LOCUS       NM_018358               2446 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily F member 3 (ABCF3),
            transcript variant 1, mRNA.
ACCESSION   NM_018358
VERSION     NM_018358.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Yang,X., Coulombe-Huntington,J., Kang,S., Sheynkman,G.M., Hao,T.,
            Richardson,A., Sun,S., Yang,F., Shen,Y.A., Murray,R.R., Spirohn,K.,
            Begg,B.E., Duran-Frigola,M., MacWilliams,A., Pevzner,S.J.,
            Zhong,Q., Wanamaker,S.A., Tam,S., Ghamsari,L., Sahni,N., Yi,S.,
            Rodriguez,M.D., Balcha,D., Tan,G., Costanzo,M., Andrews,B.,
            Boone,C., Zhou,X.J., Salehi-Ashtiani,K., Charloteaux,B., Chen,A.A.,
            Calderwood,M.A., Aloy,P., Roth,F.P., Hill,D.E., Iakoucheva,L.M.,
            Xia,Y. and Vidal,M.
  TITLE     Widespread Expansion of Protein Interaction Capabilities by
            Alternative Splicing
  JOURNAL   Cell 164 (4), 805-817 (2016)
   PUBMED   26871637
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Guo,Z., Neilson,L.J., Zhong,H., Murray,P.S., Zanivan,S. and
            Zaidel-Bar,R.
  TITLE     E-cadherin interactome complexity and robustness resolved by
            quantitative proteomics
  JOURNAL   Sci Signal 7 (354), rs7 (2014)
   PUBMED   25468996
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2446)
  AUTHORS   Zhou,J., Lin,Y., Shi,H., Huo,K. and Li,Y.
  TITLE     hABCF3, a TPD52L2 interacting partner, enhances the proliferation
            of human liver cancer cell lines in vitro
  JOURNAL   Mol Biol Rep 40 (10), 5759-5767 (2013)
   PUBMED   24052230
  REMARK    GeneRIF: hABCF3 positively regulates cell proliferation, at least
            partially through the interaction with a tumor protein D52 protein
            family member: TPD52L2.
REFERENCE   5  (bases 1 to 2446)
  AUTHORS   Ripke,S., Wray,N.R., Lewis,C.M., Hamilton,S.P., Weissman,M.M.,
            Breen,G., Byrne,E.M., Blackwood,D.H., Boomsma,D.I., Cichon,S.,
            Heath,A.C., Holsboer,F., Lucae,S., Madden,P.A., Martin,N.G.,
            McGuffin,P., Muglia,P., Noethen,M.M., Penninx,B.P., Pergadia,M.L.,
            Potash,J.B., Rietschel,M., Lin,D., Muller-Myhsok,B., Shi,J.,
            Steinberg,S., Grabe,H.J., Lichtenstein,P., Magnusson,P.,
            Perlis,R.H., Preisig,M., Smoller,J.W., Stefansson,K., Uher,R.,
            Kutalik,Z., Tansey,K.E., Teumer,A., Viktorin,A., Barnes,M.R.,
            Bettecken,T., Binder,E.B., Breuer,R., Castro,V.M., Churchill,S.E.,
            Coryell,W.H., Craddock,N., Craig,I.W., Czamara,D., De Geus,E.J.,
            Degenhardt,F., Farmer,A.E., Fava,M., Frank,J., Gainer,V.S.,
            Gallagher,P.J., Gordon,S.D., Goryachev,S., Gross,M., Guipponi,M.,
            Henders,A.K., Herms,S., Hickie,I.B., Hoefels,S., Hoogendijk,W.,
            Hottenga,J.J., Iosifescu,D.V., Ising,M., Jones,I., Jones,L.,
            Jung-Ying,T., Knowles,J.A., Kohane,I.S., Kohli,M.A., Korszun,A.,
            Landen,M., Lawson,W.B., Lewis,G., Macintyre,D., Maier,W.,
            Mattheisen,M., McGrath,P.J., McIntosh,A., McLean,A.,
            Middeldorp,C.M., Middleton,L., Montgomery,G.M., Murphy,S.N.,
            Nauck,M., Nolen,W.A., Nyholt,D.R., O'Donovan,M., Oskarsson,H.,
            Pedersen,N., Scheftner,W.A., Schulz,A., Schulze,T.G., Shyn,S.I.,
            Sigurdsson,E., Slager,S.L., Smit,J.H., Stefansson,H., Steffens,M.,
            Thorgeirsson,T., Tozzi,F., Treutlein,J., Uhr,M., van den Oord,E.J.,
            Van Grootheest,G., Volzke,H., Weilburg,J.B., Willemsen,G.,
            Zitman,F.G., Neale,B., Daly,M., Levinson,D.F. and Sullivan,P.F.
