LOCUS       NM_001025091            3405 bp    mRNA    linear   PRI 25-OCT-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1),
            transcript variant 1, mRNA.
ACCESSION   NM_001025091
VERSION     NM_001025091.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3405)
  AUTHORS   Yin,X., Xia,K., Peng,S., Tan,B., Huang,Y., Wang,M. and He,M.
  TITLE     ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell Proliferation,
            Migration, and Invasion by Activating the PI3K/AKT Signal Pathway
  JOURNAL   Dev Neurosci 46 (3), 210-220 (2024)
   PUBMED   37757768
  REMARK    GeneRIF: ABCF1/CXCL12/CXCR4 Enhances Glioblastoma Cell
            Proliferation, Migration, and Invasion by Activating the PI3K/AKT
            Signal Pathway.
REFERENCE   2  (bases 1 to 3405)
  AUTHORS   Choi,E.B., Vodnala,M., Zerbato,M., Wang,J., Ho,J.J., Inouye,C.,
            Ding,L. and Fong,Y.W.
  TITLE     ATP-binding cassette protein ABCF1 couples transcription and genome
            surveillance in embryonic stem cells through low-complexity domain
  JOURNAL   Sci Adv 7 (44), eabk2775 (2021)
   PUBMED   34714667
  REMARK    GeneRIF: ABCF1 functions as a transcriptional coactivator for OCT4
            and SOX2 to stimulate transciption of pluripotency-associated genes
            in embryonic stem cells.
REFERENCE   3  (bases 1 to 3405)
  AUTHORS   Fassler,J.S., Skuodas,S., Weeks,D.L. and Phillips,B.T.
  TITLE     Protein Aggregation and Disaggregation in Cells and Development
  JOURNAL   J Mol Biol 433 (21), 167215 (2021)
   PUBMED   34450138
  REMARK    Review article
REFERENCE   4  (bases 1 to 3405)
  AUTHORS   Cao,Q.T., Aguiar,J.A., Tremblay,B.J., Abbas,N., Tiessen,N.,
            Revill,S., Makhdami,N., Ayoub,A., Cox,G., Ask,K., Doxey,A.C. and
            Hirota,J.A.
  TITLE     ABCF1 Regulates dsDNA-induced Immune Responses in Human Airway
            Epithelial Cells
  JOURNAL   Front Cell Infect Microbiol 10, 487 (2020)
   PUBMED   33042865
  REMARK    GeneRIF: ABCF1 Regulates dsDNA-induced Immune Responses in Human
            Airway Epithelial Cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3405)
  AUTHORS   Fung,S.W., Cheung,P.F., Yip,C.W., Ng,L.W., Cheung,T.T., Chong,C.C.,
            Lee,C., Lai,P.B., Chan,A.W., Tsao,G.S., Wong,C.H., Chan,S.L.,
            Lo,K.W. and Cheung,S.T.
  TITLE     The ATP-binding cassette transporter ABCF1 is a hepatic oncofetal
            protein that promotes chemoresistance, EMT and cancer stemness in
            hepatocellular carcinoma
  JOURNAL   Cancer Lett 457, 98-109 (2019)
   PUBMED   31100412
  REMARK    GeneRIF: The ATP-binding cassette transporter ABCF1 is a hepatic
            oncofetal protein that promotes chemoresistance, epithelial
            mesenchymal transformation and cancer stemness in hepatocellular
            carcinoma cells.
REFERENCE   6  (bases 1 to 3405)
  AUTHORS   Qu,L., Jiang,Y., Cheng,C., Wu,D., Meng,B., Chen,Z., Zhu,Y.,
            Shaw,N., Ouyang,S. and Liu,Z.J.
  TITLE     Crystal Structure of ATP-Bound Human ABCF1 Demonstrates a Unique
            Conformation of ABC Proteins
  JOURNAL   Structure 26 (9), 1259-1265 (2018)
   PUBMED   30017566
  REMARK    GeneRIF: Study solves the crystal structure of an ATP-bound
            wild-type human ABCF1 at 2.3-A resolution. The comparative studies
            indicate that the structure is in a pre-activation intermediate
            conformation. This conformation is stabilized by the interaction
            between ATP and protein suggesting that this conformation is an
            important step in the activation of ABCF1.
