LOCUS       NM_001377274            8255 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 9 (ABCC9),
            transcript variant 5, mRNA.
ACCESSION   NM_001377274
VERSION     NM_001377274.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8255)
  AUTHORS   Efthymiou,S., Scala,M., Nagaraj,V., Ochenkowska,K., Komdeur,F.L.,
            Liang,R.A., Abdel-Hamid,M.S., Sultan,T., Baroy,T., Van Ghelue,M.,
            Vona,B., Maroofian,R., Zafar,F., Alkuraya,F.S., Zaki,M.S.,
            Severino,M., Duru,K.C., Tryon,R.C., Brauteset,L.V., Ansari,M.,
            Hamilton,M., van Haelst,M.M., van Haaften,G., Zara,F., Houlden,H.,
            Samarut,E., Nichols,C.G., Smeland,M.F. and McClenaghan,C.
  TITLE     Novel loss-of-function variants expand ABCC9-related intellectual
            disability and myopathy syndrome
  JOURNAL   Brain 147 (5), 1822-1836 (2024)
   PUBMED   38217872
  REMARK    GeneRIF: Novel loss-of-function variants expand ABCC9-related
            intellectual disability and myopathy syndrome.
REFERENCE   2  (bases 1 to 8255)
  AUTHORS   Sung,M.W., Yang,Z., Driggers,C.M., Patton,B.L., Mostofian,B.,
            Russo,J.D., Zuckerman,D.M. and Shyng,S.L.
  TITLE     Vascular KATP channel structural dynamics reveal regulatory
            mechanism by Mg-nucleotides
  JOURNAL   Proc Natl Acad Sci U S A 118 (44) (2021)
   PUBMED   34711681
  REMARK    GeneRIF: Vascular KATP channel structural dynamics reveal
            regulatory mechanism by Mg-nucleotides.
REFERENCE   3  (bases 1 to 8255)
  AUTHORS   Scala,R., Maqoud,F., Zizzo,N., Passantino,G., Mele,A.,
            Camerino,G.M., McClenaghan,C., Harter,T.M., Nichols,C.G. and
            Tricarico,D.
  TITLE     Consequences of SUR2[A478V] Mutation in Skeletal Muscle of Murine
            Model of Cantu Syndrome
  JOURNAL   Cells 10 (7), 1791 (2021)
   PUBMED   34359961
  REMARK    GeneRIF: Consequences of SUR2[A478V] Mutation in Skeletal Muscle of
            Murine Model of Cantu Syndrome.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8255)
  AUTHORS   Bienengraeber,M., Olson,T.M., Selivanov,V.A., Kathmann,E.C.,
            O'Cochlain,F., Gao,F., Karger,A.B., Ballew,J.D., Hodgson,D.M.,
            Zingman,L.V., Pang,Y.P., Alekseev,A.E. and Terzic,A.
  TITLE     ABCC9 mutations identified in human dilated cardiomyopathy disrupt
            catalytic KATP channel gating
  JOURNAL   Nat Genet 36 (4), 382-387 (2004)
   PUBMED   15034580
  REMARK    GeneRIF: role of mutation in human dilated cardiomyopathy and
            effect on KATP channel gating
REFERENCE   5  (bases 1 to 8255)
  AUTHORS   Davis-Taber,R., Choi,W., Feng,J., Hoogenboom,L., McNally,T.,
            Kroeger,P., Shieh,C.C., Simmer,R., Brioni,J.D., Sullivan,J.P.,
            Gopalakrishnan,M. and Scott,V.E.
  TITLE     Molecular characterization of human SUR2-containing K(ATP) channels
  JOURNAL   Gene 256 (1-2), 261-270 (2000)
   PUBMED   11054556
REFERENCE   6  (bases 1 to 8255)
  AUTHORS   Shindo,T., Yamada,M., Isomoto,S., Horio,Y. and Kurachi,Y.
  TITLE     SUR2 subtype (A and B)-dependent differential activation of the
            cloned ATP-sensitive K+ channels by pinacidil and nicorandil
  JOURNAL   Br J Pharmacol 124 (5), 985-991 (1998)
   PUBMED   9692785
REFERENCE   7  (bases 1 to 8255)
  AUTHORS   Aguilar-Bryan,L., Clement,J.P. 4th, Gonzalez,G., Kunjilwar,K.,
            Babenko,A. and Bryan,J.
