LOCUS       NM_001351295            5374 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens ATP binding cassette subfamily C member 8 (ABCC8),
            transcript variant 3, mRNA.
ACCESSION   NM_001351295 XM_017018198
VERSION     NM_001351295.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5374)
  AUTHORS   Patton,B.L., Zhu,P., ElSheikh,A., Driggers,C.M. and Shyng,S.L.
  TITLE     Dynamic duo: Kir6 and SUR in KATP channel structure and function
  JOURNAL   Channels (Austin) 18 (1), 2327708 (2024)
   PUBMED   38489043
  REMARK    GeneRIF: Dynamic duo: Kir6 and SUR in KATP channel structure and
            function.
            Review article
REFERENCE   2  (bases 1 to 5374)
  AUTHORS   Butnariu,L.I., Bizim,D.A., Paduraru,G., Paduraru,L., Moisa,S.M.,
            Popa,S., Gimiga,N., Ghiga,G., Badescu,M.C., Lupu,A., Vasiliu,I. and
            Trandafir,L.M.
  TITLE     Congenital Hyperinsulinism Caused by Mutations in ABCC8 Gene
            Associated with Early-Onset Neonatal Hypoglycemia: Genetic
            Heterogeneity Correlated with Phenotypic Variability
  JOURNAL   Int J Mol Sci 25 (10), 5533 (2024)
   PUBMED   38791571
  REMARK    GeneRIF: Congenital Hyperinsulinism Caused by Mutations in ABCC8
            Gene Associated with Early-Onset Neonatal Hypoglycemia: Genetic
            Heterogeneity Correlated with Phenotypic Variability.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5374)
  AUTHORS   Alp,E., Doguizi,S., Mutlu Icduygu,F., Akgun,E., Sekeroglu,M.A. and
            Ozer,M.A.
  TITLE     An analysis of the relationship between ABCC8 and KCNJ11 gene
            polymorphisms and diabetic retinopathy in Turkish population
  JOURNAL   Ophthalmic Genet 45 (2), 126-132 (2024)
   PUBMED   38411150
  REMARK    GeneRIF: An analysis of the relationship between ABCC8 and KCNJ11
            gene polymorphisms and diabetic retinopathy in Turkish population.
REFERENCE   4  (bases 1 to 5374)
  AUTHORS   Bryan,J., Munoz,A., Zhang,X., Dufer,M., Drews,G., Krippeit-Drews,P.
            and Aguilar-Bryan,L.
  TITLE     ABCC8 and ABCC9: ABC transporters that regulate K+ channels
  JOURNAL   Pflugers Arch 453 (5), 703-718 (2007)
   PUBMED   16897043
  REMARK    Review article
REFERENCE   5  (bases 1 to 5374)
  AUTHORS   Inagaki,N., Gonoi,T., Clement,J.P. 4th, Namba,N., Inazawa,J.,
            Gonzalez,G., Aguilar-Bryan,L., Seino,S. and Bryan,J.
  TITLE     Reconstitution of IKATP: an inward rectifier subunit plus the
            sulfonylurea receptor
  JOURNAL   Science 270 (5239), 1166-1170 (1995)
   PUBMED   7502040
REFERENCE   6  (bases 1 to 5374)
  AUTHORS   Thomas,P.M., Cote,G.J., Wohllk,N., Haddad,B., Mathew,P.M., Rabl,W.,
            Aguilar-Bryan,L., Gagel,R.F. and Bryan,J.
  TITLE     Mutations in the sulfonylurea receptor gene in familial persistent
            hyperinsulinemic hypoglycemia of infancy
  JOURNAL   Science 268 (5209), 426-429 (1995)
   PUBMED   7716548
REFERENCE   7  (bases 1 to 5374)
  AUTHORS   Aguilar-Bryan,L., Nichols,C.G., Wechsler,S.W., Clement,J.P. 4th,
            Boyd,A.E. 3rd, Gonzalez,G., Herrera-Sosa,H., Nguy,K., Bryan,J. and
            Nelson,D.A.
  TITLE     Cloning of the beta cell high-affinity sulfonylurea receptor: a
            regulator of insulin secretion
  JOURNAL   Science 268 (5209), 423-426 (1995)
   PUBMED   7716547
REFERENCE   8  (bases 1 to 5374)
  AUTHORS   Naylor,R., Knight Johnson,A. and del Gaudio,D.
