LOCUS       NM_005164               6290 bp    mRNA    linear   PRI 01-JUN-2024
DEFINITION  Homo sapiens ATP binding cassette subfamily D member 2 (ABCD2),
            transcript variant 1, mRNA.
ACCESSION   NM_005164
VERSION     NM_005164.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6290)
  AUTHORS   Tawbeh,A., Gondcaille,C., Trompier,D. and Savary,S.
  TITLE     Peroxisomal ABC Transporters: An Update
  JOURNAL   Int J Mol Sci 22 (11), 6093 (2021)
   PUBMED   34198763
  REMARK    GeneRIF: Peroxisomal ABC Transporters: An Update.
            Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6290)
  AUTHORS   Park,S., Oh,J., Kim,Y.I., Choe,S.K., Chun,C.H. and Jin,E.J.
  TITLE     Suppression of ABCD2 dysregulates lipid metabolism via
            dysregulation of miR-141:ACSL4 in human osteoarthritis
  JOURNAL   Cell Biochem Funct 36 (7), 366-376 (2018)
   PUBMED   30264402
  REMARK    GeneRIF: The functional integrity of ABCD2 may play an important
            role in OA pathogenesis via the accumulation of VLCFAs and
            stimulation of apoptotic death through altering profiles of miRNAs
            that target ACSL4.
REFERENCE   3  (bases 1 to 6290)
  AUTHORS   Okamoto,T., Kawaguchi,K., Watanabe,S., Agustina,R., Ikejima,T.,
            Ikeda,K., Nakano,M., Morita,M. and Imanaka,T.
  TITLE     Characterization of human ATP-binding cassette protein subfamily D
            reconstituted into proteoliposomes
  JOURNAL   Biochem Biophys Res Commun 496 (4), 1122-1127 (2018)
   PUBMED   29397936
REFERENCE   4  (bases 1 to 6290)
  AUTHORS   Kawaguchi,K. and Morita,M.
  TITLE     ABC Transporter Subfamily D: Distinct Differences in Behavior
            between ABCD1-3 and ABCD4 in Subcellular Localization, Function,
            and Human Disease
  JOURNAL   Biomed Res Int 2016, 6786245 (2016)
   PUBMED   27766264
  REMARK    GeneRIF: ABCD1 and ABCD2 are involved in the transport of long and
            very long chain fatty acids (VLCFA) or their CoA-derivatives into
            peroxisomes with different substrate specificities, while ABCD3 is
            involved in the transport of branched chain acyl-CoA into
            peroxisomes.ABCD4 is deduced to take part in the transport of
            vitamin B12 from lysosomes into the cytosol.
            Review article
REFERENCE   5  (bases 1 to 6290)
  AUTHORS   Li,Q., Zhu,X., Feng,C., Fang,M. and Liu,X.
  TITLE     Duration of symptom and ABCD2 score as predictors of risk of early
            recurrent events after transient ischemic attack: a hospital-based
            case series study
  JOURNAL   Med Sci Monit 21, 262-267 (2015)
   PUBMED   25604068
  REMARK    GeneRIF: ABCD2 has a role, but not a strong one, in risk of early
            recurrent events after transient ischemic attack
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6290)
  AUTHORS   Holzinger,A., Mayerhofer,P., Berger,J., Lichtner,P., Kammerer,S.
            and Roscher,A.A.
  TITLE     Full length cDNA cloning, promoter sequence, and genomic
            organization of the human adrenoleukodystrophy related (ALDR) gene
            functionally redundant to the gene responsible for X-linked
            adrenoleukodystrophy
  JOURNAL   Biochem Biophys Res Commun 258 (2), 436-442 (1999)
   PUBMED   10329405
REFERENCE   7  (bases 1 to 6290)
  AUTHORS   Netik,A., Forss-Petter,S., Holzinger,A., Molzer,B., Unterrainer,G.
            and Berger,J.
  TITLE     Adrenoleukodystrophy-related protein can compensate functionally
            for adrenoleukodystrophy protein deficiency (X-ALD): implications
            for therapy
  JOURNAL   Hum Mol Genet 8 (5), 907-913 (1999)
   PUBMED   10196381
REFERENCE   8  (bases 1 to 6290)
  AUTHORS   Holzinger,A., Kammerer,S., Berger,J. and Roscher,A.A.
