LOCUS       NM_001351297            5305 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8),
            transcript variant 5, mRNA.
ACCESSION   NM_001351297 XM_017018200
VERSION     NM_001351297.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5305)
  AUTHORS   Patton,B.L., Zhu,P., ElSheikh,A., Driggers,C.M. and Shyng,S.L.
  TITLE     Dynamic duo: Kir6 and SUR in KATP channel structure and function
  JOURNAL   Channels (Austin) 18 (1), 2327708 (2024)
   PUBMED   38489043
  REMARK    GeneRIF: Dynamic duo: Kir6 and SUR in KATP channel structure and
            function.
            Review article
REFERENCE   2  (bases 1 to 5305)
  AUTHORS   Butnariu,L.I., Bizim,D.A., Paduraru,G., Paduraru,L., Moisa,S.M.,
            Popa,S., Gimiga,N., Ghiga,G., Badescu,M.C., Lupu,A., Vasiliu,I. and
            Trandafir,L.M.
  TITLE     Congenital Hyperinsulinism Caused by Mutations in ABCC8 Gene
            Associated with Early-Onset Neonatal Hypoglycemia: Genetic
            Heterogeneity Correlated with Phenotypic Variability
  JOURNAL   Int J Mol Sci 25 (10), 5533 (2024)
   PUBMED   38791571
  REMARK    GeneRIF: Congenital Hyperinsulinism Caused by Mutations in ABCC8
            Gene Associated with Early-Onset Neonatal Hypoglycemia: Genetic
            Heterogeneity Correlated with Phenotypic Variability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5305)
  AUTHORS   Alp,E., Doguizi,S., Mutlu Icduygu,F., Akgun,E., Sekeroglu,M.A. and
            Ozer,M.A.
  TITLE     An analysis of the relationship between ABCC8 and KCNJ11 gene
            polymorphisms and diabetic retinopathy in Turkish population
  JOURNAL   Ophthalmic Genet 45 (2), 126-132 (2024)
   PUBMED   38411150
  REMARK    GeneRIF: An analysis of the relationship between ABCC8 and KCNJ11
            gene polymorphisms and diabetic retinopathy in Turkish population.
REFERENCE   4  (bases 1 to 5305)
  AUTHORS   Bryan,J., Munoz,A., Zhang,X., Dufer,M., Drews,G., Krippeit-Drews,P.
            and Aguilar-Bryan,L.
  TITLE     ABCC8 and ABCC9: ABC transporters that regulate K+ channels
  JOURNAL   Pflugers Arch 453 (5), 703-718 (2007)
   PUBMED   16897043
  REMARK    Review article
REFERENCE   5  (bases 1 to 5305)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   6  (bases 1 to 5305)
  AUTHORS   Thomas,P.M., Cote,G.J., Wohllk,N., Haddad,B., Mathew,P.M., Rabl,W.,
            Aguilar-Bryan,L., Gagel,R.F. and Bryan,J.
  TITLE     Mutations in the sulfonylurea receptor gene in familial persistent
            hyperinsulinemic hypoglycemia of infancy
  JOURNAL   Science 268 (5209), 426-429 (1995)
   PUBMED   7716548
REFERENCE   7  (bases 1 to 5305)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
REFERENCE   8  (bases 1 to 5305)
  AUTHORS   Naylor,R., Knight Johnson,A. and del Gaudio,D.
  TITLE     Maturity-Onset Diabetes of the Young Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29792621
REFERENCE   9  (bases 1 to 5305)
  AUTHORS   De Leon,D.D. and Pinney,S.E.
  TITLE     Permanent Neonatal Diabetes Mellitus
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301620
REFERENCE   10 (bases 1 to 5305)
  AUTHORS   Gillis,D.
