LOCUS       NM_007189               4527 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily F member 2 (ABCF2),
            mRNA.
ACCESSION   NM_007189
VERSION     NM_007189.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4527)
  AUTHORS   Li,W., Li,G. and Cao,L.
  TITLE     Circular RNA Eps15-homology domain-containing protein 2 induce
            resistance of renal cell carcinoma to sunitinib via
            microRNA-4731-5p/ABCF2 axis
  JOURNAL   Bioengineered 13 (4), 9729-9740 (2022)
   PUBMED   35412955
  REMARK    GeneRIF: Circular RNA Eps15-homology domain-containing protein 2
            induce resistance of renal cell carcinoma to sunitinib via
            microRNA-4731-5p/ABCF2 axis.
REFERENCE   2  (bases 1 to 4527)
  AUTHORS   Bao,L., Wu,J., Dodson,M., Rojo de la Vega,E.M., Ning,Y., Zhang,Z.,
            Yao,M., Zhang,D.D., Xu,C. and Yi,X.
  TITLE     ABCF2, an Nrf2 target gene, contributes to cisplatin resistance in
            ovarian cancer cells
  JOURNAL   Mol Carcinog 56 (6), 1543-1553 (2017)
   PUBMED   28112439
  REMARK    GeneRIF: The NRF2-overexpressing cell line, containing high levels
            of ABCF2, was more resistant to cisplatin-induced apoptosis
            compared to its control ovarian cancer cell line; whereas the NRF2
            knockdown cell line with low levels of ABCF2, was more sensitive to
            cisplatin treatment than its control cell line.
REFERENCE   3  (bases 1 to 4527)
  AUTHORS   Lauc,G., Huffman,J.E., Pucic,M., Zgaga,L., Adamczyk,B., Muzinic,A.,
            Novokmet,M., Polasek,O., Gornik,O., Kristic,J., Keser,T.,
            Vitart,V., Scheijen,B., Uh,H.W., Molokhia,M., Patrick,A.L.,
            McKeigue,P., Kolcic,I., Lukic,I.K., Swann,O., van Leeuwen,F.N.,
            Ruhaak,L.R., Houwing-Duistermaat,J.J., Slagboom,P.E., Beekman,M.,
            de Craen,A.J., Deelder,A.M., Zeng,Q., Wang,W., Hastie,N.D.,
            Gyllensten,U., Wilson,J.F., Wuhrer,M., Wright,A.F., Rudd,P.M.,
            Hayward,C., Aulchenko,Y., Campbell,H. and Rudan,I.
  TITLE     Loci associated with N-glycosylation of human immunoglobulin G show
            pleiotropy with autoimmune diseases and haematological cancers
  JOURNAL   PLoS Genet 9 (1), e1003225 (2013)
   PUBMED   23382691
REFERENCE   4  (bases 1 to 4527)
  AUTHORS   Ando-Akatsuka,Y., Shimizu,T., Numata,T. and Okada,Y.
  TITLE     Involvements of the ABC protein ABCF2 and alpha-actinin-4 in
            regulation of cell volume and anion channels in human epithelial
            cells
  JOURNAL   J Cell Physiol 227 (10), 3498-3510 (2012)
   PUBMED   22252987
  REMARK    GeneRIF: Overexpression of ABCF2 suppressed RVD.
REFERENCE   5  (bases 1 to 4527)
  AUTHORS   Ghosh,D., Lippert,D., Krokhin,O., Cortens,J.P. and Wilkins,J.A.
  TITLE     Defining the membrane proteome of NK cells
  JOURNAL   J Mass Spectrom 45 (1), 1-25 (2010)
   PUBMED   19946888
REFERENCE   6  (bases 1 to 4527)
  AUTHORS   Cheng,J., Kapranov,P., Drenkow,J., Dike,S., Brubaker,S., Patel,S.,
            Long,J., Stern,D., Tammana,H., Helt,G., Sementchenko,V.,
            Piccolboni,A., Bekiranov,S., Bailey,D.K., Ganesh,M., Ghosh,S.,
            Bell,I., Gerhard,D.S. and Gingeras,T.R.
  TITLE     Transcriptional maps of 10 human chromosomes at 5-nucleotide
            resolution
  JOURNAL   Science 308 (5725), 1149-1154 (2005)
   PUBMED   15790807
REFERENCE   7  (bases 1 to 4527)
  AUTHORS   Dean,M., Rzhetsky,A. and Allikmets,R.