  TITLE     Maturity-Onset Diabetes of the Young Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   29792621
REFERENCE   9  (bases 1 to 5374)
  AUTHORS   De Leon,D.D. and Pinney,S.E.
  TITLE     Permanent Neonatal Diabetes Mellitus
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301620
REFERENCE   10 (bases 1 to 5374)
  AUTHORS   Gillis,D.
  TITLE     Nonsyndromic Genetic Hyperinsulinism Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301549
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC124798.5.
            
            On Jun 2, 2019 this sequence version replaced NM_001351295.1.
            
            Summary: The protein encoded by this gene is a member of the
            superfamily of ATP-binding cassette (ABC) transporters. ABC
            proteins transport various molecules across extra- and
            intra-cellular membranes. ABC genes are divided into seven distinct
            subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This
            protein is a member of the MRP subfamily which is involved in
            multi-drug resistance. This protein functions as a modulator of
            ATP-sensitive potassium channels and insulin release. Mutations in
            the ABCC8 gene and deficiencies in the encoded protein have been
            observed in patients with hyperinsulinemic hypoglycemia of infancy,
            an autosomal recessive disorder of unregulated and high insulin
            secretion. Mutations have also been associated with
            non-insulin-dependent diabetes mellitus type II, an autosomal
            dominant disease of defective insulin secretion. Alternatively
            spliced transcript variants have been found for this gene.
            [provided by RefSeq, Jul 2020].
            
            Transcript Variant: This variant (3) encodes the longest isoform
            (3).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.132101.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC124798.5         126486-126702       c
            218-359             AC124798.5         124743-124884       c
            360-481             AC124798.5         119958-120079       c
            482-648             AC124798.5         113295-113461       c
            649-891             AC124798.5         111440-111682       c
            892-1080            AC124798.5         110345-110533       c
            1081-1245           AC124798.5         102976-103140       c
            1246-1401           AC124798.5         98373-98528         c
            1402-1536           AC124798.5         93035-93169         c
            1537-1699           AC124798.5         92577-92739         c
            1700-1740           AC124798.5         82061-82101         c
            1741-1886           AC124798.5         80671-80816         c
            1887-1992           AC124798.5         78422-78527         c
            1993-2175           AC124798.5         78146-78328         c
            2176-2251           AC124798.5         77724-77799         c
            2252-2357           AC124798.5         76906-77011         c
            2358-2390           AC124798.5         66787-66819         c
            2391-2426           AC124798.5         65161-65196         c
            2427-2525           AC124798.5         64369-64467         c
            2526-2610           AC124798.5         63251-63335         c
            2611-2691           AC124798.5         62523-62603         c
            2692-2829           AC124798.5         60373-60510         c
            2830-2955           AC124798.5         58249-58374         c
            2956-3055           AC124798.5         57211-57310         c
            3056-3297           AC124798.5         56745-56986         c
            3298-3464           AC124798.5         56479-56645         c
            3465-3534           AC124798.5         55351-55420         c
            3535-3692           AC124798.5         54369-54526         c
            3693-3785           AC124798.5         52518-52610         c
            3786-3888           AC124798.5         48196-48298         c
            3889-4002           AC124798.5         47541-47654         c
            4003-4123           AC124798.5         47050-47170         c
            4124-4254           AC124798.5         46773-46903         c
            4255-4333           AC124798.5         45709-45787         c
            4334-4442           AC124798.5         45467-45575         c