  TITLE     Nonsyndromic Genetic Hyperinsulinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124798.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001351297.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein functions as a modulator of
            ATP-sensitive potassium channels and insulin release. Mutations in
            the ABCC8 gene and deficiencies in the encoded protein have been
            observed in patients with hyperinsulinemic hypoglycemia of infancy,
            an autosomal recessive disorder of unregulated and high insulin
            secretion. Mutations have also been associated with
            non-insulin-dependent diabetes mellitus type II, an autosomal
            dominant disease of defective insulin secretion. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jul 2020].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.181610.1,
                                           SRR1803611.95039.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145313 [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC124798.5         126486-126702       c
            218-359             AC124798.5         124743-124884       c
            360-481             AC124798.5         119958-120079       c
            482-648             AC124798.5         113295-113461       c
            649-888             AC124798.5         111443-111682       c
            889-1077            AC124798.5         110345-110533       c
            1078-1242           AC124798.5         102976-103140       c
            1243-1398           AC124798.5         98373-98528         c
            1399-1533           AC124798.5         93035-93169         c
            1534-1696           AC124798.5         92577-92739         c
            1697-1737           AC124798.5         82061-82101         c
            1738-1883           AC124798.5         80671-80816         c
            1884-1989           AC124798.5         78422-78527         c
            1990-2106           AC124798.5         78146-78262         c
            2107-2182           AC124798.5         77724-77799         c
            2183-2288           AC124798.5         76906-77011         c
            2289-2321           AC124798.5         66787-66819         c
            2322-2357           AC124798.5         65161-65196         c
            2358-2456           AC124798.5         64369-64467         c
            2457-2541           AC124798.5         63251-63335         c
            2542-2622           AC124798.5         62523-62603         c
            2623-2760           AC124798.5         60373-60510         c
            2761-2886           AC124798.5         58249-58374         c
            2887-2986           AC124798.5         57211-57310         c
            2987-3228           AC124798.5         56745-56986         c
            3229-3395           AC124798.5         56479-56645         c
            3396-3465           AC124798.5         55351-55420         c
            3466-3623           AC124798.5         54369-54526         c
            3624-3716           AC124798.5         52518-52610         c
            3717-3819           AC124798.5         48196-48298         c
            3820-3933           AC124798.5         47541-47654         c
            3934-4054           AC124798.5         47050-47170         c
            4055-4185           AC124798.5         46773-46903         c
            4186-4264           AC124798.5         45709-45787         c
            4265-4373           AC124798.5         45467-45575         c
            4374-4477           AC124798.5         45029-45132         c
            4478-4611           AC124798.5         44123-44256         c
            4612-4674           AC124798.5         43554-43616         c
            4675-5305           AC124798.5         42355-42985         c
FEATURES             Location/Qualifiers
     source          1..5305
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..5305
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="ATP binding cassette subfamily C member 8"
                     /db_xref="GeneID:6833"
                     /db_xref="HGNC:HGNC:59"
                     /db_xref="MIM:600509"
     exon            1..217
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..4812
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="isoform 5 is encoded by transcript variant 5;
                     sulfonylurea receptor (hyperinsulinemia); ATP-binding
                     cassette transporter sub-family C member 8; sulfonylurea
                     receptor 1; ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 5"
                     /protein_id="NP_001338226.1"
                     /db_xref="CCDS:CCDS86184.1"
                     /db_xref="GeneID:6833"
                     /db_xref="HGNC:HGNC:59"
                     /db_xref="MIM:600509"
                     /translation="MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITF
                     PILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESH
                     HLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDH
                     AIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFL
                     QPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQRKD
                     IQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQ
                     PKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQT
                     KIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVIL
                     LYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLL
                     KLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFK
                     EADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCA
                     PHEPTPQGPASKYQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMG
                     GYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSS
                     LPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYK
                     MVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFS
                     ALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKD
                     FQRSECQLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEE
                     EEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDY
                     WLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTG
                     LKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTL
                     LCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAE
                     TVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA
                     VTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTE
                     AESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGR
                     TGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRF
                     NLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAF
                     VRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKR
                     GAILEFDKPEKLLSRKDSVFASFVRADK"
     exon            218..359
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..481
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..648
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..888
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            889..1077
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1078..1242
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1398
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1533
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1534..1696
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1737
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1883
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1884..1989
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1990..2106
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2182
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2183..2288
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2289..2321
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2357
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2456
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2457..2541
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2542..2622
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2623..2760
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2761..2886
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2887..2986
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2987..3228
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3229..3395
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3396..3465
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3466..3623
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3624..3716
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3717..3819
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3820..3933
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3934..4054
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4055..4185
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4186..4264
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4265..4373
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4374..4477
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..4611
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4612..4674
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4675..5305
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4894..4899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="hexamer: AATAAA"
     polyA_site      4918
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgg caggcgcgcg gagccagcgg agccagctga gcccgagccc agcccgcgcc
       61 cgcgccgcca tgcccctggc cttctgcggc agcgagaacc actcggccgc ctaccgggtg
      121 gaccaggggg tcctcaacaa cggctgcttt gtggacgcgc tcaacgtggt gccgcacgtc
      181 ttcctactct tcatcacctt ccccatcctc ttcattggat ggggaagtca gagctccaag
      241 gtgcacatcc accacagcac atggcttcat ttccctgggc acaacctgcg gtggatcctg
      301 accttcatgc tgctcttcgt cctggtgtgt gagattgcag agggcatcct gtctgatggg
      361 gtgaccgaat cccaccatct gcacctgtac atgccagccg ggatggcgtt catggctgct
      421 gtcacctccg tggtctacta tcacaacatc gagacttcca acttccccaa gctgctaatt
      481 gccctgctgg tgtattggac cctggccttc atcaccaaga ccatcaagtt tgtcaagttc
      541 ttggaccacg ccatcggctt ctcgcagcta cgcttctgcc tcacagggct gctggtgatc
      601 ctctatggga tgctgctcct cgtggaggtc aatgtcatca gggtgaggag atacatcttc
      661 ttcaagacac cgagggaggt gaagcctccc gaggacctgc aagacctggg ggtacgcttc
      721 ctgcagccct tcgtgaatct gctgtccaaa ggcacctact ggtggatgaa cgccttcatc
      781 aagactgccc acaagaagcc catcgacttg cgagccatcg ggaagctgcc catcgccatg
      841 agggccctca ccaactacca acggctctgc gaggcctttg acgcccagcg gaaggacatt
      901 cagggcactc aaggtgcccg ggccatctgg caggcactca gccatgcctt cgggaggcgc
      961 ctggtcctca gcagcacttt ccgcatcttg gccgacctgc tgggcttcgc cgggccactg