  TITLE     The human ATP-binding cassette (ABC) transporter superfamily
  JOURNAL   Genome Res 11 (7), 1156-1166 (2001)
   PUBMED   11435397
  REMARK    Review article
REFERENCE   8  (bases 1 to 4527)
  AUTHORS   Zhang,F., Hogue,D.L., Liu,L., Fisher,C.L., Hui,D., Childs,S. and
            Ling,V.
  TITLE     M-ABC2, a new human mitochondrial ATP-binding cassette membrane
            protein
  JOURNAL   FEBS Lett 478 (1-2), 89-94 (2000)
   PUBMED   10922475
REFERENCE   9  (bases 1 to 4527)
  AUTHORS   Klein,I., Sarkadi,B. and Varadi,A.
  TITLE     An inventory of the human ABC proteins
  JOURNAL   Biochim Biophys Acta 1461 (2), 237-262 (1999)
   PUBMED   10581359
  REMARK    Review article
REFERENCE   10 (bases 1 to 4527)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY165500.1, AC021097.5,
            BG720644.1 and BC001661.2.
            
            On Nov 22, 2018 this sequence version replaced NM_007189.2.
            
            Summary: This gene encodes a member of the ATP-binding cassette
            (ABC) transporter superfamily. ATP-binding cassette proteins
            transport various molecules across extra- and intracellular
            membranes. Alterations in this gene may be involved in cancer
            progression. Related pseudogenes have been identified on
            chromosomes 3 and 7. [provided by RefSeq, Mar 2019].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.178542.1,
                                           SRR1803613.268729.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287844.7/ ENSP00000287844.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               HY165500.1         174-273
            101-239             AC021097.5         14952-15090
            240-452             AC021097.5         16407-16619
            453-635             AC021097.5         17281-17463
            636-807             AC021097.5         17546-17717
            808-903             AC021097.5         18779-18874
            904-962             AC021097.5         19715-19773
            963-1344            BG720644.1         270-651
            1345-2454           BC001661.2         1346-2455
            2455-4527           AC021097.5         27839-29911
FEATURES             Location/Qualifiers
     source          1..4527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7q36.1"
     gene            1..4527
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /note="ATP binding cassette subfamily F member 2"
                     /db_xref="GeneID:10061"
                     /db_xref="HGNC:HGNC:71"
                     /db_xref="MIM:612510"
     exon            1..43
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            44..239
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..1957
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /note="ABC-type transport protein; iron-inhibited ABC
                     transporter 2; ATP-binding cassette, sub-family F (GCN20),
                     member 2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family F member 2"
                     /protein_id="NP_009120.1"
                     /db_xref="CCDS:CCDS5923.1"
                     /db_xref="GeneID:10061"
                     /db_xref="HGNC:HGNC:71"
                     /db_xref="MIM:612510"
                     /translation="MPSDLAKKKAAKKKEAAKARQRPRKGHEENGDVVTEPQVAEKNE
                     ANGRETTEVDLLTKELEDFEMKKAAARAVTGVLASHPNSTDVHIINLSLTFHGQELLS
                     DTKLELNSGRRYGLIGLNGIGKSMLLSAIGKREVPIPEHIDIYHLTREMPPSDKTPLH
                     CVMEVDTERAMLEKEAERLAHEDAECEKLMELYERLEELDADKAEMRASRILHGLGFT
                     PAMQRKKLKDFSGGWRMRVALARALFIRPFMLLLDEPTNHLDLDACVWLEEELKTFKR
                     ILVLVSHSQDFLNGVCTNIIHMHNKKLKYYTGNYDQYVKTRLELEENQMKRFHWEQDQ
