LOCUS       NM_002940               3887 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily E member 1 (ABCE1),
            transcript variant 1, mRNA.
ACCESSION   NM_002940
VERSION     NM_002940.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3887)
  AUTHORS   Tong,S., Zhu,Y., Leng,Y., Wu,Y., Xiao,X., Zhao,W. and Tan,S.
  TITLE     Restoration of miR-299-3p promotes macrophage phagocytosis and
            suppresses malignant phenotypes in breast cancer carcinogenesis via
            dual-targeting CD47 and ABCE1
  JOURNAL   Int Immunopharmacol 130, 111708 (2024)
   PUBMED   38394889
  REMARK    GeneRIF: Restoration of miR-299-3p promotes macrophage phagocytosis
            and suppresses malignant phenotypes in breast cancer carcinogenesis
            via dual-targeting CD47 and ABCE1.
REFERENCE   2  (bases 1 to 3887)
  AUTHORS   Sun,L., Ding,X. and Kang,Y.J.
  TITLE     ABCE1 selectively promotes HIF-1alpha transactivation of angiogenic
            gene expression
  JOURNAL   J Trace Elem Med Biol 80, 127307 (2023)
   PUBMED   37738929
  REMARK    GeneRIF: ABCE1 selectively promotes HIF-1alpha transactivation of
            angiogenic gene expression.
REFERENCE   3  (bases 1 to 3887)
  AUTHORS   Yu,J., Ma,H., He,J., Wang,M., Yu,B., Ge,S. and Dai,Z.
  TITLE     A pan-cancer analysis of the oncogenic role of ATP binding cassette
            subfamily E member 1 (ABCE1) in human tumors: An observational
            study
  JOURNAL   Medicine (Baltimore) 101 (46), e31849 (2022)
   PUBMED   36401432
  REMARK    GeneRIF: A pan-cancer analysis of the oncogenic role of ATP binding
            cassette subfamily E member 1 (ABCE1) in human tumors: An
            observational study.
REFERENCE   4  (bases 1 to 3887)
  AUTHORS   Xing,L., Sun,C., Han,L. and Zhu,Z.
  TITLE     The Expression and Effect of ABCE1 in Gastric Adenocarcinoma
  JOURNAL   Appl Biochem Biotechnol 194 (11), 5292-5304 (2022)
   PUBMED   35737213
  REMARK    GeneRIF: The Expression and Effect of ABCE1 in Gastric
            Adenocarcinoma.
REFERENCE   5  (bases 1 to 3887)
  AUTHORS   Wada,M. and Ito,K.
  TITLE     Human ABCE1 exhibits temperature-dependent heterologous
            co-functionality in S. cerevisiae
  JOURNAL   FEBS Open Bio 12 (10), 1782-1787 (2022)
   PUBMED   35792803
  REMARK    GeneRIF: Human ABCE1 exhibits temperature-dependent heterologous
            co-functionality in S. cerevisiae.
REFERENCE   6  (bases 1 to 3887)
  AUTHORS   Martinand,C., Montavon,C., Salehzada,T., Silhol,M., Lebleu,B. and
            Bisbal,C.
  TITLE     RNase L inhibitor is induced during human immunodeficiency virus
            type 1 infection and down regulates the 2-5A/RNase L pathway in
            human T cells
  JOURNAL   J Virol 73 (1), 290-296 (1999)
   PUBMED   9847332
REFERENCE   7  (bases 1 to 3887)
  AUTHORS   Martinand,C., Salehzada,T., Silhol,M., Lebleu,B. and Bisbal,C.
  TITLE     RNase L inhibitor (RLI) antisense constructions block partially the
            down regulation of the 2-5A/RNase L pathway in
            encephalomyocarditis-virus-(EMCV)-infected cells
  JOURNAL   Eur J Biochem 254 (2), 248-255 (1998)
   PUBMED   9660177
REFERENCE   8  (bases 1 to 3887)
  AUTHORS   Diriong,S., Salehzada,T., Bisbal,C., Martinand,C. and Taviaux,S.