  TITLE     Toward understanding the assembly and structure of KATP channels
  JOURNAL   Physiol Rev 78 (1), 227-245 (1998)
   PUBMED   9457174
  REMARK    Review article
REFERENCE   8  (bases 1 to 8255)
  AUTHORS   Grange,D.K., Nichols,C.G. and Singh,G.K.
  TITLE     Cantu Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   25275207
REFERENCE   9  (bases 1 to 8255)
  AUTHORS   Brugada,R., Campuzano,O., Sarquella-Brugada,G., Brugada,P.,
            Brugada,J. and Hong,K.
  TITLE     Brugada Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301690
REFERENCE   10 (bases 1 to 8255)
  AUTHORS   Hershberger,R.E. and Jordan,E.
  TITLE     Dilated Cardiomyopathy Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301486
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084806.14, AC008250.23,
            KF570253.1, KF459680.1 and KF495813.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein is thought to form
            ATP-sensitive potassium channels in cardiac, skeletal, and vascular
            and non-vascular smooth muscle. Protein structure suggests a role
            as the drug-binding channel-modulating subunit of the
            extra-pancreatic ATP-sensitive potassium channels. Mutations in
            this gene are associated with cardiomyopathy dilated type 1O.
            Alternative splicing results in multiple transcript variants.
            [provided by RefSeq, Apr 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.262476.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-227               AC084806.14        41846-42072
            228-343             AC084806.14        42447-42562
            344-505             AC084806.14        46578-46739
            506-647             AC084806.14        49349-49490
            648-769             AC084806.14        57209-57330
            770-964             AC008250.23        136444-136638       c
            965-1117            KF570253.1         223-375             c
            1118-1273           KF459680.1         179-334             c
            1274-1408           AC008250.23        131649-131783       c
            1409-1571           AC008250.23        129698-129860       c
            1572-1612           AC008250.23        118847-118887       c
            1613-1755           AC008250.23        117604-117746       c
            1756-1864           AC008250.23        111398-111506       c
            1865-1972           AC008250.23        106338-106445       c
            1973-2045           AC008250.23        99226-99298         c
            2046-2151           AC008250.23        96197-96302         c
            2152-2190           KF495813.1         230-268
            2191-2289           AC008250.23        86525-86623         c
            2290-2374           AC008250.23        84543-84627         c
            2375-2455           AC008250.23        83158-83238         c
            2456-2593           AC008250.23        75940-76077         c
            2594-2719           AC008250.23        75669-75794         c
            2720-2816           AC008250.23        71722-71818         c
            2817-3046           AC008250.23        69175-69404         c
            3047-3195           AC008250.23        68339-68487         c
            3196-3265           AC008250.23        68055-68124         c
            3266-3423           AC008250.23        65886-66043         c
            3424-3516           AC008250.23        61650-61742         c
            3517-3619           AC008250.23        52530-52632         c
            3620-3721           AC008250.23        41722-41823         c
            3722-3842           AC008250.23        40759-40879         c
            3843-3973           AC008250.23        39335-39465         c
            3974-4052           AC008250.23        38216-38294         c
            4053-4161           AC008250.23        35621-35729         c
            4162-4265           AC008250.23        33424-33527         c
            4266-4399           AC008250.23        30918-31051         c