  TITLE     cDNA cloning and mRNA expression of the human adrenoleukodystrophy
            related protein (ALDRP), a peroxisomal ABC transporter
  JOURNAL   Biochem Biophys Res Commun 239 (1), 261-264 (1997)
   PUBMED   9345306
REFERENCE   9  (bases 1 to 6290)
  AUTHORS   Savary,S., Troffer-Charlier,N., Gyapay,G., Mattei,M.G. and
            Chimini,G.
  TITLE     Chromosomal localization of the adrenoleukodystrophy-related gene
            in man and mice
  JOURNAL   Eur J Hum Genet 5 (2), 99-101 (1997)
   PUBMED   9195160
REFERENCE   10 (bases 1 to 6290)
  AUTHORS   Lombard-Platet,G., Savary,S., Sarde,C.O., Mandel,J.L. and
            Chimini,G.
  TITLE     A close relative of the adrenoleukodystrophy (ALD) gene codes for a
            peroxisomal protein with a specific expression pattern
  JOURNAL   Proc Natl Acad Sci U S A 93 (3), 1265-1269 (1996)
   PUBMED   8577752
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK314254.1, DB259336.1 and
            AC121334.5.
            
            On Nov 22, 2018 this sequence version replaced NM_005164.3.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the ALD subfamily, which is involved in
            peroxisomal import of fatty acids and/or fatty acyl-CoAs in the
            organelle. All known peroxisomal ABC transporters are half
            transporters which require a partner half transporter molecule to
            form a functional homodimeric or heterodimeric transporter. The
            function of this peroxisomal membrane protein is unknown; however
            this protein is speculated to function as a dimerization partner of
            ABCD1 and/or other peroxisomal ABC transporters. Mutations in this
            gene have been observed in patients with adrenoleukodystrophy, a
            severe demyelinating disease. This gene has been identified as a
            candidate for a modifier gene, accounting for the extreme variation
            among adrenoleukodystrophy phenotypes. This gene is also a
            candidate for a complement group of Zellweger syndrome, a
            genetically heterogeneous disorder of peroxisomal biogenesis.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.255673.1,
                                           SRR1660809.224460.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2154125 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308666.4/ ENSP00000310688.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AK314254.1         239-259
            22-395              DB259336.1         201-574
            396-2411            AK314254.1         634-2649
            2412-5103           AC121334.5         65740-68431
            5104-6290           AC121334.5         68432-69618
FEATURES             Location/Qualifiers
     source          1..6290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q12"
     gene            1..6290
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="ATP binding cassette subfamily D member 2"
                     /db_xref="GeneID:225"
                     /db_xref="HGNC:HGNC:66"
                     /db_xref="MIM:601081"
     exon            1..1127
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2411
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="isoform 1 is encoded by transcript variant 1;
                     adrenoleukodystrophy-like 1; ATP-binding cassette
                     sub-family D member 2; adrenoleukodystrophy-related
                     protein; ATP-binding cassette, sub-family D (ALD), member
                     2"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family D member 2
                     isoform 1"