  TITLE     Localization of the ribonuclease L inhibitor gene (RNS4I), a new
            member of the interferon-regulated 2-5A pathway, to 4q31 by
            fluorescence in situ hybridization
  JOURNAL   Genomics 32 (3), 488-490 (1996)
   PUBMED   8838820
REFERENCE   9  (bases 1 to 3887)
  AUTHORS   Aubry,F., Mattei,M.G., Barque,J.P. and Galibert,F.
  TITLE     Chromosomal localization and expression pattern of the RNase L
            inhibitor gene
  JOURNAL   FEBS Lett 381 (1-2), 135-139 (1996)
   PUBMED   8641422
REFERENCE   10 (bases 1 to 3887)
  AUTHORS   Bisbal,C., Martinand,C., Silhol,M., Lebleu,B. and Salehzada,T.
  TITLE     Cloning and characterization of a RNAse L inhibitor. A new
            component of the interferon-regulated 2-5A pathway
  JOURNAL   J Biol Chem 270 (22), 13308-13317 (1995)
   PUBMED   7539425
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA218189.1, BC016283.1 and
            AC096757.3.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_002940.2.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the OABP subfamily. Alternatively referred
            to as the RNase L inhibitor, this protein functions to block the
            activity of ribonuclease L. Activation of ribonuclease L leads to
            inhibition of protein synthesis in the 2-5A/RNase L system, the
            central pathway for viral interferon action. Two transcript
            variants encoding the same protein have been found for this gene.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.120695.1,
                                           SRR1660807.133363.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296577.9/ ENSP00000296577.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                DA218189.1         380-410
            32-3523             BC016283.1         1-3492
            3524-3887           AC096757.3         96137-96500
FEATURES             Location/Qualifiers
     source          1..3887
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.21"
     gene            1..3887
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="ATP binding cassette subfamily E member 1"
                     /db_xref="GeneID:6059"
                     /db_xref="HGNC:HGNC:69"
                     /db_xref="MIM:601213"
     exon            1..109
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            110..239
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..1936
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="ribonuclease L (2',5'-oligoisoadenylate
                     synthetase-dependent) inhibitor; huHP68; ribonuclease 4
                     inhibitor; 2'-5'-oligoadenylate-binding protein;
                     ATP-binding cassette, sub-family E (OABP), member 1; RNase
                     L inhibitor 1"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family E member 1"
                     /protein_id="NP_002931.2"
                     /db_xref="CCDS:CCDS34071.1"
                     /db_xref="GeneID:6059"
                     /db_xref="HGNC:HGNC:69"
                     /db_xref="MIM:601213"
                     /translation="MADKLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQ
                     SKIAWISETLCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRP
                     GEVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQNYFTKIL
                     EDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQLDLTHLKERNVEDLS
                     GGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRLKAAITIRSLINPDRYIIVVEHDL
                     SVLDYLSDFICCLYGVPSAYGVVTMPFSVREGINIFLDGYVPTENLRFRDASLVFKVA