            4443-4546           AC124798.5         45029-45132         c
            4547-4680           AC124798.5         44123-44256         c
            4681-4743           AC124798.5         43554-43616         c
            4744-5374           AC124798.5         42355-42985         c
FEATURES             Location/Qualifiers
     source          1..5374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.1"
     gene            1..5374
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="ATP binding cassette subfamily C member 8"
                     /db_xref="GeneID:6833"
                     /db_xref="HGNC:HGNC:59"
                     /db_xref="MIM:600509"
     exon            1..217
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             70..4881
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     sulfonylurea receptor (hyperinsulinemia); ATP-binding
                     cassette transporter sub-family C member 8; sulfonylurea
                     receptor 1; ATP-binding cassette, sub-family C (CFTR/MRP),
                     member 8"
                     /codon_start=1
                     /product="ATP-binding cassette sub-family C member 8
                     isoform 3"
                     /protein_id="NP_001338224.1"
                     /db_xref="CCDS:CCDS86183.1"
                     /db_xref="GeneID:6833"
                     /db_xref="HGNC:HGNC:59"
                     /db_xref="MIM:600509"
                     /translation="MPLAFCGSENHSAAYRVDQGVLNNGCFVDALNVVPHVFLLFITF
                     PILFIGWGSQSSKVHIHHSTWLHFPGHNLRWILTFMLLFVLVCEIAEGILSDGVTESH
                     HLHLYMPAGMAFMAAVTSVVYYHNIETSNFPKLLIALLVYWTLAFITKTIKFVKFLDH
                     AIGFSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDLQDLGVRFL
                     QPFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRK
                     DIQGTQGARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVF
                     QPKTQFLGVYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQ
                     TKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVI
                     LLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKL
                     LKLYAWENIFRTRVETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFF
                     KEADFSPSVAFASLSLFHILVTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQC
                     APHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQPLRVVNRKRPAREDCRGLT
                     GPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLSNITIRIPRGQLTMIVGQVGCG
                     KSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVAYASQKP
                     WLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR
                     QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQY
                     LPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQELEKETVTERKATE
                     PPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSSAG
                     ILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMV
                     FTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRF
                     SSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVALLPLAIVCYFIQKYFR
                     VASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFL
                     TAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNWMV
                     RNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRYDSS
                     LKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPL
                     HTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDA
                     IITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADR
                     TVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVFASFVRADK"
     exon            218..359
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            360..481
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            482..648
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            649..891
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            892..1080
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1245
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1246..1401
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1402..1536
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1699
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1700..1740
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1886