REFERENCE   7  (bases 1 to 3405)
  AUTHORS   Mancarella,C., Pasello,M., Ventura,S., Grilli,A., Calzolari,L.,
            Toracchio,L., Lollini,P.L., Donati,D.M., Picci,P., Ferrari,S. and
            Scotlandi,K.
  TITLE     Insulin-Like Growth Factor 2 mRNA-Binding Protein 3 is a Novel
            Post-Transcriptional Regulator of Ewing Sarcoma Malignancy
  JOURNAL   Clin Cancer Res 24 (15), 3704-3716 (2018)
   PUBMED   29703820
  REMARK    GeneRIF: The combined assessment of IGF2BP3 and ABCF1 predicts
            recurrence in Ewing sarcoma patients.
REFERENCE   8  (bases 1 to 3405)
  AUTHORS   Klein,I., Sarkadi,B. and Varadi,A.
  TITLE     An inventory of the human ABC proteins
  JOURNAL   Biochim Biophys Acta 1461 (2), 237-262 (1999)
   PUBMED   10581359
  REMARK    Review article
REFERENCE   9  (bases 1 to 3405)
  AUTHORS   Richard,M., Drouin,R. and Beaulieu,A.D.
  TITLE     ABC50, a novel human ATP-binding cassette protein found in tumor
            necrosis factor-alpha-stimulated synoviocytes
  JOURNAL   Genomics 53 (2), 137-145 (1998)
   PUBMED   9790762
REFERENCE   10 (bases 1 to 3405)
  AUTHORS   Allikmets,R., Gerrard,B., Hutchinson,A. and Dean,M.
  TITLE     Characterization of the human ABC superfamily: isolation and
            mapping of 21 new genes using the expressed sequence tags database
  JOURNAL   Hum Mol Genet 5 (10), 1649-1655 (1996)
   PUBMED   8894702
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BI547952.1, BC034488.2,
            AF027302.1, BM556481.1 and BU620927.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001025091.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the GCN20 subfamily. Unlike other members of
            the superfamily, this protein lacks the transmembrane domains which
            are characteristic of most ABC transporters. This protein may be
            regulated by tumor necrosis factor-alpha and play a role in
            enhancement of protein synthesis and the inflammation process.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC112923.1, SRR1803615.5546.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000326195.13/ ENSP00000313603.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 BI547952.1         69-74
            7-541               BC034488.2         1-535
            542-543             AF027302.1         590-591
            544-2584            BC034488.2         538-2578
            2585-2586           BM556481.1         298-299
            2587-3193           BC034488.2         2582-3188
            3194-3405           BU620927.1         27-238              c
FEATURES             Location/Qualifiers
     source          1..3405
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..3405
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /note="ATP binding cassette subfamily F member 1"
                     /db_xref="GeneID:23"
                     /db_xref="HGNC:HGNC:70"
                     /db_xref="MIM:603429"
     exon            1..119
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..2584
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /note="isoform a is encoded by transcript variant 1;
                     ATP-binding cassette 50 (TNF-alpha stimulated);
                     TNFalpha-inducible ATP-binding protein;
                     TNF-alpha-stimulated ABC protein; ATP-binding cassette,
                     sub-family F (GCN20), member 1"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family F member 1
                     isoform a"
                     /protein_id="NP_001020262.1"
                     /db_xref="CCDS:CCDS34380.1"
                     /db_xref="GeneID:23"
                     /db_xref="HGNC:HGNC:70"
                     /db_xref="MIM:603429"
                     /translation="MPKAPKQQPPEPEWIGDGESTSPSDKVVKKGKKDKKIKKTFFEE