                     IAHMKNYIARFGHGSAKLARQAQSKEKTLQKMMASGLTERVVSDKTLSFYFPPCGKIP
                     PPVIMVQNVSFKYTKDGPCIYNNLEFGIDLDTRVALVGPNGAGKSTLLKLLTGELLPT
                     DGMIRKHSHVKIGRYHQHLQEQLDLDLSPLEYMMKCYPEIKEKEEMRKIIGRYGLTGK
                     QQVSPIRNLSDGQKCRVCLAWLAWQNPHMLFLDEPTNHLDIETIDALADAINEFEGGM
                     MLVSHDFRLIQQVAQEIWVCEKQTITKWPGDILAYKEHLKSKLVDEEPQLTKRTHNV"
     exon            240..452
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            453..635
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            636..807
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            808..903
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1006
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1007..1102
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1222
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1312
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1313..1423
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1424..1486
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1487..1615
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1616..1819
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..4527
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2482..2487
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /note="hexamer: AATAAA"
     polyA_site      2510
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /note="major polyA site"
     regulatory      3499..3504
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /note="hexamer: AATAAA"
     polyA_site      3524
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
     regulatory      4508..4513
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
                     /note="hexamer: AATACA"
     polyA_site      4527
                     /gene="ABCF2"
                     /gene_synonym="ABC28; EST133090; HUSSY-18; HUSSY18"
ORIGIN      
        1 aaggagcagc tctgttgcga cataggccga gcagcgaggc ccagctccct gaaacaacag
       61 taacctaccc ctgtgggtca tcatcatgcc ctccgacctg gccaagaaga aggcagccaa
      121 aaagaaggag gctgccaaag ctcgacagcg gcccagaaaa ggacatgaag aaaatggaga
      181 tgttgtcaca gaaccacagg tggcagagaa gaatgaggcc aatggcagag agaccacaga
      241 agtagatttg ctgaccaagg agctagagga ctttgagatg aagaaagctg ctgctcgagc
      301 tgtcactggc gtcctggcct ctcaccccaa cagtactgat gttcacatca tcaacctctc
      361 acttaccttt catggtcaag agctgctcag tgacaccaaa ctggaattaa actcaggccg
      421 tcgttatggc ctcattggtt taaatggaat tggaaagtcc atgctgctct ctgctattgg
      481 gaagcgtgaa gtgcccatcc ctgagcacat cgacatctac catctgactc gagagatgcc
      541 ccctagtgac aagacaccct tgcattgtgt gatggaagtc gacacagagc gggccatgct
      601 ggagaaagag gcagagcggc tggctcatga ggatgcggag tgtgagaagc tcatggagct
      661 ctacgagcgc ctggaggagc tggatgccga caaggcagag atgagggcct cgcggatctt
      721 gcatggactg ggtttcacac ctgccatgca gcgcaagaag ctaaaagact tcagtggggg
      781 ctggaggatg agggttgccc ttgccagagc cctctttatt cggcccttca tgctgctcct
      841 ggatgagcct accaaccacc tggacctaga tgcttgcgtg tggttggaag aagaactaaa
      901 aacttttaag cgcatcttgg tcctcgtctc ccattcccag gattttctga atggtgtctg
      961 taccaatatc attcacatgc acaacaagaa actgaagtat tatacgggta attatgatca
     1021 gtacgtgaag acgcggctag agctggagga gaaccagatg aagaggtttc actgggagca
     1081 agatcagatt gcacacatga agaactacat tgcgaggttt ggtcatggca gtgccaagct
     1141 ggcccggcag gcccagagca aggagaagac gctacagaaa atgatggcat caggactgac
     1201 agagagggtc gtgagcgata agacactgtc attttatttc ccaccatgtg gcaagatccc
     1261 tccacctgtc attatggtgc aaaatgtgag cttcaagtat acaaaagatg ggccttgcat
     1321 ctacaataat ctagaatttg gaattgacct tgacacacga gtggctctgg tagggcccaa
     1381 tggagcaggg aagtcaactc ttctgaagct gctaactgga gagctactac ccacagatgg
     1441 catgatccga aaacactctc atgtcaagat agggcgttac catcagcatt tacaagagca