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1992
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1993..2175
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2251
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2252..2357
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2358..2390
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2391..2426
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2427..2525
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2526..2610
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2611..2691
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2692..2829
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2830..2955
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2956..3055
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3056..3297
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3298..3464
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3465..3534
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3535..3692
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3693..3785
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3786..3888
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            3889..4002
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4003..4123
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4124..4254
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4255..4333
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4334..4442
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4443..4546
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4547..4680
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4681..4743
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     exon            4744..5374
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4963..4968
                     /regulatory_class="polyA_signal_sequence"
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="hexamer: AATAAA"
     polyA_site      4987
                     /gene="ABCC8"
                     /gene_synonym="ABC36; HHF1; HI; HRINS; MRP8; PHHI; PNDM3;
                     SUR; SUR1; SUR1delta2; TNDM2"
                     /note="major polyA site"
ORIGIN      
        1 agaggcgcgg caggcgcgcg gagccagcgg agccagctga gcccgagccc agcccgcgcc
       61 cgcgccgcca tgcccctggc cttctgcggc agcgagaacc actcggccgc ctaccgggtg
      121 gaccaggggg tcctcaacaa cggctgcttt gtggacgcgc tcaacgtggt gccgcacgtc
      181 ttcctactct tcatcacctt ccccatcctc ttcattggat ggggaagtca gagctccaag
      241 gtgcacatcc accacagcac atggcttcat ttccctgggc acaacctgcg gtggatcctg
      301 accttcatgc tgctcttcgt cctggtgtgt gagattgcag agggcatcct gtctgatggg
      361 gtgaccgaat cccaccatct gcacctgtac atgccagccg ggatggcgtt catggctgct
      421 gtcacctccg tggtctacta tcacaacatc gagacttcca acttccccaa gctgctaatt
      481 gccctgctgg tgtattggac cctggccttc atcaccaaga ccatcaagtt tgtcaagttc
      541 ttggaccacg ccatcggctt ctcgcagcta cgcttctgcc tcacagggct gctggtgatc
      601 ctctatggga tgctgctcct cgtggaggtc aatgtcatca gggtgaggag atacatcttc
      661 ttcaagacac cgagggaggt gaagcctccc gaggacctgc aagacctggg ggtacgcttc
      721 ctgcagccct tcgtgaatct gctgtccaaa ggcacctact ggtggatgaa cgccttcatc
      781 aagactgccc acaagaagcc catcgacttg cgagccatcg ggaagctgcc catcgccatg
      841 agggccctca ccaactacca acggctctgc gaggcctttg acgcccaggt gcggaaggac
      901 attcagggca ctcaaggtgc ccgggccatc tggcaggcac tcagccatgc cttcgggagg
      961 cgcctggtcc tcagcagcac tttccgcatc ttggccgacc tgctgggctt cgccgggcca
     1021 ctgtgcatct ttgggatcgt ggaccacctt gggaaggaga acgacgtctt ccagcccaag
     1081 acacaatttc tcggggttta ctttgtctca tcccaagagt tccttgccaa tgcctacgtc
     1141 ttagctgtgc ttctgttcct tgccctccta ctgcaaagga catttctgca agcatcctac
     1201 tatgtggcca ttgaaactgg aattaacttg agaggagcaa tacagaccaa gatttacaat
     1261 aaaattatgc acctgtccac ctccaacctg tccatgggag aaatgactgc tggacagatc
     1321 tgtaatctgg ttgccatcga caccaatcag ctcatgtggt ttttcttctt gtgcccaaac
     1381 ctctgggcta tgccagtaca gatcattgtg ggtgtgattc tcctctacta catactcgga
     1441 gtcagtgcct taattggagc agctgtcatc attctactgg ctcctgtcca gtacttcgtg
     1501 gccaccaagc tgtctcaggc ccagcggagc acactggagt attccaatga gcggctgaag
     1561 cagaccaacg agatgctccg cggcatcaag ctgctgaagc tgtacgcctg ggagaacatc
     1621 ttccgcacgc gggtggagac gacccgcagg aaggagatga ccagcctcag ggcctttgcc
     1681 atctatacct ccatctccat tttcatgaac acggccatcc ccattgcagc tgtcctcata
     1741 actttcgtgg gccacgtcag cttcttcaaa gaggccgact tctcgccctc cgtggccttt