                     LAVEDKQAGEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLK
                     KLSVPTSDEEDEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNR
                     INKAVSEEQQPALKGKKGKEEKSKGKAKPQNKFAALDNEEEDKEEEIIKEKEPPKQGK
                     EKAKKAEQGSEEEGEGEEEEEEGGESKADDPYAHLSKKEKKKLKKQMEYERQVASLKA
                     ANAAENDFSVSQAEMSSRQAMLENASDIKLEKFSISAHGKELFVNADLYIVAGRRYGL
                     VGPNGKGKTTLLKHIANRALSIPPNIDVLLCEQEVVADETPAVQAVLRADTKRLKLLE
                     EERRLQGQLEQGDDTAAERLEKVYEELRATGAAAAEAKARRILAGLGFDPEMQNRPTQ
                     KFSGGWRMRVSLARALFMEPTLLMLDEPTNHLDLNAVIWLNNYLQGWRKTLLIVSHDQ
                     GFLDDVCTDIIHLDAQRLHYYRGNYMTFKKMYQQKQKELLKQYEKQEKKLKELKAGGK
                     STKQAEKQTKEALTRKQQKCRRKNQDEESQEAPELLKRPKEYTVRFTFPDPPPLSPPV
                     LGLHGVTFGYQGQKPLFKNLDFGIDMDSRICIVGPNGVGKSTLLLLLTGKLTPTHGEM
                     RKNHRLKIGFFNQQYAEQLRMEETPTEYLQRGFNLPYQDARKCLGRFGLESHAHTIQI
                     CKLSGGQKARVVFAELACREPDVLILDEPTNNLDIESIDALGEAINEYKGAVIVVSHD
                     ARLITETNCQLWVVEEQSVSQIDGDFEDYKREVLEALGEVMVSRPRE"
     exon            120..166
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            167..262
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            263..389
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            390..427
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            428..535
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            536..610
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            611..724
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            725..838
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            839..961
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1062
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1148
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1288
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1289..1437
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1521
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1646
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1759
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1931
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2006
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2077
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2110
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            2111..2279
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            2280..2344
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2417
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     exon            2418..3405
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3171..3176
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /note="hexamer: AATAAA"
     polyA_site      3195
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /note="major polyA site"
     regulatory      3294..3299
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /note="hexamer: ACTAAA"
     polyA_site      3314
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
                     /note="major polyA site"
     polyA_site      3405
                     /gene="ABCF1"
                     /gene_synonym="ABC27; ABC50"
ORIGIN      
        1 ggaaatagca ccgggcgccg ccacagtagc tgtaactgcc accgcgatgc cgaaggcgcc
       61 caagcagcag ccgccggagc ccgagtggat cggggacgga gagagcacga gcccatcaga
      121 caaagtggtg aagaaaggga agaaggacaa gaagatcaaa aaaacgttct ttgaagagct
      181 ggcagtagaa gataaacagg ctggggaaga agagaaagtg ctcaaggaga aggagcagca
      241 gcagcagcaa cagcaacagc agcaaaaaaa aaagcgagat acccgaaaag gcaggcggaa
      301 gaaggatgtg gatgatgatg gagaagagaa agagctcatg gagcgtctta agaagctctc
      361 agtgccaacc agtgatgagg aggatgaagt acccgcccca aaaccccgcg gagggaagaa