                     /protein_id="NP_005155.1"
                     /db_xref="CCDS:CCDS8734.1"
                     /db_xref="GeneID:225"
                     /db_xref="HGNC:HGNC:66"
                     /db_xref="MIM:601081"
                     /translation="MTHMLNAAADRVKWTRSSAAKRAACLVAAAYALKTLYPIIGKRL
                     KQSGHGKKKAAAYPAAENTEILHCTETICEKPSPGVNADFFKQLLELRKILFPKLVTT
                     ETGWLCLHSVALISRTFLSIYVAGLDGKIVKSIVEKKPRTFIIKLIKWLMIAIPATFV
                     NSAIRYLECKLALAFRTRLVDHAYETYFTNQTYYKVINMDGRLANPDQSLTEDIMMFS
                     QSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPIGPTLLAGLVVYATAKVLKACSP
                     KFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKVEMKQLQKSYKALADQMNLIL
                     SKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGEDGQKQVMVSERTEAFTTA
                     RNLLASGADAIERIMSSYKEVTELAGYTARVYNMFWVFDEVKRGIYKRTAVIQESESH
                     SKNGAKVELPLSDTLAIKGKVIDVDHGIICENVPIITPAGEVVASRLNFKVEEGMHLL
                     ITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQHMFYIPQRPYMSLGSLRDQVIYPDS
                     VDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDAVMDWKDVLSGGEKQRMGMARMFY
                     HKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSITHRPSLWKYHTHLLQFDGEGG
                     WRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELCKILGEDSVLKTIKNEDETS
                     "
     exon            1128..1308
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1424
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1425..1593
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1688
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1834
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1835..1980
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            1981..2065
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            2066..2191
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..6290
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5331..5336
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="hexamer: AGTAAA"
     polyA_site      5348
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="major polyA site"
     regulatory      5538..5543
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="hexamer: ATTAAA"
     polyA_site      5560
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="major polyA site"
     regulatory      5726..5731
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="hexamer: TATAAA"
     polyA_site      5750
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="major polyA site"
     regulatory      5947..5952
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="hexamer: AATATA"
     polyA_site      5970
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
     regulatory      6267..6272
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
                     /note="hexamer: AATAAA"
     polyA_site      6290
                     /gene="ABCD2"
                     /gene_synonym="ABC39; ALDL1; ALDR; ALDRP; hALDR"
ORIGIN      
        1 agatgcagcg gagtctgagc tctgctgcat ctgtcacagc agaacaaaat taaaaacaca
       61 acagtggaag agaaacgctg cagactatgg gacgctgtag gactttctaa aacatttgct
      121 ggggatttct gtgaagcatg atcttttaaa acgaattctt ttggaagccg gtttgggtaa
      181 ctgggaaaat gacacatatg ctaaatgcag cagctgatcg agtgaaatgg accagatcga
      241 gtgctgctaa gagggctgcc tgcctggtgg ctgcggcata tgctctgaaa accctctatc
      301 ccatcattgg caagcgttta aagcaatctg gccacgggaa gaaaaaagca gcagcttacc
      361 ctgctgcaga gaacacagaa atactgcatt gcaccgagac catttgtgaa aaaccttcgc
      421 ctggagtgaa tgcagatttc ttcaaacagc tactagaact tcggaaaatt ttgtttccaa