            4400-4462           AC008250.23        29570-29632         c
            4463-8255           AC008250.23        20961-24753         c
FEATURES             Location/Qualifiers
     source          1..8255
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p12.1"
     gene            1..8255
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /note="ATP binding cassette subfamily C member 9"
                     /db_xref="GeneID:10060"
                     /db_xref="HGNC:HGNC:60"
                     /db_xref="MIM:601439"
     exon            1..227
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            228..343
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..505
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            506..647
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            648..769
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..964
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             818..4600
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     ATP-binding cassette transporter sub-family C member 9;
                     sulfonylurea receptor 2; ATP-binding cassette, sub-family
                     C (CFTR/MRP), member 9"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 9
                     isoform 5"
                     /protein_id="NP_001364203.1"
                     /db_xref="GeneID:10060"
                     /db_xref="HGNC:HGNC:60"
                     /db_xref="MIM:601439"
                     /translation="MYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGT
                     NNTTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAM
                     IYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILL
                     YNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLK
                     LYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGN
                     NLKPAEAFASLSLFHILVTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTG
                     ESSLPFESCKKHTGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFS
                     WGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESE
                     PSFEATRRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLL
                     PFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGI
                     LKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWKTL
                     MNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVM
                     RLRTKMPWKTCWRYLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGK
                     ADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTT
                     PLGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVA
                     FYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTD
                     TNNIAYLFLSAANRWLEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNY
                     LNWVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCV
                     RYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDI
                     SKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLP
                     GGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMT
                     AFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRADM"
     exon            965..1117
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1118..1273
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..1408
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1409..1571
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1572..1612
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1755
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1756..1864
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1972
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2045
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2046..2151
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2152..2190
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2191..2289
