinct and shorter N-terminus, as
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF323661.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMN03267761,
                                           SAMN03465406 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-295               AF323661.1         1-295
            296-2427            BC029158.1         218-2349
            2428-2816           X91249.1           2301-2689
            2817-3060           BC029158.1         2740-2983
FEATURES             Location/Qualifiers
     source          1..3060
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     gene            1..3060
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /note="ATP binding cassette subfamily G member 1"
                     /db_xref="GeneID:9619"
                     /db_xref="HGNC:HGNC:73"
                     /db_xref="MIM:603076"
     exon            1..38
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            39..185
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            186..226
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            227..470
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..2185
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /note="isoform 6 is encoded by transcript variant 6; ABC
                     transporter 8; ATP-binding cassette transporter 8; homolog
                     of Drosophila white; ATP-binding cassette sub-family G
                     member 1; ATP-binding cassette transporter member 1 of
                     subfamily G; white protein homolog (ATP-binding cassette
                     transporter 8); ATP-binding cassette, sub-family G
                     (WHITE), member 1"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family G member 1
                     isoform 6"
                     /protein_id="NP_997511.1"
                     /db_xref="GeneID:9619"
                     /db_xref="HGNC:HGNC:73"
                     /db_xref="MIM:603076"
                     /translation="MTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRF
                     SSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGK
                     STLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSA
                     HLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF
                     DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYR
                     GKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRD
                     LGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSVLTHLR
                     ITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLEMGVF
                     LREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAALGT
                     MTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS
                     YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIF
                     FISLRLIAYFVLRYKIRAER"
     exon            471..588
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            589..721
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            722..772
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            773..918
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1042
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1043..1157
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1158..1306
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1408
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1577
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1678
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1679..1837
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1838..1956
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     exon            1957..3037
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3014..3019
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /note="hexamer: AATATA"
     polyA_site      3037