      481 aacttgtgac cactgaaaca gggtggctct gcctgcactc agtggctcta atctcaagaa
      541 cctttctttc tatctatgtg gctggtctgg atggaaaaat cgtgaaaagc attgtggaaa
      601 agaagcctcg gactttcatc atcaaattaa tcaagtggct tatgattgcc atccctgcta
      661 ccttcgtcaa cagtgcaata aggtacctgg aatgcaaatt ggctttggcc ttcagaactc
      721 gcctagtaga ccacgcctat gaaacctatt ttacaaatca gacttattat aaagtgatca
      781 atatggatgg gaggctggca aaccctgacc aatctcttac ggaggatatt atgatgttct
      841 cccaatctgt ggctcacttg tattccaatc tgaccaaacc tattttagat gtaatgctga
      901 cctcctatac actcattcaa actgctacat ccagaggagc aagcccaatt gggcccaccc
      961 tactagcagg acttgtggtg tatgccactg ctaaagtgtt aaaagcctgt tctcccaaat
     1021 ttggcaaact ggtggcagag gaagcacata gaaaaggcta tttgcggtat gtgcactcga
     1081 gaattatagc caatgtagaa gaaattgcct tttacagagg acataaggta gaaatgaaac
     1141 aacttcagaa aagttacaaa gctttagcag atcagatgaa cctcatttta tccaaacgtt
     1201 tgtggtacat catgatagaa cagttcctga tgaagtatgt ttggagcagc agtggactaa
     1261 ttatggtggc tatacctatt atcactgcaa ctggctttgc agatggtgag gatggccaaa
     1321 agcaagttat ggttagtgaa cggacagaag cctttaccac tgctcgaaat ttactggcct
     1381 ctggagctga tgctattgaa aggattatgt cttcatacaa agaggtcact gaattagcag
     1441 gctacactgc tcgagtgtac aatatgtttt gggtctttga tgaagtaaaa agaggcattt
     1501 ataagagaac tgctgtcatt caagaatctg aaagccatag caagaatgga gctaaggtag
     1561 aattacctct cagtgacaca ttggcaatta aaggaaaagt tattgatgtg gatcacggaa
     1621 ttatttgtga aaatgttccc ataattacac cagcaggaga agtggtggct tccaggctaa
     1681 acttcaaagt agaagaagga atgcatcttt tgataactgg tcccaatggt tgtgggaaaa
     1741 gttctctctt cagaattcta agtgggctct ggcctgtgta tgaaggagtc ctctataaac
     1801 cacctcctca acatatgttt tatattccac aaaggccata tatgtctctt ggaagtcttc
     1861 gggatcaagt catttaccct gattcagtgg atgatatgca tgataaaggt tatacagacc
     1921 aagatctgga acgtatccta cacaatgtcc atctctatca catagttcaa agagaaggag
     1981 gatgggatgc tgttatggac tggaaagatg tcctgtcagg aggggaaaag caaagaatgg
     2041 gcatggctcg tatgttttat cataaaccaa aatatgcctt gctggatgaa tgtaccagtg
     2101 ctgtcagcat tgatgtcgaa ggaaagatat ttcaggctgc aaaaggggct ggaatttcct
     2161 tactgtctat aacacacaga ccttctcttt ggaaatacca cacacattta ttacagtttg
     2221 atggtgaagg aggttggcgc tttgaacaat tggatactgc tatccgtttg acattgagtg
     2281 aagaaaaaca aaagctagaa tctcagctag ctggaattcc caaaatgcag cagagactca
     2341 atgaactatg taaaattttg ggagaagact cagtgctgaa aacaattaaa aatgaagatg
     2401 agacatctta atttgttttg acatatttta aaagttaatt attagataaa ggctcaaaga
     2461 cattctgtta tactgcatga agtatgttaa gctaagcaca gagaaaaaaa ggcagcaaga
     2521 catgttttat aagattttag cattaaggaa gtatatgatc tgacttttca gaagaaaata
     2581 aacaaatgca ttatgtaagg tcagtcatta tgacttatac taattcctag tgaaggccta
     2641 atgcacttgt aaaacaggat tttctaggtg aattcatgat gaataccaga tttactatgt
     2701 atatgtggtg tgtctgaagt tcttaacaaa catgggcaat attctggaaa tgaaacaagt
     2761 taaactgagc agcatttggg ttgataccaa gtgcataaga ttcaaacttt gagtgacatt
     2821 tagtccattt atggttgata ttaggtttaa tagctagaat tcaaattgat tattgctagt
     2881 ggccaactaa acctgtacaa aatagctgac agttttataa ataatttcaa tataaaaatt
     2941 gttttaatgg catttgttga aagaaaaaag catggctaaa atgtataaaa tgccatattt
     3001 ttaaattttg gactttaagc atcttaatga gggcatataa caaattaatt ttagtacaaa
     3061 tcttaaatat ttttaataaa tcctttcatt ttaaaaagag aattgccaat acagaaaagg
     3121 agtatccaaa caatgtctca acctgataat ttccttagca gaattaccta ttgcaacttc
     3181 tgttcagaaa tacacagctt gtttttttgc ccaaggatga gtctacattt taagaactgc
     3241 aatggtataa aggaacttaa ggattctgag aatcatagta ataacataca ttggaatagt
     3301 actttataat ttacaatccc catttacatc atttcacctt aatgttgatg acaatgtttt