     1501 gctggactta gatctctcac ctttggagta catgatgaag tgctacccag agatcaagga
     1561 gaaggaagaa atgaggaaga tcattgggcg atacggtctc actgggaaac aacaggtgag
     1621 cccaatccgg aacttgtcag acgggcagaa gtgccgagtg tgtctggcct ggctggcctg
     1681 gcagaacccc cacatgctct tcctggatga acccaccaat cacctggata tcgagaccat
     1741 cgacgccctg gcagatgcca tcaatgagtt tgagggtggt atgatgctgg tcagccatga
     1801 cttcagactc attcagcagg ttgcacagga aatttgggtc tgtgagaagc agacaatcac
     1861 caagtggcct ggagacatcc tggcttacaa ggagcacctc aagtccaagc tggtggatga
     1921 ggagccccag ctcaccaaga ggacccacaa cgtgtgagcc ctctacctgg gttcgggtca
     1981 ggagctccat ctgggaacta acagctgcta acctgaccag ccgctcagga caggaccctg
     2041 gggctacact cctgcattgc tgcaatactg ctcccccagc ctctcccctg cccctcaacc
     2101 tgccttagct gcactctctt acctacagct ggacagtacc tgtctgtttc ctgtcctcct
     2161 tccagttaca tctgtccatg tctggactcg gctggccgtt ccctccagcc ccttgctggt
     2221 tatcttactc tgagtgtgat gcagtcagag gcacctgcgg gttagcccag gggcccaagc
     2281 cctggatttg gcctgcggag gagcttagga tcctcgtttt ctgggttttg gtgatgttgg
     2341 aggagtaccc cccagcccac cgccccgatt cctttttgct tctggtttgg agctccggac
     2401 caggaccttc gtcctggtca gtttttaaat aattatttag cagtgtaact tttagacctg
     2461 cgtgacatct acaaagcgcc caataaagaa agaggaagcc acggtcccta ccttccttct
     2521 cgggtctctg gggccttctc ctccctgcag tgccaacatg cactgcccac agcaggagct
     2581 ggatccagcg tcagtgtgtc gatgggaact gaagactagt ccataggagc tggaagaact
     2641 ttgtcccttt acttctgatt tgaaattgta ccttttctca ggcctgtgat tcacagactt
     2701 taacatgaat cagaatcacc tggagggctc atgcaatcag attgccagat ctcgcctcag
     2761 cgtttctggt tcaataggtt ttgggggaga ccaagaacgt taacatttct agcaagtttc
     2821 caggtgatgc tgttgttgct ggtctagaga ctattttgag aaccactgtc caggagcgtg
     2881 gttttctgat tgtgatctga ggttctgccc caactgcaca gcagttgggc tgcttgttaa
     2941 aaatgcaggc caggtgcggt ggctcacacc tgtaatccca gcgctttggg aggctgaggc
     3001 aggtggatca cttgagctca ggagttcaag accagcttgg gaaacatggc aaaacccgtc
     3061 tttatgtgcc tggaatccca cctgctcagg tggctagggt ggatggatcg cttgagccca
     3121 ggaggtggag gttgcagtga gctgagattg caccactgca ttccagcctg gatgacagag
     3181 caaaaccctg tctcaaaaaa atgcagactg gccaggcaca gtggctcaca cctgtaatcc
     3241 gactgtaagc tcatcacctt gggaggccac tgtaggagga tcaattgagc ctagaagttc
     3301 aagaccagcc tgggcaaagt agggagaccc cttctctaca aatagtaata aaatgaaccg
     3361 ggcatagtag catgtgcctg cggtcccagc tgctctgata agaggaggct cacttgagcc
     3421 caggaggttg aggctgcagt gagcagagcg tgccgctaca ctccagcctg atgacagacc
     3481 gagacactgt ctcaaaaaaa taaaaaaatt cagattgctg agcatcagac ctattgatta
     3541 atcgcatttg gtagaatgag agaggtgcag agatggccag gagtttgcat tttcacacca
     3601 acgtctgtga acctctcttc ctattgggat acaggaaatt ttgtattttt acctgtccac
     3661 agccatagtt atcatcactg ttgaattcac ttccagccca gggctctgca taccttatct
     3721 gggtcttttg aacttcaata gcatttcacc agtggccatc cttcctggtg tggattcatc
     3781 actctgcctc tgaaatcagc catccctatg ggaagacaca gccatgattt ttcagtactc
     3841 ataatacagc caggactggc gggagcaact gtcccagatg gtgcttaaac cccttaggag
     3901 ctcatgatct tcttggaaag ccagtaagac agaaccatac aggacacaaa ttagatgcta
     3961 aattgtgatt tagataggag acagaagtat tcaaaaagga gggaaatttc ttgtgagtag
     4021 ctgcccagaa aggtggaatt ggtgtgctct cacttgaaaa atgagtagga tcttctcaga
     4081 tggccacaaa gtccaggagc tgccctgggc aacagggaca ggagcctccc gtgagacact
     4141 gcagctgaga cagatgggag tcctctgacc ccagagggta ctggcttgac tgctttatgc
     4201 cttaagtggg gcctggagca aaatggccca ggttagtctg tcctgagagt ccagagcctt
     4261 ggttcagggg agaatggcat ctggagagtg ggctgctggg ataatgggga cagtgaggga
     4321 cagagccctt gatacttaag gaagtgctgg atattgctaa gaattcaggt agtctcggga
     4381 tctccagagt ctccatacta ggacaggaga tcttcagaac ctggaggaat ggaaatagtc
     4441 tagtcagctt atttgtcaag aaaaatgtca accttggtaa tttaaataat gctttaaaag
     4501 tccacaaaat acatatttct aaaatta
//