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2374
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..2455
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2456..2593
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2594..2719
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2816
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            2817..3046
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3195
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3196..3265
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3266..3423
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3424..3516
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3517..3619
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3620..3721
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3722..3842
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3843..3973
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            3974..4052
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4053..4161
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4162..4265
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4266..4399
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4400..4462
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     exon            4463..8255
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8229..8234
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /note="hexamer: ATTAAA"
     polyA_site      8255
                     /gene="ABCC9"
                     /gene_synonym="ABC37; ATFB12; CANTU; CMD1O; IDMYS; SUR2"
                     /note="major polyA site"
ORIGIN      
        1 gtcaaagctg agcagagcag ggatggggaa ggtctccggc cccaggcgcg gcgcgcgggg
       61 cttctgccca gtttcctgct tctcagccgc ggtgtctgcc ccggcccaga gcagtctgtg
      121 caatttagaa actcgatagg aggcagcagc tggtctccca ccaccctaaa aataatccgt
      181 tccggcgcac tgcgtgcttc gcctagggga ggaaaactgt catcggagag ttctgcgtcc
      241 gggtttgaaa tttacatctt aagacagtgt aggaagtcgg tgttttgaag gtagctcaag
      301 tgcaccggca ggggtttgaa gcagcgtgaa gctattgccc aagagtaaac catataagaa
      361 gaaatgagcc tttcattttg tggtaacaac atttcttcat ataatatcaa cgatggtgta
      421 ctacaaaatt cctgctttgt ggatgccctc aacctggtcc ctcatgtctt tctgttgttt
      481 atcacttttc caatattgtt tattgggtgg gggagccaaa gctcaaaagt acaaattcac
      541 cacaacacat ggcttcattt tccgggacat aacctgagat ggattcttac attcgctctc
      601 ctgtttgtgc atgtctgtga aatagcagaa ggcattgttt cagactcgcg gcgggaatca
      661 aggcacctcc acctctttat gccagccgtg atgggattcg ttgccactac aacatcgata
      721 gtgtattatc ataatatcga aacatcaaat tttcctaaat tacttttaga aaaaagttgc
      781 agatcatcca aatcggactc catctatatg gcttgcaatg tacagagctt ttgggcgacc
      841 aattctactt agtagcacat tccgctatct ggctgattta ctgggttttg ctggacctct
      901 ttgtatttct ggaatagttc agcgtgtgaa tgaaacccag aatgggacaa ataacacaac
      961 tggaatttca gaaaccctct catcaaagga atttcttgaa aacgcttacg ttctagcagt
     1021 tcttctcttc ttggctctta ttctgcaaag gacatttttg caggcttcct actatgtaac
     1081 catagagact ggcattaacc tccgtggagc tctgctggcc atgatttata ataaaatcct
     1141 taggctctct acgtctaact tatccatggg ggagatgact ctggggcaga tcaacaactt
     1201 agtcgccatt gaaactaatc aactcatgtg gtttttgttc ctgtgtccca atctatgggc
     1261 tatgcctgtt cagatcataa tgggcgtgat tctgctctat aatttacttg gatcaagtgc
     1321 attggtcggt gcagctgtca ttgtgctcct tgcgccaatt cagtacttta ttgctacaaa
     1381 gttggcagag gctcagaaaa gtacacttga ttattccact gagagactca agaaaacaaa
     1441 tgaaatattg aaaggcatca aacttctaaa attgtatgcc tgggaacaca ttttctgcaa
     1501 aagtgtggag gaaacaagaa tgaaagaact atctagtctc aaaacctttg cactatatac
     1561 atcactctcc atcttcatga atgcagcaat tcccatagca gctgttcttg ctacatttgt
     1621 gacccatgcg tatgccagtg gaaacaatct gaaacctgca gaggcctttg cttcactgtc
     1681 tctcttccat atcctggtca caccactgtt cctgctctcc acggtggtca gatttgcagt
     1741 caaagccatc ataagtgttc aaaagctgaa tgagtttctc ttgagtgatg agattggtga
     1801 cgacagttgg cgaactggtg aaagttcgct tccttttgag tcctgtaaga agcacactgg
