LOCUS       NP_058198                666 aa            linear   PRI 27-MAR-2025
DEFINITION  ATP-binding cassette sub-family G member 1 isoform 2 [Homo
            sapiens].
ACCESSION   NP_058198
VERSION     NP_058198.2
DBSOURCE    REFSEQ: accession NM_016818.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 666)
  AUTHORS   Yazdi,M.K., Alavi,M.S. and Roohbakhsh,A.
  TITLE     The role of ATP-binding cassette transporter G1 (ABCG1) in
            Alzheimer's disease: A review of the mechanisms
  JOURNAL   Basic Clin Pharmacol Toxicol 134 (4), 423-438 (2024)
   PUBMED   38275217
  REMARK    GeneRIF: The role of ATP-binding cassette transporter G1 (ABCG1) in
            Alzheimer's disease: A review of the mechanisms.
            Review article
REFERENCE   2  (residues 1 to 666)
  AUTHORS   Zeng,G.G., Lei,Q., Jiang,W.L., Zhang,X.X., Nie,L., Gong,X. and
            Zheng,K.
  TITLE     A new perspective on the current and future development potential
            of ABCG1
  JOURNAL   Curr Probl Cardiol 49 (1 Pt C), 102161 (2024)
   PUBMED   37875209
  REMARK    GeneRIF: A new perspective on the current and future development
            potential of ABCG1.
            Review article
REFERENCE   3  (residues 1 to 666)
  AUTHORS   Li,X., Shao,X., Kou,M., Wang,X., Ma,H., Grundberg,E., Bazzano,L.A.,
            Smith,S.R., Bray,G.A., Sacks,F.M. and Qi,L.
  TITLE     DNA Methylation at ABCG1 and Long-term Changes in Adiposity and Fat
            Distribution in Response to Dietary Interventions: The POUNDS Lost
            Trial
  JOURNAL   Diabetes Care 46 (12), 2201-2207 (2023)
   PUBMED   37770056
  REMARK    GeneRIF: DNA Methylation at ABCG1 and Long-term Changes in
            Adiposity and Fat Distribution in Response to Dietary
            Interventions: The POUNDS Lost Trial.
REFERENCE   4  (residues 1 to 666)
  AUTHORS   Jin,J., Zhao,X., Zhu,C., Li,M., Wang,J., Fan,Y., Liu,C., Shen,C.
            and Yang,R.
  TITLE     Hypomethylation of ABCG1 in peripheral blood as a potential marker
            for the detection of coronary heart disease
  JOURNAL   Clin Epigenetics 15 (1), 120 (2023)
   PUBMED   37507725
  REMARK    GeneRIF: Hypomethylation of ABCG1 in peripheral blood as a
            potential marker for the detection of coronary heart disease.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 666)
  AUTHORS   Zhou,W., Sun,J., Huai,C., Liu,Y., Chen,L., Yi,Z., Lv,Q., Song,C.,
            Zhu,W., Liu,C., Weng,S., Wu,H., Sun,Y., Zhang,R., Wu,L., Li,M.,
            Zhu,J., Zhang,Y., Wei,M., Guo,Y., Huang,S., Zhang,N., Shen,R.,
            Zhang,Y., Du,H., Huang,H., He,L., Sun,X., Shen,L. and Qin,S.
  TITLE     Multi-omics analysis identifies rare variation in leptin/PPAR gene
            sets and hypermethylation of ABCG1 contribute to
            antipsychotics-induced metabolic syndromes
  JOURNAL   Mol Psychiatry 27 (12), 5195-5205 (2022)
   PUBMED   36065016
  REMARK    GeneRIF: Multi-omics analysis identifies rare variation in
            leptin/PPAR gene sets and hypermethylation of ABCG1 contribute to
            antipsychotics-induced metabolic syndromes.
REFERENCE   6  (residues 1 to 666)
  AUTHORS   Venkateswaran,A., Repa,J.J., Lobaccaro,J.M., Bronson,A.,
            Mangelsdorf,D.J. and Edwards,P.A.
  TITLE     Human white/murine ABC8 mRNA levels are highly induced in
            lipid-loaded macrophages. A transcriptional role for specific
            oxysterols
  JOURNAL   J Biol Chem 275 (19), 14700-14707 (2000)
   PUBMED   10799558
REFERENCE   7  (residues 1 to 666)
  AUTHORS   Klucken,J., Buchler,C., Orso,E., Kaminski,W.E.,
            Porsch-Ozcurumez,M., Liebisch,G., Kapinsky,M., Diederich,W.,
            Drobnik,W., Dean,M., Allikmets,R. and Schmitz,G.