                     ETANEEEVKKMCMYKYPGMKKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRML
                     AGRLKPDEGGEVPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQ
                     IENIIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARVVKRFI
                     LHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLAGMNKFLSQLEITF
                     RRDPNNYRPRINKLNSIKDVEQKKSGNYFFLDD"
     exon            240..325
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            326..423
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            424..541
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            542..679
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            680..749
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            750..846
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            847..936
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            937..1058
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1280
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1340
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1399
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1400..1510
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1653
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1776
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1777..1888
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     exon            1889..3887
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3293..3298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="hexamer: AATAAA"
     polyA_site      3328
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="major polyA site"
     regulatory      3504..3509
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="hexamer: AATAAA"
     polyA_site      3537
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="major polyA site"
     regulatory      3611..3616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="hexamer: ATTAAA"
     polyA_site      3637
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
     regulatory      3863..3868
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="hexamer: AATAAA"
     polyA_site      3887
                     /gene="ABCE1"
                     /gene_synonym="ABC38; OABP; RLI; RLI1; RNASEL1; RNASELI;
                     RNS4I"
                     /note="major polyA site"
ORIGIN      
        1 accgccattt tggccggtgg ccgtgagaac acgctgtgtg gctgaaaagt gaaggcaaga
       61 gctgatttgg cctctgtgct cccctccgca aggggatcgt tttctccaga agagctggat
      121 attctttcgc ccagttatgg cagacaagtt aacgagaatt gctattgtca accatgacaa
      181 atgtaaacct aagaaatgtc gacaggaatg caaaaagagt tgtcctgtag ttcgaatggg
      241 aaaattatgc atagaggtta caccccagag caaaatagca tggatttccg aaactctttg
      301 tattggttgt ggtatctgta ttaagaaatg cccctttggc gccttatcaa ttgtcaatct
      361 accaagcaac ttggaaaaag aaaccacaca tcgatattgt gccaatgcct tcaaacttca
      421 caggttgcct atccctcgtc caggtgaagt tttgggatta gttggaacta atggtattgg
      481 aaagtcaact gctttaaaaa ttttagcagg aaaacaaaag ccaaaccttg gaaagtacga
      541 tgatcctcct gactggcagg agattttgac ttatttccgt ggatctgaat tacaaaatta
      601 ctttacaaag attctagaag atgacctaaa agccatcatc aaacctcaat atgtagacca
      661 gattcctaag gctgcaaagg ggacagtggg atctattttg gaccgaaaag atgaaacaaa
      721 gacacaggca attgtatgtc agcagcttga tttaacccac ctaaaagaac gaaatgttga
      781 agatctttca ggaggagagt tgcagagatt tgcttgtgct gtcgtttgca tacagaaagc
      841 tgatattttc atgtttgatg agccttctag ttacctagat gtcaagcagc gtttaaaggc
      901 tgctattact atacgatctc taataaatcc agatagatat atcattgtgg tggaacatga
      961 tctaagtgta ttagactatc tctccgactt catctgctgt ttatatggtg taccaagcgc