      421 aaccaagggt ggtaatgttt ttgcagccct gattcaggat cagagtgagg aagaggagga
      481 ggaagaaaaa catcctccta agcctgccaa gccggagaag aatcggatca ataaggccgt
      541 atctgaggaa cagcagcctg cactcaaggg caaaaaggga aaggaagaga agtcaaaagg
      601 gaaggctaag cctcaaaata aattcgctgc tctggacaat gaagaggagg ataaagaaga
      661 agaaattata aaggaaaagg agcctcccaa acaagggaag gagaaggcca agaaggcaga
      721 gcagggttca gaggaagaag gagaagggga agaagaggag gaggaaggag gagagtctaa
      781 ggcagatgat ccctatgctc atcttagcaa aaaggagaag aaaaagctga aaaaacagat
      841 ggagtatgag cgccaagtgg cttcattaaa agcagccaat gcagctgaaa atgacttctc
      901 cgtgtcccag gcggagatgt cctcccgcca agccatgtta gaaaatgcat ctgacatcaa
      961 gctggagaag ttcagcatct ccgctcatgg caaggagctg ttcgtcaatg cagacctgta
     1021 cattgtagcc ggccgccgct acgggctggt aggacccaat ggcaagggca agaccacact
     1081 cctcaagcac attgccaacc gagccctgag catccctccc aacattgatg tgttgctgtg
     1141 tgagcaggag gtggtagcag atgagacacc agcagtccag gctgttcttc gagctgacac
     1201 caagcgattg aagctgctgg aagaggagcg gcggcttcag ggacagctgg aacaagggga
     1261 tgacacagct gctgagaggc tagagaaggt gtatgaggaa ttgcgggcca ctggggcggc
     1321 agctgcagag gccaaagcac ggcggatcct ggctggcctg ggctttgacc ctgaaatgca
     1381 gaatcgaccc acacagaagt tctcaggggg ctggcgcatg cgtgtctccc tggccagggc
     1441 actgttcatg gagcccacac tgctgatgct ggatgagccc accaaccacc tggacctcaa
     1501 cgctgtcatc tggcttaata actacctcca gggctggcgg aagaccttgc tgatcgtctc
     1561 ccatgaccag ggcttcttgg atgatgtctg cactgatatc atccacctcg atgcccagcg
     1621 gctccactac tataggggca attacatgac cttcaaaaag atgtaccagc agaagcagaa
     1681 agaactgctg aaacagtatg agaagcaaga gaaaaagctg aaggagctga aggcaggcgg
     1741 gaagtccacc aagcaggcgg aaaaacaaac gaaggaagcc ctgactcgga agcagcagaa
     1801 atgccgacgg aaaaaccaag atgaggaatc ccaggaggcc cctgagctcc tgaagcgccc
     1861 taaggagtac actgtgcgct tcacttttcc agacccccca ccactcagcc ctccagtgct
     1921 gggtctgcat ggtgtgacat tcggctacca gggacagaaa ccactcttta agaacttgga
     1981 ttttggcatc gacatggatt caaggatttg cattgtgggc cctaatggtg tggggaagag
     2041 tacgctactc ctgctgctga ctggcaagct gacaccgacc catggggaaa tgagaaagaa
     2101 ccaccggctg aaaattggct tcttcaacca gcagtatgca gagcagctgc gcatggagga
     2161 gacgcccact gagtacctgc agcggggctt caacctgccc taccaggatg cccgcaagtg
     2221 cctgggccgc ttcggcctgg agagtcacgc ccacaccatc cagatctgca aactctctgg
     2281 tggtcagaag gcgcgagttg tgtttgctga gctggcctgt cgggaacctg atgtcctcat
     2341 cttggacgag ccaaccaata acctggacat agagtctatt gatgctctag gggaggccat
     2401 caatgaatac aagggtgctg tgatcgttgt cagccatgat gcccgactca tcacagaaac
     2461 caattgccag ctgtgggtgg tggaggagca gagtgttagc caaatcgatg gtgactttga
     2521 agactacaag cgggaggtgt tggaggccct gggtgaagtc atggtcagcc ggccccgaga
     2581 gtgagctttc cttcccagaa gtctcccgag agacatattt gtgtggccta gaagtcctct
     2641 gtggtctccc ctcctctgaa gactgcctct ggcctgcagc tgacctggca accattcagg
     2701 cacatgaagg tggagtgtga ccttgatgtg accgggatcc cactctgatt gcatccattt
     2761 ctctgaaaga cttgtttgtt ctgcttctct tcatataact gagctggcct tatccttggc
     2821 atccccctaa acaaacaaga ggtgaccacc ttattgtgag gttccatcca gccaagttta
     2881 tgtggcctat tgtctcagga ctctcatcac tcagaagcct gcctctgatt taccctacag
     2941 cttcaggccc agctgccccc cagtctttgg gtggtgctgt tcttttctgg tggatttaat
     3001 gctgactcac tggtacaaac agctgttgaa gctcagagct ggaggtgagc ttctgaggcc
     3061 tttgccatta tccagcccaa gatttggtgc ctgcagcctc ttgtctggtt gaggacttgg
     3121 ggcaggaaag gaatgctgct gaacttgaat ttccctttac aaggggaaga aataaaggaa
     3181 aggagttgct gccgacctgt cactgtttgg agattgatgg gagttggaac tgttctcagt
     3241 cttgatttgc tttattcagt tttctagcag cttttaatag tcccctcttc cccactaaat
     3301 ggatcttgtt tgcagtcttg ctgacagtgt ttgctgttta aggatcatag gattcctttc
     3361 ccccaaccct tcacgcaagg aaaaagcaaa gtgattcata ccttc
//