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /note="major polyA site"
ORIGIN      
        1 acttcagagg gcagcagctg gactacctat gtttgtggcg ctacaccaac ctgaacttcg
       61 cttcctgaga cctaagattc agccccgtgc tcagcagaca tcagggatca ccgactctgt
      121 gccaggagct gttcttgatg ctgggaacgc aggggtggac aaaacagaga aagccctgcc
      181 ctcagtgaga aatatgctgt catgtaaatt gctttttccc ctatagaatg ccagcagtta
      241 ctctgcagag atgacggagc ccaagtcggt gtgtgtctcg gtggatgagg tggtgtccag
      301 caacatggag gccactgaga cggacctgct gaatggacat ctgaaaaaag tagataataa
      361 cctcacggaa gcccagcgct tctcctcctt gcctcggagg gcagctgtga acattgaatt
      421 cagggacctt tcctattcgg ttcctgaagg accctggtgg aggaagaaag gatacaagac
      481 cctcctgaaa ggaatttccg ggaagttcaa tagtggtgag ttggtggcca ttatgggtcc
      541 ttccggggcc gggaagtcca cgctgatgaa catcctggct ggatacaggg agacgggcat
      601 gaagggggcc gtcctcatca acggcctgcc ccgggacctg cgctgcttcc ggaaggtgtc
      661 ctgctacatc atgcaggatg acatgctgct gccgcatctc actgtgcagg aggccatgat
      721 ggtgtcggca catctgaagc ttcaggagaa ggatgaaggc agaagggaaa tggtcaagga
      781 gatactgaca gcgctgggct tgctgtcttg cgccaacacg cggaccggga gcctgtcagg
      841 tggtcagcgc aagcgcctgg ccatcgcgct ggagctggtg aacaaccctc cagtcatgtt
      901 cttcgatgag cccaccagcg gcctggacag cgcctcctgc ttccaggtgg tctcgctgat
      961 gaaagggctc gctcaagggg gtcgctccat catttgcacc atccaccagc ccagcgccaa
     1021 actcttcgag ctgttcgacc agctttacgt cctgagtcaa ggacaatgtg tgtaccgggg
     1081 aaaagtctgc aatcttgtgc catatttgag ggatttgggt ctgaactgcc caacctacca
     1141 caacccagca gattttgtca tggaggttgc atccggcgag tacggtgatc agaacagtcg
     1201 gctggtgaga gcggttcggg agggcatgtg tgactcagac cacaagagag acctcggggg
     1261 tgatgccgag gtgaaccctt ttctttggca ccggccctct gaagaggact cctcgtccat
     1321 ggaaggctgc cacagcttct ctgccagctg cctcacgcag ttctgcatcc tcttcaagag
     1381 gaccttcctc agcatcatga gggactcggt cctgacacac ctgcgcatca cctcgcacat
     1441 tgggatcggc ctcctcattg gcctgctgta cttggggatc gggaacgaag ccaagaaggt
     1501 cttgagcaac tccggcttcc tcttcttctc catgctgttc ctcatgttcg cggccctcat
     1561 gcctactgtt ctgacatttc ccctggagat gggagtcttt cttcgggaac acctgaacta
     1621 ctggtacagc ctgaaggcct actacctggc caagaccatg gcagacgtgc cctttcagat
     1681 catgttccca gtggcctact gcagcatcgt gtactggatg acgtcgcagc cgtccgacgc
     1741 cgtgcgcttt gtgctgtttg ccgcgctggg caccatgacc tccctggtgg cacagtccct
     1801 gggcctgctg atcggagccg cctccacgtc cctgcaggtg gccactttcg tgggcccagt
     1861 gacagccatc ccggtgctcc tgttctcggg gttcttcgtc agcttcgaca ccatccccac
     1921 gtacctacag tggatgtcct acatctccta tgtcaggtat gggttcgaag gggtcatcct
     1981 ctccatctat ggcttagacc gggaagatct gcactgtgac atcgacgaga cgtgccactt
     2041 ccagaagtcg gaggccatcc tgcgggagct ggacgtggaa aatgccaagc tgtacctgga
     2101 cttcatcgta ctcgggattt tcttcatctc cctccgcctc attgcctatt ttgtcctcag
     2161 gtacaaaatc cgggcagaga ggtaaaacac ctgaatgcca ggaaacagga agattagaca
     2221 ctgtggccga gggcacgtct agaatcgagg aggcaagcct gtgcccgacc gacgacacag
     2281 agactcttct gatccaaccc ctagaaccgc gttgggtttg tgggtgtctc gtgctcagcc
     2341 actctgccca gctgggttgg atcttctctc cattcccctt tctagcttta actaggaaga
     2401 tgtaggcaga ttggtggttt tttttttttt aacatacaga attttaaata ccacaactgg
     2461 ggcagaattt aaagctgcaa cacagctggt gatgagaggc ttcctcagtc cagtcgctcc
     2521 ttagcaccag gcaccgtggg tcctggatgg ggaactgcaa gcagcctctc agctgatggc
     2581 tgcacagtca gatgtctggt ggcagagagt ccgagcatgg agcgattcca ttttatgact
     2641 gttgtttttc acattttcat ctttctaagg tgtgtctctt ttccaatgag aagtcatttt
     2701 tgcaagccaa aagtcgatca atcgcattca ttttaagaaa ttataccttt ttagtacttg
     2761 ctgaagaatg attcagggta aatcacatac tttgtttaga gaggcgaggg gtttaaccga
     2821 gtcacccagc tggtctcata catagacagc acttgtgaag gattgaatgc aggttccagg
     2881 tggagggaag acgtggacac catctccact gagccatgca gacattttta aaagctatac
     2941 aaaaaattgt gagaagacat tggccaactc tttcaaagtc tttctttttc cacgtgcttc
     3001 ttattttaag cgaaatatat tgtttgtttc ttcctaaaaa aaaaaaaaaa aaaaaaaaaa
//