     1021 ctatggagtt gtcactatgc cttttagtgt aagagaaggc ataaacattt ttttggatgg
     1081 ctatgttcca acagaaaact tgagattcag agatgcatca cttgttttta aagtggctga
     1141 gacagcaaat gaagaagaag ttaaaaagat gtgtatgtat aaatatccag gaatgaagaa
     1201 aaaaatggga gaatttgagc tagcaattgt agctggagag tttacagatt ctgaaattat
     1261 ggtgatgctg ggggaaaatg gaacgggtaa aacgacattt atcagaatgc ttgctggaag
     1321 acttaaacct gatgaaggag gagaagtacc agttctaaat gtcagttata agccacagaa
     1381 aattagtccc aaatcaactg gaagtgttcg ccagttacta catgaaaaga taagagatgc
     1441 ttatactcac ccacaatttg tgaccgatgt aatgaagcct ctgcaaattg aaaacatcat
     1501 tgatcaagag gtgcagacat tatctggtgg tgaactacag cgagtagctt tagccctttg
     1561 cttgggcaaa cctgctgatg tctatttaat tgatgaacca tctgcatatt tggattctga
     1621 gcaaagactg atggcagctc gagttgtcaa acgtttcata ctccatgcaa aaaagacagc
     1681 ctttgttgtg gaacatgact tcatcatggc cacctatcta gcggatcgcg tcatcgtttt
     1741 tgatggtgtt ccatctaaga acacagttgc aaacagtcct caaacccttt tggctggcat
     1801 gaataaattt ttgtctcagc ttgaaattac attcagaaga gatccaaaca actataggcc
     1861 acgaataaac aaacttaatt caattaagga tgtagaacaa aagaagagtg gaaactactt
     1921 tttcttggat gattagactg actctgagaa tattgataag ccatttatta aaaggagtat
     1981 ttactagaat tttttgtcat ataaaacttg aatcaggatt ttatgcccca catactctgg
     2041 aacttgaagt ataatatact taatataaca taaaaagcca gttgggttct aaattgtagt
     2101 tgaaacacag aaaatgccac ttttctgttc ctgaagaggc tcttttgtgc ataatattct
     2161 aaaatgaaga catttcaagc tatacaaatt acttccaagt tttcatgatg tatgggaaga
     2221 ttttcagtag gtgtattata ttcacggtac caaatgctga ccagtgttgc tccatttttt
     2281 aaatcttgaa aagggtttct gtacttacct ggtttgccaa gtatgccagt gtaatgaaac
     2341 tgcccttatt ttaaaagcca gtcaaagatt ccactgattg acatttgata aataaacatc
     2401 aggattatgt ttattgtttg ttttcagtct ttgcactata ttaccagtat atggtttccg
     2461 aggaagatta tctactgcaa aacaccactg ttggaaaaat aggtattttt aaattgtttt
     2521 taatcttttt tggtgctttt aaacatgttt agcaaaaacc aattcagttc cattccccgc
     2581 aaaaaacccc taactttact ctgaactttt tttgtttttg cattccatga ggttctgtat
     2641 tcagtcattc tctaggtaat gtcatttttg tacacatata tttatataat cactgattga
     2701 gatttaggaa aaagcatttc taaagaatat ttgcttccct tagaactaca gactcgaaat
     2761 ctttaaagat ggtgcctaag catctatgta ttttttttaa gttccacaga tttttctgtt
     2821 gggcagccaa ggattataaa ccacttccct aaaggcaaca ttaatgcaaa agtccccaga
     2881 tggcaataca aagtatcccc tggtaccaca tatattcatt tgtgagtttg gatatagagc
     2941 acattatcta aaccattttg tagttccaaa aacccatcta aatttcttga gttcctgaat
     3001 tttgaacagg attacctgga gcctggagcc actttaagtt gtacttctga ctaaactgga
     3061 attatgagtg aggaagagtg tttactaaat aaatgactgg ggcaagcaaa attgaggagg
     3121 aaattagaaa ctgtttgaca aactttaaga gctacttgaa ataacagaag tcttgattaa
     3181 tatgcaaata atggctagaa agtatggttt aactggaccc tattatgcct tttaaaaata
     3241 atttcagtaa cccataaata catgttgtaa aaaattcaaa tatacagaat ggaataaaaa
     3301 aatgatctcc ctttattacc ctcccaaagg ttaccagcgt ttgaatttaa taatgtatat
     3361 tctttcatgc ttttttctgt gcacttacct aagtgtgaat atgtaaaggg tttgttttgt
     3421 atacaaatgg gattatacta aaataagtaa tgcctatttt taaggatagg ttaaatttgt
     3481 gaatgatcat ttcaaatata ttgaataaaa taagcaaaag ctattgttat ttactgatcc
     3541 tggattgtct taaagaaagt acttgtgata taagagcaca gttctactta ctgctaatga
     3601 cagaatatgt attaaacgta ttttcatgta aatgaaatct ttaaaatatg tatcttaaaa
     3661 ttttacatag caacagaaag gcctacaatt gctaacacaa gaaaaatact tataaaatca
     3721 gtataaaatc aatgcagatg ttagcaaaag aatgagacta cttcatatgt cctaattgga
     3781 aaaagtctca aatacttaaa aaaacaaaaa actggaacag tttattatac taccattttt
     3841 gtgaaaatat acaaaatatt gaaataaagg aatactcaag aaacaga
//