     1021 tgcatctttg ggatcgtgga ccaccttggg aaggagaacg acgtcttcca gcccaagaca
     1081 caatttctcg gggtttactt tgtctcatcc caagagttcc ttgccaatgc ctacgtctta
     1141 gctgtgcttc tgttccttgc cctcctactg caaaggacat ttctgcaagc atcctactat
     1201 gtggccattg aaactggaat taacttgaga ggagcaatac agaccaagat ttacaataaa
     1261 attatgcacc tgtccacctc caacctgtcc atgggagaaa tgactgctgg acagatctgt
     1321 aatctggttg ccatcgacac caatcagctc atgtggtttt tcttcttgtg cccaaacctc
     1381 tgggctatgc cagtacagat cattgtgggt gtgattctcc tctactacat actcggagtc
     1441 agtgccttaa ttggagcagc tgtcatcatt ctactggctc ctgtccagta cttcgtggcc
     1501 accaagctgt ctcaggccca gcggagcaca ctggagtatt ccaatgagcg gctgaagcag
     1561 accaacgaga tgctccgcgg catcaagctg ctgaagctgt acgcctggga gaacatcttc
     1621 cgcacgcggg tggagacgac ccgcaggaag gagatgacca gcctcagggc ctttgccatc
     1681 tatacctcca tctccatttt catgaacacg gccatcccca ttgcagctgt cctcataact
     1741 ttcgtgggcc acgtcagctt cttcaaagag gccgacttct cgccctccgt ggcctttgcc
     1801 tccctctccc tcttccatat cttggtcaca ccgctgttcc tgctgtccag tgtggtccga
     1861 tctaccgtca aagctctagt gagcgtgcaa aagctaagcg agttcctgtc cagtgcagag
     1921 atccgtgagg agcagtgtgc cccccatgag cccacacctc agggcccagc cagcaagtac
     1981 caggcggtgc ccctcagggt tgtgaaccgc aagcgtccag cccgggagga ttgtcggggc
     2041 ctcaccggcc cactgcagag cctggtcccc agtgcagatg gcgatgctga caactgctgt
     2101 gtccagatca tgggaggcta cttcacgtgg accccagatg gaatccccac actgtccaac
     2161 atcaccattc gtatcccccg aggccagctg actatgatcg tggggcaggt gggctgcggc
     2221 aagtcctcgc tccttctagc cgcactgggg gagatgcaga aggtctcagg ggctgtcttc
     2281 tggagcagcc ttcctgacag cgagatagga gaggacccca gcccagagcg ggagacagcg
     2341 accgacttgg atatcaggaa gagaggcccc gtggcctatg cttcgcagaa accatggctg
     2401 ctaaatgcca ctgtggagga gaacatcatc tttgagagtc ccttcaacaa acaacggtac
     2461 aagatggtca ttgaagcctg ctctctgcag ccagacatcg acatcctgcc ccatggagac
     2521 cagacccaga ttggggaacg gggcatcaac ctgtctggtg gtcaacgcca gcgaatcagt
     2581 gtggcccgag ccctctacca gcacgccaac gttgtcttct tggatgaccc cttctcagct
     2641 ctggatatcc atctgagtga ccacttaatg caggccggca tccttgagct gctccgggac
     2701 gacaagagga cagtggtctt agtgacccac aagctacagt acctgcccca tgcagactgg
     2761 atcattgcca tgaaggatgg caccatccag agggagggta ccctcaagga cttccagagg
     2821 tctgaatgcc agctctttga gcactggaag accctcatga accgacagga ccaagagctg
     2881 gagaaggaga ctgtcacaga gagaaaagcc acagagccac cccagggcct atctcgtgcc
     2941 atgtcctcga gggatggcct tctgcaggat gaggaagagg aggaagagga ggcagctgag
     3001 agcgaggagg atgacaacct gtcgtccatg ctgcaccagc gtgctgagat cccatggcga
     3061 gcctgcgcca agtacctgtc ctccgccggc atcctgctcc tgtcgttgct ggtcttctca
     3121 cagctgctca agcacatggt cctggtggcc atcgactact ggctggccaa gtggaccgac
     3181 agcgccctga ccctgacccc tgcagccagg aactgctccc tcagccagga gtgcaccctc
     3241 gaccagactg tctatgccat ggtgttcacg gtgctctgca gcctgggcat tgtgctgtgc
     3301 ctcgtcacgt ctgtcactgt ggagtggaca gggctgaagg tggccaagag actgcaccgc
     3361 agcctgctaa accggatcat cctagccccc atgaggtttt ttgagaccac gccccttggg
     3421 agcatcctga acagattttc atctgactgt aacaccatcg accagcacat cccatccacg
     3481 ctggagtgcc tgagccgctc caccctgctc tgtgtctcag ccctggccgt catctcctat
     3541 gtcacacctg tgttcctcgt ggccctcttg cccctggcca tcgtgtgcta cttcatccag
     3601 aagtacttcc gggtggcgtc cagggacctg cagcagctgg atgacaccac ccagcttcca
     3661 cttctctcac actttgccga aaccgtagaa ggactcacca ccatccgggc cttcaggtat
     3721 gaggcccggt tccagcagaa gcttctcgaa tacacagact ccaacaacat tgcttccctc
     3781 ttcctcacag ctgccaacag atggctggaa gtccgaatgg agtacatcgg tgcatgtgtg
     3841 gtgctcatcg cagcggtgac ctccatctcc aactccctgc acagggagct ctctgctggc
     3901 ctggtgggcc tgggccttac ctacgcccta atggtctcca actacctcaa ctggatggtg
     3961 aggaacctgg cagacatgga gctccagctg ggggctgtga agcgcatcca tgggctcctg
     4021 aaaaccgagg cagagagcta cgaggggctc ctggcaccat cgctgatccc aaagaactgg
     4081 ccagaccaag ggaagatcca gatccagaac ctgagcgtgc gctacgacag ctccctgaag
     4141 ccggtgctga agcacgtcaa tgccctcatc gcccctggac agaagatcgg gatctgcggc
     4201 cgcaccggca gtgggaagtc ctccttctct cttgccttct tccgcatggt ggacacgttc
     4261 gaagggcaca tcatcattga tggcattgac atcgccaaac tgccgctgca caccctgcgc
     4321 tcacgcctct ccatcatcct gcaggacccc gtcctcttca gcggcaccat ccgatttaac
     4381 ctggaccctg agaggaagtg ctcagatagc acactgtggg aggccctgga aatcgcccag
     4441 ctgaagctgg tggtgaaggc actgccagga ggcctcgatg ccatcatcac agaaggcggg
     4501 gagaatttca gccagggaca gaggcagctg ttctgcctgg cccgggcctt cgtgaggaag
     4561 accagcatct tcatcatgga cgaggccacg gcttccattg acatggccac ggaaaacatc
     4621 ctccaaaagg tggtgatgac agccttcgca gaccgcactg tggtcaccat cgcgcatcga
     4681 gtgcacacca tcctgagtgc agacctggtg atcgtcctga agcggggtgc catccttgag
     4741 ttcgataagc cagagaagct gctcagccgg aaggacagcg tcttcgcctc cttcgtccgt
     4801 gcagacaagt gacctgccag agcccaagtg ccatcccaca ttcggaccct gcccataccc
     4861 ctgcctgggt tttctaactg taaatcactt gtaaataaat agatttgatt atttcctact
     4921 agaggcccta agtctggtgg gcaggggctg gcggtggatg gtgggttcag tagaaccagc
     4981 ctggctctga catcaggcag aagctgtgtg agcaaaagcc tgcttcctta cctgtgaaat
     5041 gaggcctcta ttagtcagcc aggctgccac aacaacatat cacagactgg gtggctttaa
     5101 aacagacttt tttctcacag ttctggaggc tgaagtctgg gatcaaggtg ttggcaggtt
     5161 tggtttctcc tgaggcctct ctccttggct tgcagagggc tgccttctgg ctgtgtgctc
     5221 acatgacctt tactctgtgc acatgcatcc ctgctttctc tctgtgtctt aaaaggacac
     5281 cagtcatatt ggattagggc cccac
//