  CONSRTM   Major Depressive Disorder Working Group of the Psychiatric GWAS
            Consortium
  TITLE     A mega-analysis of genome-wide association studies for major
            depressive disorder
  JOURNAL   Mol Psychiatry 18 (4), 497-511 (2013)
   PUBMED   22472876
REFERENCE   6  (bases 1 to 2446)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 2446)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   8  (bases 1 to 2446)
  AUTHORS   Dean,M., Rzhetsky,A. and Allikmets,R.
  TITLE     The human ATP-binding cassette (ABC) transporter superfamily
  JOURNAL   Genome Res 11 (7), 1156-1166 (2001)
   PUBMED   11435397
  REMARK    Review article
REFERENCE   9  (bases 1 to 2446)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC131235.4.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Feb 4, 2021 this sequence version replaced NM_018358.2.
            
            Summary: This gene encodes a member of the ATP-binding cassette
            (ABC) transporter superfamily. ATP-binding cassette proteins
            transport various molecules across extra- and intracellular
            membranes. The protein encoded by this gene displays antiviral
            effect against flaviviruses. Alternatively spliced transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, May 2017].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC009253.2, AK002060.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000429586.7/ ENSP00000411471.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AC131235.4         25527-25608         c
            83-230              AC131235.4         25153-25300         c
            231-310             AC131235.4         24932-25011         c
            311-357             AC131235.4         24364-24410         c
            358-455             AC131235.4         24046-24143         c
            456-578             AC131235.4         23824-23946         c
            579-845             AC131235.4         23400-23666         c
            846-926             AC131235.4         22966-23046         c
            927-986             AC131235.4         22819-22878         c
            987-1043            AC131235.4         22663-22719         c
            1044-1066           AC131235.4         22530-22552         c
            1067-1122           AC131235.4         22364-22419         c
            1123-1323           AC131235.4         22050-22250         c
            1324-1400           AC131235.4         21876-21952         c
            1401-1445           AC131235.4         20764-20808         c
            1446-1578           AC131235.4         20552-20684         c
            1579-1667           AC131235.4         19118-19206         c
            1668-1759           AC131235.4         18911-19002         c
            1760-1892           AC131235.4         18573-18705         c
            1893-1980           AC131235.4         18355-18442         c
            1981-2446           AC131235.4         17802-18267         c
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q27.1"
     gene            1..2446
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /note="ATP binding cassette subfamily F member 3"
                     /db_xref="GeneID:55324"
                     /db_xref="HGNC:HGNC:72"
                     /db_xref="MIM:618967"
     exon            1..82
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     CDS             10..2139
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /note="isoform 1 is encoded by transcript variant 1;
                     ATP-binding cassette sub-family F member 3; ATP-binding
                     cassette, sub-family F (GCN20), member 3"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family F member 3
                     isoform 1"
                     /protein_id="NP_060828.2"
                     /db_xref="CCDS:CCDS3254.1"
                     /db_xref="GeneID:55324"
                     /db_xref="HGNC:HGNC:72"
                     /db_xref="MIM:618967"
                     /translation="MATCAEILRSEFPEIDGQVFDYVTGVLHSGSADFESVDDLVEAV
                     GELLQEVSGDSKDDAGIRAVCQRMYNTLRLAEPQSQGNSQVLLDAPIQLSKITENYDC
                     GTKLPGLLKREQSSTVNAKKLEKAEARLKAKQEKRSEKDTLKTSNPLVLEEASASQAG
                     SRKESRLESSGKNKSYDVRIENFDVSFGDRVLLAGADVNLAWGRRYGLVGRNGLGKTT
                     LLKMLATRSLRVPAHISLLHVEQEVAGDDTPALQSVLESDSVREDLLRRERELTAQIA
                     AGRAEGSEAAELAEIYAKLEEIEADKAPARASVILAGLGFTPKMQQQPTREFSGGWRM
                     RLALARALFARPDLLLLDEPTNMLDVRAILWLENYLQTWPSTILVVSHDRNFLNAIAT
                     DIIHLHSQRLDGYRGDFETFIKSKQERLLNQQREYEAQQQYRQHIQVFIDRFRYNANR
                     ASQVQSKLKMLEKLPELKPVDKESEVVMKFPDGFEKFSPPILQLDEVDFYYDPKHVIF
                     SRLSVSADLESRICVVGENGAGKSTMLKLLLGDLAPVRGIRHAHRNLKIGYFSQHHVE
                     QLDLNVSAVELLARKFPGRPEEEYRHQLGRYGISGELAMRPLASLSGGQKSRVAFAQM