     1801 gcctccctct ccctcttcca tatcttggtc acaccgctgt tcctgctgtc cagtgtggtc
     1861 cgatctaccg tcaaagctct agtgagcgtg caaaagctaa gcgagttcct gtccagtgca
     1921 gagatccgtg aggagcagtg tgccccccat gagcccacac ctcagggccc agccagcaag
     1981 taccaggcgg tggaagaggg gctcccttcc ctacacagct cccagcccag tgggtcctca
     2041 cctccaaacc acccccagcc cctcagggtt gtgaaccgca agcgtccagc ccgggaggat
     2101 tgtcggggcc tcaccggccc actgcagagc ctggtcccca gtgcagatgg cgatgctgac
     2161 aactgctgtg tccagatcat gggaggctac ttcacgtgga ccccagatgg aatccccaca
     2221 ctgtccaaca tcaccattcg tatcccccga ggccagctga ctatgatcgt ggggcaggtg
     2281 ggctgcggca agtcctcgct ccttctagcc gcactggggg agatgcagaa ggtctcaggg
     2341 gctgtcttct ggagcagcct tcctgacagc gagataggag aggaccccag cccagagcgg
     2401 gagacagcga ccgacttgga tatcaggaag agaggccccg tggcctatgc ttcgcagaaa
     2461 ccatggctgc taaatgccac tgtggaggag aacatcatct ttgagagtcc cttcaacaaa
     2521 caacggtaca agatggtcat tgaagcctgc tctctgcagc cagacatcga catcctgccc
     2581 catggagacc agacccagat tggggaacgg ggcatcaacc tgtctggtgg tcaacgccag
     2641 cgaatcagtg tggcccgagc cctctaccag cacgccaacg ttgtcttctt ggatgacccc
     2701 ttctcagctc tggatatcca tctgagtgac cacttaatgc aggccggcat ccttgagctg
     2761 ctccgggacg acaagaggac agtggtctta gtgacccaca agctacagta cctgccccat
     2821 gcagactgga tcattgccat gaaggatggc accatccaga gggagggtac cctcaaggac
     2881 ttccagaggt ctgaatgcca gctctttgag cactggaaga ccctcatgaa ccgacaggac
     2941 caagagctgg agaaggagac tgtcacagag agaaaagcca cagagccacc ccagggccta
     3001 tctcgtgcca tgtcctcgag ggatggcctt ctgcaggatg aggaagagga ggaagaggag
     3061 gcagctgaga gcgaggagga tgacaacctg tcgtccatgc tgcaccagcg tgctgagatc
     3121 ccatggcgag cctgcgccaa gtacctgtcc tccgccggca tcctgctcct gtcgttgctg
     3181 gtcttctcac agctgctcaa gcacatggtc ctggtggcca tcgactactg gctggccaag
     3241 tggaccgaca gcgccctgac cctgacccct gcagccagga actgctccct cagccaggag
     3301 tgcaccctcg accagactgt ctatgccatg gtgttcacgg tgctctgcag cctgggcatt
     3361 gtgctgtgcc tcgtcacgtc tgtcactgtg gagtggacag ggctgaaggt ggccaagaga
     3421 ctgcaccgca gcctgctaaa ccggatcatc ctagccccca tgaggttttt tgagaccacg
     3481 ccccttggga gcatcctgaa cagattttca tctgactgta acaccatcga ccagcacatc
     3541 ccatccacgc tggagtgcct gagccgctcc accctgctct gtgtctcagc cctggccgtc
     3601 atctcctatg tcacacctgt gttcctcgtg gccctcttgc ccctggccat cgtgtgctac
     3661 ttcatccaga agtacttccg ggtggcgtcc agggacctgc agcagctgga tgacaccacc
     3721 cagcttccac ttctctcaca ctttgccgaa accgtagaag gactcaccac catccgggcc
     3781 ttcaggtatg aggcccggtt ccagcagaag cttctcgaat acacagactc caacaacatt
     3841 gcttccctct tcctcacagc tgccaacaga tggctggaag tccgaatgga gtacatcggt
     3901 gcatgtgtgg tgctcatcgc agcggtgacc tccatctcca actccctgca cagggagctc
     3961 tctgctggcc tggtgggcct gggccttacc tacgccctaa tggtctccaa ctacctcaac
     4021 tggatggtga ggaacctggc agacatggag ctccagctgg gggctgtgaa gcgcatccat
     4081 gggctcctga aaaccgaggc agagagctac gaggggctcc tggcaccatc gctgatccca
     4141 aagaactggc cagaccaagg gaagatccag atccagaacc tgagcgtgcg ctacgacagc
     4201 tccctgaagc cggtgctgaa gcacgtcaat gccctcatcg cccctggaca gaagatcggg
     4261 atctgcggcc gcaccggcag tgggaagtcc tccttctctc ttgccttctt ccgcatggtg
     4321 gacacgttcg aagggcacat catcattgat ggcattgaca tcgccaaact gccgctgcac
     4381 accctgcgct cacgcctctc catcatcctg caggaccccg tcctcttcag cggcaccatc
     4441 cgatttaacc tggaccctga gaggaagtgc tcagatagca cactgtggga ggccctggaa
     4501 atcgcccagc tgaagctggt ggtgaaggca ctgccaggag gcctcgatgc catcatcaca
     4561 gaaggcgggg agaatttcag ccagggacag aggcagctgt tctgcctggc ccgggccttc
     4621 gtgaggaaga ccagcatctt catcatggac gaggccacgg cttccattga catggccacg
     4681 gaaaacatcc tccaaaaggt ggtgatgaca gccttcgcag accgcactgt ggtcaccatc
     4741 gcgcatcgag tgcacaccat cctgagtgca gacctggtga tcgtcctgaa gcggggtgcc
     4801 atccttgagt tcgataagcc agagaagctg ctcagccgga aggacagcgt cttcgcctcc
     4861 ttcgtccgtg cagacaagtg acctgccaga gcccaagtgc catcccacat tcggaccctg
     4921 cccatacccc tgcctgggtt ttctaactgt aaatcacttg taaataaata gatttgatta
     4981 tttcctacta gaggccctaa gtctggtggg caggggctgg cggtggatgg tgggttcagt
     5041 agaaccagcc tggctctgac atcaggcaga agctgtgtga gcaaaagcct gcttccttac
     5101 ctgtgaaatg aggcctctat tagtcagcca ggctgccaca acaacatatc acagactggg
     5161 tggctttaaa acagactttt ttctcacagt tctggaggct gaagtctggg atcaaggtgt
     5221 tggcaggttt ggtttctcct gaggcctctc tccttggctt gcagagggct gccttctggc
     5281 tgtgtgctca catgaccttt actctgtgca catgcatccc tgctttctct ctgtgtctta
     5341 aaaggacacc agtcatattg gattagggcc ccac
//