  TITLE     ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a
            regulator of macrophage cholesterol and phospholipid transport
  JOURNAL   Proc Natl Acad Sci U S A 97 (2), 817-822 (2000)
   PUBMED   10639163
REFERENCE   8  (residues 1 to 666)
  AUTHORS   Croop,J.M., Tiller,G.E., Fletcher,J.A., Lux,M.L., Raab,E.,
            Goldenson,D., Son,D., Arciniegas,S. and Wu,R.L.
  TITLE     Isolation and characterization of a mammalian homolog of the
            Drosophila white gene
  JOURNAL   Gene 185 (1), 77-85 (1997)
   PUBMED   9034316
REFERENCE   9  (residues 1 to 666)
  AUTHORS   Savary,S., Denizot,F., Luciani,M., Mattei,M. and Chimini,G.
  TITLE     Molecular cloning of a mammalian ABC transporter homologous to
            Drosophila white gene
  JOURNAL   Mamm Genome 7 (9), 673-676 (1996)
   PUBMED   8703120
REFERENCE   10 (residues 1 to 666)
  AUTHORS   Chen,H., Rossier,C., Lalioti,M.D., Lynn,A., Chakravarti,A.,
            Perrin,G. and Antonarakis,S.E.
  TITLE     Cloning of the cDNA for a human homologue of the Drosophila white
            gene and mapping to chromosome 21q22.3
  JOURNAL   Am J Hum Genet 59 (1), 66-75 (1996)
   PUBMED   8659545
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001622.1, BC029158.1 and
            X91249.1.
            
            On Apr 27, 2004 this sequence version replaced NP_058198.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the White subfamily. It is involved in
            macrophage cholesterol and phospholipids transport, and may
            regulate cellular lipid homeostasis in other cell types. Six
            alternative splice variants have been identified. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' end-region
            compared to variant 1, which includes a part of the coding region.
            The resulting isoform (2) has a distinct and shorter N-terminus, as
            compared to isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC029158.1, AF323663.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398449.8/ ENSP00000381467.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..666
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="21"
                     /map="21q22.3"
     Protein         1..666
                     /product="ATP-binding cassette sub-family G member 1
                     isoform 2"
                     /note="ABC transporter 8; ATP-binding cassette transporter
                     8; homolog of Drosophila white; ATP-binding cassette
                     sub-family G member 1; ATP-binding cassette transporter
                     member 1 of subfamily G; white protein homolog
                     (ATP-binding cassette transporter 8); ATP-binding
                     cassette, sub-family G (WHITE), member 1"
                     /calculated_mol_wt=74024
     Region          60..666
                     /region_name="3a01204"
                     /note="The Eye Pigment Precursor Transporter (EPP) Family
                     protein; TIGR00955"
                     /db_xref="CDD:273361"
     Site            415..433
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P45844.3)"
     Site            445..465
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P45844.3)"
     Site            495..513
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P45844.3)"
     Site            522..543
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P45844.3)"
     Site            556..574
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P45844.3)"
     Site            638..657
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P45844.3)"
     CDS             1..666
                     /gene="ABCG1"
                     /gene_synonym="ABC8; WHITE1"
                     /coded_by="NM_016818.3:124..2124"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS42938.1"
                     /db_xref="GeneID:9619"
                     /db_xref="HGNC:HGNC:73"
                     /db_xref="MIM:603076"
ORIGIN      
        1 maclmaafsv gtamnassys aemtepksvc vsvdevvssn meatetdlln ghlkkvdnnl
       61 teaqrfsslp rraavniefr dlsysvpegp wwrkkgyktl lkgisgkfns gelvaimgps
      121 gagkstlmni lagyretgmk gavlinglpr dlrcfrkvsc yimqddmllp hltvqeammv
      181 sahlklqekd egrremvkei ltalgllsca ntrtgslsgg qrkrlaiale lvnnppvmff
      241 deptsgldsa scfqvvslmk glaqggrsii ctihqpsakl felfdqlyvl sqgqcvyrgk
      301 vcnlvpylrd lglncptyhn padfvmevas geygdqnsrl vravregmcd sdhkrdlggd
      361 aevnpflwhr pseedsssme gchsfsascl tqfcilfkrt flsimrdsvl thlritshig
      421 iglligllyl gigneakkvl snsgflffsm lflmfaalmp tvltfplemg vflrehlnyw
      481 yslkayylak tmadvpfqim fpvaycsivy wmtsqpsdav rfvlfaalgt mtslvaqslg
      541 lligaastsl qvatfvgpvt aipvllfsgf fvsfdtipty lqwmsyisyv rygfegvils
      601 iygldredlh cdidetchfq kseailreld venaklyldf ivlgiffisl rliayfvlry
      661 kiraer
//