     1861 agttcagcca aaaactataa acaggaaaca gcctggaaga tatcacctgg acagctatga
     1921 gcaatcaaca cggcgtctac gtcccgcaga aacagaggac attgcaataa aggtcacaaa
     1981 tggatacttt tcatggggca gtggtttagc tacattatcc aatatagata ttcgaattcc
     2041 aacaggtcag ttaaccatga ttgtgggcca agtaggatgt gggaagtcct ctcttctcct
     2101 tgccatcctc ggtgagatgc agacattgga aggaaaagtt cactggagca atgtaaatga
     2161 atctgagcct tcttttgaag caaccagaag gaacaggtac tctgtggcat atgcagctca
     2221 aaagccttgg ctattaaatg ctacagtaga agaaaatatt acttttggaa gtccttttaa
     2281 caaacagagg tacaaagctg tcacagatgc ctgttctctt cagccagata ttgacttatt
     2341 accatttgga gatcaaactg aaattggaga gaggggcatc aacctgagtg ggggacagag
     2401 gcagagaatc tgtgtggcac gagcgctgta tcaaaacacc aacattgtct ttttggatga
     2461 tccattctca gccctggaca ttcacttgag tgatcattta atgcaggagg ggattttgaa
     2521 attcctgcaa gatgacaaaa ggacactcgt tcttgtgact cacaaattac agtatctgac
     2581 gcatgctgac tggatcatag ccatgaaaga tggaagtgtc ctaagagaag gaactttgaa
     2641 ggacattcaa accaaagatg ttgagcttta tgaacactgg aaaacactta tgaatcggca
     2701 agatcaagaa ttagaaaagg atatggaagc tgaccaaact actttagaga ggaaaactct
     2761 ccgacgggcc atgtattcaa gagaagccaa agcccagatg gaggacgaag acgaagagga
     2821 agaagaggag gaagatgagg atgataacat gtccactgta atgaggctca ggactaaaat
     2881 gccatggaaa acctgctggc gctacctgac atctggagga ttcttcctgc tcatcctgat
     2941 gattttctct aagcttttga agcattcggt cattgtagct atagactatt ggctggccac
     3001 atggacatcg gagtacagta taaacaatac tggaaaagct gatcagacct actatgtggc
     3061 tggctttagc atactctgtg gagcaggcat tttcctttgc cttgttacat ccctcactgt
     3121 agaatggatg ggtctcacag ctgccaaaaa tcttcaccac aaccttctca ataagataat
     3181 ccttggacca ataaggtttt ttgataccac acccctggga ctgattctca atcgcttttc
     3241 agctgatact aatatcattg atcagcacat ccctccaacc ttggaatctc taactcgctc
     3301 aacactgctc tgcctgtctg ccattgggat gatttcttat gctactcctg tgttcctggt
     3361 tgctctcctg ccccttggtg ttgcctttta ttttatccag aaatactttc gggttgcctc
     3421 taaggacctc caggaacttg acgatagtac ccagctccct ctgctctgtc acttctcaga
     3481 aacagcagaa ggactcacca ccattcgggc ctttaggcat gaaaccagat ttaaacaacg
     3541 tatgctggaa ctgacggata caaacaacat tgcctactta tttctctcag ctgccaacag
     3601 atggctggag gtcaggacgg attatctggg agcttgcatt gtcctcactg catctatagc
     3661 atccattagt gggtcttcga attctggatt ggtaggcttg ggtcttctgt atgcacttac
     3721 gataaccaat tatttgaatt gggttgtgag gaacttggct gacctggagg tccagatggg
     3781 tgcagtgaag aaggtgaaca gtttcctgac tatggagtca gagaactatg aaggcacaat
     3841 ggatccttct caagttccag aacattggcc acaagaaggg gagatcaaga tacatgatct
     3901 gtgtgtcaga tatgaaaata atctgaaacc tgttcttaag cacgtcaagg cttacatcaa
     3961 acctggacaa aaggtgggca tatgtggtcg cactggcagt gggaaatcat cgttatctct
     4021 ggctttcttc agaatggttg atatatttga tggaaaaatt gtcattgatg ggatagacat
     4081 ttccaaatta ccactgcaca cactacgttc tagactttca atcattctgc aggatccaat
     4141 actattcagt ggttccatta gatttaattt agatccagag tgcaaatgca cagatgacag
     4201 actctgggaa gccttagaaa ttgctcagct gaagaatatg gtcaaatctc tacctggagg
     4261 tctagatgcg gttgtcactg aaggtgggga gaattttagc gttggacaga gacagctatt
     4321 ttgccttgcc agggcctttg tccgcaaaag cagcattctt attatggatg aggcaacagc
     4381 ttccattgac atggccacag agaatatttt gcaaaaagta gtaatgacag cctttgcaga
     4441 ccggaccgtg gtgacaatag ctcatcgagt acacactatt ctgacggcag acctggttat
     4501 tgtgatgaag cgaggaaata ttttagaata tgacactcca gaaagcctct tggctcagga
     4561 aaatggagta tttgcttctt ttgttcgcgc agacatgtga aggagtgtct taaaacaata
     4621 catgtattta aaataatgca gtcataacct aattaatgga tcatcagctt gacctctgta
     4681 aagtggcatc ttaaaacttt tacagatttt tgcacaaaaa gtggacattt atttttcctg
     4741 tttttaaaac agtttttcaa gatattattg cttaatatgt tcattattga tgtttttata
     4801 gtgatccagc cactctagct ttaagaatag ctaggttgta ttaaaacatg taagctactt
     4861 taagtgataa atcaatagct aaagttttct cctaacttta agtctggtaa atatctctca
     4921 ggaatggaag tgtcaatgag tagtcagtat tactatactc ttgtttgtaa gaatatattt
     4981 tccttattgt tggagtctcc agaggttatt ggaaggaata aaaaaggaca tgttttctaa