     3361 gaaacaaata ctatttttcc tactttgctt ttgagaaaat tgacactcag acttgcccta
     3421 atcatgcact ttacttaagg aaagatcgag aaatcaaatg aagttctcct gactctctgg
     3481 tttagtgctc ttttgttatt atcctttaaa tcaaactggg ctataatagc aataaaagtt
     3541 agacgaagtg tagaaaataa aataaatttc ataatgttag tcttattgtt atttggttat
     3601 tgtttacaag aaatgaaaat taagtacaaa gtgcaaagat cattgttctg cggcttaaaa
     3661 tgaaatgaga aagttagtaa atcattcagc aactatgcag tcttactcaa tattaatgta
     3721 cctctaaggc attagcaatg agaagggcaa ataattatgg ttttggtaaa gttaatattt
     3781 attgaacata atgagaaata atctatatgg actagtcata tgaaatagat tttattctat
     3841 ttgtgtgcac tggagctgga aagccaagac tgaaacttta tctcttgctg cctgtgatac
     3901 cacattgaca taccagaaga atattggaat gatcagttgt tagtggccta ggattttatt
     3961 tgcctgttga gacacagcca taatagatgt taagtctgtg attcttagac ttttcaggtg
     4021 atagagtacc tggaagtcat tcataatgat cgttatagaa catcataaca tttctacatt
     4081 ttcaattctg ccatgatagc tagtgtattt ttaattttca ataaatgtaa ccaacttaca
     4141 tgaaggaatg caatataaaa ttataatcag tacatttgtc caacgttttc attagtatta
     4201 tcacctactt attcatcagt tactaatatt tcctgttaga aaagtgaggc aggaattaaa
     4261 gatttttttt taagaagcat ggaaccaaaa cttaaacttg ctaaaaatta ttcattaatc
     4321 ttttctacat aagtgattat ccagtttata ctgctacaag ggcaaaagtc tgaggcaagt
     4381 gttttaagtt aacttttaaa ggtacaagaa gaaaatgaaa aatcctcatg tgaaagatgt
     4441 gtataatttt catgccttaa ttttcataat ataaaaataa aacataattt taaaacaacc
     4501 tgataatttt gttttgaaac attgaaaaga atgccaaaac aaatattaga tttgtaatta
     4561 gtcagtattt aatatatttt acccatgagc taaagcaaaa aagactcatt atttatgatg
     4621 cacaggattc aaagatgcct aaaattctgt attaaaaact atgtacactg taatttaaat
     4681 gttaaagttc taatatgcac atgttttcca tgagcttttt gtgcctattt gttttctgaa
     4741 tttatttttc aggaccaaca tccttaactt ggaagggaaa acatctctga tttgaacttg
     4801 tatttatgta ccattcaatt gtttccaaat ggtccaatgg gtataccata ttttactact
     4861 cttatatttt acggaaaaca tgaaaaagac tgagaaacta gccatttttg aatacagcaa
     4921 gggatagatg aggaaaggaa aaaagaaaga atatttcaag tttcaaacta cttttaccat
     4981 gttatatcta tttgcccaaa cgtttgacat atttttggtc aaacaaaaag ctataagttt
     5041 atggagcttg agtttaaaat gtgcattctt taggttaact cttaaacttg aaaaataagt
     5101 tggattctat gaaaacgttg cattatattt ctacagcatg taatgttatg ccaagcatga
     5161 gtctaaaaca gtttgtgttc ttgtaagcag gataatgtgt aataatccct ctgaaataat
     5221 ctcaagaaga atgatatacc ttaaaactca actcaaattt acatttgttt acagtgggaa
     5281 tggttttctc ttgatagaaa tttggttttt gtctcaagtt ttggtctgtc agtaaaggca
     5341 taaatgaata tcctagtttt tatttgaaac attggttcca agtatagttt catatttggc
     5401 aatagattca tcttattcta atatgtttgg aatagctttt tgattcaatg agtctaggaa
     5461 aatctgttac acattgaaac ccaagtccag agaatgttac acacttctaa tatatgcata
     5521 aaatgatggt aaaggttatt aaatcattga tttaaaaaga tgactttgat ataattactt
     5581 tatgggcaaa attgtcctca tttagaagtg aaaagtactt tcacatagcc taggctattt
     5641 acagttctga ttatatacat ttagatatgt tgaatatgtt ttggggttga atatgttttg
     5701 ccacatgagc gccttcaggt ggatgtataa aatatttttt taaaaaccaa tttcttcttc
     5761 attgttgatg cttttcctga ctaccaagtt cagggctggt ttacatttca tattgtgaaa
     5821 ttttcaaaac caatggtcta tttataagcc agaattgtat taatgaaaat gaatgagaaa
     5881 aatgtcctta aaggtaaaaa tcattatgta gctaaatgaa attgtggctg tgtgtgagta
     5941 cattataata taatttccat ctgatgtgta tttacttgaa ctcatcattc cttatgaatt
     6001 ccttaaccat taagaaaaag actagattaa tcaaaggaat tacaaattat tccattttta
     6061 caaaataccc tgtttctata ctgcaaatgg ccatgttggg tatatgtcta tatacgcctt
     6121 acttagacat tgtattgtat ataaccgtgt gtagaactat agacaatagt caccaaatag
     6181 ttatttaaat attaattttc tttattaata caacacattt aataagtatc tacctatgcc
     6241 aggcactgtg ctaagttcta ttactaaata aaatttggtc cctgtccgaa
//