                     TMPCPNFYILDEPTNHLDMETIEALGRALNNFRGGVILVSHDERFIRLVCRELWVCEG
                     GGVTRVEGGFDQYRALLQEQFRREGFL"
     exon            83..230
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            231..310
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            311..357
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            358..455
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            456..578
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            579..845
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            846..926
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            927..986
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            987..1043
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1066
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1122
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1323
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1324..1400
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1401..1445
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1446..1578
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1667
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1668..1759
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1892
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1893..1980
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2446
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2427..2432
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /note="hexamer: ATTAAA"
     polyA_site      2446
                     /gene="ABCF3"
                     /gene_synonym="EST201864"
                     /note="major polyA site"
ORIGIN      
        1 gagtggaaca tggcgacttg cgccgaaatc ctgcggagcg agttccccga aattgacgga
       61 caagtcttcg actacgtgac cggcgtcttg cacagcggca gcgcggactt cgagtctgtg
      121 gatgacctgg tggaagctgt aggggaacta ttgcaagagg tgtccgggga cagcaaggat
      181 gacgcgggca tcagggccgt gtgccagcgc atgtacaaca ctctgcgtct ggctgagcca
      241 caaagccagg gaaatagcca ggtgctactg gacgccccta tccagttgtc aaagataacg
      301 gagaactacg actgtggaac caaacttcca ggactgctaa agagggaaca gtcctcgaca
      361 gtgaatgcaa agaagttaga gaaggccgag gctcgactta aggcaaagca ggagaagcgc
      421 tcagagaagg acacgctcaa gaccagcaac cctctagtct tagaagaggc atcagccagc
      481 caggcaggca gcagaaagga gagtcggttg gaatcatctg gcaagaacaa atcctatgat
      541 gtgcgaattg agaactttga tgtgtctttt ggcgatagag tactgctggc tggagcggat
      601 gtgaacctgg catggggccg ccgttacggg ctggtggggc ggaatgggtt ggggaagaca
      661 acgttactga agatgctggc cacccggagt ctgcgggttc cagcccacat ttccctgctg
      721 cacgttgagc aagaggttgc tggagatgac actcctgccc tgcagagtgt gctggagagt
      781 gacagtgtgc gagaggattt gctacggagg gagcgggagc tcactgccca gattgctgct
      841 ggcagggcgg agggctctga agctgcagag ctggcagaaa tctatgccaa actggaggag
      901 attgaggctg acaaggcacc tgccagggca tcagtcattc tcgctgggct tggctttacc
      961 cctaaaatgc agcagcagcc cacccgggag ttctcaggtg gctggaggat gaggctggcc
     1021 ctggcccggg ccctctttgc taggccagat cttctgctgt tagatgaacc tacaaacatg
     1081 ctggatgtca gggccatcct gtggctggag aattacctgc agacgtggcc ctccaccatc
     1141 ctagtcgtct cccacgaccg caacttcttg aatgccatcg ccacagacat catccacctg
     1201 cacagccagc ggctagatgg ttaccgggga gactttgaga ccttcatcaa gagtaagcag
     1261 gagcggctgc tcaaccagca gcgtgaatat gaggcgcagc agcagtatcg ccagcacatc
     1321 caggttttca ttgaccggtt tcgctacaat gccaacaggg cctctcaagt gcagagtaaa
     1381 ctcaagatgc tggagaagct gcctgagctg aagcctgtgg acaaggaatc agaggtcgta
     1441 atgaagttcc ctgatgggtt tgagaagttc tcgccgccaa ttctgcagct agatgaggtg
     1501 gatttctact acgatccgaa gcacgtcatc ttcagtcgcc tctctgtgtc tgctgatctc
     1561 gagtctcgca tctgtgtggt tggagagaat ggggctggga agtctaccat gctgaagctg
     1621 cttttggggg acctggcacc tgttcggggc atcagacacg ctcacaggaa tctgaagatt
     1681 ggctatttca gccagcacca tgtggagcag ctggacctaa acgtcagtgc tgtggaactg
     1741 ctggcacgca agtttcctgg gcggcctgag gaggagtacc gtcaccagct gggtcggtat
     1801 ggcatctccg gagaactggc catgcgtcct cttgccagcc tgtctggggg ccagaagagc
     1861 cgagtggcct ttgctcagat gactatgccc tgccccaact tctacattct ggatgaaccc
     1921 acaaaccacc tggacatgga gaccattgag gctctgggcc gtgccctcaa caatttcagg
     1981 ggtggtgtga ttctggtgtc ccacgatgag cgctttatca ggctggtgtg ccgggagttg
     2041 tgggtatgcg aaggaggcgg cgtcacccgt gtggaaggag gatttgacca gtaccgcgcc
     2101 ctcctccagg aacagttccg ccgcgaaggc ttcctctagg gccaccaggc tgaggactcg
     2161 cccaggacat ggactggtct ctcagacccc tgggccacca tgtaggccac cactccaggc
     2221 cgtggacttc ccccaacttg gggacagcct tattcccaaa tgtctctatc cttttgactg
     2281 gagcatcttc tgcacaacct tgggagccca tccaagggtt ggtgaggact ggtctcccgg
     2341 gggtgggggt ctggggggta ccctctgggg ttatagattc ccccactgcc ccagctctga
     2401 ctggacccca agtggctgct atgtaaatta aatctctccc cgcgtc
//