     5041 cgaaactctc aaattcatta tctacttcat gagaatttat ttgtattcat taacattagt
     5101 aatacctatt tttcttaaga gccttctttt ttcccttttg tttcttgtca ccaagaagtt
     5161 atcacactta tacttattct ataaggccaa agccttatct agaaagatca tgaagagttt
     5221 ggatattttt aaaactatac tcgaattttc attttttcct gtcctgtaaa gagagaattc
     5281 ttaagatatc aggcataatg tatgtacctt ttccagactg aagttcaaag aatgattagg
     5341 ttcaatcttt cagtggcagg ccagctaaac tttctatagt ttaatgatta gctgtggtta
     5401 tgatcttgag ccctaacatg ccacattact caagatttac acaggcaagt gacttcattt
     5461 ggcactgcta ataatggcag gtgaacattc ctctcaggtg tgagatattt cctatgaaac
     5521 agtccactgg caggctggag atatcttaca ctttgaagtt atatatatat aaaacaagtg
     5581 tctatttcta gctgaaagag tttacctctt ctagacattt atgcccaatg gtgtcacaca
     5641 tgatcatttg ctcctgctct aattttaatg tgcatacaaa aaatatacca aaaatgttat
     5701 tgtaatttta atgagcatgt aaagagtgta tcaaaaattg atgggatatt agtgttaggt
     5761 tttgcttaaa tgaaaattaa taaattcaaa aatactaaaa gtcaccttct ttgtcacgtt
     5821 agcaaccagt ttctactatt ctgtgcccat ccagtgtcaa tatcattgat ttctttttca
     5881 tatgaagatc cacatgcatt gtaagattgt gaagatatat aaaattgatg aattaagaga
     5941 aattatgcca ctttcctata gtttctgtgt tctgtttatt gtatggtgta ttcactcttg
     6001 gaaaatatgt aatagttgtg tatccagaat atgtgtcttc acctgaatat ttaatcttta
     6061 tatttacaaa aaaataagtt ccacaagatg gacaaaaatg gtccatgata tttagcttaa
     6121 attgtaacct tttgttgtgt atataaaact tccttggaag aaaataacct tattgttttc
     6181 ttaaagctaa acagaatagg attggtactc attaattatg tcttgcaaat attttctaaa
     6241 aattcaacca ctctcctaaa atggtgttta aatattttgt agggcagaat atgcatattg
     6301 cctgttagca agtaataatt cattctcata gagaaatggg tttttaccca tggaagtaat
     6361 cttttttttt tctttttttt ttttaatttt ttttttaata tactttaagt tttagggtac
     6421 atgtgcacat tgtgcaggtt agttacatat atatacatgt gccatgctgg tgcgctgcac
     6481 ccactaactc gtcatctagc attaggtata tctcccaatg ctatccctcc ccactccccc
     6541 caccccacca cagtccccag agtgtgatat tccccttcct gtgtccatgt gatctcattg
     6601 ttcaattccc acctatgagt gagaatatgc ggtgtttggt tttttgttct tgcgatagtt
     6661 tactgagaat gatggtttcc agtttcatcc atgtccctac aaaggacatg aactcatcat
     6721 tttgtatggc tgcatagtat tccatggtgt atatgtgcca cattttctta atccagtcta
     6781 tcattgttgg acatttgggt tggttccaag tctttgctat tgtgaataat gccgcaataa
     6841 acatacgtgt gcatgtgtct ttatagcagc atgatttata gtcatttggg tatataccca
     6901 gtaatgggat ggctgggtca aatggtattt ctagttctag atccctgagg aatcgccaca
     6961 ctgacttcca caatggttaa actaaagagc ttctgcacag caaaagaaac taccatcaga
     7021 gtgaacaggc aacctacaac atgggagaaa attttcgcaa cctactcatc tgacaaaggg
     7081 ctaatatcca gaatctacaa tgaactcaaa caaatttaca agaaaaaaac aaacaacccc
     7141 atcaaaaagt gggtgaagga catgaacaga cacttctcaa aagaagacat ttatgcagcc
     7201 aaaaaacaca tgaaaaaatg ctcatcatca ctggccatca gagaaatgca aatcaaaacc
     7261 actatgagat atcatctcac accagttaga atggcaatca ttaaaaagtc aggaaacaac
     7321 aggtgctgga gaggatgtgg agaaatagga acacttttac actgttggtg ggactgtaaa
     7381 ctagttcaac cattgtggaa gtaatctttt aatgatattt tcttattata ttgctacagg
     7441 caacatcagt agaagcctat ctagttacac taaactaaag atcacattca ccattcttac
     7501 agccaagtgg ttgctggtcc cctcataact tttagttact taagttgagt aaatgtctaa
     7561 ttgtttacaa actaaattga ctaaataagg tcaaggataa tgtttttcat tgattaacca
     7621 tttattatac atataatcta ttgaatataa aaagattcac cttgaaataa tatttgacta
     7681 tataggtaca tatctgtaaa agatgaccac cttaactaaa tcagatttta catttataaa
     7741 ttttatattt aattagtcaa atcaattttt aaatcataac tccttaatct cataagaagc
     7801 aataaatgca taaagcatta tattaaaata ccagggttac ttatgtcatt gacagggaaa
     7861 agactttgta taaacaatta tgcaccatct atttttgtac tcttactcat gatccattta
     7921 aaagtctact cagctctaga ttagatacca gaagaccctc taagtaactg ataactgaga
     7981 ttcgggacca tgtcttgttt gccattgtgc ccttggaatt taatacaagt gcctaaccca
     8041 cagtagggtt gattgattca ctgattagtt ttactgccat gtgcctataa ctataggtta
     8101 ttctctttcc ttttctatgt tgtgtttatt ctatttattc tctacaatat ataaaatgta
     8161 tttgttctct acaataaatg tgtttattct ctacaatata taaaaacata ttggactact
     8221 attacataat taaattactc ttttatttgc ttaaa
//
